Resultados de búsqueda - Geert Jan Groeneveld

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  1. 1
    Measuring blood–brain barrier penetration using the NeuroCart, a CNS test battery

    Measuring blood–brain barrier penetration using the NeuroCart, a CNS test battery por Geert Jan Groeneveld, Justin L. Hay, J M van Gerven

    Publicado 2016
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  2. 2
    A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Pharmacodynamic Effects of VX-150, a Highly Selective NaV1.8 Inhibitor, in Healthy Male Adults

    A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Pharmacodynamic Effects of VX-150, a Highly Selective NaV1.8 Inhibitor, in Healthy Male Adu... por Hemme J. Hijma, Pieter Siebenga, Marieke L. de Kam, Geert Jan Groeneveld

    Publicado 2021
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  3. 3
    Inflammatory plasma biomarkers in subjects with preclinical Alzheimer’s disease

    Inflammatory plasma biomarkers in subjects with preclinical Alzheimer’s disease por Samantha Prins, Marieke L. de Kam, Charlotte E. Teunissen, Geert Jan Groeneveld

    Publicado 2022
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  4. 4
    The Use of Biomarkers in Human Pharmacology (Phase I) Studies

    The Use of Biomarkers in Human Pharmacology (Phase I) Studies por Adam F. Cohen, Jacobus Burggraaf, Joop van Gerven, Matthijs Moerland, Geert Jan Groeneveld

    Publicado 2014
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  5. 5
    A literature review on the pharmacological sensitivity of human evoked hyperalgesia pain models

    A literature review on the pharmacological sensitivity of human evoked hyperalgesia pain models por Guido van Amerongen, Matthijs W. de Boer, Geert Jan Groeneveld, Justin L. Hay

    Publicado 2016
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  6. 6
    Lack of Detection of the Analgesic Properties of PF‐05089771, a Selective Na<sub>v</sub>1.7 Inhibitor, Using a Battery of Pain Models in Healthy Subjects

    Lack of Detection of the Analgesic Properties of PF‐05089771, a Selective Na<sub>v</sub>1.7 Inhibitor, Using a Battery of Pain Models in Healthy Subjects por Pieter Siebenga, Guido van Amerongen, Justin L. Hay, Aoibhinn McDonnell, Donal Gorman, Richard P. Butt, Geert Jan Groeneveld

    Publicado 2019
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  7. 7
    EEG machine learning for accurate detection of cholinergic intervention and Alzheimer’s disease

    EEG machine learning for accurate detection of cholinergic intervention and Alzheimer’s disease por Sonja Simpraga, Ricardo Álvarez-Jiménez, Huibert D. Mansvelder, Joop van Gerven, Geert Jan Groeneveld, Simon-Shlomo Poil, Klaus Linkenkaer‐Hansen

    Publicado 2017
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  8. 8
    Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly

    Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly por Pénélope A. Andreux, Marcus P.J. van Diemen, Maxime R. Heezen, Johan Auwerx, Chris Rinsch, Geert Jan Groeneveld, Anurag Singh

    Publicado 2018
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  9. 9
    A Randomized First‐in‐Human Study With UB‐312, a UBITh® α‐Synuclein Peptide Vaccine

    A Randomized First‐in‐Human Study With UB‐312, a UBITh® α‐Synuclein Peptide Vaccine por Hui Jing Yu, Eva Thijssen, Emilie M.J. van Brummelen, Johan L. van der Plas, Igor Radanović, Matthijs Moerland, Eric T. Hsieh, Geert Jan Groeneveld, Jean‐Cosme Dodart

    Publicado 2022
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  10. 10
    Acute Effects of Riluzole and Retigabine on Axonal Excitability in Patients With Amyotrophic Lateral Sclerosis: A Randomized, Double‐Blind, Placebo‐Controlled, Crossover Trial

    Acute Effects of Riluzole and Retigabine on Axonal Excitability in Patients With Amyotrophic Lateral Sclerosis: A Randomized, Double‐Blind, Placebo‐Controlled, Crossover Trial por Maria O. Kovalchuk, Jules A. A. C. Heuberger, Boudewijn T.H.M. Sleutjes, Dimitrios Ziagkos, Leonard H. van den Berg, Toby A. Ferguson, Hessel Franssen, Geert Jan Groeneveld

    Publicado 2018
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  11. 11
    Tolerance to Opioid‐Induced Respiratory Depression in Chronic High‐Dose Opioid Users: A Model‐Based Comparison With Opioid‐Naïve Individuals

    Tolerance to Opioid‐Induced Respiratory Depression in Chronic High‐Dose Opioid Users: A Model‐Based Comparison With Opioid‐Naïve Individuals por Marijke Hyke Algera, Erik Olofsen, Laurence Moss, Robert L. Dobbins, Marieke Niesters, Monique van Velzen, Geert Jan Groeneveld, Jules A. A. C. Heuberger, Céline M. Laffont, Albert Dahan

    Publicado 2020
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  12. 12
    PCV chemotherapy for recurrent glioblastoma multiforme

    PCV chemotherapy for recurrent glioblastoma multiforme por A.C. Kappelle, Tjeerd J. Postma, Martin Klein, Geert Jan Groeneveld, Martin J. van den Bent, C.J. van Groeningen, Bernard A. Zonnenberg, K.C.A. Sneeuw, J.J. Heimans

    Publicado 2001
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  13. 13
    Intake of polyunsaturated fatty acids and vitamin E reduces the risk of developing amyotrophic lateral sclerosis

