Search Results - Daniel Conole
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Structure-Guided Design and Optimization of Covalent VHL-Targeted Sulfonyl Fluoride PROTACs by Rishi R. Shah, Elena De Vita, Preethi S. Sathyamurthi, Daniel Conole, Xinyue Zhang, Elliot Fellows, Eleanor R. Dickinson, Carlos Martinez Fleites, Markus A. Queisser, John D. Harling, Edward W. Tate
Published 2024Artigo -
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Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles by Hamish S. Sutherland, Amy S.T. Tong, Peter J. Choi, Daniel Conole, Adrian Blaser, Scott G. Franzblau, Christopher B. Cooper, Anna M. Upton, Manisha U. Lotlikar, William A. Denny, Brian D. Palmer
Published 2018Artigo -
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Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline by Adrian Blaser, Hamish S. Sutherland, Amy S.T. Tong, Peter J. Choi, Daniel Conole, Scott G. Franzblau, Christopher B. Cooper, Anna M. Upton, Manisha U. Lotlikar, William A. Denny, Brian D. Palmer
Published 2019Artigo -
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3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel by Hamish S. Sutherland, Amy S.T. Tong, Peter J. Choi, Adrian Blaser, Daniel Conole, Scott G. Franzblau, Manisha U. Lotlikar, Christopher B. Cooper, Anna M. Upton, William A. Denny, Brian D. Palmer
Published 2019Artigo -
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6-Cyano Analogues of Bedaquiline as Less Lipophilic and Potentially Safer Diarylquinolines for Tuberculosis by Amy S.T. Tong, Peter J. Choi, Adrian Blaser, Hamish S. Sutherland, Sophia K. Y. Tsang, Jérôme Guillemont, Magali Motte, Christopher B. Cooper, Koen Andries, Walter Van den Broeck, Scott G. Franzblau, Anna M. Upton, William A. Denny, Brian D. Palmer, Daniel Conole
Published 2017Artigo -
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Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs) by Qisi Zhang, Cyrille S. Kounde, Milon Mondal, Jake L. Greenfield, Jennifer R. Baker, Sergei Kotelnikov, Mikhail Ignatov, Christopher P. Tinworth, Leran Zhang, Daniel Conole, Elena De Vita, Dima Kozakov, Adam McCluskey, John D. Harling, Matthew J. Fuchter, Edward W. Tate
Published 2022Artigo -
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Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer by Bruno M. Simões, Angélica Santiago-Gómez, Chiara Chiodo, Tiago Moreira, Daniel Conole, S. Lovell, Denis Alférez, Rachel Eyre, Katherine Spence, Aida Sarmiento-Castro, Bertram Kohler, Ludivine Morisset, Marilena Lanzino, Sebastiano Andò, Elisabetta Marangoni, Andrew H. Sims, Edward W. Tate, Sacha J. Howell, Robert B. Clarke
Published 2020Artigo
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Biochemistry
Biology
Chemistry
Gene
Medicine
Bedaquiline
Genetics
In vitro
Internal medicine
Lipophilicity
Mycobacterium tuberculosis
Pathology
Pharmacology
Potassium channel
Stereochemistry
Tuberculosis
hERG
Cell biology
Combinatorial chemistry
Computational biology
Drug
Ubiquitin
Biotechnology
Breast cancer
Cancer
Cancer research
Computer science
Deubiquitinating enzyme
Enzyme
In vivo