Rezultati - Howarth, Kimberley

Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation od Svensson, Lena, Howarth, Kimberley, McDowall, Alison, Patzak, Irene, Evans, Rachel, Ussar, Siegfried, Moser, Markus, Metin, Ayse, Fried, Mike, Tomlinson, Ian, Hogg, Nancy

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MUCH OF THE POPULATION GENETIC RISK OF COLORECTAL CANCER IS LIKELY TO BE MEDIATED THROUGH SUSCEPTIBILITY TO ADENOMAS od Carvajal-Carmona, Luis G., Zauber, Ann G., Jones, Angela M., Howarth, Kimberley, Wang, Jiping, Cheng, Timothy, Riddell, Robert, Lanas, Angel, Morton, Dion, Bertagnolli, Monica M., Tomlinson, Ian

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A mitotic recombination map proximal to the APC locus on chromosome 5q and assessment of influences on colorectal cancer risk od Howarth, Kimberley, Ranta, Susanna, Winter, Eitan, Teixeira, Ana, Schaschl, Helmut, Harvey, John J, Rowan, Andrew, Jones, Angela, Spain, Sarah, Clark, Susan, Guenther, Thomas, Stewart, Aengus, Silver, Andrew, Tomlinson, Ian

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Hereditary mixed polyposis syndrome is caused by a 40kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1 od Jaeger, Emma, Leedham, Simon, Lewis, Annabelle, Segditsas, Stefania, Becker, Martin, Cuadrado, Pedro Rodenas, Davis, Hayley, Kaur, Kulvinder, Heinimann, Karl, Howarth, Kimberley, East, James, Taylor, Jenny, Thomas, Huw, Tomlinson, Ian

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DNA polymerase ɛ and δ exonuclease domain mutations in endometrial cancer od Church, David N., Briggs, Sarah E.W., Palles, Claire, Domingo, Enric, Kearsey, Stephen J., Grimes, Jonathon M., Gorman, Maggie, Martin, Lynn, Howarth, Kimberley M., Hodgson, Shirley V., Kaur, Kulvinder, Taylor, Jenny, Tomlinson, Ian P.M.

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A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts od Leedham, Simon J, Rodenas-Cuadrado, Pedro, Howarth, Kimberley, Lewis, Annabelle, Mallappa, Sreelakshmi, Segditsas, Stefania, Davis, Hayley, Jeffery, Rosemary, Rodriguez-Justo, Manuel, Keshav, Satish, Travis, Simon P L, Graham, Trevor A, East, James, Clark, Susan, Tomlinson, Ian P M

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Thyroid cancer susceptibility polymorphisms: confirmation of loci on chromosomes 9q22 and 14q13, validation of a recessive 8q24 locus and failure to replicate a locus on 5q24 od Jones, Angela M, Howarth, Kimberley M, Martin, Lynn, Gorman, Maggie, Mihai, Radu, Moss, Laura, Auton, Adam, Lemon, Catherine, Mehanna, Hisham, Mohan, Hosahalli, Clarke, Susan E M, Wadsley, Jonathan, Macias, Elena, Coatesworth, Andrew, Beasley, Matthew, Roques, Tom, Martin, Craig, Ryan, Paul, Gerrard, Georgina, Power, Danielle, Bremmer, Caroline, Tomlinson, Ian, Carvajal-Carmona, Luis G

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Fine-mapping of colorectal cancer susceptibility loci at 8q23.3, 16q22.1 and 19q13.11: refinement of association signals and use of in silico analysis to suggest functional variati... od Carvajal-Carmona, Luis G., Cazier, Jean-Baptiste, Jones, Angela M., Howarth, Kimberley, Broderick, Peter, Pittman, Alan, Dobbins, Sara, Tenesa, Albert, Farrington, Susan, Prendergast, James, Theodoratou, Evi, Barnetson, Rebecca, Conti, David, Newcomb, Polly, Hopper, John L., Jenkins, Mark A., Gallinger, Steven, Duggan, David J., Campbell, Harry, Kerr, David, Casey, Graham, Houlston, Richard, Dunlop, Malcolm, Tomlinson, Ian

