Search Results - Elizabeth L. Lockerman

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  1. 1
    Cabozantinib Overcomes Crizotinib Resistance in ROS1 Fusion–Positive Cancer

    Cabozantinib Overcomes Crizotinib Resistance in ROS1 Fusion–Positive Cancer by Ryohei Katayama, Yuka Kobayashi, Luc Friboulet, Elizabeth L. Lockerman, Sumie Koike, Alice T. Shaw, Jeffrey A. Engelman, Naoya Fujita

    Published 2014
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  2. 2
    The Allelic Context of the C797S Mutation Acquired upon Treatment with Third-Generation EGFR Inhibitors Impacts Sensitivity to Subsequent Treatment Strategies

    The Allelic Context of the C797S Mutation Acquired upon Treatment with Third-Generation EGFR Inhibitors Impacts Sensitivity to Subsequent Treatment Strategies by Matthew J. Niederst, Haichuan Hu, Hillary E. Mulvey, Elizabeth L. Lockerman, Angel R. Garcia, Zofia Piotrowska, Lecia V. Sequist, Jeffrey A. Engelman

    Published 2015
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  3. 3
    Inhibition of mutant EGFR in lung cancer cells triggers SOX2-FOXO6-dependent survival pathways

    Inhibition of mutant EGFR in lung cancer cells triggers SOX2-FOXO6-dependent survival pathways by S. Michael Rothenberg, Kyle Concannon, Sarah Cullen, Gaylor Boulay, Alexa B. Turke, Anthony C. Faber, Elizabeth L. Lockerman, Miguel N. Rivera, Jeffrey A. Engelman, Shyamala Maheswaran, Daniel A. Haber

    Published 2015
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  4. 4
    Two Novel ALK Mutations Mediate Acquired Resistance to the Next-Generation ALK Inhibitor Alectinib

    Two Novel ALK Mutations Mediate Acquired Resistance to the Next-Generation ALK Inhibitor Alectinib by Ryohei Katayama, Luc Friboulet, Sumie Koike, Elizabeth L. Lockerman, Tahsin M. Khan, Justin F. Gainor, A. John Iafrate, Kengo Takeuchi, Makoto Taiji, Yasushi Okuno, Naoya Fujita, Jeffrey A. Engelman, Alice T. Shaw

    Published 2014
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  5. 5
    CDK 4/6 Inhibitors Sensitize PIK3CA Mutant Breast Cancer to PI3K Inhibitors

    CDK 4/6 Inhibitors Sensitize PIK3CA Mutant Breast Cancer to PI3K Inhibitors by Sadhna Vora, Dejan Juric, Nayoon Kim, Mari Mino‐Kenudson, Tiffany G. Huynh, Carlotta Costa, Elizabeth L. Lockerman, Sarah F. Pollack, Manway Liu, Xiaoyan Li, Joseph Lehár, Marion Wiesmann, Markus Wartmann, Yan Chen, Z. Alexander Cao, Maria Pinzon-Ortiz, Sunkyu Kim, Robert Schlegel, Alan Huang, Jeffrey A. Engelman

    Published 2014
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  6. 6
    Acquired Resistance to Crizotinib from a Mutation in <i>CD74</i>–<i>ROS1</i>

    Acquired Resistance to Crizotinib from a Mutation in <i>CD74</i>–<i>ROS1</i> by Mark M. Awad, Ryohei Katayama, Michele McTigue, Wei Liu, Yali Deng, Alexei Brooun, Luc Friboulet, Donghui Huang, Matthew D. Falk, Sergei Timofeevski, Keith D. Wilner, Elizabeth L. Lockerman, Tahsin M. Khan, Sidra Mahmood, Justin F. Gainor, Subba R. Digumarthy, James R. Stone, Mari Mino‐Kenudson, James G. Christensen, A. John Iafrate, Jeffrey A. Engelman, Alice T. Shaw

    Published 2013
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  7. 7
    Heterogeneity Underlies the Emergence of <i>EGFR</i>T790 Wild-Type Clones Following Treatment of T790M-Positive Cancers with a Third-Generation EGFR Inhibitor

