Výsledky vyhledávání - Dirk Heckl
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CRISPR-Cas9-induced t(11;19)/MLL-ENL translocations initiate leukemia in human hematopoietic progenitor cells <i>in vivo</i> Autor Jana Reimer, Sabine Knöß, Maurice Labuhn, Emmanuelle Charpentier, Gudrun Göhring, Brigitte Schlegelberger, Jan‐Henning Klusmann, Dirk Heckl
Vydáno 2017Artigo -
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Refined sgRNA efficacy prediction improves large- and small-scale CRISPR–Cas9 applications Autor Maurice Labuhn, Felix F. Adams, Michelle Ng, Sabine Knoess, Axel Schambach, Emmanuelle Charpentier, Adrian Schwarzer, Juan L. Mateo, Jan‐Henning Klusmann, Dirk Heckl
Vydáno 2017Artigo -
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Lentiviral Vector Induced Insertional Haploinsufficiency of Ebf1 Causes Murine Leukemia Autor Dirk Heckl, Adrian Schwarzer, Reinhard Haemmerle, Doris Steinemann, Cornelia Rudolph, Britta Skawran, Sabine Knoess, Johanna Krause, Zhixiong Li, Brigitte Schlegelberger, Christopher Baum, Ute Modlich
Vydáno 2012Artigo -
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Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing Autor Dirk Heckl, Monika S. Kowalczyk, David Yudovich, Roger Belizaire, Rishi V. Puram, Marie McConkey, Anne L. Thielke, Jon C. Aster, Aviv Regev, Benjamin L. Ebert
Vydáno 2014Artigo -
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Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells Autor Monika S. Kowalczyk, Itay Tirosh, Dirk Heckl, Tata Nageswara Rao, Atray Dixit, Brian J. Haas, Rebekka K. Schneider, Amy J. Wagers, Benjamin L. Ebert, Aviv Regev
Vydáno 2015Artigo -
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Transient Retrovirus-Based CRISPR/Cas9 All-in-One Particles for Efficient, Targeted Gene Knockout Autor Yvonne Knopp, Franziska K. Geis, Dirk Heckl, Stefan Horn, Thomas Neumann, Johannes Kuehle, Janine Meyer, Boris Fehse, Christopher Baum, Michael Morgan, Johann Meyer, Axel Schambach, Melanie Galla
Vydáno 2018Artigo -
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Role of Casein Kinase 1A1 in the Biology and Targeted Therapy of del(5q) MDS Autor Rebekka K. Schneider, Vera Ademà, Dirk Heckl, Marcus Järås, Mar Mallo, Allegra M. Lord, Lisa P. Chu, Marie McConkey, Rafael Kramann, Ann Mullally, Rafael Bejar, Françesc Solé, Benjamin L. Ebert
Vydáno 2014Artigo -
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Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis Autor Rafael Kramann, Susanne Fleig, Rebekka K. Schneider, Steven Fabian, Derek P. DiRocco, Omar H. Maarouf, Janewit Wongboonsin, Yoichiro Ikeda, Dirk Heckl, Steven L. Chang, Helmut G. Rennke, Sushrut S. Waikar, Benjamin D. Humphreys
Vydáno 2015Artigo -
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LncRNA-SLC16A1-AS1 induces metabolic reprogramming during Bladder Cancer progression as target and co-activator of E2F1 Autor Stella Logotheti, Stephan Marquardt, Shailendra K. Gupta, Christin Richter, Berdien A. H. Edelhäuser, David Engelmann, Julia Brenmoehl, Christoph Söhnchen, Nico Murr, Michael P. Alpers, Krishna P. Singh, Olaf Wolkenhauer, Dirk Heckl, Alf Spitschak, Brigitte M. Pützer
Vydáno 2020Artigo -
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Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera Autor Ann Mullally, Claudia Bruedigam, Luke Poveromo, Florian H. Heidel, Amy S. Purdon, Therese Vu, Rebecca Austin, Dirk Heckl, Lawrence J. Breyfogle, Catherine Paine Kuhn, Demetrios Kalaitzidis, Scott A. Armstrong, David A. Williams, Geoffrey R. Hill, Benjamin L. Ebert, Steven Lane
