Resultados de procura - David E. Heppner

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  1. 1
    Lazertinib: Breaking the mold of third-generation EGFR inhibitors

    Lazertinib: Breaking the mold of third-generation EGFR inhibitors por Kishan B. Patel, David E. Heppner

    Publicado 2025
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  2. 2
    Redox-dependent regulation of epidermal growth factor receptor signaling

    Redox-dependent regulation of epidermal growth factor receptor signaling por David E. Heppner, Albert van der Vliet

    Publicado 2015
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  3. 3
    Molecular Origin of Rapid versus Slow Intramolecular Electron Transfer in the Catalytic Cycle of the Multicopper Oxidases

    Molecular Origin of Rapid versus Slow Intramolecular Electron Transfer in the Catalytic Cycle of the Multicopper Oxidases por David E. Heppner, Christian H. Kjaergaard, Edward I. Solomon

    Publicado 2013
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  4. 4
    Dual oxidase: a novel therapeutic target in allergic disease

    Dual oxidase: a novel therapeutic target in allergic disease por Albert van der Vliet, Karamatullah Danyal, David E. Heppner

    Publicado 2018
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  5. 5
    The role of sulfenic acids in cellular redox signaling: Reconciling chemical kinetics and molecular detection strategies

    The role of sulfenic acids in cellular redox signaling: Reconciling chemical kinetics and molecular detection strategies por David E. Heppner, Yvonne Janssen‐Heininger, Albert van der Vliet

    Publicado 2017
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  6. 6
    Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors

    Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors por David E. Heppner, Marcel Günther, Florian Wittlinger, Stefan Laufer, Michael J. Eck

    Publicado 2020
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  7. 7
    Redox regulation of tyrosine kinase signalling: more than meets the eye

    Redox regulation of tyrosine kinase signalling: more than meets the eye por Christopher M. Dustin, David E. Heppner, Miao-chong J. Lin, Albert van der Vliet

    Publicado 2019
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  8. 8
    The NADPH Oxidases DUOX1 and NOX2 Play Distinct Roles in Redox Regulation of Epidermal Growth Factor Receptor Signaling

    The NADPH Oxidases DUOX1 and NOX2 Play Distinct Roles in Redox Regulation of Epidermal Growth Factor Receptor Signaling por David E. Heppner, Milena Hristova, Christopher M. Dustin, Karamatullah Danyal, Aida Habibovic, Albert van der Vliet

    Publicado 2016
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  9. 9
    Paradoxical roles of dual oxidases in cancer biology

    Paradoxical roles of dual oxidases in cancer biology por Andrew C. Little, Arvis Sulovari, Karamatullah Danyal, David E. Heppner, David J. Seward, Albert van der Vliet

    Publicado 2017
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  10. 10
    Reaction Coordinate of a Functional Model of Tyrosinase: Spectroscopic and Computational Characterization

    Reaction Coordinate of a Functional Model of Tyrosinase: Spectroscopic and Computational Characterization por Bryan T. Op’t Holt, M.A. Vance, Liviu M. Mirica, David E. Heppner, T. Daniel P. Stack, Edward I. Solomon

    Publicado 2009
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  11. 11
    Architecture of the NADPH oxidase family of enzymes

    Architecture of the NADPH oxidase family of enzymes por Blessing C. Ogboo, Uriy V. Grabovyy, Aniket Maini, Scott Scouten, Albert van der Vliet, Andrea Mattevi, David E. Heppner

    Publicado 2022
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  12. 12
    Pitfalls and Considerations in Determining the Potency and Mutant Selectivity of Covalent Epidermal Growth Factor Receptor Inhibitors

    Pitfalls and Considerations in Determining the Potency and Mutant Selectivity of Covalent Epidermal Growth Factor Receptor Inhibitors por Kristopher W. Hoyt, Daniel A. Urul, Blessing C. Ogboo, Florian Wittlinger, Stefan Laufer, Erik Schaefer, Earl W. May, David E. Heppner

