Rezultati - Dongwei Kang

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  1. 1
    Recent developments in the medicinal chemistry of single boron atom-containing compounds

    Recent developments in the medicinal chemistry of single boron atom-containing compounds od Shu Song, Ping Gao, Lin Sun, Dongwei Kang, Jacob Kongsted, Vasanthanathan Poongavanam, Peng Zhan, Xinyong Liu

    Izdano 2021
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  2. 2
    Newly Emerging Strategies in Antiviral Drug Discovery: Dedicated to Prof. Dr. Erik De Clercq on Occasion of His 80th Anniversary

    Newly Emerging Strategies in Antiviral Drug Discovery: Dedicated to Prof. Dr. Erik De Clercq on Occasion of His 80th Anniversary od Shujing Xu, Dang Ding, Xujie Zhang, Lin Sun, Dongwei Kang, Boshi Huang, Xinyong Liu, Peng Zhan

    Izdano 2022
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  3. 3
    Design, synthesis and biological evaluation of tacrine-1,2,3-triazole derivatives as potent cholinesterase inhibitors

    Design, synthesis and biological evaluation of tacrine-1,2,3-triazole derivatives as potent cholinesterase inhibitors od Gaochan Wu, Yun Gao, Dongwei Kang, Boshi Huang, Zhipeng Huo, Huiqing Liu, Vasanthanathan Poongavanam, Peng Zhan, Xinyong Liu

    Izdano 2017
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  4. 4
    Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors

    Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors od Yang Yang, Dongwei Kang, Laura A. Nguyen, Z.B. Smithline, Christophe Pannecouque, Peng Zhan, Xinyong Liu, Thomas A. Steitz

    Izdano 2018
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  5. 5
    Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties

    Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties od Dongwei Kang, Da Feng, Yanying Sun, Zengjun Fang, Fenju Wei, Erik De Clercq, Christophe Pannecouque, Xinyong Liu, Peng Zhan

    Izdano 2020
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  6. 6
    Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses

    Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses od Yue Ma, Estrella Frutos-Beltrán, Dongwei Kang, Christophe Pannecouque, Erik De Clercq, Luis Menéndez‐Arias, Xinyong Liu, Peng Zhan

    Izdano 2021
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  7. 7
    Molecular design opportunities presented by solvent‐exposed regions of target proteins

    Molecular design opportunities presented by solvent‐exposed regions of target proteins od Xiangyi Jiang, Ji Yu, Zhongxia Zhou, Jacob Kongsted, Yuning Song, Christophe Pannecouque, Erik De Clercq, Dongwei Kang, Vasanthanathan Poongavanam, Xinyong Liu, Peng Zhan

    Izdano 2019
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  8. 8
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling

    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling od Yi Zheng, Meng-Wei Zhuang, Lulu Han, Jing Zhang, Mei-Ling Nan, Peng Zhan, Dongwei Kang, Xinyong Liu, Chengjiang Gao, Pei‐Hui Wang

    Izdano 2020
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  9. 9
    Contemporary Medicinal Chemistry Strategies for the Discovery and Development of Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors

    Contemporary Medicinal Chemistry Strategies for the Discovery and Development of Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors od Zhao Wang, Srinivasulu Cherukupalli, Minghui Xie, Wenbo Wang, Xiangyi Jiang, Ruifang Jia, Christophe Pannecouque, Erik De Clercq, Dongwei Kang, Peng Zhan, Xinyong Liu

    Izdano 2022
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  10. 10
    Exploring the hydrophobic channel of NNIBP leads to the discovery of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives as potent HIV-1 NNRTIs

    Exploring the hydrophobic channel of NNIBP leads to the discovery of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives as potent HIV-1 NNRTIs od Dongwei Kang, Da Feng, Tiziana Ginex, Jinmi Zou, Fenju Wei, Tong Zhao, Boshi Huang, Yanying Sun, Samuel Desta, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu

    Izdano 2019
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  11. 11
    Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library

    Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library od Gaochan Wu, Waleed A. Zalloum, Megan E. Meuser, Lanlan Jing, Dongwei Kang, Chin‐Ho Chen, Ye Tian, Fangfang Zhang, Simon Cocklin, Kuo‐Hsiung Lee, Xinyong Liu, Peng Zhan

    Izdano 2018
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  12. 12
    Development of enhanced HIV-1 non-nucleoside reverse transcriptase inhibitors with improved resistance and pharmacokinetic profiles

    Development of enhanced HIV-1 non-nucleoside reverse transcriptase inhibitors with improved resistance and pharmacokinetic profiles od Zhao Wang, Shawn Rumrill, Dongwei Kang, Samuel Desta Guma, Da Feng, Erik De Clercq, Christophe Pannecouque, Chin‐Ho Chen, Eddy Arnold, Francesc X. Ruiz, Xinyong Liu, Peng Zhan

