检索结果 - Gazal, Steven

Consanguinity around the world: what do the genomic data of the HGDP-CEPH diversity panel tell us? 由 Leutenegger, Anne-Louise, Sahbatou, Mourad, Gazal, Steven, Cann, Howard, Génin, Emmanuelle

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Reconciling S-LDSC and LDAK functional enrichment estimates 由 Gazal, Steven, Marquez-Luna, Carla, Finucane, Hilary K., Price, Alkes L.

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Partitioning gene-mediated disease heritability without eQTLs 由 Weiner, Daniel J., Gazal, Steven, Robinson, Elise B., O’Connor, Luke J.

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Mixed model association for biobank-scale data sets 由 Loh, Po-Ru, Kichaev, Gleb, Gazal, Steven, Schoech, Armin P, Price, Alkes L

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Liability threshold modeling of case-control status and family history of disease increases association power 由 Hujoel, Margaux L.A., Gazal, Steven, Loh, Po-Ru, Patterson, Nick, Price, Alkes L.

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Partitioning gene-level contributions to complex-trait heritability by allele frequency identifies disease-relevant genes 由 Burch, Kathryn S., Hou, Kangcheng, Ding, Yi, Wang, Yifei, Gazal, Steven, Shi, Huwenbo, Pasaniuc, Bogdan

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Disease Heritability Enrichment of Regulatory Elements Is Concentrated in Elements with Ancient Sequence Age and Conserved Function across Species 由 Hujoel, Margaux L.A., Gazal, Steven, Hormozdiari, Farhad, van de Geijn, Bryce, Price, Alkes L.

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Improving the informativeness of Mendelian disease-derived pathogenicity scores for common disease 由 Kim, Samuel S., Dey, Kushal K., Weissbrod, Omer, Márquez-Luna, Carla, Gazal, Steven, Price, Alkes L.

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Can whole-exome sequencing data be used for linkage analysis? 由 Gazal, Steven, Gosset, Simon, Verdura, Edgard, Bergametti, Françoise, Guey, Stéphanie, Babron, Marie-Claude, Tournier-Lasserve, Elisabeth

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Extreme Polygenicity of Complex Traits Is Explained by Negative Selection 由 O'Connor, Luke J., Schoech, Armin P., Hormozdiari, Farhad, Gazal, Steven, Patterson, Nick, Price, Alkes L.

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Functional architecture of low-frequency variants highlights strength of negative selection across coding and noncoding annotations 由 Gazal, Steven, Loh, Po-Ru, Finucane, Hilary K., Ganna, Andrea, Schoech, Armin, Sunyaev, Shamil, Price, Alkes L.

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Incorporating functional priors improves polygenic prediction accuracy in UK Biobank and 23andMe data sets 由 Márquez-Luna, Carla, Gazal, Steven, Loh, Po-Ru, Kim, Samuel S., Furlotte, Nicholas, Auton, Adam, Price, Alkes L.

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SNP-to-gene linking strategies reveal contributions of enhancer-related and candidate master-regulator genes to autoimmune disease 由 Dey, Kushal K., Gazal, Steven, van de Geijn, Bryce, Kim, Samuel Sungil, Nasser, Joseph, Engreitz, Jesse M., Price, Alkes L.

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Leveraging Polygenic Functional Enrichment to Improve GWAS Power 由 Kichaev, Gleb, Bhatia, Gaurav, Loh, Po-Ru, Gazal, Steven, Burch, Kathryn, Freund, Malika K., Schoech, Armin, Pasaniuc, Bogdan, Price, Alkes L.

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Variants of genes implicated in type 1 interferon pathway and B-cell activation modulate the EULAR response to rituximab at 24 weeks in rheumatoid arthritis 由 Juge, Pierre-Antoine, Gazal, Steven, Constantin, Arnaud, Mariette, Xavier, Combe, Bernard, Tebib, Jacques, Dougados, Maxime, Sibilia, Jean, Le Loet, Xavier, Dieudé, Philippe

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Identifying disease-critical cell types and cellular processes across the human body by integration of single-cell profiles and human genetics 由 Jagadeesh, Karthik A., Dey, Kushal K., Montoro, Daniel T., Mohan, Rahul, Gazal, Steven, Engreitz, Jesse M., Xavier, Ramnik J., Price, Alkes L., Regev, Aviv

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Leveraging fine-mapping and multi-population training data to improve cross-population polygenic risk scores 由 Weissbrod, Omer, Kanai, Masahiro, Shi, Huwenbo, Gazal, Steven, Peyrot, Wouter J., Khera, Amit V., Okada, Yukinori, Martin, Alicia R., Finucane, Hilary, Price, Alkes L.

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Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations 由 Luo, Yang, Li, Xinyi, Wang, Xin, Gazal, Steven, Mercader, Josep Maria, Neale, Benjamin M, Florez, Jose C, Auton, Adam, Price, Alkes L, Finucane, Hilary K, Raychaudhuri, Soumya

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Annotations capturing cell type-specific TF binding explain a large fraction of disease heritability 由 van de Geijn, Bryce, Finucane, Hilary, Gazal, Steven, Hormozdiari, Farhad, Amariuta, Tiffany, Liu, Xuanyao, Gusev, Alexander, Loh, Po-Ru, Reshef, Yakir, Kichaev, Gleb, Raychauduri, Soumya, Price, Alkes L

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Functional Architectures of Local and Distal Regulation of Gene Expression in Multiple Human Tissues 由 Liu, Xuanyao, Finucane, Hilary K., Gusev, Alexander, Bhatia, Gaurav, Gazal, Steven, O’Connor, Luke, Bulik-Sullivan, Brendan, Wright, Fred A., Sullivan, Patrick F., Neale, Benjamin M., Price, Alkes L.

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