Результаты поиска - Hayk Davtyan

Отмена результатов
  1. 1
    Development and validation of a simplified method to generate human microglia from pluripotent stem cells

    Development and validation of a simplified method to generate human microglia from pluripotent stem cells по Amanda McQuade, Morgan Coburn, Christina Tu, Jonathan Hasselmann, Hayk Davtyan, Mathew Blurton‐Jones

    Опубликовано 2018
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    Artigo
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  2. 2
    Epitope‐based DNA vaccine for Alzheimer's disease: Translational study in macaques

    Epitope‐based DNA vaccine for Alzheimer's disease: Translational study in macaques по Claire F. Evans, Hayk Davtyan, Irina Petrushina, Armine Hovakimyan, Arpine Davtyan, Drew Hannaman, David H. Cribbs, Michael G. Agadjanyan, Anahit Ghochikyan

    Опубликовано 2013
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    Artigo
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  3. 3
    Induction of Mesoderm and Neural Crest-Derived Pericytes from Human Pluripotent Stem Cells to Study Blood-Brain Barrier Interactions

    Induction of Mesoderm and Neural Crest-Derived Pericytes from Human Pluripotent Stem Cells to Study Blood-Brain Barrier Interactions по Tannaz Faal, Duc T. T. Phan, Hayk Davtyan, Vanessa M. Scarfone, Erika Varady, Mathew Blurton‐Jones, Christopher C.W. Hughes, Matthew A. Inlay

    Опубликовано 2019
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    Artigo
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  4. 4
    Alzheimer's Disease Peptide Epitope Vaccine Reduces Insoluble But Not Soluble/Oligomeric Aβ Species in Amyloid Precursor Protein Transgenic Mice

    Alzheimer's Disease Peptide Epitope Vaccine Reduces Insoluble But Not Soluble/Oligomeric Aβ Species in Amyloid Precursor Protein Transgenic Mice по Irina Petrushina, Anahit Ghochikyan, Mikayel Mktrichyan, G. Mamikonyan, Nina Movsesyan, Hayk Davtyan, Archita Patel, Elizabeth Head, David H. Cribbs, Michael G. Agadjanyan

    Опубликовано 2007
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    Artigo
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  5. 5
    Reducing AD-Like Pathology in 3xTg-AD Mouse Model by DNA Epitope Vaccine — A Novel Immunotherapeutic Strategy

    Reducing AD-Like Pathology in 3xTg-AD Mouse Model by DNA Epitope Vaccine — A Novel Immunotherapeutic Strategy по Nina Movsesyan, Anahit Ghochikyan, Mikayel Mkrtichyan, Irina Petrushina, Hayk Davtyan, Purevdorj B. Olkhanud, Elizabeth Head, Arya Biragyn, David H. Cribbs, Michael G. Agadjanyan

    Опубликовано 2008
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    Artigo
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  6. 6
    Alzheimer’s disease AdvaxCpG- adjuvanted MultiTEP-based dual and single vaccines induce high-titer antibodies against various forms of tau and Aβ pathological molecules

    Alzheimer’s disease AdvaxCpG- adjuvanted MultiTEP-based dual and single vaccines induce high-titer antibodies against various forms of tau and Aβ pathological molecules по Hayk Davtyan, Karen Zagorski, Harinda Rajapaksha, Armine Hovakimyan, Arpine Davtyan, Irina Petrushina, Konstantin Kazarian, David H. Cribbs, Nikolai Petrovsky, Michael G. Agadjanyan, Anahit Ghochikyan

    Опубликовано 2016
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    Artigo
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  7. 7
    Modeling Sporadic Alzheimer's Disease in Human Brain Organoids under Serum Exposure

    Modeling Sporadic Alzheimer's Disease in Human Brain Organoids under Serum Exposure по Xianwei Chen, Guoqiang Sun, Erpo Tian, Mingzi Zhang, Hayk Davtyan, Thomas G. Beach, Eric M. Reiman, Mathew Blurton‐Jones, David M. Holtzman, Yanhong Shi

