Resultats de la cerca - Francesc X. Ruiz

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  1. 1
    Evolving understanding of HIV-1 reverse transcriptase structure, function, inhibition, and resistance

    Evolving understanding of HIV-1 reverse transcriptase structure, function, inhibition, and resistance per Francesc X. Ruiz, Eddy Arnold

    Publicat 2020
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  2. 2
    Biological Role of Aldo–Keto Reductases in Retinoic Acid Biosynthesis and Signaling

    Biological Role of Aldo–Keto Reductases in Retinoic Acid Biosynthesis and Signaling per Francesc X. Ruiz, Sergio Porté, Xavier Parés, Jaume Farrés

    Publicat 2012
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  3. 3
    X-Ray Crystal Structure of the Full Length Human Chitotriosidase (CHIT1) Reveals Features of Its Chitin Binding Domain

    X-Ray Crystal Structure of the Full Length Human Chitotriosidase (CHIT1) Reveals Features of Its Chitin Binding Domain per Firas Fadel, Yuguang Zhao, A. Cousido-Siah, Francesc X. Ruiz, A. Mitschler, A. Podjarny

    Publicat 2016
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  4. 4
    Structural basis for the high <i>all-trans</i> -retinaldehyde reductase activity of the tumor marker AKR1B10

    Structural basis for the high <i>all-trans</i> -retinaldehyde reductase activity of the tumor marker AKR1B10 per Oriol Gallego, Francesc X. Ruiz, Albert Ardèvol, Marta Domínguez, Rosana Álvarez, Ángel R. de Lera, Carme Rovira, Jaume Farrés, Ignacio Fita, Xavier Parés

    Publicat 2007
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  5. 5
    Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids

    Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids per Oriol Gallego, Olga V. Belyaeva, Sergio Porté, Francesc X. Ruiz, Anton V. Stetsenko, Elena Shabrova, Natalia V. Kostereva, Jaume Farrés, Xavier Parés, Natalia Y. Kedishvili

    Publicat 2006
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  6. 6
    Design of quinoline SARS-CoV-2 papain-like protease inhibitors as oral antiviral drug candidates

    Design of quinoline SARS-CoV-2 papain-like protease inhibitors as oral antiviral drug candidates per Prakash D. Jadhav, Xueying Liang, Ahmadullah Ansari, Bin Tan, Haozhou Tan, Kan Li, Xiang Chi, Alexandra K. Ford, Francesc X. Ruiz, Eddy Arnold, Xufang Deng, Jun Wang

    Publicat 2025
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  7. 7
    Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model

    Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model per Bin Tan, Xiaoming Zhang, Ahmadullah Ansari, Prakash D. Jadhav, Haozhou Tan, Kan Li, Ashima Chopra, Alexandra Ford, Xiang Chi, Francesc X. Ruiz, Eddy Arnold, Xufang Deng, Jun Wang

    Publicat 2024
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  8. 8
    Development of enhanced HIV-1 non-nucleoside reverse transcriptase inhibitors with improved resistance and pharmacokinetic profiles

    Development of enhanced HIV-1 non-nucleoside reverse transcriptase inhibitors with improved resistance and pharmacokinetic profiles per Zhao Wang, Shawn Rumrill, Dongwei Kang, Samuel Desta Guma, Da Feng, Erik De Clercq, Christophe Pannecouque, Chin‐Ho Chen, Eddy Arnold, Francesc X. Ruiz, Xinyong Liu, Peng Zhan

    Publicat 2025
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  9. 9
    Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53

    Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53 per Denise Martinez-Zapien, Francesc X. Ruiz, Juline Poirson, A. Mitschler, Juan Antonio Ortega, Anne Förster, A. Cousido-Siah, Murielle Masson, Scott Vande Pol, A. Podjarny, Gilles Travé, Katia Zanier

    Publicat 2016
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  10. 10
    Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel

    Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion... per Dongwei Kang, Francesc X. Ruiz, Da Feng, Alyssa Pilch, Tong Zhao, Fenju Wei, Zhao Wang, Yanying Sun, Zengjun Fang, Erik De Clercq, Christophe Pannecouque, Eddy Arnold, Xinyong Liu, Peng Zhan

    Publicat 2020
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  11. 11
    Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors

    Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors per Xiangyi Jiang, Boshi Huang, Shawn Rumrill, David Pople, Waleed A. Zalloum, Dongwei Kang, Fabao Zhao, Xiangkai Ji, Zhen Gao, Lide Hu, Zhao Wang, Minghui Xie, Erik De Clercq, Francesc X. Ruiz, Eddy Arnold, Christophe Pannecouque, Xinyong Liu, Peng Zhan

    Publicat 2023
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  12. 12
    Discovery of (<i>R</i>)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury

    Discovery of (<i>R</i>)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial... per M.C. Van Zandt, Darren L. Whitehouse, Adam Gołȩbiowski, Min Koo Ji, Mingbao Zhang, R. Paul Beckett, G. Erik Jagdmann, Todd R. Ryder, Ryan Sheeler, Monica Andreoli, Barbara R. Conway, Keyvan Mahboubi, Gerard D’Angelo, A. Mitschler, A. Cousido-Siah, Francesc X. Ruiz, Eduardo Howard, A. Podjarny, Hagen Schroeter

    Publicat 2013
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  13. 13
    Evolution of the <scp>SARS‐CoV</scp>‐2 proteome in three dimensions (3D) during the first 6 months of the <scp>COVID</scp>‐19 pandemic

    Evolution of the <scp>SARS‐CoV</scp>‐2 proteome in three dimensions (3D) during the first 6 months of the <scp>COVID</scp>‐19 pandemic per Joseph H. Lubin, Christine Zardecki, Elliott M. Dolan, Changpeng Lu, Zhuofan Shen, Shuchismita Dutta, John D. Westbrook, Brian P. Hudson, David S. Goodsell, Jonathan K. Williams, Maria Voigt, Vidur Sarma, Lingjun Xie, Thejasvi Venkatachalam, Steven E. Arnold, Luz Helena Alfaro Alvarado, Kevin Catalfano, Aaliyah Khan, Erika McCarthy, Sophia Staggers, Brea Tinsley, Alan Trudeau, Jitendra Singh, Lindsey Whitmore, Helen Zheng, Matthew Benedek, Jenna Currier, Mark Dresel, Ashish Duvvuru, Britney Dyszel, Emily Fingar, Elizabeth M. Hennen, Michael Kirsch, Ali A. Khan, Charlotte Labrie‐Cleary, Stephanie Laporte, Evan Lenkeit, Kailey N. Martin, Marilyn Orellana, Melanie Ortiz Alvarez de la Campa, Isaac Paredes, Baleigh Wheeler, Allison Rupert, Andrew Sam, Katherine See, Santiago Soto Zapata, P. Craig, Bonnie L. Hall, Jennifer Jiang, Julia R. Koeppe, Stephen A. Mills, Michael J. Pikaart, Rebecca Roberts, Yana Bromberg, J. Steen Hoyer, Siobain Duffy, Jay A. Tischfield, Francesc X. Ruiz, Eddy Arnold, Jean Baum, Jesse Sandberg, Grace Brannigan, Sagar D. Khare, S.K. Burley

    Publicat 2021
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