Resultados da busca - Dina Robaa

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  1. 1
    Proteolysis targeting chimeras (PROTACs) for epigenetics research

    Proteolysis targeting chimeras (PROTACs) for epigenetics research por Anja Vogelmann, Dina Robaa, Wolfgang Sippl, Manfred Jung

    Publicado em 2020
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  2. 2
    The Current State of NAD<sup>+</sup>‐Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets

    The Current State of NAD<sup>+</sup>‐Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets por Matthias Schiedel, Dina Robaa, Tobias Rumpf, Wolfgang Sippl, Manfred Jung

    Publicado em 2017
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  3. 3
    Comparative Structure-Based Virtual Screening Utilizing Optimized AlphaFold Model Identifies Selective HDAC11 Inhibitor

    Comparative Structure-Based Virtual Screening Utilizing Optimized AlphaFold Model Identifies Selective HDAC11 Inhibitor por Fady Baselious, Sebastian Hilscher, Dina Robaa, Cyril Bařinka, Mike Schutkowski, Wolfgang Sippl

    Publicado em 2024
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  4. 4
    HADDOCK-Guided modeling and molecular simulations of cereblon-based ternary complexes: Development of novel PROTACs for Ataxia telangiectasia and RAD3-Related (ATR) kinase

    HADDOCK-Guided modeling and molecular simulations of cereblon-based ternary complexes: Development of novel PROTACs for Ataxia telangiectasia and RAD3-Related (ATR) kinase por Anne‐Christin Sarnow, Husam Nassar, Abdallah M. Alfayomy, Dina Robaa, Wolfgang Sippl

    Publicado em 2025
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  5. 5
    Ternary Complex Modeling, Induced Fit Docking and Molecular Dynamics Simulations as a Successful Approach for the Design of VHL‐Mediated PROTACs Targeting the Kinase FLT3

    Ternary Complex Modeling, Induced Fit Docking and Molecular Dynamics Simulations as a Successful Approach for the Design of VHL‐Mediated PROTACs Targeting the Kinase FLT3 por Husam Nassar, Anne‐Christin Sarnow, İ. Çelik, Mohamed Abdelsalam, Dina Robaa, Wolfgang Sippl

    Publicado em 2025
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  6. 6
    Evolutionary relationships among protein lysine deacetylases of parasites causing neglected diseases

    Evolutionary relationships among protein lysine deacetylases of parasites causing neglected diseases por Larissa Scholte, Marina de Moraes Mourão, Fabiano Pais, Jelena Melesina, Dina Robaa, Ângela C. Volpini, Wolfgang Sippl, Raymond J. Pierce, Guilherme Oliveira, Laila Alves Nahum

    Publicado em 2017
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  7. 7
    A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing

    A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing por Conrad V. Simoben, Dina Robaa, Alokta Chakrabarti, Matthias Schmidt, Martin Marek, Julien Lancelot, Srinivasaraghavan Kannan, Jelena Melesina, T.B. Shaik, Raymond J. Pierce, Christophe Romier, Manfred Jung, Wolfgang Sippl

    Publicado em 2018
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  8. 8
    Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity

    Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity por Salma Darwish, Ehab Ghazy, Tino Heimburg, Daniel Herp, Patrik Zeyen, Rabia Salem-Altintas, Johannes Ridinger, Dina Robaa, Matthias Schmidt, Frank Erdmann, Matthias Schmidt, Christophe Romier, Manfred Jung, Ina Oehme, Wolfgang Sippl

    Publicado em 2022
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  9. 9
    Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from <i>Schistosoma mansoni</i> for the Treatment of Schistosomiasis

    Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from <i>Schistosoma mansoni</i> for the Treatment of Schistosomiasis por Tino Heimburg, Alokta Chakrabarti, Julien Lancelot, Martin Marek, Jelena Melesina, Alexander‐Thomas Hauser, T.B. Shaik, Sylvie Duclaud, Dina Robaa, Frank Erdmann, Matthias Schmidt, Christophe Romier, Raymond J. Pierce, Manfred Jung, Wolfgang Sippl

    Publicado em 2016
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  10. 10
    Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors

    Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors por Katharina Vögerl, Nghia Ong, Johanna Senger, Daniel Herp, Matthias Schmidt, Martin Marek, Martin Müller, Karin Bartel, T.B. Shaik, Nicholas J. Porter, Dina Robaa, D.W. Christianson, Christophe Romier, Wolfgang Sippl, Manfred Jung, Franz Bracher

    Publicado em 2019
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  11. 11
    Development of Alkylated Hydrazides as Highly Potent and Selective Class I Histone Deacetylase Inhibitors with T cell Modulatory Properties

