Sökresultat - Issam Ben‐Sahra

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  1. 1
    Regulation of nucleotide metabolism in cancers and immune disorders

    Regulation of nucleotide metabolism in cancers and immune disorders av Eunüs S. Ali, Issam Ben‐Sahra

    Publicerad 2023
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  2. 2
    Purifying and profiling lysosomes to expand understanding of lysosomal dysfunction–associated diseases

    Purifying and profiling lysosomes to expand understanding of lysosomal dysfunction–associated diseases av Ali Shilatifard, Issam Ben‐Sahra

    Publicerad 2025
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  3. 3
    mTORC1 signaling and the metabolic control of cell growth

    mTORC1 signaling and the metabolic control of cell growth av Issam Ben‐Sahra, Brendan D. Manning

    Publicerad 2017
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  4. 4
    The combination of metformin and 2 deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells

    The combination of metformin and 2 deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells av Issam Ben Sahra, Jean‐François Tanti, Frédéric Bost

    Publicerad 2010
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  5. 5
    Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides

    Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides av Elodie Villa, Eunüs S. Ali, Umakant Sahu, Issam Ben‐Sahra

    Publicerad 2019
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  6. 6
    Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

    Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1 av Issam Ben‐Sahra, Jessica J. Howell, John M. Asara, Brendan D. Manning

    Publicerad 2013
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  7. 7
    Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP

    Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP av Stéphane J. H. Ricoult, Jessica L. Yecies, Issam Ben‐Sahra, Brendan D. Manning

    Publicerad 2015
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  8. 8
    mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

    mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle av Issam Ben‐Sahra, Gerta Hoxhaj, Stéphane J. H. Ricoult, John M. Asara, Brendan D. Manning

    Publicerad 2016
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  9. 9
    Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death

    Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death av Issam Ben‐Sahra, Béatrice Dirat, Kathiane Laurent, Alexandre Puissant, Patrick Auberger, Andrei V. Budanov, Jean‐François Tanti, Frédéric Bost

    Publicerad 2012
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  10. 10
    The TSC-mTOR pathway regulates macrophage polarization

    The TSC-mTOR pathway regulates macrophage polarization av Vanessa Byles, Anthony J. Covarrubias, Issam Ben‐Sahra, Dudley W. Lamming, David M. Sabatini, Brendan D. Manning, Tiffany Horng

    Publicerad 2013
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  11. 11
    The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels

    The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels av Gerta Hoxhaj, James Hughes-Hallett, Rebecca C. Timson, Erika Ilagan, Min Yuan, John M. Asara, Issam Ben‐Sahra, Brendan D. Manning

    Publicerad 2017
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  12. 12
    ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis

    ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis av Xuesong Liu, Jenna E. Haines, Elie K. Mehanna, Matthew Genet, Issam Ben‐Sahra, John M. Asara, Brendan D. Manning, Zhi-Min Yuan

    Publicerad 2014
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  13. 13
    Acadesine Kills Chronic Myelogenous Leukemia (CML) Cells through PKC-Dependent Induction of Autophagic Cell Death

    Acadesine Kills Chronic Myelogenous Leukemia (CML) Cells through PKC-Dependent Induction of Autophagic Cell Death av Guillaume Robert, Issam Ben Sahra, Alexandre Puissant, Pascal Colosetti, Nathalie Belhacène, Pierre Gounon, Paul Hofman, Frédéric Bost, J.P. Cassuto, Patrick Auberger

    Publicerad 2009
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  14. 14
    Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC–MS/MS

    Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC–MS/MS av Min Yuan, Daniel M. Kremer, He Huang, Susanne B. Breitkopf, Issam Ben‐Sahra, Brendan D. Manning, Costas A. Lyssiotis, John M. Asara

    Publicerad 2019
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  15. 15
    The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

    The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level av Issam Ben Sahra, Kathiane Laurent, Agnès Loubat, Sophie Giorgetti‐Peraldi, Pascal Colosetti, Patrick Auberger, Jean‐François Tanti, Y. Le Marchand‐Brustel, Frédéric Bost

    Publicerad 2008
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  16. 16
    ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis

    ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis av Eunüs S. Ali, Umakant Sahu, Elodie Villa, Brendan P. O’Hara, Peng Gao, Cynthia Beaudet, Antony W. Wood, John M. Asara, Issam Ben‐Sahra

    Publicerad 2020
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  17. 17
    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis

    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis av Elodie Villa, Umakant Sahu, Brendan P. O’Hara, Eunüs S. Ali, Kathryn A. Helmin, John M. Asara, Peng Gao, Benjamin D. Singer, Issam Ben‐Sahra

    Publicerad 2021
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  18. 18
    The hexokinase “HKDC1” interaction with the mitochondria is essential for liver cancer progression

    The hexokinase “HKDC1” interaction with the mitochondria is essential for liver cancer progression av Md. Wasim Khan, Alexander R. Terry, Medha Priyadarshini, Vladimir Ilievski, Zeenat Farooq, Grace Guzman, José Córdoba‐Chacón, Issam Ben‐Sahra, Barton Wicksteed, Brian T. Layden

    Publicerad 2022
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  19. 19
    Hypoxia Decreases Insulin Signaling Pathways in Adipocytes

    Hypoxia Decreases Insulin Signaling Pathways in Adipocytes av Claire Regazzetti, Pascal Peraldi, Thierry Grémeaux, Rosanna Najem-Lendom, Issam Ben‐Sahra, Mireille Cormont, Frédéric Bost, Y. Le Marchand‐Brustel, Jean‐François Tanti, Sophie Giorgetti‐Peraldi

    Publicerad 2008
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  20. 20
    Direct stimulation of NADP <sup>+</sup> synthesis through Akt-mediated phosphorylation of NAD kinase

    Direct stimulation of NADP <sup>+</sup> synthesis through Akt-mediated phosphorylation of NAD kinase av Gerta Hoxhaj, Issam Ben‐Sahra, Sophie E. Lockwood, Rebecca C. Timson, Vanessa Byles, Graham T. Henning, Peng Gao, Laura M. Selfors, John M. Asara, Brendan D. Manning

    Publicerad 2019
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