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A candidate gene study of capecitabine-related toxicity in colorectal cancer identifies new toxicity variants at DPYD and a putative role for ENOSF1 rather than TYMS od Rosmarin, Dan, Palles, Claire, Pagnamenta, Alistair, Kaur, Kulvinder, Pita, Guillermo, Martin, Miguel, Domingo, Enric, Jones, Angela, Howarth, Kimberley, Freeman-Mills, Luke, Johnstone, Elaine, Wang, Haitao, Love, Sharon, Scudder, Claire, Julier, Patrick, Fernández-Rozadilla, Ceres, Ruiz-Ponte, Clara, Carracedo, Angel, Castellvi-Bel, Sergi, Castells, Antoni, Gonzalez-Neira, Anna, Taylor, Jenny, Kerr, Rachel, Kerr, David, Tomlinson, Ian

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Association between CASP8 –652 6N Del Polymorphism (rs3834129) and Colorectal Cancer Risk: Results from a Multi-Centric Study od Pardini, Barbara, Verderio, Paolo, Pizzamiglio, Sara, Nici, Carmela, Maiorana, Maria Valeria, Naccarati, Alessio, Vodickova, Ludmila, Vymetalkova, Veronika, Veneroni, Silvia, Daidone, Maria Grazia, Ravagnani, Fernando, Bianchi, Tiziana, Bujanda, Luis, Carracedo, Angel, Castells, Antoni, Ruiz-Ponte, Clara, Morreau, Hans, Howarth, Kimberley, Jones, Angela, Castellví-Bel, Sergi, Li, Li, Tomlinson, Ian, Van Wezel, Tom, Vodicka, Pavel, Radice, Paolo, Peterlongo, Paolo

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Breast cancer susceptibility polymorphisms and endometrial cancer risk: a Collaborative Endometrial Cancer Study od Healey, Catherine S., Ahmed, Shahana, O’Mara, Tracy A., Ferguson, Kaltin, Lambrechts, Diether, Garcia-Dios, Diego A., Vergote, Ignace, Amant, Frederic, Howarth, Kimberley, Gorman, Maggie, Hodgson, Shirley, Tomlinson, Ian, Yang, Hannah P., Lissowska, Jolanta, Brinton, Louise A., Chanock, Stephen, Garcia-Closas, Montserrat, Hall, Per, Liu, Jianjun, Shah, Mitul, Pharoah, Paul D.P., Thompson, Deborah J., Rebbeck, Timothy R., Strom, Brian L., Dunning, Alison M., Easton, Douglas F., Spurdle, Amanda B.

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Refinement of the associations between risk of colorectal cancer and polymorphisms on chromosomes 1q41 and 12q13.13 od Spain, Sarah L., Carvajal-Carmona, Luis G., Howarth, Kimberley M., Jones, Angela M., Su, Zhan, Cazier, Jean-Baptiste, Williams, Jennet, Aaltonen, Lauri A., Pharoah, Paul, Kerr, David J., Cheadle, Jeremy, Li, Li, Casey, Graham, Vodicka, Pavel, Sieber, Oliver, Lipton, Lara, Gibbs, Peter, Martin, Nicholas G., Montgomery, Grant W., Young, Joanne, Baird, Paul N., Morreau, Hans, van Wezel, Tom, Ruiz-Ponte, Clara, Fernandez-Rozadilla, Ceres, Carracedo, Angel, Castells, Antoni, Castellvi-Bel, Sergi, Dunlop, Malcolm, Houlston, Richard S., Tomlinson, Ian P.M.

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Germline mutations in the proof-reading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas od Palles, Claire, Cazier, Jean-Baptiste, Howarth, Kimberley M, Domingo, Enric, Jones, Angela M., Broderick, Peter, Kemp, Zoe, Spain, Sarah L, Almeida, Estrella Guarino, Salguero, Israel, Sherborne, Amy, Chubb, Daniel, Carvajal-Carmona, Luis G, Ma, Yusanne, Kaur, Kulvinder, Dobbins, Sara, Barclay, Ella, Gorman, Maggie, Martin, Lynn, Kovac, Michal B, Humphray, Sean, Lucassen, Anneke, Holmes, Christopher, Bentley, David, Donnelly, Peter, Taylor, Jenny, Petridis, Christos, Roylance, Rebecca, Sawyer, Elinor J, Kerr, David J., Clark, Susan, Grimes, Jonathan, Kearsey, Stephen E, Thomas, Huw JW, McVean, Gilean, Houlston, Richard S, Tomlinson, Ian

