Search Results - David B. Darr

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  1. 1
    Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model

    Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model by Christin E. Burd, Jessica A. Sorrentino, Kelly S. Clark, David B. Darr, Janakiraman Krishnamurthy, Allison M. Deal, Nabeel Bardeesy, Diego H. Castrillón, David Beach, Norman E. Sharpless

    Published 2013
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  2. 2
    The Role of Calcineurin/NFAT in SFRP2 Induced Angiogenesis—A Rationale for Breast Cancer Treatment with the Calcineurin Inhibitor Tacrolimus

    The Role of Calcineurin/NFAT in SFRP2 Induced Angiogenesis—A Rationale for Breast Cancer Treatment with the Calcineurin Inhibitor Tacrolimus by Sharareh Siamakpour‐Reihani, Joseph M. Caster, Desh Bandhu Nepal, Andrew Courtwright, Eleanor Hilliard, Jerry Usary, David Ketelsen, David B. Darr, Xiang Shen, Cam Patterson, Nancy Klauber‐DeMore

    Published 2011
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  3. 3
    Poly(2-oxazoline) based micelles with high capacity for 3rd generation taxoids: Preparation, in vitro and in vivo evaluation

    Poly(2-oxazoline) based micelles with high capacity for 3rd generation taxoids: Preparation, in vitro and in vivo evaluation by Zhijian He, Anita Schulz, Xiaomeng Wan, Joshua D. Seitz, Herdis Bludau, Daria Y. Alakhova, David B. Darr, Charles M. Perou, Rainer Jordan, Iwao Ojima, Alexander V. Kabanov, Robert Luxenhofer

    Published 2015
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  4. 4
    Multiple Roles of Cyclin-Dependent Kinase 4/6 Inhibitors in Cancer Therapy

    Multiple Roles of Cyclin-Dependent Kinase 4/6 Inhibitors in Cancer Therapy by Patrick J. Roberts, John E. Bisi, Jay C. Strum, Austin J. Combest, David B. Darr, Jerry Usary, William C. Zamboni, Kwok‐Kin Wong, Charles M. Perou, Norman E. Sharpless

    Published 2012
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  5. 5
    New Mechanisms of Resistance to MEK Inhibitors in Melanoma Revealed by Intravital Imaging

    New Mechanisms of Resistance to MEK Inhibitors in Melanoma Revealed by Intravital Imaging by Hailey E. Brighton, Steven P. Angus, Tao Bo, Jose Roques, Alicia C. Tagliatela, David B. Darr, Kübra Karagoz, Noah Sciaky, Michael L. Gatza, Norman E. Sharpless, Gary L. Johnson, James E. Bear

    Published 2017
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  6. 6
    Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells

    Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells by Jason I. Herschkowitz, Wei Zhao, Mei Zhang, Jerry Usary, George Murrow, David G. Edwards, Jana Knezevic, Stephanie Greene, David B. Darr, Melissa A. Troester, Susan G. Hilsenbeck, Daniel Medina, Charles M. Perou, Jeffrey M. Rosen

    Published 2011
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  7. 7
    Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2 + Breast Cancer

    Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2 + Breast Cancer by Yazan Alwarawrah, Philip F. Hughes, David R. Loiselle, David A. Carlson, David B. Darr, Jamie L. Jordan, Jessie Xiong, Lucas Hunter, Laura G. Dubois, J. Will Thompson, Manjusha Kulkarni, Annette N. Ratcliff, Jesse J. Kwiek, Timothy Haystead

    Published 2016
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  8. 8
    Coexistent ARID1A–PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling

    Coexistent ARID1A–PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling by Ronald L. Chandler, Jeffrey S. Damrauer, Jesse R. Raab, Jonathan C. Schisler, Matthew D. Wilkerson, John P. Didion, Joshua Starmer, Daniel Serber, Della Yee, Jessie Xiong, David B. Darr, Fernando Pardo‐Manuel de Villena, William Y. Kim, Terry Magnuson

    Published 2015
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  9. 9
    Pharmacokinetics and Efficacy of PEGylated Liposomal Doxorubicin in an Intracranial Model of Breast Cancer

    Pharmacokinetics and Efficacy of PEGylated Liposomal Doxorubicin in an Intracranial Model of Breast Cancer by Carey K. Anders, Bárbara Adamo, Olga Karginova, Allison M. Deal, Sumit Rawal, David B. Darr, Allison N. Schorzman, Charlene Santos, Ryan Bash, Tal Kafri, Lisa A. Carey, C. Ryan Miller, Charles M. Perou, Norman E. Sharpless, William C. Zamboni

