Search Results - Hiroshi Yasui

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  1. 1
    Novel therapeutic strategies targeting growth factor signalling cascades in multiple myeloma

    Novel therapeutic strategies targeting growth factor signalling cascades in multiple myeloma by Hiroshi Yasui, Teru Hideshima, Paul G. Richardson, Kenneth C. Anderson

    Published 2005
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  2. 2
    Nuclear Export of Glucocorticoid Receptor is Enhanced by c-Jun N-Terminal Kinase-Mediated Phosphorylation

    Nuclear Export of Glucocorticoid Receptor is Enhanced by c-Jun N-Terminal Kinase-Mediated Phosphorylation by Motoyuki Itoh, M Adachi, Hiroshi Yasui, Mutsuhiro Takekawa, Hirotoshi Tanaka, Kohsuke Imai

    Published 2002
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  3. 3
    Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells

    Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells by Teru Hideshima, Laurence Catley, Hiroshi Yasui, Kenji Ishitsuka, Noopur Raje, Constantine S. Mitsiades, Klaus Podar, Nikhil C. Munshi, Dharminder Chauhan, Paul G. Richardson, Kenneth C. Anderson

    Published 2006
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  4. 4
    Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma

    Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma by Noopur Raje, Shaji Kumar, Teru Hideshima, Aldo M. Roccaro, Kenji Ishitsuka, Hiroshi Yasui, Norihiko Shiraishi, Dharminder Chauhan, Nikhil C. Munshi, Simon R. Green, Kenneth C. Anderson

    Published 2005
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  5. 5
    Microbiota-reprogrammed phosphatidylcholine inactivates cytotoxic CD8 T cells through UFMylation via exosomal SerpinB9 in multiple myeloma

    Microbiota-reprogrammed phosphatidylcholine inactivates cytotoxic CD8 T cells through UFMylation via exosomal SerpinB9 in multiple myeloma by Wei Yan, Xue Shi, Zhao Yun, Xiaoyu Liu, Xuewei Jia, Le Gao, Jin Yuan, Liao Ai-jun, Hiroshi Yasui, Xiaobin Wang, Xiaotian Wang, Rui Zhang, Huihan Wang

    Published 2025
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  6. 6
    The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma

    The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma by Klaus Podar, Giovanni Tonon, Martin Sattler, Yu‐Tzu Tai, Steven Le Gouill, Hiroshi Yasui, Kenji Ishitsuka, Shaji Kumar, Rakesh Kumar, Lini Pandite, Teru Hideshima, Dharminder Chauhan, Kenneth C. Anderson

    Published 2006
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  7. 7
    Targeting the β-catenin/TCF transcriptional complex in the treatment of multiple myeloma

    Targeting the β-catenin/TCF transcriptional complex in the treatment of multiple myeloma by Kumar Sukhdeo, Mala Mani, Yunyu Zhang, Jui Dutta, Hiroshi Yasui, Melissa Rooney, Daniel E. Carrasco, Mei Zheng, Haiying He, Yu-Tzu Tai, Constantine Mitsiades, Kenneth C. Anderson, Daniel R. Carrasco

    Published 2007
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  8. 8
    Transforming Growth Factor β Receptor I Kinase Inhibitor Down-Regulates Cytokine Secretion and Multiple Myeloma Cell Growth in the Bone Marrow Microenvironment

    Transforming Growth Factor β Receptor I Kinase Inhibitor Down-Regulates Cytokine Secretion and Multiple Myeloma Cell Growth in the Bone Marrow Microenvironment by Toshiaki Hayashi, Teru Hideshima, Aaron Nguyen, Olivier Munoz, Klaus Podar, Makoto Hamasaki, Kenji Ishitsuka, Hiroshi Yasui, Paul G. Richardson, Sarvajit Chakravarty, Alison Murphy, Dharminder Chauhan, Linda S. Higgins, Kenneth C. Anderson

    Published 2004
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  9. 9
    MLN120B, a Novel IκB Kinase β Inhibitor, Blocks Multiple Myeloma Cell Growth <i>In vitro</i> and <i>In vivo</i>

