Výsledky vyhledávání - David H. Hackos
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TRPA1 as a drug target—promise and challenges Autor Jun Chen, David H. Hackos
Vydáno 2015Revisão -
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Cross-species transcriptomic atlas of dorsal root ganglia reveals species-specific programs for sensory function Autor Min Jung, Michelle Dourado, James Maksymetz, Amanda Jacobson, Benjamin I. Laufer, Miriam Baca, Oded Foreman, David H. Hackos, Lorena Riol‐Blanco, Joshua S. Kaminker
Vydáno 2023Artigo -
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Behavioral characterization of a CRISPR-generated TRPA1 knockout rat in models of pain, itch, and asthma Autor Rebecca M. Reese, Michelle Dourado, Keith R. Anderson, Søren Warming, Kimberly L. Stark, Alessia Balestrini, Eric Suto, Wyne Lee, Lorena Riol‐Blanco, Shannon D. Shields, David H. Hackos
Vydáno 2020Artigo -
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AF‐353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist Autor Joel R. Gever, Rothschild Soto, Robert Henningsen, Renée S. Martin, David H. Hackos, Sandip Panicker, Werner Rubas, Ian B. Oglesby, Michael P. Dillon, Marcos E. Milla, Geoffrey Burnstock, Anthony Ford
Vydáno 2010Artigo -
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Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin Autor Hui Xu, Tianbo Li, Alexis Rohou, Christopher P. Arthur, Foteini Tzakoniati, Evera Wong, Alberto Estevez, Christine Kugel, Yvonne Franke, Jun Chen, Claudio Ciferri, David H. Hackos, Christopher M. Koth, Jian Payandeh
Vydáno 2019Errata/Corrigenda -
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Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin Autor Hui Xu, Tianbo Li, Alexis Rohou, Christopher P. Arthur, Foteini Tzakoniati, Evera Wong, Alberto Estevez, Christine Kugel, Yvonne Franke, Jun Chen, Claudio Ciferri, David H. Hackos, Christopher M. Koth, Jian Payandeh
Vydáno 2019Artigo -
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Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions Autor Eugene Y. Chiang, Tianbo Li, Surinder Jeet, Ivan Peng, Juan Zhang, Wyne P. Lee, Jason DeVoss, Patrick Caplazi, Jun Chen, Søren Warming, David H. Hackos, Susmith Mukund, Christopher M. Koth, Jane L. Grogan
Vydáno 2017Artigo -
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Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function Autor David H. Hackos, Patrick J. Lupardus, Teddy Grand, Yelin Chen, Tzu-Ming Wang, Paul Reynen, Amy Gustafson, Heidi J.A. Wallweber, Matthew Volgraf, Benjamin D. Sellers, Jacob B. Schwarz, Pierre Paoletti, Morgan Sheng, Qiang Zhou, Jesse E. Hanson
Vydáno 2016Artigo -
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Structural basis of α-scorpion toxin action on Na <sub>v</sub> channels Autor Thomas Clairfeuille, Alexander Cloake, Daniel T. Infield, José P. Llongueras, Christopher P. Arthur, Zhong Rong Li, Yuwen Jian, Marie‐France Martin‐Eauclaire, Pierre E. Bougis, Claudio Ciferri, Christopher A. Ahern, Frank Bosmans, David H. Hackos, Alexis Rohou, Jian Payandeh
Vydáno 2019Artigo -
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Cryo-EM reveals an unprecedented binding site for NaV1.7 inhibitors enabling rational design of potent hybrid inhibitors Autor Marc Kschonsak, Christine C. Jao, Christopher P. Arthur, Alexis Rohou, Philippe Bergeron, Daniel F. Ortwine, Steven J. McKerrall, David H. Hackos, Lunbin Deng, Jun Chen, Tianbo Li, Peter S. Dragovich, Matthew Volgraf, Matthew Wright, Jian Payandeh, Claudio Ciferri, John C. Tellis
Vydáno 2023Artigo -
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Nav1.7 is essential for nociceptor action potentials in the mouse in a manner independent of endogenous opioids Autor Lunbin Deng, Michelle Dourado, Rebecca M. Reese, Kevin Huang, Shannon D. Shields, Kimberly L. Stark, James Maksymetz, Han Lin, Joshua S. Kaminker, Min Jung, Oded Foreman, Janet Tao, Hai Ngu, Victory Joseph, Meron Roose-Girma, Lucinda Tam, Susanne Lardell, Linnea Strid Orrhult, Paul Karila, Julien Allard, David H. Hackos
Vydáno 2023Artigo -
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A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel Autor Chang Liu, Rebecca M. Reese, Simon Vu, Lionel Rougé, Shannon D. Shields, Satoko Kakiuchi-Kiyota, Huifen Chen, Kevin M. Johnson, Yu Shi, Tania Chernov-Rogan, Demi Maria Zabala Greiner, Pawan Bir Kohli, David H. Hackos, Bobby Brillantes, Christine Tam, Tianbo Li, Jianyong Wang, Brian S. Safina, Steve Magnuson, Matthew Volgraf, Jian Payandeh, Jie Zheng, Alexis Rohou, Jun Chen
Vydáno 2020Artigo -
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Selective NaV1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain Autor Girish Bankar, Samuel J. Goodchild, Sarah Howard, Karen Nelkenbrecher, Matthew Waldbrook, Michelle Dourado, Noah Gregory Shuart, Sophia Lin, Clint Young, Zhiwei Xie, Kuldip Khakh, Elaine Chang, Luis Sojo, Andrea Lindgren, Sultan Chowdhury, Shannon Decker, Michael Grimwood, Jean‐Christophe Andrez, Christoph M. Dehnhardt, Jodie Pang, Jae H. Chang, Brian S. Safina, Daniel P. Sutherlin, J. P. Johnson, David H. Hackos, Carole Robinette, Charles J. Cohen
Vydáno 2018Artigo -
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GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer’s Disease Models Autor Jesse E. Hanson, Keran Ma, Justin Elstrott, Martin Weber, Sandrine Saillet, Md. Abdullah Saeed Khan, Jeffrey A. Simms, Benjamin Liu, Thomas A. Kim, Gui-Qiu Yu, Yelin Chen, Tzu-Ming Wang, Zhiyu Jiang, Bianca M. Liederer, Gauri Deshmukh, Hilda Solanoy, Connie Chan, Benjamin D. Sellers, Matthew Volgraf, Jacob B. Schwarz, David H. Hackos, Robby M. Weimer, Morgan Sheng, Thomas Gill, Kimberly Scearce‐Levie, Jorge J. Palop
Vydáno 2020Artigo
Vyhledávací nástroje:
Související témata
Receptor
Biochemistry
Biology
Chemistry
Pharmacology
Biophysics
Medicine
Neuroscience
Organic chemistry
Ion channel
Cell biology
Gene
Physics
Sodium
Sodium channel
Gating
Internal medicine
Materials science
Quantum mechanics
Transient receptor potential channel
Anesthesia
Antagonist
Genetics
Nociception
Psychology
Toxin
Action (physics)
Alanine scanning
Allosteric modulator
Allosteric regulation