检索结果 - David S. Lamb

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  1. 1
    Unusual properties of the cytochrome P450 superfamily

    Unusual properties of the cytochrome P450 superfamily 由 David C. Lamb, Michael R. Waterman

    出版 2013
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  2. 2
    Y132H substitution in<i>Candida albicans</i>sterol 14α-demethylase confers fluconazole resistance by preventing binding to haem

    Y132H substitution in<i>Candida albicans</i>sterol 14α-demethylase confers fluconazole resistance by preventing binding to haem 由 Steven L. Kelly, David C. Lamb, Diane Kelly

    出版 1999
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  3. 3
    Structure–Function Analysis of the Self-Sufficient CYP102 Family Provides New Insights into Their Biochemistry

    Structure–Function Analysis of the Self-Sufficient CYP102 Family Provides New Insights into Their Biochemistry 由 Tiara Padayachee, David C. Lamb, David R. Nelson, Khajamohiddin Syed

    出版 2025
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  4. 4
    The R467K Amino Acid Substitution in <i>Candida albicans</i> Sterol 14α-Demethylase Causes Drug Resistance through Reduced Affinity

    The R467K Amino Acid Substitution in <i>Candida albicans</i> Sterol 14α-Demethylase Causes Drug Resistance through Reduced Affinity 由 David C. Lamb, Diane Kelly, Theodore C. White, Steven L. Kelly

    出版 2000
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  5. 5
    Characterization of Saccharomyces cerevisiae CYP61, Sterol Δ22-Desaturase, and Inhibition by Azole Antifungal Agents

    Characterization of Saccharomyces cerevisiae CYP61, Sterol Δ22-Desaturase, and Inhibition by Azole Antifungal Agents 由 Steven L. Kelly, David C. Lamb, Brian C. Baldwin, Andrew J. Corran, Diane Kelly

    出版 1997
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  6. 6
    Multiple Molecular Mechanisms Contribute to a Stepwise Development of Fluconazole Resistance in Clinical <i>Candida albicans</i> Strains

    Multiple Molecular Mechanisms Contribute to a Stepwise Development of Fluconazole Resistance in Clinical <i>Candida albicans</i> Strains 由 R. Franz, Steven L. Kelly, David C. Lamb, Diane Kelly, Markus Ruhnke, Joachim Morschhäuser

    出版 1998
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  7. 7
    Structure-Functional Characterization of Cytochrome P450 Sterol 14α-Demethylase (CYP51B) from Aspergillus fumigatus and Molecular Basis for the Development of Antifungal Drugs

    Structure-Functional Characterization of Cytochrome P450 Sterol 14α-Demethylase (CYP51B) from Aspergillus fumigatus and Molecular Basis for the Development of Antifungal Drugs 由 Tatiana Y. Hargrove, Z. Wawrzak, David C. Lamb, F. Peter Guengerich, Galina I. Lepesheva

    出版 2015
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  8. 8
    Genetic and structural analyses of cytochrome P450 hydroxylases in sex hormone biosynthesis: Sequential origin and subsequent coevolution

    Genetic and structural analyses of cytochrome P450 hydroxylases in sex hormone biosynthesis: Sequential origin and subsequent coevolution 由 Jared V. Goldstone, Munirathinam Sundaramoorthy, Bin Zhao, Michael R. Waterman, John J. Stegeman, David C. Lamb

    出版 2015
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  9. 9
    Resistance to amphotericin B associated with defective sterol<i>Δ</i><sup>8→7</sup>isomerase in a<i>Cryptococcus neoformans</i>strain from an AIDS patient

    Resistance to amphotericin B associated with defective sterol<i>Δ</i><sup>8→7</sup>isomerase in a<i>Cryptococcus neoformans</i>strain from an AIDS patient 由 Steven L. Kelly, David C. Lamb, Mark Taylor, Andrew J. Corran, Brian C. Baldwin, William G. Powderly

    出版 1994
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  10. 10
    Biosynthesis of the Sesquiterpene Antibiotic Albaflavenone in Streptomyces coelicolor A3(2)

    Biosynthesis of the Sesquiterpene Antibiotic Albaflavenone in Streptomyces coelicolor A3(2) 由 Bin Zhao, Xin Lin, Lei Li, David C. Lamb, Steven L. Kelly, Michael R. Waterman, David E. Cane

    出版 2008
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  11. 11
    Resistance to fluconazole and cross‐resistance to amphotericin B in <i>Candida albicans</i> from AIDS patients caused by defective sterol Δ<sup>5,6</sup>‐desaturation