    Heterogeneity Underlies the Emergence of <i>EGFR</i>T790 Wild-Type Clones Following Treatment of T790M-Positive Cancers with a Third-Generation EGFR Inhibitor by Zofia Piotrowska, Matthew J. Niederst, Chris Karlovich, Heather A. Wakelee, Joel W. Neal, Mari Mino‐Kenudson, Linnea Fulton, Aaron N. Hata, Elizabeth L. Lockerman, Anuj Kalsy, Subba R. Digumarthy, Alona Muzikansky, Mitch Raponi, Angel R. Garcia, Hillary E. Mulvey, Melissa Parks, Richard H. DiCecca, Dora Dias‐Santagata, A. John Iafrate, Alice T. Shaw, Andrew R. Allen, Jeffrey A. Engelman, Lecia V. Sequist

    Published 2015
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  8. 8
    The ALK Inhibitor Ceritinib Overcomes Crizotinib Resistance in Non–Small Cell Lung Cancer

    The ALK Inhibitor Ceritinib Overcomes Crizotinib Resistance in Non–Small Cell Lung Cancer by Luc Friboulet, Nanxin Li, Ryohei Katayama, Christian C. Lee, Justin F. Gainor, Adam S. Crystal, Pierre‐Yves Michellys, Mark M. Awad, Noriko Yanagitani, Sung Joon Kim, AnneMarie Culazzo Pferdekamper, Jie Li, Shailaja Kasibhatla, Frank F. Sun, Xiuying Sun, Su Hua, Peter McNamara, Sidra Mahmood, Elizabeth L. Lockerman, Naoya Fujita, Makoto Nishio, Jennifer L. Harris, Alice T. Shaw, Jeffrey A. Engelman

    Published 2014
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  9. 9
    Patient-derived models of acquired resistance can identify effective drug combinations for cancer

    Patient-derived models of acquired resistance can identify effective drug combinations for cancer by Adam S. Crystal, Alice T. Shaw, Lecia V. Sequist, Luc Friboulet, Matthew J. Niederst, Elizabeth L. Lockerman, Rosa L. Frias, Justin F. Gainor, Arnaud Amzallag, Patricia Greninger, Dana Lee, Anuj Kalsy, María Gomez‐Caraballo, Leila Elamine, Emily Howe, Wooyoung Hur, Eugene Lifshits, Hayley Robinson, Ryohei Katayama, Anthony C. Faber, Mark M. Awad, Sridhar Ramaswamy, Mari Mino‐Kenudson, A. John Iafrate, Cyril H. Benes, Jeffrey A. Engelman

    Published 2014
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  10. 10
    RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer

    RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer by Matthew J. Niederst, Lecia V. Sequist, John T. Poirier, Craig H. Mermel, Elizabeth L. Lockerman, Angel R. Garcia, Ryohei Katayama, Carlotta Costa, Kenneth N. Ross, Teresa Morán, Emily Howe, Linnea Fulton, Hillary E. Mulvey, Lindsay A. Bernardo, Farhiya Mohamoud, Norikatsu Miyoshi, Paul A. VanderLaan, Daniel B. Costa, Pasi A. Jänne, Darrell R. Borger, Sridhar Ramaswamy, Toshi Shioda, A. John Iafrate, Gad Getz, Charles M. Rudin, Mari Mino‐Kenudson, Jeffrey A. Engelman

    Published 2015
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  11. 11
    Clinical Acquired Resistance to RAF Inhibitor Combinations in <i>BRAF</i>-Mutant Colorectal Cancer through MAPK Pathway Alterations

    Clinical Acquired Resistance to RAF Inhibitor Combinations in <i>BRAF</i>-Mutant Colorectal Cancer through MAPK Pathway Alterations by Leanne G. Ahronian, Erin M. Sennott, Eliezer M. Van Allen, Nikhil Wagle, Eunice L. Kwak, Jason E. Faris, Jason T. Godfrey, Koki Nishimura, Kerry D. Lynch, Craig H. Mermel, Elizabeth L. Lockerman, Anuj Kalsy, Joseph M. Gurski, Samira Bahl, Kristin Anderka, Lisa M. Green, Niall J. Lennon, Tiffany G. Huynh, Mari Mino‐Kenudson, Gad Getz, Dora Dias‐Santagata, A. John Iafrate, Jeffrey A. Engelman, Levi A. Garraway, Ryan B. Corcoran

