Search Results - Ignacio Moraga

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  1. 1
    Receptor Density Is Key to the Alpha2/Beta Interferon Differential Activities

    Receptor Density Is Key to the Alpha2/Beta Interferon Differential Activities by Ignacio Moraga, Daniel Harari, Gideon Schreiber, Gilles Uzé, Sandra Pellegrini

    Published 2009
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  2. 2
    Insights into Cytokine–Receptor Interactions from Cytokine Engineering

    Insights into Cytokine–Receptor Interactions from Cytokine Engineering by Jamie B. Spangler, Ignacio Moraga, Juan L. Mendoza, K. Christopher García

    Published 2014
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  3. 3
    Multifarious Determinants of Cytokine Receptor Signaling Specificity

    Multifarious Determinants of Cytokine Receptor Signaling Specificity by Ignacio Moraga, Jamie B. Spangler, Juan L. Mendoza, K. Christopher García

    Published 2014
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  4. 4
    Structural insights into the assembly and activation of the <scp>IL</scp>‐27 signaling complex

    Structural insights into the assembly and activation of the <scp>IL</scp>‐27 signaling complex by Yibo Jin, Paul K. Fyfe, Scott Gardner, Stephan Wilmes, Doryen Bubeck, Ignacio Moraga

    Published 2022
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  5. 5
    Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers

    Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers by Ignacio Moraga, Jamie B. Spangler, Juan L. Mendoza, Milica Gakovic, Tom S. Wehrman, Peter O. Krutzik, K. Christopher García

    Published 2017
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  6. 6
    Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency

    Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency by Ignacio Moraga, David Richter, Stephan Wilmes, Hauke Winkelmann, Kevin M. Jude, Christoph Thomas, Megan M. Suhoski, Edgar G. Engleman, Jacob Piehler, K. Christopher García

    Published 2015
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  7. 7
    Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses

    Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses by Claire Gorby, Junel Sotolongo Bellón, Stephan Wilmes, Walid Warda, Elizabeth Pöhler, Paul K. Fyfe, Adeline Cozzani, Christophe Ferrand, Mark R. Walter, Suman Mitra, Jacob Piehler, Ignacio Moraga

    Published 2020
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  8. 8
    Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

    Kinetics of cytokine receptor trafficking determine signaling and functional selectivity by Jonathan Martínez‐Fábregas, Stephan Wilmes, Luopin Wang, Maximillian Hafer, Elizabeth Pöhler, Juliane Lokau, Christoph Garbers, Adeline Cozzani, Paul K. Fyfe, Jacob Piehler, Majid Kazemian, Suman Mitra, Ignacio Moraga

    Published 2019
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  9. 9
    Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15

    Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15 by Aaron M. Ring, Jian‐Xin Lin, Dan Feng, Suman Mitra, Mathias Rickert, Gregory R. Bowman, Vijay S. Pande, Peng Li, Ignacio Moraga, Rosanne Spolski, Engin Özkan, Warren J. Leonard, K. Christopher García

    Published 2012
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  10. 10
    Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons

    Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons by Christoph Thomas, Ignacio Moraga, Doron Levin, Peter O. Krutzik, Yulia Podoplelova, Angelica Trejo, Choong-Ho Lee, Ganit Yarden, Susan E. Vleck, Jeffrey S. Glenn, Garry P. Nolan, Jacob Piehler, Gideon Schreiber, K. Christopher García

    Published 2011
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  11. 11
    The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity

    The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity by Juan L. Mendoza, William M. Schneider, Hans-Heinrich Hoffmann, Koen Vercauteren, Kevin M. Jude, Anming Xiong, Ignacio Moraga, Timothy M. Horton, Jeffrey S. Glenn, Ype P. de Jong, Charles M. Rice, K. Christopher García

    Published 2017
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  12. 12
    Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’

    Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’ by Aron M. Levin, D.L. Bates, Aaron M. Ring, Carsten Krieg, Jack T. Lin, Leon Su, Ignacio Moraga, Miro E. Raeber, Gregory R. Bowman, Paul Novick, Vijay S. Pande, C. Garrison Fathman, Onur Boyman, K. Christopher García

    Published 2012
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  13. 13
    Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines

    Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines by Ilkka Junttila, Rémi J. Creusot, Ignacio Moraga, D.L. Bates, Michael T. Wong, Michael N. Alonso, Megan M. Suhoski, Patrick J. Lupardus, Martin Meier‐Schellersheim, Edgar G. Engleman, Paul J. Utz, C. Garrison Fathman, William E. Paul, K. Christopher García

    Published 2012
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  14. 14
    Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands

    Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands by Ignacio Moraga, Gerlinde Wernig, Stephan Wilmes, Vitalina Gryshkova, Christian Richter, Wan‐Jen Hong, Rahul Sinha, Feng Guo, Hyna Fabionar, Tom S. Wehrman, Peter O. Krutzik, Samuel Demharter, Isabelle Plo, Irving L. Weissman, Péter Mináry, Ravindra Majeti, Stefan N. Constantinescu, Jacob Piehler, K. Christopher García

    Published 2015
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  15. 15
    Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations

    Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations by Stephan Wilmes, Maximillian Hafer, Joni Vuorio, Julie A. Tucker, Hauke Winkelmann, Sara Löchte, Tess A. Stanly, Katiuska Daniela Pulgar Prieto, Chetan Poojari, Vivek Sharma, Christian Richter, Rainer Kurre, Stevan R. Hubbard, K. Christopher García, Ignacio Moraga, Ilpo Vattulainen, Ian S. Hitchcock, Jacob Piehler

    Published 2020
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  16. 16
    Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling

    Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling by Chia Chi M. Ho, Akanksha Chhabra, Philipp Starkl, Peter J. Schnorr, Stephan Wilmes, Ignacio Moraga, Hye-Sook Kwon, Nicolas Gaudenzio, Riccardo Sibilano, Tom S. Wehrman, Milica Gakovic, Jonathan T. Sockolosky, Matthew Tiffany, Aaron M. Ring, Jacob Piehler, I L Weissman, Stephen J. Galli, Judith A. Shizuru, K. Christopher García

    Published 2017
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  17. 17
    Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation

    Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation by Ah Ram Kim, Jacob C. Ulirsch, Stephan Wilmes, Ekrem Ünal, Ignacio Moraga, Musa Karakükçü, Daniel Yuan, Shideh Kazerounian, Nour J. Abdulhay, David S. King, Namrata Gupta, Stacey Gabriel, Eric S. Lander, Türkan Patıroğlu, Alper Özcan, Mehmet Akif Özdemir, K. Christopher García, Jacob Piehler, Hanna T. Gazda, Daryl E. Klein, Vijay G. Sankaran

    Published 2017
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  18. 18
    IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein

    IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein by Silvia Gaggero, Jonathan Martínez‐Fábregas, Adeline Cozzani, Paul K. Fyfe, Malo Leprohon, Jie Yang, F. Emil Thomasen, Hauke Winkelmann, Romain Magnez, Alberto G. Conti, Stephan Wilmes, Elizabeth Pöhler, Manuel van Gijsel‐Bonnello, Xavier Thuru, Bruno Quesnel, Fabrice Soncin, Jacob Piehler, Kresten Lindorff‐Larsen, Rahul Roychoudhuri, Ignacio Moraga, Suman Mitra

    Published 2022
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