Search Results - David Sumpton

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  1. 1
    Pyruvate transamination and NAD biosynthesis enable proliferation of succinate dehydrogenase-deficient cells by supporting aerobic glycolysis

    Pyruvate transamination and NAD biosynthesis enable proliferation of succinate dehydrogenase-deficient cells by supporting aerobic glycolysis by Luisa Ricci, Federico Uchenna Stanley, Tanja Eberhart, Francesco Mainini, David Sumpton, Simone Cardaci

    Published 2023
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  2. 2
    Comparative Large Scale Characterization of Plant versus Mammal Proteins Reveals Similar and Idiosyncratic N-α-Acetylation Features

    Comparative Large Scale Characterization of Plant versus Mammal Proteins Reveals Similar and Idiosyncratic N-α-Acetylation Features by Willy V. Bienvenut, David Sumpton, Aude Martinez, Sérgio Lilla, Christelle Espagne, Thierry Meinnel, Carmela Giglione

    Published 2012
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  3. 3
    Improving the metabolic fidelity of cancer models with a physiological cell culture medium

    Improving the metabolic fidelity of cancer models with a physiological cell culture medium by Johan Vande Voorde, Tobias Ackermann, Nadja Pfetzer, David Sumpton, Gillian Mackay, Gabriela Kalna, Colin Nixon, Karen Blyth, Eyal Gottlieb, Saverio Tardito

    Published 2019
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  4. 4
    Structural insights into ADP-ribosylation of ubiquitin by Deltex family E3 ubiquitin ligases

    Structural insights into ADP-ribosylation of ubiquitin by Deltex family E3 ubiquitin ligases by Chatrin Chatrin, Mads Gabrielsen, Lori Buetow, Mark A. Nakasone, Syed Feroj Ahmed, David Sumpton, Gary Sibbet, Brian O. Smith, Danny T. Huang

    Published 2020
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  5. 5
    D-mannose suppresses macrophage IL-1β production

    D-mannose suppresses macrophage IL-1β production by Simone Torretta, Alessandra Scagliola, Luisa Ricci, Francesco Mainini, Sabrina Di Marco, Ivan Cuccovillo, Anna Kajaste‐Rudnitski, David Sumpton, Kevin M. Ryan, Simone Cardaci

    Published 2020
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  6. 6
    PPAR-gamma induced AKT3 expression increases levels of mitochondrial biogenesis driving prostate cancer

    PPAR-gamma induced AKT3 expression increases levels of mitochondrial biogenesis driving prostate cancer by Laura C.A. Galbraith, Ernest Mui, Colin Nixon, Ann Hedley, David Strachan, Gillian Mackay, David Sumpton, Owen J. Sansom, Hing Y. Leung, Imran Ahmad

    Published 2021
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  7. 7
    Polarized Cell Motility Induces Hydrogen Peroxide to Inhibit Cofilin via Cysteine Oxidation

    Polarized Cell Motility Induces Hydrogen Peroxide to Inhibit Cofilin via Cysteine Oxidation by Jenifer Cameron, Mads Gabrielsen, Ya Hua Chim, June Munro, Ewan J. McGhee, David Sumpton, Philip Eaton, Kurt I. Anderson, Huabing Yin, Michael F. Olson

    Published 2015
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  8. 8
    Venetoclax causes metabolic reprogramming independent of BCL-2 inhibition

    Venetoclax causes metabolic reprogramming independent of BCL-2 inhibition by Alba Roca-Portoles, Giovanny Rodriguez Blanco, David Sumpton, Catherine Cloix, Margaret Mullin, Gillian Mackay, Katelyn O’Neill, Leandro Lemgruber, Xu Luo, Stephen W. G. Tait

    Published 2020
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  9. 9
    Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing

    Inhibition of mitochondrial folate metabolism drives differentiation through mTORC1 mediated purine sensing by Martha M. Zarou, Kevin M. Rattigan, Daniele Sarnello, Engy Shokry, Amy Dawson, Angela Ianniciello, Karen Dunn, Mhairi Copland, David Sumpton, Alexei Vázquez, G. Vignir Helgason

    Published 2024
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  10. 10
    Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: Identification of mitochondrial fission factor as a new AMPK substrate

    Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: Identification of mitochondrial fission factor as a new AMPK substrate by Serge Ducommun, Mária Deák, David Sumpton, Rebecca J. Ford, Antonio Núñez Galindo, Martin Kussmann, Benoı̂t Viollet, Gregory R. Steinberg, Marc Foretz, Loı̈c Dayon, Nicholas A. Morrice, Kei Sakamoto

    Published 2015
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  11. 11
    Blebs produced by actin–myosin contraction during apoptosis release damage-associated molecular pattern proteins before secondary necrosis occurs

    Blebs produced by actin–myosin contraction during apoptosis release damage-associated molecular pattern proteins before secondary necrosis occurs by Grant Wickman, Linda Julian, Katerina Mardilovich, Stephanie Schumacher, June Munro, Nicola Rath, Serge A.L. Zander, Andrzej Mleczak, David Sumpton, Nicholas A. Morrice, Willy V. Bienvenut, Michael F. Olson

