检索结果 - Debananda Das

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  1. 1
    Discovery and Development of Anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication

    Discovery and Development of Anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication 由 Kenji Maeda, Debananda Das, Takuya Kobayakawa, Hirokazu Tamamura, Hiroaki Takeuchi

    出版 2019
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  2. 2
    Mechanism of Darunavir (DRV)’s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV Resistance

    Mechanism of Darunavir (DRV)’s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV... 由 Manabu Aoki, Debananda Das, Hironori Hayashi, Hiromi Aoki-Ogata, Yuki Takamatsu, Arun K. Ghosh, Hiroaki Mitsuya

    出版 2018
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  3. 3
    Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir

    Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir 由 Hironori Hayashi, Nobutoki Takamune, Takashi Nirasawa, Manabu Aoki, Yoshihiko Morishita, Debananda Das, Yasuhiro Koh, Arun K. Ghosh, Shogo Misumi, Hiroaki Mitsuya

    出版 2014
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  4. 4
    Involvement of the Second Extracellular Loop and Transmembrane Residues of CCR5 in Inhibitor Binding and HIV-1 Fusion: Insights into the Mechanism of Allosteric Inhibition

    Involvement of the Second Extracellular Loop and Transmembrane Residues of CCR5 in Inhibitor Binding and HIV-1 Fusion: Insights into the Mechanism of Allosteric Inhibition 由 Kenji Maeda, Debananda Das, Philip D. Yin, K. Tsuchiya, Hiromi Ogata-Aoki, Hirotomo Nakata, Rachael Norman, Lauren Hackney, Yoshikazu Takaoka, Hiroaki Mitsuya

    出版 2008
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  5. 5
    A Novel Bis-Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI), GRL-98065, Is Potent against Multiple-PI-Resistant Human Immunodeficiency Virus In Vitro

    A Novel Bis-Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI), GRL-98065, Is Potent against Multiple-PI-Resistant Human Immunodeficiency Virus In Vitro 由 Masayuki Amano, Yasuhiro Koh, Debananda Das, Jianfeng Li, Sofiya Leschenko, Yuan-Fang Wang, Péter Boross, Irene T. Weber, Arun K. Ghosh, Hiroaki Mitsuya

    出版 2007
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  6. 6
    <i>In Vitro</i> Selection of Highly Darunavir-Resistant and Replication-Competent HIV-1 Variants by Using a Mixture of Clinical HIV-1 Isolates Resistant to Multiple Conventional Protease Inhibitors

    <i>In Vitro</i> Selection of Highly Darunavir-Resistant and Replication-Competent HIV-1 Variants by Using a Mixture of Clinical HIV-1 Isolates Resistant to Multiple Conventional Pr... 由 Yasuhiro Koh, Masayuki Amano, Tomomi Towata, Matthew Danish, Sofiya Leshchenko-Yashchuk, Debananda Das, Maki Nakayama, Yasushi Tojo, Arun K. Ghosh, Hiroaki Mitsuya

    出版 2010
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  7. 7
    Structural and Molecular Interactions of CCR5 Inhibitors with CCR5

    Structural and Molecular Interactions of CCR5 Inhibitors with CCR5 由 Kenji Maeda, Debananda Das, Hiromi Ogata-Aoki, Hirotomo Nakata, Toshikazu Miyakawa, Yasushi Tojo, Rachael Norman, Yoshikazu Takaoka, Jianping Ding, Gail Ferstandig Arnold, Eddy Arnold, Hiroaki Mitsuya

    出版 2006
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  8. 8
    Potent Inhibition of HIV-1 Replication by Novel Non-peptidyl Small Molecule Inhibitors of Protease Dimerization

    Potent Inhibition of HIV-1 Replication by Novel Non-peptidyl Small Molecule Inhibitors of Protease Dimerization 由 Yasuhiro Koh, Shintaro Matsumi, Debananda Das, Masayuki Amano, David A. Davis, Jianfeng Li, Sofiya Leschenko, Abigail Baldridge, Tatsuo Shioda, Robert Yarchoan, Arun K. Ghosh, Hiroaki Mitsuya

