检索结果 - Guillaume Lessène

Refine Results
  1. 1
    Inhibitors of SARS-CoV-2 PLpro

    Inhibitors of SARS-CoV-2 PLpro 由 Dale J. Calleja, Guillaume Lessène, David Komander

    出版 2022
    获取全文 获取全文
    Revisão
    加到收藏夹
    Saved in:
  2. 2
    Cell death and the mitochondria: therapeutic targeting of the <scp>BCL</scp>‐2 family‐driven pathway

    Cell death and the mitochondria: therapeutic targeting of the <scp>BCL</scp>‐2 family‐driven pathway 由 Michael J. Roy, Amelia Vom, Peter E. Czabotar, Guillaume Lessène

    出版 2013
    获取全文 获取全文
    Artigo
    加到收藏夹
    Saved in:
  3. 3
    BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines

    BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines 由 Delphine Mérino, Gemma L. Kelly, Guillaume Lessène, Andrew H. Wei, Andrew W. Roberts, Andreas Strasser

    出版 2018
    获取全文
    Revisão
    加到收藏夹
    Saved in:
  4. 4
    Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use

    Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use 由 Margs S. Brennan, Catherine Chang, Lin Tai, Guillaume Lessène, Andreas Strasser, Grant Dewson, Gemma L. Kelly, Marco J. Herold

    出版 2018
    获取全文 获取全文
    Artigo
    加到收藏夹
    Saved in:
  5. 5
    From (Tool)Bench to Bedside: The Potential of Necroptosis Inhibitors

    From (Tool)Bench to Bedside: The Potential of Necroptosis Inhibitors 由 Christopher R. Gardner, Katherine A. Davies, Ying Zhang, Martin Brzozowski, Peter E. Czabotar, James M. Murphy, Guillaume Lessène

    出版 2023
    获取全文
    Revisão
    加到收藏夹
    Saved in:
  6. 6
    Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands

    Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands 由 Erinna F. Lee, Peter E. Czabotar, Hong Yang, Brad E. Sleebs, Guillaume Lessène, Peter M. Colman, Brian J. Smith, W. Douglas Fairlie

    出版 2009
    获取全文 获取全文
    Artigo
    加到收藏夹
    Saved in:
  7. 7
    Analysis of Ca <sup>2</sup> <sup>+</sup> mediated signaling regulating <i>Toxoplasma</i> infectivity reveals complex relationships between key molecules

    Analysis of Ca <sup>2</sup> <sup>+</sup> mediated signaling regulating <i>Toxoplasma</i> infectivity reveals complex relationships between key molecules 由 Rebecca J. Stewart, Lachlan Whitehead, Brunda Nijagal, Brad E. Sleebs, Guillaume Lessène, Malcolm J. McConville, Kelly L. Rogers, Christopher J. Tonkin

    出版 2016
    获取全文 获取全文
    Artigo
    加到收藏夹
    Saved in:
  8. 8
    Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1

    Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1 由 Jia-Nan Gong, Tiffany Khong, David Segal, Yuan Yao, Chris Riffkin, Jean-Marc Garnier, Seong Lin Khaw, Guillaume Lessène, Andrew Spencer, Marco J. Herold, Andrew W. Roberts, David C.S. Huang

    出版 2016
    获取全文 获取全文
    Artigo
    加到收藏夹
    Saved in:
  9. 9
    Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

    Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production 由 M. J. D. White, Kate McArthur, Donald Metcalf, Rachael M. Lane, John C. Cambier, Marco J. Herold, Mark F. van Delft, Sammy Bedoui, Guillaume Lessène, Matthew E. Ritchie, David C.S. Huang, Benjamin T. Kile

    出版 2014
    获取全文
    Artigo
    加到收藏夹
    Saved in:
  10. 10
    Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations

    Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations 由 Richard W. Birkinshaw, Jianan Gong, Cindy S. Luo, Daisy Lio, Christine White, Mary Ann Anderson, Piers Blombery, Guillaume Lessène, Ian J. Majewski, Rachel Thijssen, Andrew W. Roberts, David C.S. Huang, Peter M. Colman, Peter E. Czabotar

    出版 2019
    获取全文
    Artigo
    加到收藏夹
    Saved in:
  11. 11
    BH3 mimetic drugs cooperate with Temozolomide, JQ1 and inducers of ferroptosis in killing glioblastoma multiforme cells

    BH3 mimetic drugs cooperate with Temozolomide, JQ1 and inducers of ferroptosis in killing glioblastoma multiforme cells 由 Diane Moujalled, Adam Southon, Eiman Saleh, Kerstin Brinkmann, Francine Ke, Melinda Iliopoulos, Ryan S. Cross, Misty R. Jenkins, Duong Nhu, Zilu Wang, Melissa X. Shi, Ruth M. Kluck, Guillaume Lessène, Stephanie Grabow, Ashley I. Bush, Andreas Strasser

    出版 2022
    获取全文 获取全文
    Artigo
    加到收藏夹
    Saved in:
  12. 12
    Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression

    Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression 由 Ashleigh R. Poh, Christopher G. Love, Frédérick Masson, Adele Preaudet, Cary Tsui, Lachlan Whitehead, Simon Monard, Yelena Khakham, Lotta Burstroem, Guillaume Lessène, Oliver M. Sieber, Clifford Lowell, Tracy L. Putoczki, Robert J.J. O’Donoghue, Matthias Ernst

    出版 2017
    获取全文
    Artigo
    加到收藏夹
    Saved in:
  13. 13
    HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death

    HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death 由 Annette V. Jacobsen, Kym N. Lowes, Maria C. Tanzer, Isabelle S. Lucet, Joanne M. Hildebrand, Emma J. Petrie, Mark F. van Delft, Zikou Liu, Stephanie A. Conos, Jian‐Guo Zhang, David C.S. Huang, John Silke, Guillaume Lessène, James M. Murphy

    出版 2016
    获取全文 获取全文
    Artigo
    加到收藏夹
    Saved in:
  14. 14
    Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis

    Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis 由 Yanxiang Meng, Katherine A. Davies, Cheree Fitzgibbon, Samuel N. Young, Sarah E. Garnish, Christopher R. Horne, Cindy S. Luo, Jean‐Marc Garnier, Lung‐Yu Liang, Angus D. Cowan, André L. Samson, Guillaume Lessène, Jarrod J. Sandow, Peter E. Czabotar, James M. Murphy

    出版 2021
    获取全文 获取全文
    Artigo
    加到收藏夹
    Saved in:
  15. 15
    ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity to HDAC Inhibitors across Tumor Types

    ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity to HDAC Inhibitors across Tumor Types 由 Anderly C. Chüeh, Janson W.T. Tse, Michael Dickinson, Paul Ioannidis, Laura J. Jenkins, Lars Tögel, BeeShin Tan, Ian Y. Luk, Mercedes Dávalos-Salas, Rebecca Nightingale, Matthew R. Thompson, Bryan Williams, Guillaume Lessène, Erinna F. Lee, W. Douglas Fairlie, Amardeep S. Dhillon, John M. Mariadason

    出版 2017
    获取全文 获取全文
    Artigo
    加到收藏夹
    Saved in:
  16. 16
    Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

    Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer 由 S. A. Berger, Erik Procko, Daciana Margineantu, Erinna F. Lee, Betty Shen, Alex Zelter, Daniel‐Adriano Silva, Kusum Chawla, Marco J. Herold, Jean-Marc Garnier, Richard S. Johnson, Michael J. MacCoss, Guillaume Lessène, Trisha N. Davis, Patrick S. Stayton, Barry Stoddard, W. Douglas Fairlie, David M. Hockenbery, David Baker

    出版 2016
    获取全文
    Artigo
    加到收藏夹
    Saved in:
  17. 17
    The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells

    The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells 由 Zilu Wang, Huimin Hu, Luuk Heitink, Kelly L. Rogers, Yue You, Tao Tan, Connie S.N. Li Wai Suen, Alex Garnham, Hao Chen, Elizabeth Lieschke, Sarah T. Diepstraten, Catherine Chang, Tianwei Chen, Diane Moujalled, Kate D. Sutherland, Guillaume Lessène, Oliver M. Sieber, Jane E. Visvader, Gemma L. Kelly, Andreas Strasser

    出版 2023
    获取全文 获取全文
    Artigo
    加到收藏夹
    Saved in:
  18. 18
    The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation

    The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation 由 James E. Vince, Dominic De Nardo, Wenqing Gao, Angelina J. Vince, Cathrine Hall, Kate McArthur, Daniel S. Simpson, Swarna Lekha Vijayaraj, Lisa Lindqvist, Philippe Bouillet, Mark A. Rizzacasa, Si Ming Man, John Silke, Seth L. Masters, Guillaume Lessène, David C.S. Huang, Daniel H.D. Gray, Benjamin T. Kile, Feng Shao, Kate E. Lawlor

    出版 2018
    获取全文
    Artigo
    加到收藏夹
    Saved in:
  19. 19
    Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3

    Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3 由 Emma J. Petrie, Jarrod J. Sandow, Wil I. L. Lehmann, Lung‐Yu Liang, Diane Coursier, Samuel N. Young, Wilhelmus J. A. Kersten, Cheree Fitzgibbon, André L. Samson, Annette V. Jacobsen, Kym N. Lowes, Amanda E. Au, Hélène Jousset Sabroux, Najoua Lalaoui, Andrew I. Webb, Guillaume Lessène, Gerard Manning, Isabelle S. Lucet, James M. Murphy

    出版 2019
    获取全文
    Artigo
    加到收藏夹
    Saved in:
  20. 20
    Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

    Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death 由 Joanne M. Hildebrand, Maria C. Tanzer, Isabelle S. Lucet, Samuel N. Young, Sukhdeep K. Spall, Pooja Sharma, Catia L. Pierotti, Jean‐Marc Garnier, Renwick C. J. Dobson, Andrew I. Webb, Anne Tripaydonis, Jeffrey J. Babon, Mark D. Mulcair, M.J. Scanlon, Warren S. Alexander, Andrew F. Wilks, Peter E. Czabotar, Guillaume Lessène, James M. Murphy, John Silke

    出版 2014
    获取全文 获取全文
    Artigo
    加到收藏夹
    Saved in:

检索工具: