Search Results - David Spetzler

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  1. 1
    Direct observation of stepped proteolipid ring rotation in E. coli FoF1-ATP synthase

    Direct observation of stepped proteolipid ring rotation in E. coli FoF1-ATP synthase by Robert Ishmukhametov, Tassilo Hornung, David Spetzler, Wayne D. Frasch

    Published 2010
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  2. 2
    Microsatellite instability status determined by next‐generation sequencing and compared with <scp>PD</scp>‐L1 and tumor mutational burden in 11,348 patients

    Microsatellite instability status determined by next‐generation sequencing and compared with <scp>PD</scp>‐L1 and tumor mutational burden in 11,348 patients by Ari M. Vanderwalde, David Spetzler, Nianqing Xiao, Zoran Gatalica, John L. Marshall

    Published 2018
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  3. 3
    Elastic coupling power stroke mechanism of the F <sub>1</sub> -ATPase molecular motor

    Elastic coupling power stroke mechanism of the F <sub>1</sub> -ATPase molecular motor by James L. Martin, Robert Ishmukhametov, David Spetzler, Tassilo Hornung, Wayne D. Frasch

    Published 2018
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  4. 4
    Microsecond Time Scale Rotation Measurements of Single F<sub>1</sub>-ATPase Molecules

    Microsecond Time Scale Rotation Measurements of Single F<sub>1</sub>-ATPase Molecules by David Spetzler, Justin York, Douglas Daniel, Raimund Fromme, David Lowry, Wayne D. Frasch

    Published 2006
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  5. 5
    Targetable Gene Fusions Associate With the IDH Wild-Type Astrocytic Lineage in Adult Gliomas

    Targetable Gene Fusions Associate With the IDH Wild-Type Astrocytic Lineage in Adult Gliomas by Sherise D. Ferguson, Shouhao Zhou, Jason T. Huse, John de Groot, Joanne Xiu, Deepa S. Subramaniam, Shwetal Mehta, Zoran Gatalica, Jeffrey Swensen, Nader Sanai, David Spetzler, Amy B. Heimberger

    Published 2018
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  6. 6
    Mutational burden, immune checkpoint expression, and mismatch repair in glioma: implications for immune checkpoint immunotherapy

    Mutational burden, immune checkpoint expression, and mismatch repair in glioma: implications for immune checkpoint immunotherapy by Tiffany R. Hodges, Martina Ott, Joanne Xiu, Zoran Gatalica, Jeffrey Swensen, Shouhao Zhou, Jason T. Huse, John de Groot, Shulin Li, Willem W. Overwijk, David Spetzler, Amy B. Heimberger

    Published 2017
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  7. 7
    Real-world evidence provides clinical insights into tissue-agnostic therapeutic approvals

    Real-world evidence provides clinical insights into tissue-agnostic therapeutic approvals by George W. Sledge, Takayuki Yoshino, Joanne Xiu, Anthony Helmstetter, Jennifer R. Ribeiro, Sergey Klimov, Brady Gilg, Jianguo Gao, Jeff Elton, Matthew J. Oberley, Milan Radovich, Jim Abraham, David Spetzler

    Published 2025
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  8. 8
    Somatic 9p24.1 alterations in HPV <sup>–</sup> head and neck squamous cancer dictate immune microenvironment and anti-PD-1 checkpoint inhibitor activity

    Somatic 9p24.1 alterations in HPV <sup>–</sup> head and neck squamous cancer dictate immune microenvironment and anti-PD-1 checkpoint inhibitor activity by Xin Zhao, Ezra E.W. Cohen, William N. William, Joy J. Bianchi, Jim Abraham, Daniel Magee, David Spetzler, J. Silvio Gutkind, Ludmil B. Alexandrov, Webster K. Cavenee, Scott M. Lippman, Teresa Davoli

    Published 2022
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  9. 9
    Immune checkpoint blockade as a potential therapeutic target: surveying CNS malignancies

    Immune checkpoint blockade as a potential therapeutic target: surveying CNS malignancies by Sarah T. Garber, Yuuri Hashimoto, Shiao-Pei Weathers, Joanne Xiu, Zoran Gatalica, Roel G.W. Verhaak, Shouhao Zhou, Gregory N. Fuller, Mustafa Khasraw, John de Groot, Sandeep K. Reddy, David Spetzler, Amy B. Heimberger

    Published 2016
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  10. 10
    Pan-tumor survey of RET fusions as detected by next-generation RNA sequencing identified RET fusion positive colorectal carcinoma as a unique molecular subset