    Intake of polyunsaturated fatty acids and vitamin E reduces the risk of developing amyotrophic lateral sclerosis por Jan H. Veldink, Sandra Kalmijn, Geert Jan Groeneveld, Wendy Wunderink, Annemarie Koster, J.H.M. de Vries, Jolanda van der Luyt, John H. J. Wokke, Leonard H. van den Berg

    Publicado 2006
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  14. 14
    A Phase <scp>1B</scp> Trial in <i><scp>GBA1</scp>‐</i>Associated Parkinson's Disease of BIA‐28‐6156, a Glucocerebrosidase Activator

    A Phase <scp>1B</scp> Trial in <i><scp>GBA1</scp>‐</i>Associated Parkinson's Disease of BIA‐28‐6156, a Glucocerebrosidase Activator por Jonas M. den Heijer, Annelieke C. Kruithof, Matthijs Moerland, Mike Walker, Lindsay Dudgeon, Craig Justman, Imelda Solomini, Leslie Splitalny, Nancy Leymarie, Kshitij Khatri, Valerie Cullen, Dana Hilt, Geert Jan Groeneveld, Peter T. Lansbury

    Publicado 2023
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  15. 15
    Effects on Spasticity and Neuropathic Pain of an Oral Formulation of Δ9-tetrahydrocannabinol in Patients With Progressive Multiple Sclerosis

    Effects on Spasticity and Neuropathic Pain of an Oral Formulation of Δ9-tetrahydrocannabinol in Patients With Progressive Multiple Sclerosis por Guido van Amerongen, Kawita M. S. Kanhai, Anne Catrien Baakman, Jules A. A. C. Heuberger, Erica S. Klaassen, Tim L. Beumer, R.L.M. Strijers, Joep Killestein, Joop van Gerven, Adam F. Cohen, Geert Jan Groeneveld

    Publicado 2017
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  16. 16
    <scp>DNL</scp>104, a Centrally Penetrant <scp>RIPK</scp>1 Inhibitor, Inhibits <scp>RIP</scp>1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunteers

    <scp>DNL</scp>104, a Centrally Penetrant <scp>RIPK</scp>1 Inhibitor, Inhibits <scp>RIP</scp>1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunte... por Hendrika W. Grievink, Jules A. A. C. Heuberger, Fen Huang, Rinkal Chaudhary, Willem Birkhoff, George Tonn, Sofia Mosesova, Rebecca Erickson, Matthijs Moerland, Patrick C. G. Haddick, Kimberly Scearce‐Levie, Carole Ho, Geert Jan Groeneveld

    Publicado 2019
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  17. 17
    Effect of sustained high buprenorphine plasma concentrations on fentanyl-induced respiratory depression: A placebo-controlled crossover study in healthy volunteers and opioid-tolerant patients

    Effect of sustained high buprenorphine plasma concentrations on fentanyl-induced respiratory depression: A placebo-controlled crossover study in healthy volunteers and opioid-toler... por Laurence Moss, Marijke Hyke Algera, Robert L. Dobbins, Frank Gray, Stephanie Strafford, Amy Heath, Monique van Velzen, Jules A. A. C. Heuberger, Marieke Niesters, Erik Olofsen, Céline M. Laffont, Albert Dahan, Geert Jan Groeneveld

    Publicado 2022
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  18. 18
    A Biomarker Study in Patients with <i>GBA1</i> ‐Parkinson's Disease and Healthy Controls

    A Biomarker Study in Patients with <i>GBA1</i> ‐Parkinson's Disease and Healthy Controls por Jonas M. den Heijer, Valerie Cullen, D. Pereira, Yalçin Yavuz, Marieke L. de Kam, Hendrika W. Grievink, Matthijs Moerland, Nancy Leymarie, Kshitij Khatri, Imelda Sollomoni, Leslie Spitalny, Lindsay Dungeon, Dana Hilt, Craig Justman, Peter T. Lansbury, Geert Jan Groeneveld

    Publicado 2023
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  19. 19
    A randomized single and multiple ascending dose study in healthy volunteers of LTI‐291, a centrally penetrant glucocerebrosidase activator

    A randomized single and multiple ascending dose study in healthy volunteers of LTI‐291, a centrally penetrant glucocerebrosidase activator por Jonas M. den Heijer, Annelieke C. Kruithof, Guido van Amerongen, Marieke L. de Kam, Eva Thijssen, Hendrika W. Grievink, Matthijs Moerland, Mike Walker, Kees Been, Renato T. Skerlj, Craig Justman, Lindsay Dudgeon, Peter T. Lansbury, Valerie Cullen, Dana Hilt, Geert Jan Groeneveld

    Publicado 2021
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  20. 20
    Target engagement and immunogenicity of an active immunotherapeutic targeting pathological α-synuclein: a phase 1 placebo-controlled trial

    Target engagement and immunogenicity of an active immunotherapeutic targeting pathological α-synuclein: a phase 1 placebo-controlled trial por Pepijn Eijsvogel, Pinaki Misra, Luis Concha‐Marambio, Justin D. Boyd, Shuang Ding, Lauren Fedor, Yueh-Ting Hsieh, Yu Sun, Madeline M. Vroom, Carly M. Farris, Yihua Ma, Marieke L. de Kam, Igor Radanović, Maurits F. J. M. Vissers, Dario Mirski, Ghazal Shareghi, Mohammad Shahnawaz, Wolfgang Singer, Philip H. C. Kremer, Geert Jan Groeneveld, Hui Jing Yu, Jean‐Cosme Dodart

    Publicado 2024
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