    Published 2015
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  12. 12
    EGF816 Exerts Anticancer Effects in Non–Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor

    EGF816 Exerts Anticancer Effects in Non–Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor by Yong Jia, Jose Juarez, Jie Li, Mari Manuia, Matthew J. Niederst, Celin Tompkins, Noelito Timple, Mei-Ting Vaillancourt, AnneMarie Culazzo Pferdekamper, Elizabeth L. Lockerman, Chun Li, Jennifer M. Anderson, Carlotta Costa, Debbie Liao, Eric A. Murphy, Michael DiDonato, Badry Bursulaya, G. Lelais, Jordi Barretina, Matthew McNeill, Robert Epple, Thomas H. Marsilje, Nazima Pathan, Jeffrey A. Engelman, Pierre‐Yves Michellys, Peter McNamara, Jennifer L. Harris, Steven L. Bender, Shailaja Kasibhatla

    Published 2016
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  13. 13
    Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition

    Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition by Aaron N. Hata, Matthew J. Niederst, Hannah L. Archibald, María Gomez‐Caraballo, Faria M. Siddiqui, Hillary E. Mulvey, Yosef E. Maruvka, Fei Ji, Hyo-Eun Carrie Bhang, Viveksagar Krishnamurthy Radhakrishna, Giulia Siravegna, Haichuan Hu, Sana Raoof, Elizabeth L. Lockerman, Anuj Kalsy, Dana Lee, Celina L Keating, David A. Ruddy, Leah J. Damon, Adam S. Crystal, Carlotta Costa, Zofia Piotrowska, Alberto Bardelli, A. John Iafrate, Ruslan I. Sadreyev, Frank Stegmeier, Gad Getz, Lecia V. Sequist, Anthony C. Faber, Jeffrey A. Engelman

    Published 2016
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  14. 14
    Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM

    Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM by Kyung-A Song, Matthew J. Niederst, Timothy L. Lochmann, Aaron N. Hata, Hidenori Kitai, Jungoh Ham, Konstantinos V. Floros, Mark Hicks, Haichuan Hu, Hillary E. Mulvey, Yotam Drier, Daniel A.R. Heisey, Mark T. Hughes, Neha U. Patel, Elizabeth L. Lockerman, Angel E. Garcı́a, Shawn Gillepsie, Hannah L. Archibald, María Gomez‐Caraballo, Tara J. Nulton, Brad E. Windle, Zofia Piotrowska, Sinem E. Sahingur, Shirley M. Taylor, Mikhail G. Dozmorov, Lecia V. Sequist, B Bernstein, Hiromichi Ebi, Jeffrey A. Engelman, Anthony C. Faber

    Published 2017
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  15. 15
    Molecular Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in<i>ALK</i>-Rearranged Lung Cancer

    Molecular Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in<i>ALK</i>-Rearranged Lung Cancer by Justin F. Gainor, Leila Dardaei, Satoshi Yoda, Luc Friboulet, Ignaty Leshchiner, Ryohei Katayama, Ibiayi Dagogo‐Jack, Shirish M. Gadgeel, Katherine R. Schultz, Manrose Singh, Emily Chin, Melissa Parks, Dana Lee, Richard H. DiCecca, Elizabeth L. Lockerman, Tiffany G. Huynh, Jennifer Logan, Lauren L. Ritterhouse, Long P. Le, Ashok Muniappan, Subba R. Digumarthy, Colleen L. Channick, Colleen Keyes, Gad Getz, Dora Dias‐Santagata, Rebecca S. Heist, Jochen K. Lennerz, Lecia V. Sequist, Cyril H. Benes, A. John Iafrate, Mari Mino‐Kenudson, Jeffrey A. Engelman, Alice T. Shaw

    Published 2016
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