    MLN120B, a Novel IκB Kinase β Inhibitor, Blocks Multiple Myeloma Cell Growth <i>In vitro</i> and <i>In vivo</i> by Teru Hideshima, Paola Neri, Pierfrancesco Tassone, Hiroshi Yasui, Kenji Ishitsuka, Noopur Raje, Dharminder Chauhan, Klaus Podar, Constantine S. Mitsiades, Lenny Dang, Nikhil C. Munshi, Paul G. Richardson, David P. Schenkein, Kenneth C. Anderson

    Published 2006
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  10. 10
    Genomic Screening for Genes Silenced by DNA Methylation Revealed an Association between RASD1 Inactivation and Dexamethasone Resistance in Multiple Myeloma

    Genomic Screening for Genes Silenced by DNA Methylation Revealed an Association between RASD1 Inactivation and Dexamethasone Resistance in Multiple Myeloma by Masanori Nojima, Reo Maruyama, Hiroshi Yasui, Hiromu Suzuki, Yumiko Maruyama, Isao Tarasawa, Yasushi Sasaki, Hideki Asaoku, Hajime Sakai, Toshiaki Hayashi, Mitsuru Mori, Kohzoh Imai, Takashi Tokino, Tadao Ishida, Minoru Toyota, Yasuhisa Shinomura

    Published 2009
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  11. 11
    SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK

    SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating sign... by Yutaka Okawa, Teru Hideshima, Paul M. Steed, Sonia Vallet, Steven E. Hall, Ken Huang, John W. Rice, Amy F. Barabasz, Brianna Foley, Hiroshi Ikeda, Noopur Raje, Tanyel Kiziltepe, Hiroshi Yasui, Sotaro Enatsu, Kenneth C. Anderson

    Published 2008
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  12. 12
    Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis

    Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis by Kenji Ishitsuka, Teru Hideshima, Makoto Hamasaki, Noopur Raje, Shaji Kumar, Hiromasa Hideshima, Norihiko Shiraishi, Hiroshi Yasui, Aldo M. Roccaro, Paul G. Richardson, Klaus Podar, Steven Le Gouill, Dharminder Chauhan, Kazuo Tamura, Jack L. Arbiser, Kenneth C. Anderson

    Published 2005
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  13. 13
    Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells

    Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells by Teru Hideshima, Laurence Catley, Noopur Raje, Dharminder Chauhan, Klaus Podar, Constantine S. Mitsiades, Yu‐Tzu Tai, Sonia Vallet, Tanyel Kiziltepe, Enrique M. Ocio, Hiroshi Ikeda, Yutaka Okawa, Hiromasa Hideshima, Nikhil C. Munshi, Hiroshi Yasui, Paul G. Richardson, Kenneth C. Anderson

    Published 2007
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  14. 14
    A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

    A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib by Dharminder Chauhan, Laurence Catley, Guilan Li, Klaus Podar, Teru Hideshima, Mugdha Velankar, Constantine S. Mitsiades, Nicholas Mitsiades, Hiroshi Yasui, Anthony Letai, Huib Ovaa, Celia R. Berkers, Benjamin Nicholson, Ta‐Hsiang Chao, Saskia Neuteboom, Paul G. Richardson, Michael A. Palladino, Kenneth C. Anderson

    Published 2005
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  15. 15
    JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells

    JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple... by Tanyel Kiziltepe, Teru Hideshima, Kenji Ishitsuka, Enrique M. Ocio, Noopur Raje, Laurence Catley, Chun-Qi Li, Laura J. Trudel, Hiroshi Yasui, Sonia Vallet, Jeffery L. Kutok, Dharminder Chauhan, Constantine S. Mitsiades, Joseph E. Saavedra, Gerald N. Wogan, Larry K. Keefer, Paul J. Shami, Kenneth C. Anderson

    Published 2007
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  16. 16
    MLN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclasts

