Risultati della ricerca - Gazal, Steven

Consanguinity around the world: what do the genomic data of the HGDP-CEPH diversity panel tell us? di Leutenegger, Anne-Louise, Sahbatou, Mourad, Gazal, Steven, Cann, Howard, Génin, Emmanuelle

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Reconciling S-LDSC and LDAK functional enrichment estimates di Gazal, Steven, Marquez-Luna, Carla, Finucane, Hilary K., Price, Alkes L.

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Partitioning gene-mediated disease heritability without eQTLs di Weiner, Daniel J., Gazal, Steven, Robinson, Elise B., O’Connor, Luke J.

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Mixed model association for biobank-scale data sets di Loh, Po-Ru, Kichaev, Gleb, Gazal, Steven, Schoech, Armin P, Price, Alkes L

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Liability threshold modeling of case-control status and family history of disease increases association power di Hujoel, Margaux L.A., Gazal, Steven, Loh, Po-Ru, Patterson, Nick, Price, Alkes L.

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Partitioning gene-level contributions to complex-trait heritability by allele frequency identifies disease-relevant genes di Burch, Kathryn S., Hou, Kangcheng, Ding, Yi, Wang, Yifei, Gazal, Steven, Shi, Huwenbo, Pasaniuc, Bogdan

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Disease Heritability Enrichment of Regulatory Elements Is Concentrated in Elements with Ancient Sequence Age and Conserved Function across Species di Hujoel, Margaux L.A., Gazal, Steven, Hormozdiari, Farhad, van de Geijn, Bryce, Price, Alkes L.

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Improving the informativeness of Mendelian disease-derived pathogenicity scores for common disease di Kim, Samuel S., Dey, Kushal K., Weissbrod, Omer, Márquez-Luna, Carla, Gazal, Steven, Price, Alkes L.

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Can whole-exome sequencing data be used for linkage analysis? di Gazal, Steven, Gosset, Simon, Verdura, Edgard, Bergametti, Françoise, Guey, Stéphanie, Babron, Marie-Claude, Tournier-Lasserve, Elisabeth

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Extreme Polygenicity of Complex Traits Is Explained by Negative Selection di O'Connor, Luke J., Schoech, Armin P., Hormozdiari, Farhad, Gazal, Steven, Patterson, Nick, Price, Alkes L.

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Functional architecture of low-frequency variants highlights strength of negative selection across coding and noncoding annotations di Gazal, Steven, Loh, Po-Ru, Finucane, Hilary K., Ganna, Andrea, Schoech, Armin, Sunyaev, Shamil, Price, Alkes L.

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Incorporating functional priors improves polygenic prediction accuracy in UK Biobank and 23andMe data sets di Márquez-Luna, Carla, Gazal, Steven, Loh, Po-Ru, Kim, Samuel S., Furlotte, Nicholas, Auton, Adam, Price, Alkes L.

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SNP-to-gene linking strategies reveal contributions of enhancer-related and candidate master-regulator genes to autoimmune disease di Dey, Kushal K., Gazal, Steven, van de Geijn, Bryce, Kim, Samuel Sungil, Nasser, Joseph, Engreitz, Jesse M., Price, Alkes L.

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Leveraging Polygenic Functional Enrichment to Improve GWAS Power di Kichaev, Gleb, Bhatia, Gaurav, Loh, Po-Ru, Gazal, Steven, Burch, Kathryn, Freund, Malika K., Schoech, Armin, Pasaniuc, Bogdan, Price, Alkes L.

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Variants of genes implicated in type 1 interferon pathway and B-cell activation modulate the EULAR response to rituximab at 24 weeks in rheumatoid arthritis di Juge, Pierre-Antoine, Gazal, Steven, Constantin, Arnaud, Mariette, Xavier, Combe, Bernard, Tebib, Jacques, Dougados, Maxime, Sibilia, Jean, Le Loet, Xavier, Dieudé, Philippe

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Identifying disease-critical cell types and cellular processes across the human body by integration of single-cell profiles and human genetics di Jagadeesh, Karthik A., Dey, Kushal K., Montoro, Daniel T., Mohan, Rahul, Gazal, Steven, Engreitz, Jesse M., Xavier, Ramnik J., Price, Alkes L., Regev, Aviv

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Leveraging fine-mapping and multi-population training data to improve cross-population polygenic risk scores di Weissbrod, Omer, Kanai, Masahiro, Shi, Huwenbo, Gazal, Steven, Peyrot, Wouter J., Khera, Amit V., Okada, Yukinori, Martin, Alicia R., Finucane, Hilary, Price, Alkes L.

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Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations di Luo, Yang, Li, Xinyi, Wang, Xin, Gazal, Steven, Mercader, Josep Maria, Neale, Benjamin M, Florez, Jose C, Auton, Adam, Price, Alkes L, Finucane, Hilary K, Raychaudhuri, Soumya

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Annotations capturing cell type-specific TF binding explain a large fraction of disease heritability di van de Geijn, Bryce, Finucane, Hilary, Gazal, Steven, Hormozdiari, Farhad, Amariuta, Tiffany, Liu, Xuanyao, Gusev, Alexander, Loh, Po-Ru, Reshef, Yakir, Kichaev, Gleb, Raychauduri, Soumya, Price, Alkes L

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Functional Architectures of Local and Distal Regulation of Gene Expression in Multiple Human Tissues di Liu, Xuanyao, Finucane, Hilary K., Gusev, Alexander, Bhatia, Gaurav, Gazal, Steven, O’Connor, Luke, Bulik-Sullivan, Brendan, Wright, Fred A., Sullivan, Patrick F., Neale, Benjamin M., Price, Alkes L.

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