    出版 2007
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    Artigo
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  9. 9
    Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity

    Single atom changes in newly synthesized HIV protease inhibitors reveal structural basis for extreme affinity, high genetic barrier, and adaptation to the HIV protease plasticity 由 Haydar Bulut, Shin‐ichiro Hattori, Hiromi Aoki-Ogata, Hironori Hayashi, Debananda Das, Manabu Aoki, David A. Davis, Kalapala Venkateswara Rao, Prasanth R. Nyalapatla, Arun K. Ghosh, Hiroaki Mitsuya

    出版 2020
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    Artigo
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  10. 10
    Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants

    Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants 由 Arun K. Ghosh, Kalapala Venkateswara Rao, Prasanth R. Nyalapatla, Heather L. Osswald, Cuthbert D. Martyr, Manabu Aoki, Hironori Hayashi, Johnson Agniswamy, Yuan-Fang Wang, Haydar Bulut, Debananda Das, Irene T. Weber, Hiroaki Mitsuya

    出版 2017
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  11. 11
    GRL-0920, an Indole Chloropyridinyl Ester, Completely Blocks SARS-CoV-2 Infection

    GRL-0920, an Indole Chloropyridinyl Ester, Completely Blocks SARS-CoV-2 Infection 由 Shin-ichiro Hattori, Nobuyo Higshi-Kuwata, Jakka Raghavaiah, Debananda Das, Haydar Bulut, David A. Davis, Yuki Takamatsu, Kouki Matsuda, Nobutoki Takamune, Naoki Kishimoto, Tadashi Okamura, Shogo Misumi, Robert Yarchoan, Kenji Maeda, Arun K. Ghosh, Hiroaki Mitsuya

    出版 2020
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  12. 12
    4′‐modified nucleoside analogs: Potent inhibitors active against entecavir‐resistant hepatitis B virus

    4′‐modified nucleoside analogs: Potent inhibitors active against entecavir‐resistant hepatitis B virus 由 Yuki Takamatsu, Yasuhito Tanaka, Satoru Kohgo, Shuko Murakami, Kamalendra Singh, Debananda Das, David Venzon, Masayuki Amano, Nobuyo Higashi‐Kuwata, Manabu Aoki, Nicole S. Delino, Sanae Hayashi, Satoru Takahashi, Yoshikazu Sukenaga, Kazuhiro Haraguchi, Stefan G. Sarafianos, Kenji Maeda, Hiroaki Mitsuya

    出版 2015
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    Artigo
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  13. 13
    A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency

    A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency 由 Manabu Aoki, Hironori Hayashi, Kalapala Venkateswara Rao, Debananda Das, Nobuyo Higashi‐Kuwata, Haydar Bulut, Hiromi Aoki-Ogata, Yuki Takamatsu, Ravikiran S. Yedidi, David A. Davis, Shin-ichiro Hattori, Noriko Nishida, Kazuya Hasegawa, Nobutoki Takamune, Prasanth R. Nyalapatla, Heather L. Osswald, Hirofumi Jono, Hideyuki Saito, Robert Yarchoan, Shogo Misumi, Arun K. Ghosh, Hiroaki Mitsuya

    出版 2017
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    Artigo
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  14. 14
    A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication

    A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication 由 Shin-ichiro Hattori, Nobuyo Higashi‐Kuwata, Hironori Hayashi, Srinivasa Rao Allu, Jakka Raghavaiah, Haydar Bulut, Debananda Das, Brandon J. Anson, Emma K. Lendy, Yuki Takamatsu, Nobutoki Takamune, Naoki Kishimoto, Kazutaka Murayama, Kazuya Hasegawa, Mi Li, David A. Davis, Eiichi Kodama, Robert Yarchoan, Alexander Wlodawer, Shogo Misumi, Andrew D. Mesecar, Arun K. Ghosh, Hiroaki Mitsuya

    出版 2021
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