Vydáno 2013Artigo -
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Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells Autor Jan Krönke, Namrata D. Udeshi, Anupama Narla, Peter Grauman, Slater N. Hurst, Marie McConkey, Tanya Svinkina, Dirk Heckl, Eamon Comer, Xiaoyu Li, Christie Ciarlo, Emily C. Hartman, Nikhil C. Munshi, Monica Schenone, Stuart L. Schreiber, Steven A. Carr, Benjamin L. Ebert
Vydáno 2013Artigo -
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Using a novel panel of drug-resistant triple-negative breast cancer cell lines to identify candidate therapeutic targets and biomarkers Autor Helen E. Grimsley, Magdalena Antczak, Ian Reddin, Nina Weiler, Katie-May McLaughlin, Florian Rothweiler, Johannes Haas, Andrea Nist, Marco Mernberger, Thorsten Stiewe, Tim R. Fenton, Daniel Speidel, Catherine Harper‐Wynne, Karina Cox, Dirk Heckl, Jindrich Cínatl, Mark N. Wass, Michelle D. Garrett, Martin Michaelis
Vydáno 2025Artigo -
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Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML Autor Rishi V. Puram, Monika S. Kowalczyk, Carl G. de Boer, Rebekka K. Schneider, Peter G. Miller, Marie McConkey, Zuzana Tóthová, Héctor Tejero, Dirk Heckl, Marcus Järås, Michelle C. Chen, Hubo Li, Alfred Tamayo, Glenn S. Cowley, Orit Rozenblatt–Rosen, Fátima Al‐Shahrour, Aviv Regev, Benjamin L. Ebert
Vydáno 2016Artigo -
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Gli1 + Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target Autor Rebekka K. Schneider, Ann Mullally, Aurélien Dugourd, Fabian Peisker, Remco M. Hoogenboezem, Paulina M. H. van Strien, Eric M. Bindels, Dirk Heckl, Guntram Büsche, David Fleck, Gerhard Müller‐Newen, Janewit Wongboonsin, Mónica Ventura Ferreira, Victor G. Puelles, Julio Sáez-Rodríguez, Benjamin L. Ebert, Benjamin D. Humphreys, Rafael Kramann
Vydáno 2017Artigo -
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The non-coding RNA landscape of human hematopoiesis and leukemia Autor Adrian Schwarzer, Stephan Emmrich, Franziska Schmidt, Dominik Beck, Michelle Ng, Christina Reimer, Felix F. Adams, Sarah Grasedieck, Damian Witte, Sebastian Käbler, Jason W.H. Wong, Anushi Shah, Yizhou Huang, Razan Jammal, Aliaksandra Maroz, Mojca Jongen‐Lavrencic, Axel Schambach, Florian Kuchenbauer, John E. Pimanda, Dirk Reinhardt, Dirk Heckl, Jan‐Henning Klusmann
Vydáno 2017Artigo -
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Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation Autor Sébastien Jacquelin, Jasmin Straube, Leanne Cooper, Therese Vu, Axia Song, Megan J. Bywater, Eva Baxter, Matthew Heidecker, Brad Wackrow, Amy H. Porter, Victoria Y. Ling, Jonathan Green, Rebecca Austin, Stephen H. Kazakoff, Nicola Waddell, Luke B. Hesson, John E. Pimanda, Frank Stegelmann, Lars Bullinger, Konstanze Döhner, Raajit K. Rampal, Dirk Heckl, Geoffrey R. Hill, Steven Lane
Vydáno 2018Artigo
Vyhledávací nástroje:
Související témata
Biology
Genetics
Cancer research
Gene
Medicine
Stem cell
Haematopoiesis
Immunology
Myeloid leukemia
Computational biology
Leukemia
Cell biology
Myeloid
CRISPR
Cas9
Genome editing
Progenitor cell
Bone marrow
Cancer
Down syndrome
Genome
Internal medicine
Myelofibrosis
RNA
Biochemistry
Bioinformatics
Computer science
Epigenetics
Fibrosis
GLI1