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Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution od Kovac, Michal, Navas, Carolina, Horswell, Stuart, Salm, Max, Bardella, Chiara, Rowan, Andrew, Stares, Mark, Castro-Giner, Francesc, Fisher, Rosalie, de Bruin, Elza C., Kovacova, Monika, Gorman, Maggie, Makino, Seiko, Williams, Jennet, Jaeger, Emma, Jones, Angela, Howarth, Kimberley, Larkin, James, Pickering, Lisa, Gore, Martin, Nicol, David L., Hazell, Steven, Stamp, Gordon, O’Brien, Tim, Challacombe, Ben, Matthews, Nik, Phillimore, Benjamin, Begum, Sharmin, Rabinowitz, Adam, Varela, Ignacio, Chandra, Ashish, Horsfield, Catherine, Polson, Alexander, Tran, Maxine, Bhatt, Rupesh, Terracciano, Luigi, Eppenberger-Castori, Serenella, Protheroe, Andrew, Maher, Eamonn, El Bahrawy, Mona, Fleming, Stewart, Ratcliffe, Peter, Heinimann, Karl, Swanton, Charles, Tomlinson, Ian

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Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33 od Houlston, Richard S, Cheadle, Jeremy, Dobbins, Sara E, Tenesa, Albert, Jones, Angela M, Howarth, Kimberley, Spain, Sarah L, Broderick, Peter, Domingo, Enric, Farrington, Susan, Prendergast, James GD, Pittman, Alan M, Theodoratou, Evi, Smith, Christopher G, Olver, Bianca, Walther, Axel, Barnetson, Rebecca A, Churchman, Michael, Jaeger, Emma EM, Penegar, Steven, Barclay, Ella, Martin, Lynn, Gorman, Maggie, Mager, Rachel, Johnstone, Elaine, Midgley, Rachel, Niittymäki, Iina, Tuupanen, Sari, Colley, James, Idziaszczyk, Shelley, Thomas, Huw JM, Lucassen, Anneke M, Evans, D Gareth R, Maher, Eamonn R, Maughan, Timothy, Dimas, Antigone, Dermitzakis, Emmanouil, Cazier, Jean-Baptiste, Aaltonen, Lauri A, Pharoah, Paul, Kerr, David J, Carvajal-Carmona, Luis G, Campbell, Harry, Dunlop, Malcolm G, Tomlinson, Ian PM

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Genome-wide association study identifies a common variant associated with risk of endometrial cancer od Spurdle, Amanda B., Thompson, Deborah J., Ahmed, Shahana, Ferguson, Kaltin, Healey, Catherine S., O’Mara, Tracy, Walker, Logan C., Montgomery, Stephen B., Dermitzakis, Emmanouil T., Fahey, Paul, Montgomery, Grant, Webb, Penelope M., Fasching, Peter A., Beckmann, Matthias W., Ekici, Arif B., Hein, Alexander, Lambrechts, Diether, Coenegrachts, Lieve, Vergote, Ignace, Amant, Frederic, Salvesen, Helga B., Trovik, Jone, Njolstad, Tormund S, Helland, Harald, Scott, Rodney, Ashton, Katie, Proietto, Tony, Otton, Geoffrey, Tomlinson, Ian, Gorman, Maggie, Howarth, Kimberley, Hodgson, Shirley, Garcia-Closas, Montserrat, Wentzensen, Nicolas, Yang, Hannah, Chanock, Stephen, Hall, Per, Czene, Kamila, Liu, Jianjun, Li, Jingmei, Shu, Xiao-Ou, Zheng, Wei, Long, Jirong, Xiang, Yong-Bing, Shah, Mitul, Morrison, Jonathan, Michailidou, Kyriaki, Pharoah, Paul P., Dunning, Alison M., Easton, Douglas F.

