Søgeresultater - Isaacs, Adrian M

C9orf72 amyotrophic lateral sclerosis and frontotemporal dementia: gain or loss of function? af Mizielinska, Sarah, Isaacs, Adrian M.

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The snowball effect of RNA binding protein dysfunction in amyotrophic lateral sclerosis af Fratta, Pietro, Isaacs, Adrian M

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C9orf72-mediated ALS and FTD: multiple pathways to disease af Balendra, Rubika, Isaacs, Adrian M.

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Progranulin and TMEM106B: when two become wan af Clayton, Emma L, Isaacs, Adrian M

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Specific biomarkers for C9orf72 FTD/ALS could expedite the journey towards effective therapies af Balendra, Rubika, Moens, Thomas G, Isaacs, Adrian M

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Soluble and insoluble dipeptide repeat protein measurements in C9orf72-frontotemporal dementia brains show regional differential solubility and correlation of poly-GR with clinical... af Quaegebeur, Annelies, Glaria, Idoia, Lashley, Tammaryn, Isaacs, Adrian M.

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TDP-43 is a culprit in human neurodegeneration, and not just an innocent bystander af Banks, Gareth T., Kuta, Anna, Isaacs, Adrian M., Fisher, Elizabeth M. C.

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Quantitative analysis of cryptic splicing associated with TDP-43 depletion af Humphrey, Jack, Emmett, Warren, Fratta, Pietro, Isaacs, Adrian M., Plagnol, Vincent

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Acceleration of Amyloid β-Peptide Aggregation by Physiological Concentrations of Calcium af Isaacs, Adrian M., Senn, David B., Yuan, Menglan, Shine, James P., Yankner, Bruce A.

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Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain af Morón-Oset, Javier, Supèr, Tessa, Esser, Jacqueline, Isaacs, Adrian M., Grönke, Sebastian, Partridge, Linda

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Heterogeneous nuclear ribonucleoproteins R and Q accumulate in pathological inclusions in FTLD-FUS af Gittings, Lauren M., Foti, Sandrine C., Benson, Bridget C., Gami-Patel, Priya, Isaacs, Adrian M., Lashley, Tammaryn

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C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms RNA G-quadruplexes af Fratta, Pietro, Mizielinska, Sarah, Nicoll, Andrew J., Zloh, Mire, Fisher, Elizabeth M. C., Parkinson, Gary, Isaacs, Adrian M.

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C9orf72 frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense RNA foci af Mizielinska, Sarah, Lashley, Tammaryn, Norona, Frances E., Clayton, Emma L., Ridler, Charlotte E., Fratta, Pietro, Isaacs, Adrian M.

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Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration af Mizielinska, Sarah, Ridler, Charlotte E., Balendra, Rubika, Thoeng, Annora, Woodling, Nathan S., Grässer, Friedrich A., Plagnol, Vincent, Lashley, Tammaryn, Partridge, Linda, Isaacs, Adrian M.

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The integration site of the APP transgene in the J20 mouse model of Alzheimer’s disease af Tosh, Justin L., Rickman, Matthew, Rhymes, Ellie, Norona, Frances E., Clayton, Emma, Mucke, Lennart, Isaacs, Adrian M., Fisher, Elizabeth M.C., Wiseman, Frances K.

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Frontotemporal dementia causative CHMP2B impairs neuronal endolysosomal traffic-rescue by TMEM106B knockdown af Clayton, Emma L, Milioto, Carmelo, Muralidharan, Bhavana, Norona, Frances E, Edgar, James R, Soriano, Armand, Jafar-nejad, Paymaan, Rigo, Frank, Collinge, John, Isaacs, Adrian M

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Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD af Moens, Thomas G., Mizielinska, Sarah, Niccoli, Teresa, Mitchell, Jamie S., Thoeng, Annora, Ridler, Charlotte E., Grönke, Sebastian, Esser, Jacqueline, Heslegrave, Amanda, Zetterberg, Henrik, Partridge, Linda, Isaacs, Adrian M.

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Symmetric dimethylation of poly-GR correlates with disease duration in C9orf72 FTLD and ALS and reduces poly-GR phase separation and toxicity af Gittings, Lauren M., Boeynaems, Steven, Lightwood, Daniel, Clargo, Alison, Topia, Sarfaraj, Nakayama, Lisa, Troakes, Claire, Mann, David M. A., Gitler, Aaron D., Lashley, Tammaryn, Isaacs, Adrian M.

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Sizing, stabilising, and cloning repeat-expansions for gene targeting constructs af Nair, Remya R., Tibbit, Charlotte, Thompson, David, McLeod, Ross, Nakhuda, Asif, Simon, Michelle M., Baloh, Robert H., Fisher, Elizabeth M.C., Isaacs, Adrian M., Cunningham, Thomas J.

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Regulation of Postsynaptic Function by the Dementia-Related ESCRT-III Subunit CHMP2B af Chassefeyre, Romain, Martínez-Hernández, José, Bertaso, Federica, Bouquier, Nathalie, Blot, Béatrice, Laporte, Marine, Fraboulet, Sandrine, Couté, Yohann, Devoy, Anny, Isaacs, Adrian M., Pernet-Gallay, Karin, Sadoul, Rémy, Fagni, Laurent, Goldberg, Yves

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