    Published 2013
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  10. 10
    Combined PI3K/mTOR and MEK Inhibition Provides Broad Antitumor Activity in Faithful Murine Cancer Models

    Combined PI3K/mTOR and MEK Inhibition Provides Broad Antitumor Activity in Faithful Murine Cancer Models by Patrick J. Roberts, Jerry Usary, David B. Darr, Patrick M. Dillon, Adam D. Pfefferle, Martin C. Whittle, James S. Duncan, Søren M. Johnson, Austin J. Combest, Jian Jin, William C. Zamboni, Gary L. Johnson, Charles M. Perou, Norman E. Sharpless

    Published 2012
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  11. 11
    Erythropoietin promotes breast tumorigenesis through tumor-initiating cell self-renewal

    Erythropoietin promotes breast tumorigenesis through tumor-initiating cell self-renewal by Bing Zhou, Jeffrey S. Damrauer, Sean T. Bailey, Tanja Hadzic, Youngtae Jeong, Kelly S. Clark, Huihui Fan, Laura Murphy, Cleo Y. Lee, Melissa A. Troester, C. Ryan Miller, Jian Jin, David B. Darr, Charles M. Perou, Ross L. Levine, Maximilian Diehn, William Y. Kim

    Published 2014
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  12. 12
    Identification of an Allosteric Small-Molecule Inhibitor Selective for the Inducible Form of Heat Shock Protein 70

    Identification of an Allosteric Small-Molecule Inhibitor Selective for the Inducible Form of Heat Shock Protein 70 by Matthew K. Howe, Khaldon Bodoor, David A. Carlson, Philip F. Hughes, Yazan Alwarawrah, David R. Loiselle, Alex M. Jaeger, David B. Darr, Jamie L. Jordan, Lucas Hunter, Eileen T. Molzberger, Theodore A. Gobillot, Dennis J. Thiele, Jeffrey L. Brodsky, Neil L. Spector, Timothy Haystead

    Published 2014
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  13. 13
    Mutation-Specific RAS Oncogenicity Explains NRAS Codon 61 Selection in Melanoma

    Mutation-Specific RAS Oncogenicity Explains NRAS Codon 61 Selection in Melanoma by Christin E. Burd, Wenjin Liu, Minh V. Huynh, Meriam A. Waqas, James E. Gillahan, Kelly S. Clark, Kailing Fu, Brit L. Martin, William R. Jeck, George P. Souroullas, David B. Darr, Daniel C. Zedek, Michael J. Miley, Bruce C. Baguley, Sharon L. Campbell, Norman E. Sharpless

    Published 2014
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  14. 14
    Predicting Drug Responsiveness in Human Cancers Using Genetically Engineered Mice

    Predicting Drug Responsiveness in Human Cancers Using Genetically Engineered Mice by Jerry Usary, Wei Zhao, David B. Darr, Patrick J. Roberts, Mei Liu, Lorraine Balletta, Olga Karginova, Jamie Jordan, Austin J. Combest, Arlene S. Bridges, Aleix Prat, Maggie C.U. Cheang, Jason I. Herschkowitz, Jeffrey M. Rosen, William C. Zamboni, Norman E. Sharpless, Charles M. Perou

    Published 2013
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  15. 15
    A nanoparticle-incorporated STING activator enhances antitumor immunity in PD-L1–insensitive models of triple-negative breast cancer

    A nanoparticle-incorporated STING activator enhances antitumor immunity in PD-L1–insensitive models of triple-negative breast cancer by Ning Cheng, Rebekah Watkins-Schulz, Robert D. Junkins, Clément N. David, Brandon M. Johnson, Stephanie A. Montgomery, Kevin J. Peine, David B. Darr, Hong Yuan, Karen P. McKinnon, Qi Liu, Lei Miao, Leaf Huang, Eric M. Bachelder, Kristy M. Ainslie, Jenny P.‐Y. Ting

    Published 2018
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  16. 16
    Efficacy of Carboplatin Alone and in Combination with ABT888 in Intracranial Murine Models of <i>BRCA</i>-Mutated and <i>BRCA</i>–Wild-Type Triple-Negative Breast Cancer

