Search Results - Evan C. Lien

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  1. 1
    PI3K signaling in cancer: beyond AKT

    PI3K signaling in cancer: beyond AKT by Evan C. Lien, Christian C. Dibble, Alex Toker

    Published 2017
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  2. 2
    Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT

    Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT by Evan C. Lien, Laura Ghisolfi, Renee C. Geck, John M. Asara, Alex Toker

    Published 2017
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  3. 3
    Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer

    Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer by Evan C. Lien, Costas A. Lyssiotis, Ashish Juvekar, Hai Hu, John M. Asara, Lewis C. Cantley, Alex Toker

    Published 2016
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  4. 4
    A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments

    A CRISPRi/a screening platform to study cellular nutrient transport in diverse microenvironments by Christopher Chidley, Alicia M. Darnell, Benjamin L. Gaudio, Evan C. Lien, Anna M. Barbeau, Matthew G. Vander Heiden, Peter K. Sorger

    Published 2024
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  5. 5
    Low glycaemic diets alter lipid metabolism to influence tumour growth

    Low glycaemic diets alter lipid metabolism to influence tumour growth by Evan C. Lien, Anna M. Westermark, Yin Zhang, Chen Yuan, Zhaoqi Li, Allison N. Lau, Kiera M. Sapp, Brian M. Wolpin, Matthew G. Vander Heiden

    Published 2021
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  6. 6
    REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks

    REV1 inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks by Nimrat Chatterjee, Matthew A. Whitman, Cynthia Harris, Sophia M. Min, Oliver Jonas, Evan C. Lien, Alba Luengo, Matthew G. Vander Heiden, Jiyong Hong, Pei Zhou, Michael T. Hemann, Graham C. Walker

    Published 2020
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  7. 7
    NF1 deficiency drives metabolic reprogramming in ER+ breast cancer

    NF1 deficiency drives metabolic reprogramming in ER+ breast cancer by Rachel J. House, Elizabeth A. Tovar, Luke N. Redlon, Curt J. Essenburg, Patrick S. Dischinger, Abigail E. Ellis, Ian Beddows, Ryan D. Sheldon, Evan C. Lien, Carrie R. Graveel, Matthew R. Steensma

    Published 2024
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  8. 8
    Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt

    Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt by Jinfang Zhang, Kai Xu, Pengda Liu, Yan Geng, Bin Wang, Wenjian Gan, Jianping Guo, Fei Wu, Y. Rebecca Chin, Christian Berrios, Evan C. Lien, Alex Toker, James A. DeCaprio, Piotr Siciński, Wenyi Wei

    Published 2016
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  9. 9
    Lipid availability influences ferroptosis sensitivity in cancer cells by regulating polyunsaturated fatty acid trafficking

    Lipid availability influences ferroptosis sensitivity in cancer cells by regulating polyunsaturated fatty acid trafficking by Kelly H. Sokol, Cameron J. Lee, Thomas J. Rogers, Althea N. Waldhart, Abigail E. Ellis, Sahithi Madireddy, Samuel Daniels, Xinyu Ye, Mary Olesnavich, Amy Johnson, Benjamin R. Furness, Ryan D. Sheldon, Evan C. Lien

    Published 2024
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  10. 10
    Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited

    Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited by Zhaoqi Li, Brian W. Ji, Purushottam D. Dixit, Konstantine Tchourine, Evan C. Lien, Aaron M. Hosios, Keene L. Abbott, Justine C. Rutter, Anna M. Westermark, Elizabeth Gorodetsky, Lucas B. Sullivan, Matthew G. Vander Heiden, Dennis Vitkup

    Published 2022
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  11. 11
    Lipid availability influences ferroptosis sensitivity in cancer cells by regulating polyunsaturated fatty acid trafficking

    Lipid availability influences ferroptosis sensitivity in cancer cells by regulating polyunsaturated fatty acid trafficking by Kelly H. Sokol, Cameron J. Lee, Thomas J. Rogers, Althea N. Waldhart, Abigail E. Ellis, Sahithi Madireddy, Samuel Daniels, Rachel J. House, Xinyu Ye, Mary Olesnavich, Amy Johnson, Benjamin R. Furness, Ryan D. Sheldon, Evan C. Lien

    Published 2024
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  12. 12
    Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion

    Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion by Ashish Juvekar, Hai Hu, Sina Yadegarynia, Costas A. Lyssiotis, Soumya Ullas, Evan C. Lien, Gary Bellinger, Jaekyoung Son, Rosanna Hok, Pankaj Seth, Michele B. Daly, Baek Kim, Ralph Scully, John M. Asara, Lewis C. Cantley, Gerburg M. Wulf

    Published 2016
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  13. 13
    MSC-Regulated MicroRNAs Converge on the Transcription Factor FOXP2 and Promote Breast Cancer Metastasis

