檢索結果 - Dirk Heckl

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  1. 1
    Molecular Mechanisms of the Genetic Predisposition to Acute Megakaryoblastic Leukemia in Infants With Down Syndrome

    Molecular Mechanisms of the Genetic Predisposition to Acute Megakaryoblastic Leukemia in Infants With Down Syndrome 由 Juliane Grimm, Dirk Heckl, Jan‐Henning Klusmann

    出版 2021
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  2. 2
    RNA-Binding Proteins in Acute Leukemias

    RNA-Binding Proteins in Acute Leukemias 由 K Schuschel, Matthias Helwig, Stefan Hüttelmaier, Dirk Heckl, Jan‐Henning Klusmann, Jessica I. Hoell

    出版 2020
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  3. 3
    Preclinical testing of miRNA-193b-3p mimic in acute myeloid leukemias

    Preclinical testing of miRNA-193b-3p mimic in acute myeloid leukemias 由 H Issa, R Bhayadia, Robert Winkler, Laura E. Swart, Dirk Heckl, Jan‐Henning Klusmann

    出版 2023
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  4. 4
    CRISPR-Cas9-induced t(11;19)/MLL-ENL translocations initiate leukemia in human hematopoietic progenitor cells <i>in vivo</i>

    CRISPR-Cas9-induced t(11;19)/MLL-ENL translocations initiate leukemia in human hematopoietic progenitor cells <i>in vivo</i> 由 Jana Reimer, Sabine Knöß, Maurice Labuhn, Emmanuelle Charpentier, Gudrun Göhring, Brigitte Schlegelberger, Jan‐Henning Klusmann, Dirk Heckl

    出版 2017
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  5. 5
    Refined sgRNA efficacy prediction improves large- and small-scale CRISPR–Cas9 applications

    Refined sgRNA efficacy prediction improves large- and small-scale CRISPR–Cas9 applications 由 Maurice Labuhn, Felix F. Adams, Michelle Ng, Sabine Knoess, Axel Schambach, Emmanuelle Charpentier, Adrian Schwarzer, Juan L. Mateo, Jan‐Henning Klusmann, Dirk Heckl

    出版 2017
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  6. 6
    Lentiviral Vector Induced Insertional Haploinsufficiency of Ebf1 Causes Murine Leukemia

    Lentiviral Vector Induced Insertional Haploinsufficiency of Ebf1 Causes Murine Leukemia 由 Dirk Heckl, Adrian Schwarzer, Reinhard Haemmerle, Doris Steinemann, Cornelia Rudolph, Britta Skawran, Sabine Knoess, Johanna Krause, Zhixiong Li, Brigitte Schlegelberger, Christopher Baum, Ute Modlich

    出版 2012
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  7. 7
    Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing

    Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing 由 Dirk Heckl, Monika S. Kowalczyk, David Yudovich, Roger Belizaire, Rishi V. Puram, Marie McConkey, Anne L. Thielke, Jon C. Aster, Aviv Regev, Benjamin L. Ebert

    出版 2014
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  8. 8
    Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells

    Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells 由 Monika S. Kowalczyk, Itay Tirosh, Dirk Heckl, Tata Nageswara Rao, Atray Dixit, Brian J. Haas, Rebekka K. Schneider, Amy J. Wagers, Benjamin L. Ebert, Aviv Regev

    出版 2015
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  9. 9
    Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

    Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells 由 Ophir Shalem, Neville E. Sanjana, Ella Hartenian, Xi Shi, David Scott, Tarjei S. Mikkelsen, Dirk Heckl, Benjamin L. Ebert, David E. Root, John G. Doench, Feng Zhang

    出版 2013
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  10. 10
    Transient Retrovirus-Based CRISPR/Cas9 All-in-One Particles for Efficient, Targeted Gene Knockout

    Transient Retrovirus-Based CRISPR/Cas9 All-in-One Particles for Efficient, Targeted Gene Knockout 由 Yvonne Knopp, Franziska K. Geis, Dirk Heckl, Stefan Horn, Thomas Neumann, Johannes Kuehle, Janine Meyer, Boris Fehse, Christopher Baum, Michael Morgan, Johann Meyer, Axel Schambach, Melanie Galla

    出版 2018
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  11. 11
    Role of Casein Kinase 1A1 in the Biology and Targeted Therapy of del(5q) MDS

    Role of Casein Kinase 1A1 in the Biology and Targeted Therapy of del(5q) MDS 由 Rebekka K. Schneider, Vera Ademà, Dirk Heckl, Marcus Järås, Mar Mallo, Allegra M. Lord, Lisa P. Chu, Marie McConkey, Rafael Kramann, Ann Mullally, Rafael Bejar, Françesc Solé, Benjamin L. Ebert

    出版 2014
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  12. 12
    Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis

    Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis 由 Rafael Kramann, Susanne Fleig, Rebekka K. Schneider, Steven Fabian, Derek P. DiRocco, Omar H. Maarouf, Janewit Wongboonsin, Yoichiro Ikeda, Dirk Heckl, Steven L. Chang, Helmut G. Rennke, Sushrut S. Waikar, Benjamin D. Humphreys