    Efficacy of Carboplatin Alone and in Combination with ABT888 in Intracranial Murine Models of <i>BRCA</i>-Mutated and <i>BRCA</i>–Wild-Type Triple-Negative Breast Cancer by Olga Karginova, Marni B. Siegel, Amanda E.D. Van Swearingen, Allison M. Deal, Bárbara Adamo, Maria J. Sambade, Soha Bazyar, Nana Nikolaishvili‐Feinberg, Ryan Bash, Sara O’Neal, Katie Sandison, Joel S. Parker, Charlene Santos, David B. Darr, William C. Zamboni, Yueh Z. Lee, C. Ryan Miller, Carey K. Anders

    Published 2015
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  17. 17
    Targeted inhibition of gut bacterial β-glucuronidase activity enhances anticancer drug efficacy

    Targeted inhibition of gut bacterial β-glucuronidase activity enhances anticancer drug efficacy by Aadra P. Bhatt, Samuel J. Pellock, Kristen A. Biernat, William G. Walton, Bret D. Wallace, Benjamin C. Creekmore, Marine P. M. Letertre, Jonathan R. Swann, Ian D. Wilson, Jose Roques, David B. Darr, Sean T. Bailey, Stephanie A. Montgomery, Jeffrey Roach, M. Andrea Azcárate-Peril, R. Balfour Sartor, Raad Z. Gharaibeh, Scott J. Bultman, Matthew R. Redinbo

    Published 2020
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  18. 18
    Enhancer Remodeling during Adaptive Bypass to MEK Inhibition Is Attenuated by Pharmacologic Targeting of the P-TEFb Complex

    Enhancer Remodeling during Adaptive Bypass to MEK Inhibition Is Attenuated by Pharmacologic Targeting of the P-TEFb Complex by Jon S. Zawistowski, Samantha M. Bevill, Daniel R. Goulet, Timothy J. Stuhlmiller, Adriana S. Beltrán, José F. Olivares-Quintero, Darshan Singh, Noah Sciaky, Joel S. Parker, Naim U. Rashid, Xin Chen, James S. Duncan, Martin C. Whittle, Steven P. Angus, Sara H. Velarde, Brian T. Golitz, Xiaping He, Charlene Santos, David B. Darr, Kristalyn Gallagher, Lee M. Graves, Charles M. Perou, Lisa A. Carey, H. Shelton Earp, Gary L. Johnson

    Published 2017
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  19. 19
    Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer

    Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer by John S. Duncan, Martin C. Whittle, Kazuhiro Nakamura, Amy N. Abell, Alicia A. Midland, Jon S. Zawistowski, Nancy L. Johnson, Deborah A. Granger, Nicole Vincent Jordan, David B. Darr, Jerry Usary, Pei Fen Kuan, David M. Smalley, Michael B. Major, Xiaping He, Katherine A. Hoadley, Bing Zhou, Norman E. Sharpless, Charles M. Perou, William Y. Kim, Shawn M. Gomez, Xin Chen, Jian Jin, Stephen V. Frye, H. Shelton Earp, Lee M. Graves, Gary L. Johnson

    Published 2012
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  20. 20
    A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma

    A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma by Clemens Krepler, Katrin Sproesser, Patricia Brafford, Marilda Beqiri, Bradley Garman, Min Xiao, Batool Shannan, Andrea Watters, Michela Perego, Gao Zhang, Adina Vultur, Xiangfan Yin, Qin Liu, Ioannis N. Anastopoulos, Bradley Wubbenhorst, Melissa Wilson, Wei Xu, Giorgos C. Karakousis, Michael D. Feldman, Xiaowei Xu, Ravi K. Amaravadi, Tara C. Gangadhar, David E. Elder, Lauren E. Haydu, Jennifer A. Wargo, Michael A. Davies, Yiling Lu, Gordon B. Mills, Dennie T. Frederick, Michal Barzily-Rokni, Keith T. Flaherty, Dave S.�B. Hoon, Michael J. Guarino, Joseph Bennett, R Ryan, Nicholas J. Petrelli, Carol L. Shields, Mizue Terai, Takami Sato, Andrew E. Aplin, Alexander Roesch, David B. Darr, Steven P. Angus, Rakesh Kumar, Ensar Halilovic, Giordano Caponigro, Sébastien Jeay, Jens Wuerthner, Annette O. Walter, Matthias Ocker, Matthew B. Boxer, Lynn M. Schuchter, Katherine L. Nathanson, Meenhard Herlyn

    Published 2017
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