Torthaí cuardaigh - Gruber, Harry

A short discussion about the SARS-CoV-2 mRNA-1273 vaccine de réir Oronsky, Bryan, Gruber, Harry E., Reiners, Wendy, Reid, Tony R.

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ET-23 THERAPEUTIC EFFICACY OF RETROVIRAL REPLICATING VECTORS IN HUMAN BREAST CANCER CNS METASTASIS MODEL de réir Inagaki, Akihito, Hiraoka, Kei, Kamijima, Shuichi, Robbins, Joan, Jolly, Douglas, Gruber, Harry, Kasahara, Noriyuki

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RETROVIRAL REPLICATING VECTORS IN CANCER de réir Logg, Christopher R., Robbins, Joan M., Jolly, Douglas J., Gruber, Harry E., Kasahara, Noriyuki

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TMIC-42. TOCA 511 AND 5-FC INDUCES T CELL-MEDIATED ANTITUMOR IMMUNITY IN A MOUSE GLIOMA MODEL WHICH IS ENHANCED BY THE ADDITION OF A THERAPEUTIC ANTIBODY AGAINST CTLA-4 AND CORRELA... de réir Jolly, Douglas, Mitchell, Leah, Yagiz, Kader, Espinoza, Fernando Lopez, Mendoza, Daniel, Munday, Anthony, Gruber, Harry

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Blockade of Type I Interferon (IFN) Production by Retroviral Replicating Vectors and Reduced Tumor Cell Responses to IFN Likely Contribute To Tumor Selectivity de réir Lin, Amy H., Burrascano, Cindy, Pettersson, Par L., Ibañez, Carlos E., Gruber, Harry E., Jolly, Douglas J.

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AT-29 INTRAVENOUS ADMINISTRATION OF TOCA 511 IN PATIENTS WITH RECURRENT GLIOBLASTOMA de réir Kalkanis, Steven, Jolly, Doug J., Pertschuk, Dan, Ostertag, Derek, Robbins, Joan M., Huang, Tiffany T., Gruber, Harry, Mikkelsen, Tom

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THER-06. THERAPEUTIC EFFICACY OF RRV-MEDIATED PRODRUG ACTIVATOR GENE THERAPY IN CLINICAL TRIALS OF RECURRENT HIGH-GRADE GLIOMA AND IN MURINE ORTHOTOPIC MODELS OF INTRACEREBRAL GLIO... de réir Richardson, Angela, Collins, Sara, Inagaki, Akihito, Armstrong, Valerie, Robbins, David, Ayad, Nagi, Gruber, Harry, Jolly, Douglas, Cloughesy, Timothy, Kasahara, Noriyuki

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Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models de réir Yagiz, Kader, Huang, Tiffany T., Lopez Espinoza, Fernando, Mendoza, Daniel, Ibañez, Carlos E., Gruber, Harry E., Jolly, Douglas J., Robbins, Joan M.

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CADD-23. PD-L1 CHECKPOINT BLOCKADE USING A SINGLE-CHAIN VARIABLE FRAGMENT TARGETING PD-L1 DELIVERED BY RETROVIRAL REPLICATING VECTOR (TOCA 521) ENHANCES ANTI-TUMOR EFFECT IN CANCER... de réir Lin, Amy, Yagiz, Kader, Hofacre, Andrew, Munday, Anthony, Espinoza, Fernando Lopez, Mendoza, Daniel, Burrascano, Cynthia, Gruber, Harry, Mitchell, Leah, Jolly, Douglas

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Retroviral Replicating Vector Delivery of miR-PDL1 Inhibits Immune Checkpoint PDL1 and Enhances Immune Responses In Vitro de réir Lin, Amy H., Twitty, Christopher G., Burnett, Ryan, Hofacre, Andrew, Mitchell, Leah A., Espinoza, Fernando Lopez, Gruber, Harry E., Jolly, Douglas J.

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Extensive Replication of a Retroviral Replicating Vector Can Expand the A Bulge in the Encephalomyocarditis Virus Internal Ribosome Entry Site and Change Translation Efficiency of... de réir Lin, Amy H., Liu, Yanzheng, Burrascano, Cynthia, Cunanan, Kathrina, Logg, Christopher R., Robbins, Joan M., Kasahara, Noriyuki, Gruber, Harry, Ibañez, Carlos, Jolly, Douglas J.

