Søgeresultater - Debashis Sarker

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  1. 1
    Pharmacodynamic Biomarker Development for PI3K Pathway Therapeutics

    Pharmacodynamic Biomarker Development for PI3K Pathway Therapeutics af Debra H. Josephs, Debashis Sarker

    Udgivet 2015
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  2. 2
    Targeting the PI3K/AKT Pathway for the Treatment of Prostate Cancer

    Targeting the PI3K/AKT Pathway for the Treatment of Prostate Cancer af Debashis Sarker, Alison Reid, Timothy A. Yap, Johann S. de Bono

    Udgivet 2009
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  3. 3
    Improving the outcome of patients with castration-resistant prostate cancer through rational drug development

    Improving the outcome of patients with castration-resistant prostate cancer through rational drug development af Gerhardt Attard, Debashis Sarker, Alison Reid, R. Molife, Chris Parker, Johann S. de Bono

    Udgivet 2006
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  4. 4
    Effect of Patient Socioeconomic Status on Access to Early-Phase Cancer Trials

    Effect of Patient Socioeconomic Status on Access to Early-Phase Cancer Trials af Aisyah Mohd Noor, Debashis Sarker, Suzanne Vizor, Blair Kp McLennan, Sarah Hunter, Aneta Suder, Henrik Møller, James Spicer, Sophie Papa

    Udgivet 2012
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  5. 5
    Chronic inflammation markers are associated with risk of pancreatic cancer in the Swedish AMORIS cohort study

    Chronic inflammation markers are associated with risk of pancreatic cancer in the Swedish AMORIS cohort study af Sam Sollie, Dominique S. Michaud, Debashis Sarker, Sophia N. Karagiannis, Debra H. Josephs, Niklas Hammar, Aida Santaolalla, Göran Walldius, Hans Garmo, Lars Holmberg, Ingmar Jungner, Mieke Van Hemelrijck

    Udgivet 2019
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  6. 6
    First-in-human study of LY3039478, an oral Notch signaling inhibitor in advanced or metastatic cancer

    First-in-human study of LY3039478, an oral Notch signaling inhibitor in advanced or metastatic cancer af Christophe Massard, A. Ázaro, Jean‐Charles Soria, Ulrik Lassen, Christophe Le Tourneau, Debashis Sarker, Claire Smith, U. Ohnmacht, Gerard J. Oakley, Bharvin K.R. Patel, Eunice Yuen, Karim A. Benhadji, Jordi Rodón

    Udgivet 2018
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  7. 7
    First-in-human study of the PARP/tankyrase inhibitor E7449 in patients with advanced solid tumours and evaluation of a novel drug-response predictor

    First-in-human study of the PARP/tankyrase inhibitor E7449 in patients with advanced solid tumours and evaluation of a novel drug-response predictor af Ruth Plummer, Divyanshu Dua, Nicola Cresti, Yvette Drew, Peter Stephens, Marie L. Foegh, Steen Knudsen, Perminder S. Sachdev, Bipin Mistry, Vaishali Dixit, Sharon McGonigle, Nancy Hall, Mark Matijevic, Shannon McGrath, Debashis Sarker

    Udgivet 2020
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  8. 8
    A Phase 1/2 trial of SRA737 (a Chk1 inhibitor) administered orally in patients with advanced cancer

    A Phase 1/2 trial of SRA737 (a Chk1 inhibitor) administered orally in patients with advanced cancer af Rebecca Kristeleit, Ruth Plummer, Robert H. Jones, Louise Carter, Sarah P. Blagden, Debashis Sarker, Hendrik‐Tobias Arkenau, T.R. Jeffry Evans, Sarah Danson, Stefan N. Symeonides, Gareth J. Veal, Barbara Klencke, Mark Kowalski, Udai Banerji

    Udgivet 2023
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  9. 9
    Chemotherapy with 5-fluorouracil, cisplatin and streptozocin for neuroendocrine tumours

    Chemotherapy with 5-fluorouracil, cisplatin and streptozocin for neuroendocrine tumours af Nicholas C. Turner, Sandra J. Strauss, Debashis Sarker, Roopinder Gillmore, Amy A. Kirkwood, A. Hackshaw, Anthie Papadopoulou, J. Bell, Irfan Kayani, Christos Toumpanakis, Federica Grillo, A Mayer, Daniel Hochhauser, Richard H. J. Beǵent, Martyn Caplin, Tim Meyer

    Udgivet 2010
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  10. 10
    A Phase I Pharmacokinetic and Pharmacodynamic Study of TKI258, an Oral, Multitargeted Receptor Tyrosine Kinase Inhibitor in Patients with Advanced Solid Tumors