    出版 2015
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  13. 13
    LncRNA-SLC16A1-AS1 induces metabolic reprogramming during Bladder Cancer progression as target and co-activator of E2F1

    LncRNA-SLC16A1-AS1 induces metabolic reprogramming during Bladder Cancer progression as target and co-activator of E2F1 由 Stella Logotheti, Stephan Marquardt, Shailendra K. Gupta, Christin Richter, Berdien A. H. Edelhäuser, David Engelmann, Julia Brenmoehl, Christoph Söhnchen, Nico Murr, Michael P. Alpers, Krishna P. Singh, Olaf Wolkenhauer, Dirk Heckl, Alf Spitschak, Brigitte M. Pützer

    出版 2020
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  14. 14
    Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera

    Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera 由 Ann Mullally, Claudia Bruedigam, Luke Poveromo, Florian H. Heidel, Amy S. Purdon, Therese Vu, Rebecca Austin, Dirk Heckl, Lawrence J. Breyfogle, Catherine Paine Kuhn, Demetrios Kalaitzidis, Scott A. Armstrong, David A. Williams, Geoffrey R. Hill, Benjamin L. Ebert, Steven Lane

    出版 2013
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  15. 15
    Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells

    Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells 由 Jan Krönke, Namrata D. Udeshi, Anupama Narla, Peter Grauman, Slater N. Hurst, Marie McConkey, Tanya Svinkina, Dirk Heckl, Eamon Comer, Xiaoyu Li, Christie Ciarlo, Emily C. Hartman, Nikhil C. Munshi, Monica Schenone, Stuart L. Schreiber, Steven A. Carr, Benjamin L. Ebert

    出版 2013
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  16. 16
    Using a novel panel of drug-resistant triple-negative breast cancer cell lines to identify candidate therapeutic targets and biomarkers

    Using a novel panel of drug-resistant triple-negative breast cancer cell lines to identify candidate therapeutic targets and biomarkers 由 Helen E. Grimsley, Magdalena Antczak, Ian Reddin, Nina Weiler, Katie-May McLaughlin, Florian Rothweiler, Johannes Haas, Andrea Nist, Marco Mernberger, Thorsten Stiewe, Tim R. Fenton, Daniel Speidel, Catherine Harper‐Wynne, Karina Cox, Dirk Heckl, Jindrich Cínatl, Mark N. Wass, Michelle D. Garrett, Martin Michaelis

    出版 2025
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  17. 17
    Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML

    Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML 由 Rishi V. Puram, Monika S. Kowalczyk, Carl G. de Boer, Rebekka K. Schneider, Peter G. Miller, Marie McConkey, Zuzana Tóthová, Héctor Tejero, Dirk Heckl, Marcus Järås, Michelle C. Chen, Hubo Li, Alfred Tamayo, Glenn S. Cowley, Orit Rozenblatt–Rosen, Fátima Al‐Shahrour, Aviv Regev, Benjamin L. Ebert

    出版 2016
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  18. 18
    Gli1 + Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target

    Gli1 + Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target 由 Rebekka K. Schneider, Ann Mullally, Aurélien Dugourd, Fabian Peisker, Remco M. Hoogenboezem, Paulina M. H. van Strien, Eric M. Bindels, Dirk Heckl, Guntram Büsche, David Fleck, Gerhard Müller‐Newen, Janewit Wongboonsin, Mónica Ventura Ferreira, Victor G. Puelles, Julio Sáez-Rodríguez, Benjamin L. Ebert, Benjamin D. Humphreys, Rafael Kramann

    出版 2017
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  19. 19
    The non-coding RNA landscape of human hematopoiesis and leukemia

    The non-coding RNA landscape of human hematopoiesis and leukemia 由 Adrian Schwarzer, Stephan Emmrich, Franziska Schmidt, Dominik Beck, Michelle Ng, Christina Reimer, Felix F. Adams, Sarah Grasedieck, Damian Witte, Sebastian Käbler, Jason W.H. Wong, Anushi Shah, Yizhou Huang, Razan Jammal, Aliaksandra Maroz, Mojca Jongen‐Lavrencic, Axel Schambach, Florian Kuchenbauer, John E. Pimanda, Dirk Reinhardt, Dirk Heckl, Jan‐Henning Klusmann

    出版 2017
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  20. 20
    Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation

    Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation 由 Sébastien Jacquelin, Jasmin Straube, Leanne Cooper, Therese Vu, Axia Song, Megan J. Bywater, Eva Baxter, Matthew Heidecker, Brad Wackrow, Amy H. Porter, Victoria Y. Ling, Jonathan Green, Rebecca Austin, Stephen H. Kazakoff, Nicola Waddell, Luke B. Hesson, John E. Pimanda, Frank Stegelmann, Lars Bullinger, Konstanze Döhner, Raajit K. Rampal, Dirk Heckl, Geoffrey R. Hill, Steven Lane

    出版 2018
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