Søgeresultater - Goldring, Christopher

Current Perspective: 3D Spheroid Models Utilizing Human-Based Cells for Investigating Metabolism-Dependent Drug-Induced Liver Injury af Cox, Christopher R., Lynch, Stephen, Goldring, Christopher, Sharma, Parveen

Få fuldtekst Få fuldtekst Få fuldtekst

A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3 af Bone, Heather K., Nelson, Adam S., Goldring, Christopher E., Tosh, David, Welham, Melanie J.

Få fuldtekst Få fuldtekst Få fuldtekst

Proteomic profiling of murine biliary-derived hepatic organoids and their capacity for drug disposition, bioactivation and detoxification af Howell, Lawrence, Jenkins, Rosalind E., Lynch, Stephen, Duckworth, Carrie, Kevin Park, B., Goldring, Christopher

Få fuldtekst Få fuldtekst Få fuldtekst

Early detection of paracetamol toxicity using circulating liver microRNA and markers of cell necrosis af Dear, James W, Antoine, Daniel J, Starkey-Lewis, Philip, Goldring, Christopher E, Park, B Kevin

Få fuldtekst Få fuldtekst Få fuldtekst

Tetracycline-inducible protein expression in pancreatic cancer cells: Effects of CapG overexpression af Tonack, Sarah, Patel, Sabina, Jalali, Mehdi, Nedjadi, Taoufik, Jenkins, Rosalind E, Goldring, Christopher, Neoptolemos, John, Costello, Eithne

Få fuldtekst Få fuldtekst Få fuldtekst

The application of cytokeratin-18 as a biomarker for drug-induced liver injury af Korver, Samantha, Bowen, Joanne, Pearson, Kara, Gonzalez, Raymond J., French, Neil, Park, Kevin, Jenkins, Rosalind, Goldring, Christopher

Få fuldtekst Få fuldtekst Få fuldtekst

Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-κB() af Chia, Alvin J.L., Goldring, Christopher E., Kitteringham, Neil R., Wong, Shi Quan, Morgan, Paul, Park, B. Kevin

Få fuldtekst Få fuldtekst Få fuldtekst

Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity af Forootan, Shiva S., Mutter, Fiona E., Kipar, Anja, Iwawaki, Takao, Francis, Ben, Goldring, Christopher E., Park, B. Kevin, Copple, Ian M.

Få fuldtekst Få fuldtekst Få fuldtekst

Critical considerations for targeting colorectal liver metastases with nanotechnology af Arshad, Usman, Sutton, Paul A., Ashford, Marianne B., Treacher, Kevin E., Liptrott, Neill J., Rannard, Steve P., Goldring, Christopher E., Owen, Andrew

Få fuldtekst Få fuldtekst Få fuldtekst

Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway af Copple, Ian M., Lister, Adam, Obeng, Akua D., Kitteringham, Neil R., Jenkins, Rosalind E., Layfield, Robert, Foster, Brian J., Goldring, Christopher E., Park, B. Kevin

Få fuldtekst Få fuldtekst Få fuldtekst

Chemical Tuning Enhances Both Potency Toward Nrf2 and In Vitro Therapeutic Index of Triterpenoids af Copple, Ian M., Shelton, Luke M., Walsh, Joanne, Kratschmar, Denise V., Lister, Adam, Odermatt, Alex, Goldring, Christopher E., Dinkova-Kostova, Albena T., Honda, Tadashi, Park, B. Kevin

Få fuldtekst Få fuldtekst Få fuldtekst

Development of an orthotopic syngeneic murine model of colorectal cancer for use in translational research af Evans, Jonathan P, Winiarski, Boleslaw K, Sutton, Paul A, Ressel, Lorenzo, Duckworth, Carrie A, Pritchard, D Mark, Palmer, Daniel H, Goldring, Christopher E, Kitteringham, Neil R

Få fuldtekst Få fuldtekst Få fuldtekst

Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications af Walsh, Joanne, Jenkins, Rosalind E., Wong, Michael, Olayanju, Adedamola, Powell, Helen, Copple, Ian, O’Neill, Paul M., Goldring, Christopher E.P., Kitteringham, Neil R., Park, B. Kevin

Få fuldtekst Få fuldtekst Få fuldtekst

Circulating levels of miR-122 increase post-mortem, particularly following lethal dosing with pentobarbital sodium: implications for pre-clinical liver injury studies af Clarke, Joanna I., Forootan, Shiva Seyed, Lea, Jonathan D., Howell, Lawrence S., Rodriguez, Josep Monne, Kipar, Anja, Goldring, Christopher E., Park, B. Kevin, Copple, Ian M., Antoine, Daniel J.

Få fuldtekst Få fuldtekst Få fuldtekst

Loss of Transcription Factor Nuclear Factor-Erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Leads to Dysregulation of Immune Functions, Redox Homeostasis, and Intracellular Signali... af Yeang, Han Xian Aw, Hamdam, Junnat M., Al-Huseini, Laith M. A., Sethu, Swaminathan, Djouhri, Laiche, Walsh, Joanne, Kitteringham, Neil, Park, B. Kevin, Goldring, Christopher E., Sathish, Jean G.

Få fuldtekst Få fuldtekst Få fuldtekst

Nuclear Factor-erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Modulates Dendritic Cell Immune Function through Regulation of p38 MAPK-cAMP-responsive Element Binding Protein/Activ... af Al-Huseini, Laith M. A., Aw Yeang, Han Xian, Sethu, Swaminathan, Alhumeed, Naif, Hamdam, Junnat M., Tingle, Yulia, Djouhri, Laiche, Kitteringham, Neil, Park, B. Kevin, Goldring, Christopher E., Sathish, Jean G.

Få fuldtekst Få fuldtekst Få fuldtekst

Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver af Kitteringham, Neil R., Abdullah, Azman, Walsh, Joanne, Randle, Laura, Jenkins, Rosalind E., Sison, Rowena, Goldring, Christopher E.P., Powell, Helen, Sanderson, Christopher, Williams, Samantha, Higgins, Larry, Yamamoto, Masayuki, Hayes, John, Park, B. Kevin

Få fuldtekst Få fuldtekst Få fuldtekst

Safety perspectives on presently considered drugs for the treatment of COVID‐19 af Penman, Sophie L., Kiy, Robyn T., Jensen, Rebecca L., Beoku‐Betts, Christopher, Alfirevic, Ana, Back, David, Khoo, Saye H., Owen, Andrew, Pirmohamed, Munir, Park, B. Kevin, Meng, Xiaoli, Goldring, Christopher E., Chadwick, Amy E.

Få fuldtekst Få fuldtekst Få fuldtekst

Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital af Antoine, Daniel J, Dear, James W, Lewis, Philip Starkey, Platt, Vivien, Coyle, Judy, Masson, Moyra, Thanacoody, Ruben H, Gray, Alasdair J, Webb, David J, Moggs, Jonathan G, Bateman, D Nicholas, Goldring, Christopher E, Park, B Kevin

Få fuldtekst Få fuldtekst Få fuldtekst

NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis af Lister, Adam, Bourgeois, Soline, Imenez Silva, Pedro H., Rubio-Aliaga, Isabel, Marbet, Philippe, Walsh, Joanne, Shelton, Luke M., Keller, Bettina, Verrey, Francois, Devuyst, Olivier, Giesbertz, Pieter, Daniel, Hannelore, Goldring, Christopher E., Copple, Ian M., Wagner, Carsten A., Odermatt, Alex

Få fuldtekst Få fuldtekst Få fuldtekst