    Опубликовано 2021
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    Artigo
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  8. 8
    Humanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potency

    Humanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potency по Michael G. Agadjanyan, Karen Zagorski, Irina Petrushina, Hayk Davtyan, Konstantin Kazarian, Maxim Antonenko, Joy Davis, Charles Bon, Mathew Blurton‐Jones, David H. Cribbs, Anahit Ghochikyan

    Опубликовано 2017
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    Artigo
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  9. 9
    Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer’s disease

    Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer’s disease по Christel Claes, Emma Danhash, Jonathan Hasselmann, Jean Paul Chadarevian, Sepideh Kiani Shabestari, Whitney England, Tau En Lim, Jorge Luis Silva Hidalgo, Robert C. Spitale, Hayk Davtyan, Mathew Blurton‐Jones

    Опубликовано 2021
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    Artigo
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  10. 10
    Astrocytic response mediated by the CLU risk allele inhibits OPC proliferation and myelination in a human iPSC model

    Astrocytic response mediated by the CLU risk allele inhibits OPC proliferation and myelination in a human iPSC model по Zhenqing Liu, Jianfei Chao, Cheng Wang, Guihua Sun, Daniel Roeth, Wei Liu, Xianwei Chen, Li Li, Erpo Tian, Lizhao Feng, Hayk Davtyan, Mathew Blurton‐Jones, Markus Kalkum, Yanhong Shi

    Опубликовано 2023
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    Artigo
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  11. 11
    The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function

    The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function по Samuel E. Marsh, Edsel M. Abud, Anita Lakatos, Alborz Karimzadeh, Stephen T. Yeung, Hayk Davtyan, Gianna Fote, Lydia Lau, Jason G. Weinger, Thomas E. Lane, Matthew A. Inlay, Wayne W. Poon, Mathew Blurton‐Jones

    Опубликовано 2016
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    Artigo
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  12. 12
    Exosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation

    Exosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation по M. Rezaa Mohammadi, Samuel Rodriguez, Jennifer Luong, Shiri Li, Rui Cao, Hamad Alshetaiwi, Hien Lau, Hayk Davtyan, Mathew Blurton‐Jones, Mahtab Jafari, Kai Kessenbrock, S. Armando Villalta, Paul de Vos, Weian Zhao, Jonathan R. T. Lakey

    Опубликовано 2021
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    Artigo
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  13. 13
    Immunogenicity, Efficacy, Safety, and Mechanism of Action of Epitope Vaccine (Lu AF20513) for Alzheimer's Disease: Prelude to a Clinical Trial

    Immunogenicity, Efficacy, Safety, and Mechanism of Action of Epitope Vaccine (Lu AF20513) for Alzheimer's Disease: Prelude to a Clinical Trial по Hayk Davtyan, Anahit Ghochikyan, Irina Petrushina, Armine Hovakimyan, Arpine Davtyan, Anna Poghosyan, Annette M. Marleau, Nina Movsesyan, Anatoly Kiyatkin, Suhail Rasool, Anna Kirstine Larsen, Peter Juul Madsen, Karen Malene Wegener, Dorte Kornerup Ditlevsen, David H. Cribbs, Lars Østergaard Pedersen, Michael G. Agadjanyan

    Опубликовано 2013
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    Artigo
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  14. 14
    Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins

    Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins по Jean Paul Chadarevian, Hayk Davtyan, Alina L Chadarevian, Jasmine Nguyen, Joia K. Capocchi, Lauren Le, Adrian Escobar, Talar Chadarevian, Malek Mansour, Ekaterina Deynega, Michael Mgerian, Christina Tu, Sepideh Kiani Shabestari, William Carlen-Jones, Ghazaleh Eskandari‐Sedighi, Jonathan Hasselmann, Robert C. Spitale, Mathew Blurton‐Jones

