نتائج البحث - Doench, John G
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Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons حسب Zdraljevic, Stefan, Strand, Christine, Seidel, Hannah S., Cook, Daniel E., Doench, John G., Andersen, Erik C.
منشور في 2017نص -
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Alternative to the soft-agar assay that permits high-throughput drug and genetic screens for cellular transformation حسب Rotem, Asaf, Janzer, Andreas, Izar, Benjamin, Ji, Zhe, Doench, John G., Garraway, Levi A., Struhl, Kevin
منشور في 2015نص -
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Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death حسب Balsa, Eduardo, Perry, Elizabeth A., Bennett, Christopher F., Jedrychowski, Mark, Gygi, Steven P., Doench, John G., Puigserver, Pere
منشور في 2020نص -
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Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool حسب Donovan, Katherine F., Hegde, Mudra, Sullender, Meagan, Vaimberg, Emma W., Johannessen, Cory M., Root, David E., Doench, John G.
منشور في 2017نص -
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A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation حسب Arroyo, Jason D., Jourdain, Alexis A., Calvo, Sarah E., Ballarano, Carmine A., Doench, John G., Root, David E., Mootha, Vamsi K.
منشور في 2016نص -
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Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects حسب Singh, Shantanu, Wu, Xiaoyun, Ljosa, Vebjorn, Bray, Mark-Anthony, Piccioni, Federica, Root, David E., Doench, John G., Boehm, Jesse S., Carpenter, Anne E.
منشور في 2015نص -
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A FACS-Based Genome-wide CRISPR Screen Reveals a Requirement for COPI in Chlamydia trachomatis Invasion حسب Park, Joseph S., Helble, Jennifer D., Lazarus, Jacob E., Yang, Guanhua, Blondel, Carlos J., Doench, John G., Starnbach, Michael N., Waldor, Matthew K.
منشور في 2018نص -
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Genetic screens in isogenic mammalian cell lines without single cell cloning حسب DeWeirdt, Peter C., Sangree, Annabel K., Hanna, Ruth E., Sanson, Kendall R., Hegde, Mudra, Strand, Christine, Persky, Nicole S., Doench, John G.
منشور في 2020نص -
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Targeted shRNA screening identified critical roles of pleckstrin-2 in erythropoiesis حسب Zhao, Baobing, Keerthivasan, Ganesan, Mei, Yang, Yang, Jing, McElherne, James, Wong, Piu, Doench, John G., Feng, Gang, Root, David E., Ji, Peng
منشور في 2014نص -
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CRISPR-Cas9 Genome-wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells حسب Grant, Corena V., Cai, Shengxin, Risinger, April L., Liang, Huiyun, O’Keefe, Barry R., Doench, John G., Cichewicz, Robert H., Mooberry, Susan L.
منشور في 2020نص -
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Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation حسب Doench, John G., Hartenian, Ella, Graham, Daniel B., Tothova, Zuzana, Hegde, Mudra, Smith, Ian, Sullender, Meagan, Ebert, Benjamin L., Xavier, Ramnik J., Root, David E.
منشور في 2014نص -
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CRISPR Screen Reveals that EHEC’s T3SS and Shiga Toxin Rely on Shared Host Factors for Infection حسب Pacheco, Alline R., Lazarus, Jacob E., Sit, Brandon, Schmieder, Stefanie, Lencer, Wayne I., Blondel, Carlos J., Doench, John G., Davis, Brigid M., Waldor, Matthew K.
منشور في 2018نص -
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Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS حسب Shi, Xiaojian, Reinstadler, Bryn, Shah, Hardik, To, Tsz-Leung, Byrne, Katie, Summer, Luanna, Calvo, Sarah E., Goldberger, Olga, Doench, John G., Mootha, Vamsi K., Shen, Hongying
منشور في 2022نص -
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Prediction of off-target activities for the end-to-end design of CRISPR guide RNAs حسب Listgarten, Jennifer, Weinstein, Michael, Kleinstiver, Benjamin P., Sousa, Alexander A., Joung, J. Keith, Crawford, Jake, Gao, Kevin, Hoang, Luong, Elibol, Melih, Doench, John G., Fusi, Nicolo
منشور في 2018نص