Search Results - Jacob A. McPhail

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  1. 1
    The Molecular Basis of Aichi Virus 3A Protein Activation of Phosphatidylinositol 4 Kinase IIIβ, PI4KB, through ACBD3

    The Molecular Basis of Aichi Virus 3A Protein Activation of Phosphatidylinositol 4 Kinase IIIβ, PI4KB, through ACBD3 by Jacob A. McPhail, Erik H. Ottosen, Meredith L. Jenkins, John E. Burke

    Published 2016
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  2. 2
    Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5

    Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5 by Meredith L. Jenkins, Jean Piero Margaria, Jordan TB Stariha, Reece M. Hoffmann, Jacob A. McPhail, David Hamelin, Martin J. Boulanger, Emilio Hirsch, John E. Burke

    Published 2018
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  3. 3
    Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ

    Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ by Florentine U. Rutaganira, M.L. Fowler, Jacob A. McPhail, Michael A. Gelman, Khanh Cong Nguyen, Anming Xiong, Gillian L. Dornan, Brandon Tavshanjian, Jeffrey S. Glenn, Kevan M. Shokat, John E. Burke

    Published 2016
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  4. 4
    Microglia internalize tau monomers and fibrils using distinct receptors but similar mechanisms

    Microglia internalize tau monomers and fibrils using distinct receptors but similar mechanisms by Kristian F. Falkon, Liliana Danford, Eduardo Gutierrez Kuri, Paulina Esquinca‐Moreno, Yaren L. Peña Señeriz, Sabrina Smith, Jessica L. Wickline, Ariel Louwrier, Jacob A. McPhail, N. Sayre, Sarah C. Hopp

    Published 2024
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  5. 5
    (<i>S</i>)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase

    (<i>S</i>)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor... by Denise Rageot, Thomas Bohnacker, Erhan Keleş, Jacob A. McPhail, Reece M. Hoffmann, Anna Melone, Chiara Borsari, Rohitha Sriramaratnam, Alexander Sele, Florent Beaufils, Paul Hebeisen, Doriano Fabbro, Petra Hillmann, John E. Burke, Matthias P. Wymann

    Published 2019
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  6. 6
    Characterization of the c10orf76‐PI4KB complex and its necessity for Golgi PI4P levels and enterovirus replication

    Characterization of the c10orf76‐PI4KB complex and its necessity for Golgi PI4P levels and enterovirus replication by Jacob A. McPhail, Heyrhyoung Lyoo, Joshua Pemberton, Reece M. Hoffmann, Wendy van Elst, Jeroen R. P. M. Strating, Meredith L. Jenkins, Jordan TB Stariha, Cameron J. Powell, Martin J. Boulanger, Tamás Balla, Frank J. M. van Kuppeveld, John E. Burke

    Published 2019
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  7. 7
    UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria

    UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria by Christel Brunschwig, Nina Lawrence, Dale Taylor, Efrem Abay, Mathew Njoroge, Gregory S. Basarab, Claire Le Manach, Tanya Paquet, Diego Gonzàlez Cabrera, Aloysius T. Nchinda, Carmen De Kock, Lubbe Wiesner, Paolo Denti, David Waterson, Benjamin Blasco, Didier Leroy, Michael J. Witty, Cristina Donini, James Duffy, Sergio Wittlin, Karen L. White, Susan A. Charman, Marı́a Belén Jiménez-Dı́az, Íñigo Angulo‐Barturen, Esperanza Herreros, Francisco‐Javier Gamo, Rosemary Rochford, Dalu Mancama, Thérèsa L. Coetzer, Mariëtte van der Watt, Janette Reader, Lyn‐Marié Birkholtz, Kennan C. Marsh, Suresh Solapure, John E. Burke, Jacob A. McPhail, Manu Vanaerschot, David A. Fidock, Paul V. Fish, Peter K. S. Siegl, Dennis A. Smith, Grennady Wirjanata, Rintis Noviyanti, Ric N. Price, Jutta Marfurt, Kigbafori D. Silué, Leslie J. Street, Kelly Chibale

    Published 2018
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  8. 8
    Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

    Diversity-oriented synthesis yields novel multistage antimalarial inhibitors by Nobutaka Kato, Eamon Comer, Tomoyo Sakata‐Kato, Arvind Sharma, Manmohan Sharma, Micah Maetani, Jessica Bastien, Nicolas M. B. Brancucci, Joshua A. Bittker, Victoria Corey, David C. Clarke, Emily R. Derbyshire, Gillian L. Dornan, Sandra Duffy, Sean Eckley, Maurice A. Itoe, Karin M. J. Koolen, Timothy A. Lewis, Ping S. Lui, Amanda K. Lukens, Emily Lund, Sandra March, Elamaran Meibalan, Bennett C. Meier, Jacob A. McPhail, Branko Mitasev, Eli L. Moss, Morgane Sayes, Yvonne Van Gessel, Mathias J. Wawer, Takashi Yoshinaga, Anne‐Marie Zeeman, Vicky M. Avery, Sangeeta N. Bhatia, John E. Burke, Flaminia Catteruccia, Jon Clardy, Paul A. Clemons, Koen J. Dechering, Jeremy R. Duvall, Michael A. Foley, Fabian Gusovsky, Clemens H. M. Kocken, Matthias Marti, Marshall Morningstar, Benito Muñoz, Daniel E. Neafsey, Amit Sharma, Elizabeth A. Winzeler, Dyann F. Wirth, Christina Scherer, Stuart L. Schreiber

    Published 2016
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