    Опубликовано 2025
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    Artigo
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  15. 15
    A Transgenic Alzheimer Rat with Plaques, Tau Pathology, Behavioral Impairment, Oligomeric Aβ, and Frank Neuronal Loss

    A Transgenic Alzheimer Rat with Plaques, Tau Pathology, Behavioral Impairment, Oligomeric Aβ, and Frank Neuronal Loss по Robert M. Cohen, Kavon Rezai‐Zadeh, Tara M. Weitz, Altan Rentsendorj, David Gate, Inna Spivak, Yasmin Bholat, Vitaly Vasilevko, Charles Glabe, Joshua J. Breunig, Pasko Rakić, Hayk Davtyan, Michael G. Agadjanyan, Vladimir Kepe, Jorge R. Barrio, Serguei Bannykh, Christine A. Szekely, Robert N. Pechnick, Terrence Town

    Опубликовано 2013
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    Artigo
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  16. 16
    Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related leukoencephalopathy

    Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related leukoencephalopathy по Jean Paul Chadarevian, Jonathan Hasselmann, Alina Lahian, Joia K. Capocchi, Adrian Escobar, Tau En Lim, Lauren Le, Christina Tu, Jasmine Nguyen, Sepideh Kiani Shabestari, William Carlen-Jones, Sunil Gandhi, Guojun Bu, David Hume, Clare Pridans, Zbigniew K. Wszołek, Robert C. Spitale, Hayk Davtyan, Mathew Blurton‐Jones

    Опубликовано 2024
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    Artigo
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  17. 17
    The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model

    The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model по Christel Claes, Whitney England, Emma Danhash, Sepideh Kiani Shabestari, Amit Jairaman, Jean Paul Chadarevian, Jonathan Hasselmann, Andy P. Tsai, Morgan Coburn, Jessica Sanchez, Tau En Lim, Jorge Luis Silva Hidalgo, Christina Tu, Michael D. Cahalan, Bruce T. Lamb, Gary E. Landreth, Robert C. Spitale, Mathew Blurton‐Jones, Hayk Davtyan

    Опубликовано 2022
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    Artigo
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  18. 18
    Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo

    Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo по Jonathan Hasselmann, Morgan Coburn, Whitney England, Dario X. Figueroa Velez, Sepideh Kiani Shabestari, Christina Tu, Amanda McQuade, Mahshad Kolahdouzan, Karla Echeverria, Christel Claes, Taylor Nakayama, Ricardo Azevedo, Nicole G. Coufal, Claudia Z. Han, B. Cummings, Hayk Davtyan, Christopher K. Glass, Luke M. Healy, Sunil Gandhi, Robert C. Spitale, Mathew Blurton‐Jones

    Опубликовано 2019
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    Artigo
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  19. 19
    C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation

    C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation по Deepti Lall, Ileana Lorenzini, Thomas A. Mota, Shaughn Bell, Thomas E. Mahan, Jason D. Ulrich, Hayk Davtyan, Jessica E. Rexach, A.K.M. Ghulam Muhammad, Oksana Shelest, Jesse Landeros, Michael Vazquez, Junwon Kim, Layla T. Ghaffari, Jacqueline G. O’Rourke, Daniel H. Geschwind, Mathew Blurton‐Jones, David M. Holtzman, Rita Sattler, Robert H. Baloh

    Опубликовано 2021
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    Artigo
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  20. 20
    Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice

    Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice по Sepideh Kiani Shabestari, Samuel Morabito, Emma Danhash, Amanda McQuade, Jessica Sanchez, Emily Miyoshi, Jean Paul Chadarevian, Christel Claes, Morgan Coburn, Jonathan Hasselmann, Jorge Luis Silva Hidalgo, Kayla Nhi Tran, Alessandra Cadete Martini, Winston Chang Rothermich, Jesse R. Pascual, Elizabeth Head, David Hume, Clare Pridans, Hayk Davtyan, Vivek Swarup, Mathew Blurton‐Jones

    Опубликовано 2022
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    Artigo
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