    Pan-tumor survey of RET fusions as detected by next-generation RNA sequencing identified RET fusion positive colorectal carcinoma as a unique molecular subset by Misako Nagasaka, Danielle Brazel, Yasmine Baca, Joanne Xiu, Mohammed Najeeb Al Hallak, Chul Kim, Jorge J. Nieva, Jeffrey Swensen, David Spetzler, W. Michael Korn, Mark A. Socinski, Luis E. Raez, Balázs Halmos, Sai‐Hong Ignatius Ou

    Published 2023
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  11. 11
    Immune evasion in HPV<sup>−</sup>head and neck precancer–cancer transition is driven by an aneuploid switch involving chromosome 9p loss

    Immune evasion in HPV<sup>−</sup>head and neck precancer–cancer transition is driven by an aneuploid switch involving chromosome 9p loss by William N. William, Xin Zhao, Joy J. Bianchi, Heather Lin, Pan Cheng, J. Jack Lee, Hannah Carter, Ludmil B. Alexandrov, Jim Abraham, David Spetzler, Steven M. Dubinett, Don W. Cleveland, Webster K. Cavenee, Teresa Davoli, Scott M. Lippman

    Published 2021
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  12. 12
    Plasma Exosome Profiling of Cancer Patients by a Next Generation Systems Biology Approach

    Plasma Exosome Profiling of Cancer Patients by a Next Generation Systems Biology Approach by Valeriy Domenyuk, Zhenyu Zhong, Adam Stark, Nianqing Xiao, Heather A. O’Neill, Xixi Wei, Jie Wang, Teresa T. Tinder, Sonal S. Tonapi, Janet E. Duncan, Tassilo Hornung, Andrew W. Hunter, Mark Miglarese, Joachim Schorr, David D. Halbert, John Quackenbush, George Poste, Donald A. Berry, Günter Mayer, Michael Famulok, David Spetzler

    Published 2017
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  13. 13
    Clinical Validation of a Machine-learning–derived Signature Predictive of Outcomes from First-line Oxaliplatin-based Chemotherapy in Advanced Colorectal Cancer

    Clinical Validation of a Machine-learning–derived Signature Predictive of Outcomes from First-line Oxaliplatin-based Chemotherapy in Advanced Colorectal Cancer by Jim Abraham, Daniel Magee, Chiara Cremolini, Carlotta Antoniotti, David D. Halbert, Joanne Xiu, Phillip Stafford, Donald A. Berry, Matthew J. Oberley, Anthony F. Shields, John L. Marshall, Mohamed E. Salem, Alfredo Falcone, Axel Grothey, Michael J. Hall, Alan P. Venook, Heinz‐Josef Lenz, Anthony Helmstetter, W. Michael Korn, David Spetzler

    Published 2020
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  14. 14
    Molecular Characterization of<i>KRAS</i>Wild-type Tumors in Patients with Pancreatic Adenocarcinoma

    Molecular Characterization of<i>KRAS</i>Wild-type Tumors in Patients with Pancreatic Adenocarcinoma by Philip A. Philip, Ibrahim Azar, Joanne Xiu, Michael J. Hall, Andrew Hendifar, Emil Lou, Jimmy J. Hwang, Jun Gong, Rebecca Feldman, Michelle Ellis, Phil Stafford, David Spetzler, Moh’d Khushman, Davendra Sohal, A. Craig Lockhart, Benjamin A. Weinberg, Wafik S. El‐Deiry, John L. Marshall, Anthony F. Shields, W. Michael Korn

    Published 2022
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  15. 15
    Mutational analysis of microsatellite-stable gastrointestinal cancer with high tumour mutational burden: a retrospective cohort study

    Mutational analysis of microsatellite-stable gastrointestinal cancer with high tumour mutational burden: a retrospective cohort study by Jingyuan Wang, Joanne Xiu, Alex Farrell, Yasmine Baca, Hiroyuki Arai, Francesca Battaglin, Natsuko Kawanishi, Shivani Soni, Wu Zhang, Joshua Millstein, Anthony F. Shields, Axel Grothey, Benjamin A. Weinberg, John L. Marshall, Emil Lou, Moh’d Khushman, Davendra Sohal, Michael J. Hall, Tianshu Liu, Matthew J. Oberley, David Spetzler, W. Michael Korn, Lin Shen, Heinz‐Josef Lenz

    Published 2023
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  16. 16
    Homologous Recombination Deficiency Alterations in Colorectal Cancer: Clinical, Molecular, and Prognostic Implications

