Search Results - Gavin Pharaoh

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  1. 1
    The Mitochondria‐Targeted Peptide Therapeutic Elamipretide Improves Cardiac and Skeletal Muscle Function During Aging Without Detectable Changes in Tissue Epigenetic or Transcriptomic Age

    The Mitochondria‐Targeted Peptide Therapeutic Elamipretide Improves Cardiac and Skeletal Muscle Function During Aging Without Detectable Changes in Tissue Epigenetic or Transcripto... by Wayne Mitchell, Gavin Pharaoh, Alexander Tyshkovskiy, Matthew D. Campbell, David J. Marcinek, Vadim N. Gladyshev

    Published 2025
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  2. 2
    AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization

    AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization by Anja Bastian, Satoshi Matsuzaki, Kenneth M. Humphries, Gavin Pharaoh, Arpit Doshi, Nilesh Zaware, Aleem Gangjee, Michael A. Ihnat

    Published 2016
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  3. 3
    Metabolic and Stress Response Changes Precede Disease Onset in the Spinal Cord of Mutant SOD1 ALS Mice

    Metabolic and Stress Response Changes Precede Disease Onset in the Spinal Cord of Mutant SOD1 ALS Mice by Gavin Pharaoh, Kavithalakshmi Sataranatarajan, Kaitlyn Street, Shauna Hill, Jake Gregston, Bumsoo Ahn, Caroline Kinter, Michael Kinter, Holly Van Remmen

    Published 2019
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  4. 4
    Restoration of Sarcoplasmic Reticulum Ca2+ ATPase (SERCA) Activity Prevents Age-Related Muscle Atrophy and Weakness in Mice

    Restoration of Sarcoplasmic Reticulum Ca2+ ATPase (SERCA) Activity Prevents Age-Related Muscle Atrophy and Weakness in Mice by Rizwan Qaisar, Gavin Pharaoh, Shylesh Bhaskaran, Hongyang Xu, Rojina Ranjit, Jan Bian, Bumsoo Ahn, Constantin Georgescu, Jonathan D. Wren, Holly Van Remmen

    Published 2020
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  5. 5
    Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass

    Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass by Bumsoo Ahn, Gavin Pharaoh, Pavithra Premkumar, Kendra Huseman, Rojina Ranjit, Michael Kinter, Luke I. Szweda, Tamás Kiss, Gábor Áron Fülöp, Stefano Tarantini, Anna Csiszár, Zoltán Ungvári, Holly Van Remmen

    Published 2018
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  6. 6
    Loss of mitochondrial protease ClpP protects mice from diet‐induced obesity and insulin resistance

    Loss of mitochondrial protease ClpP protects mice from diet‐induced obesity and insulin resistance by Shylesh Bhaskaran, Gavin Pharaoh, Rojina Ranjit, Ashley R. Murphy, Satoshi Matsuzaki, Binoj C. Nair, Brittany Forbes, Suzana Gispert, Georg Auburger, Kenneth M. Humphries, Michael Kinter, Timothy M. Griffin, Sathyaseelan S. Deepa

    Published 2018
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  7. 7
    The mitochondrially targeted peptide elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT)

    The mitochondrially targeted peptide elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT) by Gavin Pharaoh, Varun Kamat, Sricharan Kannan, Rudolph Stuppard, Jeremy Whitson, Miguel Martı́n-Pérez, Weijun Qian, Michael J. MacCoss, Judit Villén, Peter S. Rabinovitch, Matthew D. Campbell, Ian R. Sweet, David J. Marcinek

    Published 2023
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  8. 8
    Cancer cachexia in a mouse model of oxidative stress

    Cancer cachexia in a mouse model of oxidative stress by Jacob L. Brown, Marcus M. Lawrence, Bumsoo Ahn, Parker Kneis, Katarzyna M. Piekarz, Rizwan Qaisar, Rojina Ranjit, Jan Bian, Gavin Pharaoh, Chase A. Brown, Fredrick F. Peelor, Michael Kinter, Benjamin F. Miller, Arlan Richardson, Holly Van Remmen

    Published 2020
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  9. 9
    Time-Restricted Feeding Improves Aortic Endothelial Relaxation by Enhancing Mitochondrial Function and Attenuating Oxidative Stress in Aged Mice

    Time-Restricted Feeding Improves Aortic Endothelial Relaxation by Enhancing Mitochondrial Function and Attenuating Oxidative Stress in Aged Mice by Madison Milan, Jacob Brown, Colleen L. O'Reilly, Matthew P. Bubak, Sharon Negri, Priya Balasubramanian, Arjune Dhanekula, Gavin Pharaoh, Zeke Reyff, Cade Ballard, Helen Shi, Andriy Yabluchanskiy, Michael C. Rudolph, Zoltán Ungvári, David J. Marcinek, Benjamin F. Miller, Holly Van Remmen, Stefano Tarantini

    Published 2024
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  10. 10
    Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes

    Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes by Sreemathi Logan, Gavin Pharaoh, M. Caleb Marlin, Dustin R. Masser, Satoshi Matsuzaki, Benjamin Wronowski, Alexander Yeganeh, Eileen E. Parks, Pavithra Premkumar, Julie A. Farley, Daniel B. Owen, Kenneth M. Humphries, Michael Kinter, Willard M. Freeman, Luke I. Szweda, Holly Van Remmen, William E. Sonntag

    Published 2018
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  11. 11
    Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching

    Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching by Bumsoo Ahn, Rojina Ranjit, Pavithra Premkumar, Gavin Pharaoh, Katarzyna M. Piekarz, Satoshi Matsuzaki, Dennis R. Claflin, Kaitlyn Riddle, Jennifer Judge, Shylesh Bhaskaran, Kavithalakshmi Satara Natarajan, Erika Barboza, Benjamin Wronowski, Michael Kinter, Kenneth M. Humphries, Timothy M. Griffin, Willard M. Freeman, Arlan Richardson, Susan V. Brooks, Holly Van Remmen

    Published 2019
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