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Convection-enhanced delivery improves distribution and efficacy of tumor-selective retroviral replicating vectors (RRV) in a rodent brain tumor model de réir Yin, Dali, Zhai, Yuying, Gruber, Harry E., Ibanez, Carlos E., Robbins, Joan M., Kells, Adrian P., Kasahara, Noriyuki, Forsayeth, John, Jolly, Douglas J., Bankiewicz, Krystof S.

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Toca 511 gene transfer and treatment with the prodrug, 5-fluorocytosine, promotes durable antitumor immunity in a mouse glioma model de réir Mitchell, Leah A., Lopez Espinoza, Fernando, Mendoza, Daniel, Kato, Yuki, Inagaki, Akihito, Hiraoka, Kei, Kasahara, Noriyuki, Gruber, Harry E., Jolly, Douglas J., Robbins, Joan M.

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TMOD-15. TOCA 511 & TOCA FC: PRE-CLINICAL PROOF OF CONCEPT IN CNS METASTATIC BREAST CANCER de réir Inagaki, Akihito, Richardson, Angela M, Collins, Sara A, Hiraoka, Kei, Kamijima, Shuichi, Shorr, Jolene, Gruber, Harry, Jolly, Douglas, Merchan, Jaime, Slingerland, Joyce M, Kasahara, Noriyuki

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Efficient Therapeutic Protein Expression Using Retroviral Replicating Vector with 2A Peptide in Cancer Models de réir Hofacre, Andrew, Yagiz, Kader, Mendoza, Daniel, Lopez Espinoza, Fernando, Munday, Anthony W., Burrascano, Cynthia, Singer, Oded, Gruber, Harry E., Jolly, Douglas J., Lin, Amy H.

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SCDT-06. QUANTIFIABLE LEVELS OF THE TRANSGENE, CYTOSINE DEAMINASE, IN TUMOR SAMPLES FOLLOWING INTRAVENOUS DELIVERY OF TOCA 511 IN PATIENTS WITH RECURRENT HIGH GRADE GLIOMA de réir Walbert, Tobias, Bota, Danilella, Vogelbaum, Michael, Kalkanis, Steven, Liau, Linda, Mikkelsen, Tom, Gruber, Harry, Shorr, Jolene, Rodriguez-Aguirre, Maria, Ostertag, Derek, Mitchell, Leah, Jolly, Doug, Cloughesy, Timothy

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ATIM-21. INTRAVENOUS DELIVERY OF TOCA 511 IN PATIENTS WITH HIGH GRADE GLIOMA RESULTS IN QUANTIFIABLE EXPRESSION OF CYTOSINE DEAMINASE IN TUMOR TISSUE de réir Walbert, Tobias, Bota, Daniela, Vogelbaum, Michael, Kalkanis, Steven, Liau, Linda, Mikkelsen, Tom, Gruber, Harry, Shorr, Jolene, Rodriguez-Aquirre, Maria, Ostertag, Derek, Mitchell, Leah, Jolly, Douglas, Cloughesy, Timothy

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Radio-sensitization of gliomas by intracellular generation of 5-fluorouracil potentiates prodrug activator gene therapy with a retroviral replicating vector de réir Takahashi, Masamichi, Valdes, Gilmer, Hiraoka, Kei, Inagaki, Akihito, Kamijima, Shuichi, Micewicz, Ewa, Gruber, Harry E., Robbins, Joan M., Jolly, Douglas J., McBride, William H., Iwamoto, Keisuke S., Kasahara, Noriyuki

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A Retroviral Replicating Vector Encoding Cytosine Deaminase and 5-FC Induces Immune Memory in Metastatic Colorectal Cancer Models de réir Yagiz, Kader, Rodriguez-Aguirre, Maria E., Lopez Espinoza, Fernando, Montellano, Tiffany T., Mendoza, Daniel, Mitchell, Leah A., Ibanez, Carlos E., Kasahara, Noriyuki, Gruber, Harry E., Jolly, Douglas J., Robbins, Joan M.

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MicroRNA 142-3p Attenuates Spread of Replicating Retroviral Vector in Hematopoietic Lineage-Derived Cells While Maintaining an Antiviral Immune Response de réir Lin, Amy H., Timberlake, Nina, Logg, Christopher R., Liu, Yanzheng, Kamijima, Shuichi, Diago, Oscar, Wong, Kenneth, Gammon, Dawn K., Ostertag, Derek, Hacke, Katrin, Yang, Emily C., Gruber, Harry, Kasahara, Noriyuki, Jolly, Douglas J.

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