Výsledky vyhledávání - Jadhav, Vasant

Zeptomole detection of a viral nucleic acid using a target-activated ribozyme Autor VAISH, NARENDRA K., JADHAV, VASANT R., KOSSEN, KARL, PASKO, CHRISTOPHER, ANDREWS, LORI E., MCSWIGGEN, JAMES A., POLISKY, BARRY, SEIWERT, SCOTT D.

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Intratracheal Administration of siRNA Triggers mRNA Silencing in the Lung to Modulate T Cell Immune Response and Lung Inflammation Autor Ng, Bruce, Cash-Mason, Tanesha, Wang, Yi, Seitzer, Jessica, Burchard, Julja, Brown, Duncan, Dudkin, Vadim, Davide, Joseph, Jadhav, Vasant, Sepp-Lorenzino, Laura, Cejas, Pedro J.

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Computational Design and Experimental Characterization of Peptides Intended for pH-Dependent Membrane Insertion and Pore Formation Autor Zhang, Yao, Bartz, René, Grigoryan, Gevorg, Bryant, Michael, Aaronson, Jeff, Beck, Stephen, Innocent, Nathalie, Klein, Lee, Procopio, William, Tucker, Tom, Jadhav, Vasant, Tellers, David M., DeGrado, William F.

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Silencing Myostatin Using Cholesterol-conjugated siRNAs Induces Muscle Growth Autor Khan, Tayeba, Weber, Hans, DiMuzio, Jillian, Matter, Andrea, Dogdas, Belma, Shah, Tosha, Thankappan, Anil, Disa, Jyoti, Jadhav, Vasant, Lubbers, Laura, Sepp-Lorenzino, Laura, Strapps, Walter R, Tadin-Strapps, Marija

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Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates Autor Foster, Donald J., Brown, Christopher R., Shaikh, Sarfraz, Trapp, Casey, Schlegel, Mark K., Qian, Kun, Sehgal, Alfica, Rajeev, Kallanthottathil G., Jadhav, Vasant, Manoharan, Muthiah, Kuchimanchi, Satya, Maier, Martin A., Milstein, Stuart

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Molecular Umbrella Conjugate for the Ocular Delivery of siRNA Autor Janout, Vaclav, Cline, Lauren L., Feuston, Bradley P., Klein, Lee, O’Brien, Ann, Tucker, Tom, Yuan, Yu, O’Neill-Davis, Lynn A., Peiffer, Robert L., Nerurkar, Sandhya S., Jadhav, Vasant, Tellers, David M., Regen, Steven L.

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Evaluation of Efficacy, Biodistribution, and Inflammation for a Potent siRNA Nanoparticle: Effect of Dexamethasone Co-treatment Autor Abrams, Marc T, Koser, Martin L, Seitzer, Jessica, Williams, Stephanie C, DiPietro, Martha A, Wang, Weimin, Shaw, Andrew W, Mao, Xianzhi, Jadhav, Vasant, Davide, Joseph P, Burke, Paul A, Sachs, Alan B, Stirdivant, Steven M, Sepp-Lorenzino, Laura

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Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity Autor Janas, Maja M., Schlegel, Mark K., Harbison, Carole E., Yilmaz, Vedat O., Jiang, Yongfeng, Parmar, Rubina, Zlatev, Ivan, Castoreno, Adam, Xu, Huilei, Shulga-Morskaya, Svetlana, Rajeev, Kallanthottathil G., Manoharan, Muthiah, Keirstead, Natalie D., Maier, Martin A., Jadhav, Vasant

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Centyrin ligands for extrahepatic delivery of siRNA Autor Klein, Donna, Goldberg, Shalom, Theile, Christopher S., Dambra, Richard, Haskell, Kathleen, Kuhar, Elise, Lin, Tricia, Parmar, Rubina, Manoharan, Muthiah, Richter, Mark, Wu, Meizhen, Mendrola Zarazowski, Jeannine, Jadhav, Vasant, Maier, Martin A., Sepp-Lorenzino, Laura, O’Neil, Karyn, Dudkin, Vadim

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Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression Autor Willoughby, Jennifer L.S., Chan, Amy, Sehgal, Alfica, Butler, James S., Nair, Jayaprakash K., Racie, Tim, Shulga-Morskaya, Svetlana, Nguyen, Tuyen, Qian, Kun, Yucius, Kristina, Charisse, Klaus, van Berkel, Theo J.C., Manoharan, Muthiah, Rajeev, Kallanthottathil G., Maier, Martin A., Jadhav, Vasant, Zimmermann, Tracy S.

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Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing Autor Jahns, Hartmut, Degaonkar, Rohan, Podbevsek, Peter, Gupta, Swati, Bisbe, Anna, Aluri, Krishna, Szeto, John, Kumar, Pawan, LeBlanc, Sarah, Racie, Tim, Brown, Christopher R, Castoreno, Adam, Guenther, Dale C, Jadhav, Vasant, Maier, Martin A, Plavec, Janez, Egli, Martin, Manoharan, Muthiah, Zlatev, Ivan

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Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates Autor Nair, Jayaprakash K., Attarwala, Husain, Sehgal, Alfica, Wang, Qianfan, Aluri, Krishna, Zhang, Xuemei, Gao, Minggeng, Liu, Ju, Indrakanti, Ramesh, Schofield, Sally, Kretschmer, Philip, Brown, Christopher R., Gupta, Swati, Willoughby, Jennifer L.S., Boshar, Julie A., Jadhav, Vasant, Charisse, Klaus, Zimmermann, Tracy, Fitzgerald, Kevin, Manoharan, Muthiah, Rajeev, Kallanthottathil G., Akinc, Akin, Hutabarat, Renta, Maier, Martin A.

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Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates Autor Brown, Christopher R, Gupta, Swati, Qin, June, Racie, Timothy, He, Guo, Lentini, Scott, Malone, Ryan, Yu, Mikyung, Matsuda, Shigeo, Shulga-Morskaya, Svetlana, Nair, Anil V, Theile, Christopher S, Schmidt, Karyn, Shahraz, Azar, Goel, Varun, Parmar, Rubina G, Zlatev, Ivan, Schlegel, Mark K, Nair, Jayaprakash K, Jayaraman, Muthusamy, Manoharan, Muthiah, Brown, Dennis, Maier, Martin A, Jadhav, Vasant

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Pharmacological Characterization of a Novel ENaCα siRNA (GSK2225745) With Potential for the Treatment of Cystic Fibrosis Autor Clark, Kenneth L, Hughes, Stephen A, Bulsara, Pallav, Coates, Jill, Moores, Kitty, Parry, Joel, Carr, Michael, Mayer, Ruth J, Wilson, Paul, Gruenloh, Chris, Levin, Daren, Darton, Jill, Weber, Wolf-Michael, Sobczak, Katja, Gill, Deborah R, Hyde, Stephen C, Davies, Lee A, Pringle, Ian A, Sumner-Jones, Stephanie G, Jadhav, Vasant, Jamison, Sharon, Strapps, Walter R, Pickering, Victoria, Edbrooke, Mark R

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From bench to bedside: Improving the clinical safety of GalNAc–siRNA conjugates using seed-pairing destabilization Autor Schlegel, Mark K, Janas, Maja M, Jiang, Yongfeng, Barry, Joseph D, Davis, Wendell, Agarwal, Saket, Berman, Daniel, Brown, Christopher R, Castoreno, Adam, LeBlanc, Sarah, Liebow, Abigail, Mayo, Tara, Milstein, Stuart, Nguyen, Tuyen, Shulga-Morskaya, Svetlana, Hyde, Sarah, Schofield, Sally, Szeto, John, Woods, Lauren Blair, Yilmaz, Vedat O, Manoharan, Muthiah, Egli, Martin, Charissé, Klaus, Sepp-Lorenzino, Laura, Haslett, Patrick, Fitzgerald, Kevin, Jadhav, Vasant, Maier, Martin A

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Safety evaluation of 2′-deoxy-2′-fluoro nucleotides in GalNAc-siRNA conjugates Autor Janas, Maja M, Zlatev, Ivan, Liu, Ju, Jiang, Yongfeng, Barros, Scott A, Sutherland, Jessica E, Davis, Wendell P, Liu, Jingxuan, Brown, Christopher R, Liu, Xiumin, Schlegel, Mark K, Blair, Lauren, Zhang, Xuemei, Das, Biplab, Tran, Chris, Aluri, Krishna, Li, Jing, Agarwal, Saket, Indrakanti, Ramesh, Charisse, Klaus, Nair, Jayaprakash, Matsuda, Shigeo, Rajeev, Kallanthottathil G, Zimmermann, Tracy, Sepp-Lorenzino, Laura, Xu, Yuanxin, Akinc, Akin, Fitzgerald, Kevin, Vaishnaw, Akshay K, Smith, Peter F, Manoharan, Muthiah, Jadhav, Vasant, Wu, Jing-Tao, Maier, Martin A

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