    Development of Alkylated Hydrazides as Highly Potent and Selective Class I Histone Deacetylase Inhibitors with T cell Modulatory Properties por Ping Sun, Jing Wang, Khadija Shahed Khan, Weiqin Yang, Wai‐Lung Ng, Nikita V. Ilment, Matthes Zessin, Emre F. Bülbül, Dina Robaa, Frank Erdmann, Matthias Schmidt, Christophe Romier, Mike Schutkowski, Alfred S.L. Cheng, Wolfgang Sippl

    Publicado em 2022
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  12. 12
    Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells

    Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells por Patrik Zeyen, Yanira Zeyn, Daniel Herp, Fereshteh Mahmoudi, Talha Z. Yesiloglu, Frank Erdmann, Matthias Schmidt, Dina Robaa, Christophe Romier, Johannes Ridinger, Corey J. Herbst‐Gervasoni, D.W. Christianson, Ina Oehme, Manfred Jung, Oliver H. Krämer, Wolfgang Sippl

    Publicado em 2022
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  13. 13
    Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants

    Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants por Martin Marek, T.B. Shaik, Tino Heimburg, Alokta Chakrabarti, Julien Lancelot, Elizabeth Ramos‐Morales, Cyrielle da Veiga, Dmitrii V. Kalinin, Jelena Melesina, Dina Robaa, Matthias Schmidt, Takayoshi Suzuki, Ralph Holl, Eric Ennifar, Raymond J. Pierce, Manfred Jung, Wolfgang Sippl, Christophe Romier

    Publicado em 2018
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  14. 14
    Synthesis, Molecular Docking and Biological Characterization of Pyrazine Linked 2-Aminobenzamides as New Class I Selective Histone Deacetylase (HDAC) Inhibitors with Anti-Leukemic Activity

    Synthesis, Molecular Docking and Biological Characterization of Pyrazine Linked 2-Aminobenzamides as New Class I Selective Histone Deacetylase (HDAC) Inhibitors with Anti-Leukemic... por Hany S. Ibrahim, Mohamed Abdelsalam, Yanira Zeyn, Matthes Zessin, Al‐Hassan M. Mustafa, Marten A. Fischer, Patrik Zeyen, Ping Sun, Emre F. Bülbül, Anita Vecchio, Frank Erdmann, Matthias Schmidt, Dina Robaa, Cyril Bařinka, Christophe Romier, Mike Schutkowski, Oliver H. Krämer, Wolfgang Sippl

    Publicado em 2021
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  15. 15
    Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells

    Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells por Eva Plesch, Cheng‐Chang Chen, Elisabeth Butz, Anna Scotto Rosato, Einar Krogsaeter, Hua Yinan, Karin Bartel, Marco Keller, Dina Robaa, Daniel Teupser, Lesca M. Holdt, Angelika M. Vollmar, Wolfgang Sippl, Rosa Puertollano, Diego L. Medina, Martin Biel, Christian Wahl‐Schott, Franz Bracher, Christian Grimm

    Publicado em 2018
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  16. 16
    Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in <i>Schistosoma mansoni</i>

    Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in <i>Schistoso... por Vitor Coutinho Carneiro, Isabel Caetano de Abreu da Silva, Murilo Sena Amaral, Adriana S. A. Pereira, Gilbert O. Silveira, David da Silva Pires, Sérgio Verjovski-Almeida, Frank J. Dekker, Dante Rotili, Antonello Mai, Eduardo José Lopes Torres, Dina Robaa, Wolfgang Sippl, Raymond J. Pierce, María Teresa Borrello, A. Ganesan, Julien Lancelot, Silvana Carvalho Thiengo, Mônica Ammon Fernandez, Amanda Roberta Revoredo Vicentino, Marina de Moraes Mourão, Fernanda Sales Coelho, Marcelo Rosado Fantappíé

    Publicado em 2019
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  17. 17
    Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni

    Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma... por Vitor Coutinho Carneiro, Isabel Caetano de Abreu da Silva, Murilo Sena Amaral, Adriana S. A. Pereira, Gilbert O. Silveira, David da Silva Pires, Sérgio Verjovski-Almeida, Frank J. Dekker, Dante Rotili, Antonello Mai, Eduardo José Lopes Torres, Dina Robaa, Wolfgang Sippl, Raymond J. Pierce, María Teresa Borrello, A. Ganesan, Julien Lancelot, Silvana Carvalho Thiengo, Mônica Ammon Fernandez, Amanda Roberta Revoredo Vicentino, Marina de Moraes Mourão, Fernanda Sales Coelho, Marcelo Rosado Fantappíé

    Publicado em 2020
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