    Homologous Recombination Deficiency Alterations in Colorectal Cancer: Clinical, Molecular, and Prognostic Implications by Roberto Moretto, Andrew Elliott, Jian Zhang, Hiroyuki Arai, Marco Maria Germani, Veronica Conca, Joanne Xiu, Phillip Stafford, Matthew J. Oberley, Jim Abraham, David Spetzler, Daniele Rossini, Carlotta Antoniotti, John L. Marshall, Anthony F. Shields, Gilberto Lopes, Sara Lonardi, Filippo Pietrantonio, Gianluca Tomasello, Alessandro Passardi, Emiliano Tamburini, Daniele Santini, Giuseppe Aprile, Gianluca Masi, Alfredo Falcone, Heinz‐Josef Lenz, Michael Korn, Chiara Cremolini

    Published 2021
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  17. 17
    Characterization of plasma cell-free DNA variants as of tumor- or clonal hematopoiesis-origin in 16,812 advanced cancer patients

    Characterization of plasma cell-free DNA variants as of tumor- or clonal hematopoiesis-origin in 16,812 advanced cancer patients by Daniel Magee, Valeriy Domenyuk, Jim Abraham, Nieves Perdigones Borderias, Jeffrey Swensen, Praveena Solipuram, Adanma Ayanambakkam, Raja Mehdi, Jagathi Challagalla, Elisabeth I. Heath, Megan Landsverk, Magdalena Jurkiewicz, Brian Shimkus, Ian Pinto, Daniel Patterson, David Hsiehchen, Supriya Koya, Bradley G. Somer, Michel Velez, Anthony F. Shields, Jennifer L. Cultrera, Jennifer R. Ribeiro, Robert Hahn-Lowry, George W. Sledge, Matthew J. Oberley, Milan Radovich, David Spetzler

    Published 2025
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  18. 18
    Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

    Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade by Dung T. Le, Jennifer N. Durham, Kellie N. Smith, Hao Wang, Bjarne R. Bartlett, Laveet K. Aulakh, Steve Lu, Holly Kemberling, Cara Wilt, Brandon Luber, Fay Wong, Nilofer S. Azad, Agnieszka A. Rucki, Dan Laheru, Ross C. Donehower, Atif Zaheer, George A. Fisher, Todd S. Crocenzi, James J. Lee, Tim F. Greten, Austin G. Duffy, Kristen K. Ciombor, Aleksandra Eyring, Bao H. Lam, Andrew K. Joe, Soonmo Peter Kang, Matthias Holdhoff, Ludmila Danilova, Leslie Cope, Christian F. Meyer, Shibin Zhou, Richard M. Goldberg, Deborah K. Armstrong, Katherine M. Bever, Amanda N. Fader, Janis M. Taube, Franck Housseau, David Spetzler, Nianqing Xiao, Drew M. Pardoll, Nickolas Papadopoulos, Kenneth W. Kinzler, James R. Eshleman, Bert Vogelstein, Robert A. Anders, Luis A. Díaz

    Published 2017
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  19. 19
    Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses

    Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses by William Chen, Abrar Choudhury, Mark W. Youngblood, Mei‐Yin C. Polley, Calixto‐Hope G. Lucas, Kanish Mirchia, Sybren L. N. Maas, Abigail K. Suwala, Minhee Won, James C. Bayley, Akdes Serin Harmancı, Arif O. Harmanci, Tiemo J. Klisch, Minh Nguyen, Harish N. Vasudevan, Kathleen McCortney, Theresa Yu, Varun Bhave, Tai‐Chung Lam, Jenny Kan-Suen Pu, Lai‐Fung Li, Gkk Leung, Jason W. Chan, Haley K. Perlow, Joshua D. Palmer, Christine Haberler, Anna S. Berghoff, Matthias Preusser, Theodore Nicolaides, Christian Mawrin, Sameer Agnihotri, Adam Resnick, Brian R. Rood, Jessica Chew, Jacob S. Young, Lauren Boreta, Steve Braunstein, Jessica Schulte, Nicholas Butowski, Sandro Santagata, David Spetzler, Nancy Ann Oberheim Bush, Javier Villanueva-Meyer, James P. Chandler, David A. Solomon, Leland Rogers, Stephanie L. Pugh, Minesh P. Mehta, Penny K. Sneed, Mitchel S. Berger, Craig Horbinski, Michael McDermott, Arie Perry, Wenya Linda Bi, Akash J. Patel, Felix Sahm, Stephen T. Magill, David R. Raleigh

    Published 2023
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