    A Phase I Pharmacokinetic and Pharmacodynamic Study of TKI258, an Oral, Multitargeted Receptor Tyrosine Kinase Inhibitor in Patients with Advanced Solid Tumors af Debashis Sarker, R. Molife, T. R. J. Evans, Maryon Hardie, Cheryl Marriott, Priska Butzberger-Zimmerli, Rosemary Morrison, Judith A. Fox, Carla Heise, Sharianne G. Louie, Natasha Aziz, F. Garzon, Glenn Michelson, Ian Judson, Dalal Jadayel, Edgar Braendle, Johann S. de Bono

    Udgivet 2008
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  11. 11
    USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer

    USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer af Jessica K. Nelson, May Zaw Thin, Theodore Evan, Steven Howell, Mary Wu, Bruna Almeida, Nathalie Legrave, Duco S. Koenis, Gabriela Koifman, Yoichiro Sugimoto, Miriam Llorián Sopeña, James I. MacRae, Emma Nye, Michael Howell, Ambrosius P. Snijders, Andreas Prachalias, Yoh Zen, Debashis Sarker, Axel Behrens

    Udgivet 2022
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  12. 12
    Quantification of Pancreatic Cancer Proteome and Phosphorylome: Indicates Molecular Events Likely Contributing to Cancer and Activity of Drug Targets

    Quantification of Pancreatic Cancer Proteome and Phosphorylome: Indicates Molecular Events Likely Contributing to Cancer and Activity of Drug Targets af D. Britton, Yoh Zen, Alberto Quaglia, Stefan Selzer, Vikram Mitra, Christopher Lößner, Stephan Jung, Gitte Böhm, Peter Schmid, Petra Prefot, Claudia Hoehle, Saša Končarević, Julia M.W. Gee, Robert I. Nicholson, Malcolm Ward, Leandro Castellano, Justin Stebbing, Hans Dieter Zucht, Debashis Sarker, Nigel Heaton, Ian Pike

    Udgivet 2014
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  13. 13
    1913O Results from the registrational phase I/II ARROW trial of pralsetinib (BLU-667) in patients (pts) with advanced RET mutation-positive medullary thyroid cancer (RET+ MTC)

    1913O Results from the registrational phase I/II ARROW trial of pralsetinib (BLU-667) in patients (pts) with advanced RET mutation-positive medullary thyroid cancer (RET+ MTC) af Mimi I. Hu, Vivek Subbiah, Lori J. Wirth, M Schuler, Aaron S. Mansfield, Marcia S. Brose, Giuseppe Curigliano, Sophie Leboulleux, Viola W. Zhu, Bhumsuk Keam, Ignacio Matos, C-C. Lin, D.R. Adkins, Christina S. Baik, G. Lopes, Yann Godbert, Debashis Sarker, H. Zhang, Christopher D. Turner, Matthew Taylor

    Udgivet 2020
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  14. 14
    The First-in-Human Study of the Hydrogen Sulfate (Hyd-Sulfate) Capsule of the MEK1/2 Inhibitor AZD6244 (ARRY-142886): A Phase I Open-Label Multicenter Trial in Patients with Advanced Cancer

    The First-in-Human Study of the Hydrogen Sulfate (Hyd-Sulfate) Capsule of the MEK1/2 Inhibitor AZD6244 (ARRY-142886): A Phase I Open-Label Multicenter Trial in Patients with Advanc... af Udai Banerji, D. Ross Camidge, Henk M.W. Verheul, Roshan Agarwal, Debashis Sarker, Stan B. Kaye, Ingrid M.E. Desar, Johanna N.H. Timmer-Bonte, Sabine Eckhardt, Karl D. Lewis, Kathryn H. Brown, Mireille Cantarini, Clive Morris, Sarah M.A. George, Paul D. Smith, Carla M.L. van Herpen

    Udgivet 2010
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  15. 15
    Updated efficacy and safety of KEYNOTE-224: a phase II study of pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib

    Updated efficacy and safety of KEYNOTE-224: a phase II study of pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib af Masatoshi Kudo, Richard S. Finn, Julien Edeline, Stéphane Cattan, Sadahisa Ogasawara, Daniel H. Palmer, Chris Verslype, Vittorina Zagonel, Lætitia Fartoux, Arndt Vogel, Debashis Sarker, Gontran Verset, Stephen L. Chan, Jennifer J. Knox, Bruno Daniele, Thomas Yau, Ellen B. Gurary, Abby B. Siegel, Anran Wang, Ann‐Lii Cheng, Andrew X. Zhu