    MSC-Regulated MicroRNAs Converge on the Transcription Factor FOXP2 and Promote Breast Cancer Metastasis by Benjamin Cuiffo, Antoine Campagne, George W. Bell, Antonio Lembo, Francesca Orso, Evan C. Lien, Manoj Bhasin, Monica Raimo, Summer E. Hanson, Andriy Marusyk, Dorraya El‐Ashry, Peiman Hematti, Kornélia Polyák, Fatima Mechta‐Grigoriou, Odette Mariani, Stefano Volinia, Anne Vincent‐Salomon, Daniela Taverna, Antoine E. Karnoub

    Published 2014
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  14. 14
    PI3K drives the de novo synthesis of coenzyme A from vitamin B5

    PI3K drives the de novo synthesis of coenzyme A from vitamin B5 by Christian C. Dibble, Samuel A. Barritt, Grace E. Perry, Evan C. Lien, Renee C. Geck, Sarah DuBois-Coyne, David Bartee, Thomas Zengeya, Emily B. Cohen, Min Yuan, Benjamin D. Hopkins, Jordan L. Meier, John G. Clohessy, John M. Asara, Lewis C. Cantley, Alex Toker

    Published 2022
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  15. 15
    Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton

    Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton by Hai Hu, Ashish Juvekar, Costas A. Lyssiotis, Evan C. Lien, John G. Albeck, Doogie Oh, Gopal Varma, Yin P. Hung, Soumya Ullas, Josh Lauring, Pankaj Seth, Mark R. Lundquist, Dean R. Tolan, Aaron K. Grant, Daniel Needleman, John M. Asara, Lewis C. Cantley, Gerburg M. Wulf

    Published 2016
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  16. 16
    The SCF <sup>β-TRCP</sup> E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis

    The SCF <sup>β-TRCP</sup> E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis by Kouhei Shimizu, Hidefumi Fukushima, Kohei Ogura, Evan C. Lien, Naoe Taira Nihira, Jinfang Zhang, Brian J. North, Ailan Guo, Katsuyuki Nagashima, Tadashi Nakagawa, Seira Hoshikawa, Asami Watahiki, Koji Okabe, Aya Yamada, Alex Toker, John M. Asara, Satoshi Fukumoto, Keiichi I. Nakayama, Keiko Nakayama, Hiroyuki Inuzuka, Wenyi Wei

    Published 2017
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  17. 17
    Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis

    Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis by Andrew G. Cox, Allison Tsomides, Andrew J. Kim, Diane C. Saunders, Katie L. Hwang, Kimberley Evason, Jerry R. Heidel, Kristin Brown, Min Yuan, Evan C. Lien, Byung Cheon Lee, Sahar Nissim, Bryan C. Dickinson, Sagar Chhangawala, Christopher J. Chang, John M. Asara, Yariv Houvras, Vadim N. Gladyshev, Wolfram Goessling

    Published 2016
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  18. 18
    Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma

    Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma by Allison N. Lau, Zhaoqi Li, Laura V. Danai, Anna M. Westermark, Alicia M. Darnell, Raphaël Ferreira, Vasilena Gocheva, Sharanya Sivanand, Evan C. Lien, Kiera M. Sapp, Jared R. Mayers, Giulia Biffi, Christopher R. Chin, Shawn M. Davidson, David A. Tuveson, Tyler Jacks, Nicholas J. Matheson, Ömer Yılmaz, Matthew G. Vander Heiden

    Published 2020
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  19. 19
    Ketogenic HMG‐CoA lyase and its product β‐hydroxybutyrate promote pancreatic cancer progression

    Ketogenic HMG‐CoA lyase and its product β‐hydroxybutyrate promote pancreatic cancer progression by Victoire Gouirand, Tristan Gicquel, Evan C. Lien, Emilie Jaune, Quentin Da Costa, Pascal Finetti, Elodie Metay, Camille Duluc, Jared R. Mayers, Stéphane Audebert, Luc Camoin, Laurence Borge, Marion Rubis, Julie Leca, Jérémy Nigri, François Bertucci, Nelson Dusetti, Juan Iovanna, Richard Tomasini, Ghislain Bidaut, Fabienne Guillaumond, Matthew G. Vander Heiden, Sophie Vasseur

    Published 2022
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  20. 20
    Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth

    Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth by Andrew G. Cox, Katie L. Hwang, Kristin Brown, Kimberley Evason, Sebastian Beltz, Allison Tsomides, Keelin O’Connor, Giorgio Giacomo Galli, Dean Yimlamai, Sagar Chhangawala, Min Yuan, Evan C. Lien, Julia Wücherpfennig, Sahar Nissim, Akihiro Minami, David E. Cohen, Fernando D. Camargo, John M. Asara, Yariv Houvras, Didier Y. R. Stainier, Wolfram Goessling

    Published 2016
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