    MLN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclasts by Sonia Vallet, Noopur Raje, Kenji Ishitsuka, Teru Hideshima, Klaus Podar, Shweta Chhetri, Samantha Pozzi, Iris Breitkreutz, Tanyel Kiziltepe, Hiroshi Yasui, Enrique M. Ocio, Norihiko Shiraishi, Janice Jin, Yutaka Okawa, Hiroshi Ikeda, Siddhartha Mukherjee, Nileshwari Vaghela, Diana Cirstea, Marco Ladetto, Mario Boccadoro, Kenneth C. Anderson

    Published 2007
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  17. 17
    PI3K/p110δ is a novel therapeutic target in multiple myeloma

    PI3K/p110δ is a novel therapeutic target in multiple myeloma by Hiroshi Ikeda, Teru Hideshima, Mariateresa Fulciniti, Giulia Perrone, Naoya Miura, Hiroshi Yasui, Yutaka Okawa, Tanyel Kiziltepe, Loredana Santo, Sonia Vallet, Diana Cristea, Elisabetta Calabrese, Güllü Görgün, Noopur Raje, Paul G. Richardson, Nikhil C. Munshi, Brian J. Lannutti, Kamal D. Puri, Neill A. Giese, Kenneth C. Anderson

    Published 2010
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  18. 18
    The Monoclonal Antibody nBT062 Conjugated to Cytotoxic Maytansinoids Has Selective Cytotoxicity Against CD138-Positive Multiple Myeloma Cells<i>In vitro</i>and<i>In vivo</i>

    The Monoclonal Antibody nBT062 Conjugated to Cytotoxic Maytansinoids Has Selective Cytotoxicity Against CD138-Positive Multiple Myeloma Cells<i>In vitro</i>and<i>In vivo</i> by Hiroshi Ikeda, Teru Hideshima, Mariateresa Fulciniti, Robert J. Lutz, Hiroshi Yasui, Yutaka Okawa, Tanyel Kiziltepe, Sonia Vallet, Samantha Pozzi, Loredana Santo, Giulia Perrone, Yu‐Tzu Tai, Diana Cirstea, Noopur Raje, Christoph Uherek, Benjamin Dälken, Silke Aigner, Frank Osterroth, Nikhil C. Munshi, Paul G. Richardson, Kenneth C. Anderson

    Published 2009
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  19. 19
    Loss-of-function mutations of CHST14 in a new type of Ehlers-Danlos syndrome

    Loss-of-function mutations of CHST14 in a new type of Ehlers-Danlos syndrome by Noriko Miyake, Tomoki Kosho, Shuji Mizumoto, Tatsuya Furuichi, Atsushi Hatamochi, Yoji Nagashima, Eiichi Arai, Kazuo Takahashi, Rie Kawamura, Keiko Wakui, Jun Takahashi, Hiroyuki Kato, Hiroshi Yasui, Tadao Ishida, Hirofumi Ohashi, Gen Nishimura, Masaaki Shiina, Hirotomo Saitsu, Yoshinori Tsurusaki, Hiroshi Doi, Yoshimitsu Fukushima, Shiro Ikegawa, Shuhei Yamada, Kazuyuki Sugahara, Naomichi Matsumoto

    Published 2010
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  20. 20
    Randomized phase <scp>II</scp> trial of survivin 2B peptide vaccination for patients with <scp>HLA</scp>‐A24‐positive pancreatic adenocarcinoma

    Randomized phase <scp>II</scp> trial of survivin 2B peptide vaccination for patients with <scp>HLA</scp>‐A24‐positive pancreatic adenocarcinoma by Hiroaki Shima, Giichiro Tsurita, Satoshi Wada, Yoshihiko Hirohashi, Hiroshi Yasui, Hiroshi Hayashi, Takashi Miyakoshi, Kazue Watanabe, Aiko Murai, Hiroko Asanuma, Serina Tokita, Terufumi Kubo, Munehide Nakatsugawa, Takayuki Kanaseki, Tomohide Tsukahara, Yutaka Nakae, Osamu Sugita, Yoichi M. Ito, Yasunori Ota, Yasutoshi Kimura, Goro Kutomi, Koichi Hirata, Toru Mizuguchi, Kohzoh Imai, Ichiro Takemasa, Noriyuki Sato, Toshihiko Torigoe

    Published 2019
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