    Udgivet 2022
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  16. 16
    Study protocol: multi-centre, randomised controlled clinical trial exploring stromal targeting in locally advanced pancreatic cancer; STARPAC2

    Study protocol: multi-centre, randomised controlled clinical trial exploring stromal targeting in locally advanced pancreatic cancer; STARPAC2 af Hemant M. Kocher, Charlotte Ackerman, Garima Priyadarshini, Cheryl Lawrence, Nishtha Kotriwala, Ramona Georgescu, Rhiannon Roberts, Christine S. Hughes, Ahmet Imrali, Claude Chelala, Judith Dixon-Hughes, David K. Chang, Peter Sasieni, Pippa Corrie, Mairéad G. McNamara, Debashis Sarker, Fieke E. M. Froeling, Alan Christie, Roopinder Gillmore, Khurum Khan, David Propper

    Udgivet 2025
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  17. 17
    Phase I clinical trial repurposing all-trans retinoic acid as a stromal targeting agent for pancreatic cancer

    Phase I clinical trial repurposing all-trans retinoic acid as a stromal targeting agent for pancreatic cancer af Hemant M. Kocher, Bristi Basu, Fieke E. M. Froeling, Debashis Sarker, Sarah Slater, Dominic Carlin, Nandita M. deSouza, Katja N. De Paepe, Michelle R. Goulart, Christine S. Hughes, Ahmet Imrali, Rhiannon Roberts, Maria Pawula, Richard Houghton, Cheryl Lawrence, Yathushan Yogeswaran, Kelly Mousa, Carike Coetzee, Peter Sasieni, Aaron Prendergast, David Propper

    Udgivet 2020
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  18. 18
    First-in-Human Phase I Study of Pictilisib (GDC-0941), a Potent Pan–Class I Phosphatidylinositol-3-Kinase (PI3K) Inhibitor, in Patients with Advanced Solid Tumors

    First-in-Human Phase I Study of Pictilisib (GDC-0941), a Potent Pan–Class I Phosphatidylinositol-3-Kinase (PI3K) Inhibitor, in Patients with Advanced Solid Tumors af Debashis Sarker, Joo Ern Ang, Richard D. Baird, Rebecca Kristeleit, Krunal Shah, Víctor Moreno, Paul A. Clarke, Florence I. Raynaud, Gallia G. Levy, Joseph A. Ware, Kathryn Mazina, Ray Lin, Jenny Wu, Jill Fredrickson, Jill M. Spoerke, Mark R. Lackner, Yibing Yan, Lori S. Friedman, Stan B. Kaye, Mika K. Derynck, Paul Workman, Johann S. de Bono

    Udgivet 2014
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  19. 19
    Pembrolizumab Monotherapy for Previously Untreated Advanced Hepatocellular Carcinoma: Data from the Open-Label, Phase II KEYNOTE-224 Trial

    Pembrolizumab Monotherapy for Previously Untreated Advanced Hepatocellular Carcinoma: Data from the Open-Label, Phase II KEYNOTE-224 Trial af Gontran Verset, Ivan Borbath, Mark Karwal, Chris Verslype, Hans Van Vlierberghe, Adel Kardosh, Vittorina Zagonel, Per Stål, Debashis Sarker, Daniel H. Palmer, Arndt Vogel, Julien Edeline, Stéphane Cattan, Masatoshi Kudo, Ann‐Lii Cheng, Sadahisa Ogasawara, Bruno Daniele, Stephen L. Chan, Jennifer J. Knox, Shukui Qin, Abby B. Siegel, Michael Chisamore, Ken Hatogai, Anran Wang, Richard S. Finn, Andrew X. Zhu

    Udgivet 2022
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  20. 20
    CD73 controls Myosin II–driven invasion, metastasis, and immunosuppression in amoeboid pancreatic cancer cells

    CD73 controls Myosin II–driven invasion, metastasis, and immunosuppression in amoeboid pancreatic cancer cells af Rémi Samain, Óscar Maiques, Joanne Monger, Hoyin Lam, Juliana Candido, Samantha L. George, Nicola Ferrari, Leonie KohIhammer, Sophia Lunetto, A. Senra Varela, José L. Orgaz, F Vilardell, Jorge Juan Olsina Kissler, Xavier Matías‐Guiu, Debashis Sarker, Adrian Biddle, Frances R. Balkwill, Jim Eyles, Robert W. Wilkinson, Hemant M. Kocher, Fernando Calvo, Claire M. Wells, Victoria Sanz‐Moreno

    Udgivet 2023
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