    Publicado 2023
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  13. 13
    DUOX1 silencing in lung cancer promotes EMT, cancer stem cell characteristics and invasive properties

    DUOX1 silencing in lung cancer promotes EMT, cancer stem cell characteristics and invasive properties por Andrew C. Little, Derek Sham, Milena Hristova, Karamatullah Danyal, David E. Heppner, R Bauer, Lynn Sipsey, Aida Habibovic, Albert van der Vliet

    Publicado 2016
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  14. 14
    Copper Active Sites in Biology

    Copper Active Sites in Biology por Edward I. Solomon, David E. Heppner, Esther M. Johnston, Jake W. Ginsbach, Jordi Cirera, Munzarin F. Qayyum, Matthew T. Kieber‐Emmons, Christian H. Kjaergaard, Ryan G. Hadt, Li Tian

    Publicado 2014
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  15. 15
    Cysteine perthiosulfenic acid (Cys-SSOH): A novel intermediate in thiol-based redox signaling?

    Cysteine perthiosulfenic acid (Cys-SSOH): A novel intermediate in thiol-based redox signaling? por David E. Heppner, Milena Hristova, Tomoaki Ida, Ana Mijušković, Christopher M. Dustin, Virág Bogdándi, Jon M. Fukuto, Tobias P. Dick, Péter Nagy, Jianing Li, Takaaki Akaike, Albert van der Vliet

    Publicado 2017
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  16. 16
    Direct cysteine sulfenylation drives activation of the Src kinase

    Direct cysteine sulfenylation drives activation of the Src kinase por David E. Heppner, Christopher M. Dustin, Chenyi Liao, Milena Hristova, Carmen Veith, Andrew C. Little, Bethany A. Ahlers, Sheryl L. White, Bin Deng, Ying‐Wai Lam, Jianing Li, Albert van der Vliet

    Publicado 2018
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  17. 17
    Lung epithelial protein disulfide isomerase A3 (PDIA3) plays an important role in influenza infection, inflammation, and airway mechanics

    Lung epithelial protein disulfide isomerase A3 (PDIA3) plays an important role in influenza infection, inflammation, and airway mechanics por Nicolas Chamberlain, Bethany R. Korwin-Mihavics, Emily M. Nakada, S. Bruno, David E. Heppner, David G. Chapman, Sidra M. Hoffman, Albert van der Vliet, Benjamin T. Suratt, Oliver Dienz, John F. Alcorn, Vikas Anathy

    Publicado 2019
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  18. 18
    Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors

    Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors por Tyler S. Beyett, Ciric To, David E. Heppner, Jaimin K. Rana, Anna M. Schmoker, Jaebong Jang, Dries J.H. De Clercq, Gabriel Gómez, David A. Scott, Nathanael S. Gray, Pasi A. Jänne, Michael J. Eck

    Publicado 2022
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  19. 19
    DUOX1 mediates persistent epithelial EGFR activation, mucous cell metaplasia, and airway remodeling during allergic asthma

    DUOX1 mediates persistent epithelial EGFR activation, mucous cell metaplasia, and airway remodeling during allergic asthma por Aida Habibovic, Milena Hristova, David E. Heppner, Karamatullah Danyal, Jennifer L. Ather, Yvonne Janssen‐Heininger, Charles G. Irvin, Matthew E. Poynter, Lennart K. A. Lundblad, Anne E. Dixon, Miklós Geiszt, Albert van der Vliet

    Publicado 2016
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  20. 20
    Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors

    Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors por Dries J.H. De Clercq, David E. Heppner, Ciric To, Jaebong Jang, Eunyoung Park, Cai‐Hong Yun, Mierzhati Mushajiang, Bo Hee Shin, Thomas W. Gero, David A. Scott, Pasi A. Jänne, Michael J. Eck, Nathanael S. Gray

    Publicado 2019
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