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Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21 od Tenesa, Albert, Farrington, Susan M, Prendergast, James GD, Porteous, Mary E, Walker, Marion, Haq, Naila, Barnetson, Rebecca A, Theodoratou, Evropi, Cetnarskyj, Roseanne, Cartwright, Nicola, Semple, Colin, Clark, Andrew J, Reid, Fiona JL, Smith, Lorna A, Kavoussanakis, Kostas, Koessler, Thibaud, Pharoah, Paul DP, Buch, Stephan, Schafmayer, Clemens, Tepel, Jürgen, Schreiber, Stefan, Völzke, Henry, Schmidt, Carsten O, Hampe, Jochen, Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann, Wilkening, Stefan, Canzian, Federico, Capella, Gabriel, Moreno, Victor, Deary, Ian J, Starr, John M, Tomlinson, Ian PM, Kemp, Zoe, Howarth, Kimberley, Carvajal-Carmona, Luis, Webb, Emily, Broderick, Peter, Vijayakrishnan, Jayaram, Houlston, Richard S, Rennert, Gad, Ballinger, Dennis, Rozek, Laura, Gruber, Stephen B, Matsuda, Koichi, Kidokoro, Tomohide, Nakamura, Yusuke, Zanke, Brent W, Greenwood, Celia MT, Rangrej, Jagadish, Kustra, Rafal, Montpetit, Alexandre, Hudson, Thomas J, Gallinger, Steven, Campbell, Harry, Dunlop, Malcolm G

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Multiple Common Susceptibility Variants near BMP Pathway Loci GREM1, BMP4, and BMP2 Explain Part of the Missing Heritability of Colorectal Cancer od Tomlinson, Ian P. M., Carvajal-Carmona, Luis G., Dobbins, Sara E., Tenesa, Albert, Jones, Angela M., Howarth, Kimberley, Palles, Claire, Broderick, Peter, Jaeger, Emma E. M., Farrington, Susan, Lewis, Annabelle, Prendergast, James G. D., Pittman, Alan M., Theodoratou, Evropi, Olver, Bianca, Walker, Marion, Penegar, Steven, Barclay, Ella, Whiffin, Nicola, Martin, Lynn, Ballereau, Stephane, Lloyd, Amy, Gorman, Maggie, Lubbe, Steven, Howie, Bryan, Marchini, Jonathan, Ruiz-Ponte, Clara, Fernandez-Rozadilla, Ceres, Castells, Antoni, Carracedo, Angel, Castellvi-Bel, Sergi, Duggan, David, Conti, David, Cazier, Jean-Baptiste, Campbell, Harry, Sieber, Oliver, Lipton, Lara, Gibbs, Peter, Martin, Nicholas G., Montgomery, Grant W., Young, Joanne, Baird, Paul N., Gallinger, Steven, Newcomb, Polly, Hopper, John, Jenkins, Mark A., Aaltonen, Lauri A., Kerr, David J., Cheadle, Jeremy, Pharoah, Paul, Casey, Graham, Houlston, Richard S., Dunlop, Malcolm G.

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Candidate locus analysis of the TERT–CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk od Carvajal-Carmona, Luis G., O’Mara, Tracy A., Painter, Jodie N., Lose, Felicity A., Dennis, Joe, Michailidou, Kyriaki, Tyrer, Jonathan P., Ahmed, Shahana, Ferguson, Kaltin, Healey, Catherine S., Pooley, Karen, Beesley, Jonathan, Cheng, Timothy, Jones, Angela, Howarth, Kimberley, Martin, Lynn, Gorman, Maggie, Hodgson, Shirley, Wentzensen, Nicholas, Fasching, Peter A., Hein, Alexander, Beckmann, Matthias W., Renner, Stefan P., Dörk, Thilo, Hillemanns, Peter, Dürst, Matthias, Runnebaum, Ingo, Lambrechts, Diether, Coenegrachts, Lieve, Schrauwen, Stefanie, Amant, Frederic, Winterhoff, Boris, Dowdy, Sean C., Goode, Ellen L., Teoman, Attila, Salvesen, Helga B., Trovik, Jone, Njolstad, Tormund S., Werner, Henrica M. J., Scott, Rodney J., Ashton, Katie, Proietto, Tony, Otton, Geoffrey, Wersäll, Ofra, Mints, Miriam, Tham, Emma, Hall, Per, Czene, Kamila, Liu, Jianjun, Li, Jingmei, Hopper, John L., Southey, Melissa C., Ekici, Arif B., Ruebner, Matthias, Johnson, Nichola, Peto, Julian, Burwinkel, Barbara, Marme, Frederik, Brenner, Hermann, Dieffenbach, Aida K., Meindl, Alfons, Brauch, Hiltrud, Lindblom, Annika, Depreeuw, Jeroen, Moisse, Matthieu, Chang-Claude, Jenny, Rudolph, Anja, Couch, Fergus J., Olson, Janet E., Giles, Graham G., Bruinsma, Fiona, Cunningham, Julie M., Fridley, Brooke L., Børresen-Dale, Anne-Lise, Kristensen, Vessela N., Cox, Angela, Swerdlow, Anthony J., Orr, Nicholas, Bolla, Manjeet K., Wang, Qin, Weber, Rachel Palmieri, Chen, Zhihua, Shah, Mitul, Pharoah, Paul D. P., Dunning, Alison M., Tomlinson, Ian, Easton, Douglas F., Spurdle, Amanda B., Thompson, Deborah J.