    Published 2013
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  12. 12
    Cell fate decisions are specified by the dynamic ERK interactome

    Cell fate decisions are specified by the dynamic ERK interactome by Alex von Kriegsheim, Daniela Baiocchi, Marc R. Birtwistle, David Sumpton, Willy V. Bienvenut, Nicholas A. Morrice, Kayo Yamada, Angus I. Lamond, Gabriella Kalna, Richard Orton, David Gilbert, Walter Kölch

    Published 2009
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  13. 13
    Targeting the Metabolic Response to Statin-Mediated Oxidative Stress Produces a Synergistic Antitumor Response

    Targeting the Metabolic Response to Statin-Mediated Oxidative Stress Produces a Synergistic Antitumor Response by Grace H. McGregor, Andrew D. Campbell, Sigrid K. Fey, Sergey Tumanov, David Sumpton, Giovanny Rodriguez Blanco, Gillian Mackay, Colin Nixon, Alexei Vázquez, Owen J. Sansom, Jurre J. Kamphorst

    Published 2019
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  14. 14
    Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells

    Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells by Emmanuel Dornier, Nicolas Rabas, Louise Mitchell, David Novo, Sandeep Dhayade, Sergi Marco, Gillian Mackay, David Sumpton, Maria Pallarès-Masmitjà, Colin Nixon, Karen Blyth, Iain R. Macpherson, Elena Rainero, Jim C. Norman

    Published 2017
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  15. 15
    Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth

    Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth by Nicola Rath, June Munro, Marie F.A. Cutiongco, Alicja Jagiełło, Nikolaj Gadegaard, Lynn McGarry, Mathieu Unbekandt, Evdokia Michalopoulou, Jurre J. Kamphorst, David Sumpton, Gillian Mackay, Claire Vennin, Marina Pajic, Paul Timpson, Michael F. Olson

    Published 2018
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  16. 16
    Formate induces a metabolic switch in nucleotide and energy metabolism

    Formate induces a metabolic switch in nucleotide and energy metabolism by Kristell Oizel, Jacqueline Tait-Mulder, Jorge Fernández-de-Cossio-Díaz, Matthias Pietzke, Holly Brunton, Sérgio Lilla, Sandeep Dhayade, Dimitris Athineos, Giovanny Rodriguez Blanco, David Sumpton, Gillian Mackay, Karen Blyth, Sara Zanivan, Johannes Meiser, Alexei Vázquez

    Published 2020
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  17. 17
    Increased formate overflow is a hallmark of oxidative cancer

    Increased formate overflow is a hallmark of oxidative cancer by Johannes Meiser, Anne Schuster, Matthias Pietzke, Johan Vande Voorde, Dimitris Athineos, Kristell Oizel, Guillermo Burgos-Barragan, Niek Wit, Sandeep Dhayade, Jennifer P. Morton, Emmanuel Dornier, David Sumpton, Gillian Mackay, Karen Blyth, Ketan J. Patel, Simone P. Niclou, Alexei Vázquez

    Published 2018
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  18. 18
    PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle

    PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle by Mohaned Benzarti, Laura Neises, Anaïs Oudin, Christina Krötz, Elodie Viry, Ernesto Gargiulo, Coralie Pulido, Maryse Schmoetten, Vitaly I. Pozdeev, Nadia I. Lorenz, Michael Ronellenfitsch, David Sumpton, Marc O. Warmoes, Christian Jaeger, Antoine Lesur, Björn Becker, Etienne Moussay, Jérôme Paggetti, Simone P. Niclou, Elisabeth Letellier, Johannes Meiser

    Published 2024
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  19. 19
    Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress

    Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress by Jennifer Port, Nathiya Muthalagu, Meera Raja, Fatih Ceteci, Tiziana Monteverde, Björn Kruspig, Ann Hedley, Gabriela Kalna, Sérgio Lilla, Lisa J. Neilson, Martina Brucoli, Katarína Gyurászová, Jacqueline Tait-Mulder, Mokdad Mezna, Silvija Svambaryte, Amy Bryson, David Sumpton, Allan McVie, Colin Nixon, Martin J. Drysdale, Hiroyasu Esumi, Graeme I. Murray, Owen J. Sansom, Sara Zanivan, Daniel J. Murphy

    Published 2018
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  20. 20
    2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer

    2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer by Arnaud Blomme, Catriona A. Ford, Ernest Mui, Rachana Patel, Chara Ntala, Lauren E. Jamieson, Mélanie Planque, Grace H. McGregor, Paul Peixoto, Éric Hervouet, Colin Nixon, Mark J. Salji, Luke Gaughan, Elke Markert, Peter Repiščák, David Sumpton, Giovanny Rodriguez Blanco, Sérgio Lilla, Jurre J. Kamphorst, Duncan Graham, Karen Faulds, Gillian Mackay, Sarah‐Maria Fendt, Sara Zanivan, Hing Y. Leung

    Published 2020
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