    Izdano 2025
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  13. 13
    Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus

    Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutan... od Ye Tian, Zhaoqiang Liu, Jinghan Liu, Boshi Huang, Dongwei Kang, H. Zhang, Erik De Clercq, Dirk Daelemans, Christophe Pannecouque, Kuo‐Hsiung Lee, Chin‐Ho Chen, Peng Zhan, Xinyong Liu

    Izdano 2018
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  14. 14
    Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel

    Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion... od Dongwei Kang, Francesc X. Ruiz, Da Feng, Alyssa Pilch, Tong Zhao, Fenju Wei, Zhao Wang, Yanying Sun, Zengjun Fang, Erik De Clercq, Christophe Pannecouque, Eddy Arnold, Xinyong Liu, Peng Zhan

    Izdano 2020
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  15. 15
    Structure-Based Optimization of N-Substituted Oseltamivir Derivatives as Potent Anti-Influenza A Virus Agents with Significantly Improved Potency against Oseltamivir-Resistant N1-H274Y Variant

    Structure-Based Optimization of N-Substituted Oseltamivir Derivatives as Potent Anti-Influenza A Virus Agents with Significantly Improved Potency against Oseltamivir-Resistant N1-H... od Jian Zhang, N. Arul Murugan, Ye Tian, Chiara Bertagnin, Zengjun Fang, Dongwei Kang, Xiujie Kong, Haiyong Jia, Zhuosen Sun, Ruifang Jia, Ping Gao, Vasanthanathan Poongavanam, Arianna Loregian, Wenfang Xu, Xiuli Ma, Xiao Ding, Bing Huang, Peng Zhan, Xinyong Liu

    Izdano 2018
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  16. 16
    Design, Synthesis, and Mechanism Study of Benzenesulfonamide-Containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities

    Design, Synthesis, and Mechanism Study of Benzenesulfonamide-Containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities od Lin Sun, Alexej Dick, Megan E. Meuser, Tianguang Huang, Waleed A. Zalloum, Chin‐Ho Chen, Srinivasulu Cherukupalli, Shujing Xu, Xiao Ding, Ping Gao, Dongwei Kang, Erik De Clercq, Christophe Pannecouque, Simon Cocklin, Kuo‐Hsiung Lee, Xinyong Liu, Peng Zhan

    Izdano 2020
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  17. 17
    Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors

    Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors od Xiangyi Jiang, Boshi Huang, Shawn Rumrill, David Pople, Waleed A. Zalloum, Dongwei Kang, Fabao Zhao, Xiangkai Ji, Zhen Gao, Lide Hu, Zhao Wang, Minghui Xie, Erik De Clercq, Francesc X. Ruiz, Eddy Arnold, Christophe Pannecouque, Xinyong Liu, Peng Zhan

    Izdano 2023
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  18. 18
    Identification of Dihydrofuro[3,4-<i>d</i>]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties

    Identification of Dihydrofuro[3,4-<i>d</i>]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable P... od Dongwei Kang, Heng Zhang, Zhao Wang, Tong Zhao, Tiziana Ginex, F. Javier Luque, Yang Yang, Gaochan Wu, Da Feng, Fenju Wei, Jian Zhang, Erik De Clercq, Christophe Pannecouque, Chin Ho Chen, Kuo‐Hsiung Lee, N. Arul Murugan, Thomas A. Steitz, Peng Zhan, Xinyong Liu

    Izdano 2019
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  19. 19
    Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant

    Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant od Jian Zhang, Vasanthanathan Poongavanam, Dongwei Kang, Chiara Bertagnin, Huamei Lu, Xiujie Kong, Han Ju, Xueyi Lu, Ping Gao, Ye Tian, Haiyong Jia, Samuel Desta, Xiao Ding, Lin Sun, Zengjun Fang, Boshi Huang, Xuewu Liang, Ruifang Jia, Xiuli Ma, Wenfang Xu, N. Arul Murugan, Arianna Loregian, Bing Huang, Peng Zhan, Xinyong Liu

    Izdano 2018
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  20. 20
    Structural and signaling mechanisms of TAAR1 enabled preferential agonist design

    Structural and signaling mechanisms of TAAR1 enabled preferential agonist design od Pan Shang, Naikang Rong, Jingjing Jiang, Jie Cheng, Minghui Zhang, Dongwei Kang, Lei S. Qi, Lulu Guo, Yang Gong-ming, Qun Liu, Zhenzhen Zhou, Xiaobing Li, Kongkai Zhu, Qing-Biao Meng, Xiang Han, Wenqi Yan, Yalei Kong, Lejin Yang, Xiaohui Wang, Dapeng Lei, Xin Feng, Xinyong Liu, Xiao Yu, Yue Wang, Qian Li, Zhenhua Shao, Fan Yang, Jin‐Peng Sun

    Izdano 2023
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