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Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk od Painter, Jodie N., O'Mara, Tracy A., Batra, Jyotsna, Cheng, Timothy, Lose, Felicity A., Dennis, Joe, Michailidou, Kyriaki, Tyrer, Jonathan P., Ahmed, Shahana, Ferguson, Kaltin, Healey, Catherine S., Kaufmann, Susanne, Hillman, Kristine M., Walpole, Carina, Moya, Leire, Pollock, Pamela, Jones, Angela, Howarth, Kimberley, Martin, Lynn, Gorman, Maggie, Hodgson, Shirley, De Polanco, Ma. Magdalena Echeverry, Sans, Monica, Carracedo, Angel, Castellvi-Bel, Sergi, Rojas-Martinez, Augusto, Santos, Erika, Teixeira, Manuel R., Carvajal-Carmona, Luis, Shu, Xiao-Ou, Long, Jirong, Zheng, Wei, Xiang, Yong-Bing, Montgomery, Grant W., Webb, Penelope M., Scott, Rodney J., McEvoy, Mark, Attia, John, Holliday, Elizabeth, Martin, Nicholas G., Nyholt, Dale R., Henders, Anjali K., Fasching, Peter A., Hein, Alexander, Beckmann, Matthias W., Renner, Stefan P., Dörk, Thilo, Hillemanns, Peter, Dürst, Matthias, Runnebaum, Ingo, Lambrechts, Diether, Coenegrachts, Lieve, Schrauwen, Stefanie, Amant, Frederic, Winterhoff, Boris, Dowdy, Sean C., Goode, Ellen L., Teoman, Attila, Salvesen, Helga B., Trovik, Jone, Njolstad, Tormund S., Werner, Henrica M.J., Ashton, Katie, Proietto, Tony, Otton, Geoffrey, Tzortzatos, Gerasimos, Mints, Miriam, Tham, Emma, Hall, Per, Czene, Kamila, Liu, Jianjun, Li, Jingmei, Hopper, John L., Southey, Melissa C., Ekici, Arif B., Ruebner, Matthias, Johnson, Nicola, Peto, Julian, Burwinkel, Barbara, Marme, Frederik, Brenner, Hermann, Dieffenbach, Aida K., Meindl, Alfons, Brauch, Hiltrud, Lindblom, Annika, Depreeuw, Jeroen, Moisse, Matthieu, Chang-Claude, Jenny, Rudolph, Anja, Couch, Fergus J., Olson, Janet E., Giles, Graham G., Bruinsma, Fiona, Cunningham, Julie M., Fridley, Brooke L., Børresen-Dale, Anne-Lise, Kristensen, Vessela N., Cox, Angela, Swerdlow, Anthony J., Orr, Nicholas, Bolla, Manjeet K., Wang, Qin, Weber, Rachel Palmieri, Chen, Zhihua, Shah, Mitul, French, Juliet D., Pharoah, Paul D.P., Dunning, Alison M., Tomlinson, Ian, Easton, Douglas F., Edwards, Stacey L., Thompson, Deborah J., Spurdle, Amanda B.

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