    Resistance to fluconazole and cross‐resistance to amphotericin B in <i>Candida albicans</i> from AIDS patients caused by defective sterol Δ<sup>5,6</sup>‐desaturation 由 Steven L. Kelly, David C. Lamb, Diane Kelly, N. J. Manning, Juergen Loeffler, Holger Hebart, Ulrike Schumacher, Hermann Einsele

    出版 1997
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  12. 12
    Neuropsychologic impairment in adult bone marrow transplant candidates

    Neuropsychologic impairment in adult bone marrow transplant candidates 由 Michael A. Andrykowski, Frederick A. Schmitt, Megan E. Gregg, Marianne I. Brady, David G. Lamb, P. Jean Henslee‐Downey

    出版 1992
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  13. 13
    Identification of Potent and Selective Inhibitors of <i>Acanthamoeba</i>: Structural Insights into Sterol 14α-Demethylase as a Key Drug Target

    Identification of Potent and Selective Inhibitors of <i>Acanthamoeba</i>: Structural Insights into Sterol 14α-Demethylase as a Key Drug Target 由 Tatiana Y. Hargrove, David C. Lamb, Z. Wawrzak, Marcus Hull, Steven L. Kelly, F. Peter Guengerich, Galina I. Lepesheva

    出版 2024
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  14. 14
    The First Virally Encoded Cytochrome P450

    The First Virally Encoded Cytochrome P450 由 David C. Lamb, Li Lei, Andrew G. S. Warrilow, Galina I. Lepesheva, Jonathan G.L. Mullins, Michael R. Waterman, Steven L. Kelly

    出版 2009
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  15. 15
    The Mechanism of the Acyl-Carbon Bond Cleavage Reaction Catalyzed by Recombinant Sterol 14α-Demethylase of Candida albicans (Other Names Are: Lanosterol 14α-Demethylase, P-45014DM, and CYP51)

    The Mechanism of the Acyl-Carbon Bond Cleavage Reaction Catalyzed by Recombinant Sterol 14α-Demethylase of Candida albicans (Other Names Are: Lanosterol 14α-Demethylase, P-45014DM,... 由 Akbar Z. Shyadehi, David C. Lamb, Steven L. Kelly, Diane Kelly, Wolf‐Hagen Schunck, J. Neville Wright, David L. Corina, Muhammad Akhtar

    出版 1996
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  16. 16
    The Mutation T315A in Candida albicans Sterol 14α-Demethylase Causes Reduced Enzyme Activity and Fluconazole Resistance through Reduced Affinity

    The Mutation T315A in Candida albicans Sterol 14α-Demethylase Causes Reduced Enzyme Activity and Fluconazole Resistance through Reduced Affinity 由 David C. Lamb, Diane Kelly, Wolf‐Hagen Schunck, Akbar Z. Shyadehi, Muhammed Akhtar, David J. Lowe, Brian C. Baldwin, Steven L. Kelly

    出版 1997
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  17. 17
    Crystal Structure of Albaflavenone Monooxygenase Containing a Moonlighting Terpene Synthase Active Site

    Crystal Structure of Albaflavenone Monooxygenase Containing a Moonlighting Terpene Synthase Active Site 由 Bin Zhao, Lei Li, Dmitry G. Vassylyev, Xin Lin, David E. Cane, Steven L. Kelly, Hang Yuan, David C. Lamb, Michael R. Waterman

    出版 2009
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  18. 18
    Azole Binding Properties of <i>Candida albicans</i> Sterol 14-α Demethylase (CaCYP51)

    Azole Binding Properties of <i>Candida albicans</i> Sterol 14-α Demethylase (CaCYP51) 由 Andrew G. S. Warrilow, Claire M. Martel, Josie E. Parker, Nadja Rodrigues de Melo, David C. Lamb, W. David Nes, Diane Kelly, Steven L. Kelly

    出版 2010
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  19. 19
    The Cytochrome P450 Complement (CYPome) of Streptomyces coelicolor A3(2)

    The Cytochrome P450 Complement (CYPome) of Streptomyces coelicolor A3(2) 由 David C. Lamb, Tove Skaug, Honglin Song, Colin J. Jackson, Larissa M. Podust, Michael R. Waterman, Douglas B. Kell, Diane Kelly, Steven L. Kelly

    出版 2002
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  20. 20
    The 1.92-Å Structure of Streptomyces coelicolor A3(2) CYP154C1

    The 1.92-Å Structure of Streptomyces coelicolor A3(2) CYP154C1 由 Larissa M. Podust, Youngchang Kim, Miharu Arase, Benjamin A. Neely, Brian J. Beck, Horacio Bach, David H. Sherman, David C. Lamb, Steven Kelly, Michael R. Waterman

    出版 2003
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