Rezultati - Groeneveld, Geert Jan
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A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Pharmacodynamic Effects of VX-150, a Highly Selective Na(V)1.8 Inhibitor, in Healthy Male A... od Hijma, Hemme J, Siebenga, Pieter S, de Kam, Marieke L, Groeneveld, Geert Jan
Izdano 2021Text -
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Targeting for Success: Demonstrating Proof-of-Concept with Mechanistic Early Phase Clinical Pharmacology Studies for Disease-Modification in Neurodegenerative Disorders od Vissers, Maurits F. J. M., Heuberger, Jules A. A. C., Groeneveld, Geert Jan
Izdano 2021Text -
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A cross-sectional study in healthy elderly subjects aimed at development of an algorithm to increase identification of Alzheimer pathology for the purpose of clinical trial partici... od Prins, Samantha, Zhuparris, Ahnjili, Hart, Ellen P., Doll, Robert-Jan, Groeneveld, Geert Jan
Izdano 2021Text -
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A phase I, randomized, double‐blind, placebo‐controlled, single‐ and multiple dose escalation study evaluating the safety, pharmacokinetics and pharmacodynamics of VX‐128, a highly... od Hijma, Hemme J., van Brummelen, Emilie M. J., Siebenga, Pieter S., Groeneveld, Geert Jan
Izdano 2021Text -
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Pharmacokinetics and pharmacodynamics of intrathecally administered Xen2174, a synthetic conopeptide with norepinephrine reuptake inhibitor and analgesic properties od Okkerse, Pieter, Hay, Justin L., Sitsen, Elske, Dahan, Albert, Klaassen, Erica, Houghton, William, Groeneveld, Geert Jan
Izdano 2016Text -
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The ultraviolet B inflammation model: Postinflammatory hyperpigmentation and validation of a reduced UVB exposure paradigm for inducing hyperalgesia in healthy subjects od Siebenga, Pieter S., van Amerongen, Guido, Klaassen, Erica S., de Kam, Marieke L., Rissmann, Robert, Groeneveld, Geert Jan
Izdano 2019Text -
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Lack of Detection of the Analgesic Properties of PF‐05089771, a Selective Na(v)1.7 Inhibitor, Using a Battery of Pain Models in Healthy Subjects od Siebenga, Pieter, van Amerongen, Guido, Hay, Justin L., McDonnell, Aoibhinn, Gorman, Donal, Butt, Richard, Groeneveld, Geert Jan
Izdano 2019Text -
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No synergistic effect of subtherapeutic doses of donepezil and EVP-6124 in healthy elderly subjects in a scopolamine challenge model od Baakman, Anne Catrien, Alvarez-Jimenez, Ricardo, Loewen, Gordon, de Kam, Marieke L., Broekhuizen, Karen, Hilt, Dana C., Groeneveld, Geert Jan
Izdano 2019Text -
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Pharmacokinetics and pharmacodynamics of multiple doses of BG00010, a neurotrophic factor with anti‐hyperalgesic effects, in patients with sciatica od Okkerse, Pieter, Hay, Justin L., Versage, Eve, Tang, Yongqiang, Galluppi, Gerald, Ravina, Bernard, Verma, Ajay, Williams, Leslie, Aycardi, Ernesto, Groeneveld, Geert Jan
Izdano 2016Text -
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Model‐based exposure‐response analysis to quantify age related differences in the response to scopolamine in healthy subjects od Alvarez‐Jimenez, Ricardo, Groeneveld, Geert Jan, van Gerven, Joop M. A., Goulooze, Sebastiaan C., Baakman, Anne Catrien, Hay, Justin L., Stevens, Jasper
Izdano 2016Text -
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EEG machine learning for accurate detection of cholinergic intervention and Alzheimer’s disease od Simpraga, Sonja, Alvarez-Jimenez, Ricardo, Mansvelder, Huibert D., van Gerven, Joop M. A., Groeneveld, Geert Jan, Poil, Simon-Shlomo, Linkenkaer-Hansen, Klaus
Izdano 2017Text