Resultats de la cerca - Conor R. Caffrey

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  1. 1
    From innovation to application: Social–ecological context, diagnostics, drugs and integrated control of schistosomiasis

    From innovation to application: Social–ecological context, diagnostics, drugs and integrated control of schistosomiasis per Jürg Utzinger, Eliézer K. N’Goran, Conor R. Caffrey, Jennifer Keiser

    Publicat 2010
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  2. 2
    Targeting proteasomes in infectious organisms to combat disease

    Targeting proteasomes in infectious organisms to combat disease per Betsaida Bibo‐Verdugo, Zhenze Jiang, Conor R. Caffrey, Anthony J. O’Donoghue

    Publicat 2017
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  3. 3
    Proteomic Identification of IPSE/alpha-1 as a Major Hepatotoxin Secreted by Schistosoma mansoni Eggs

    Proteomic Identification of IPSE/alpha-1 as a Major Hepatotoxin Secreted by Schistosoma mansoni Eggs per Maha‐Hamadien Abdulla, Kee‐Chong Lim, James H. McKerrow, Conor R. Caffrey

    Publicat 2011
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  4. 4
    Schistosomiasis Mansoni: Novel Chemotherapy Using a Cysteine Protease Inhibitor

    Schistosomiasis Mansoni: Novel Chemotherapy Using a Cysteine Protease Inhibitor per Maha‐Hamadien Abdulla, Kee‐Chong Lim, Mohammed Sajid, James H. McKerrow, Conor R. Caffrey

    Publicat 2007
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  5. 5
    Chemical and Genetic Validation of the Statin Drug Target to Treat the Helminth Disease, Schistosomiasis

    Chemical and Genetic Validation of the Statin Drug Target to Treat the Helminth Disease, Schistosomiasis per Liliana Rojo‐Arreola, Thavy Long, Daniel Asarnow, Brian M. Suzuki, Rahul Singh, Conor R. Caffrey

    Publicat 2014
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  6. 6
    Profiling of proteolytic enzymes in the gut of the tick Ixodes ricinus reveals an evolutionarily conserved network of aspartic and cysteine peptidases

    Profiling of proteolytic enzymes in the gut of the tick Ixodes ricinus reveals an evolutionarily conserved network of aspartic and cysteine peptidases per Daniel Sojka, Zdeněk Franta, Martin Horn, Ondřej Hajdušek, Conor R. Caffrey, Michael A. Mares, Petr Kopáček

    Publicat 2008
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  7. 7
    Cysteine proteases during larval migration and development of helminths in their final host

    Cysteine proteases during larval migration and development of helminths in their final host per Alexandra Grote, Conor R. Caffrey, Karina M. Rebello, David W. Smith, John P. Dalton, Sara Lustigman

    Publicat 2018
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  8. 8
    Aryl ureas represent a new class of anti-trypanosomal agents

    Aryl ureas represent a new class of anti-trypanosomal agents per Xiaohui Du, Elizabeth Hansell, Juan C. Engel, Conor R. Caffrey, Fred E. Cohen, James H. McKerrow

    Publicat 2000
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  9. 9
    A Comparative Chemogenomics Strategy to Predict Potential Drug Targets in the Metazoan Pathogen, Schistosoma mansoni

    A Comparative Chemogenomics Strategy to Predict Potential Drug Targets in the Metazoan Pathogen, Schistosoma mansoni per Conor R. Caffrey, Andreas Rohwer, Frank Oellien, Richard J. Marhöfer, Bryony Braschi, Guilherme Oliveira, James H. McKerrow, Paul M. Selzer

    Publicat 2009
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  10. 10
    A single-cell RNA-seq atlas of <i>Schistosoma mansoni</i> identifies a key regulator of blood feeding

    A single-cell RNA-seq atlas of <i>Schistosoma mansoni</i> identifies a key regulator of blood feeding per George Wendt, Lu Zhao, Rui Chen, Chenxi Liu, Anthony J. O’Donoghue, Conor R. Caffrey, Michael L. Reese, James J. Collins

    Publicat 2020
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  11. 11
    Quantification and clustering of phenotypic screening data using time-series analysis for chemotherapy of schistosomiasis

    Quantification and clustering of phenotypic screening data using time-series analysis for chemotherapy of schistosomiasis per Hyokyeong Lee, Asher Moody-Davis, Utsab Saha, Brian M. Suzuki, Daniel Asarnow, Steven Chen, Michelle R. Arkin, Conor R. Caffrey, Rahul Singh

    Publicat 2012
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  12. 12
    A Multienzyme Network Functions in Intestinal Protein Digestion by a Platyhelminth Parasite

    A Multienzyme Network Functions in Intestinal Protein Digestion by a Platyhelminth Parasite per Melaine Delcroix, Mohammed Sajid, Conor R. Caffrey, Kee-C Lim, Jan Dvořák, Ivy Hsieh, Mahmoud Mohamed Bahgat, Colette Dissous, James H. McKerrow

    Publicat 2006
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  13. 13
    Rapid induction of IgE responses to a worm cysteine protease during murine pre-patent schistosome infection

    Rapid induction of IgE responses to a worm cysteine protease during murine pre-patent schistosome infection per Lúcia Alves de Oliveira Fraga, Erika Lamb, Elizabeth Castro Moreno, Mitali Chatterjee, Jan Dvořák, Melaine Delcroix, Mohammed Sajid, Conor R. Caffrey, Stephen J. Davies

    Publicat 2010
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  14. 14
    Hemoglobin Digestion in Blood-Feeding Ticks: Mapping a Multipeptidase Pathway by Functional Proteomics

    Hemoglobin Digestion in Blood-Feeding Ticks: Mapping a Multipeptidase Pathway by Functional Proteomics per Martin Horn, Martina Nussbaumerová, Miloslav Šanda, Zuzana Kovářová, Jindřich Srba, Zdeněk Franta, Daniel Sojka, Matthew Bogyo, Conor R. Caffrey, Petr Kopáček, Michael A. Mares

    Publicat 2009
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  15. 15
    Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni

    Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni per Adéla Jílková, Pavlína Řezáčová, Martin Lepšı́k, Martin Horn, Jana Váchová, Jindřich Fanfrlík, J. Brynda, James H. McKerrow, Conor R. Caffrey, Michael A. Mares

    Publicat 2011
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  16. 16
    Evaluation of the CCA Immuno-Chromatographic Test to Diagnose Schistosoma mansoni in Minas Gerais State, Brazil

    Evaluation of the CCA Immuno-Chromatographic Test to Diagnose Schistosoma mansoni in Minas Gerais State, Brazil per Alda Maria Soares Silveira, Emanuele Gama Dutra Costa, Debalina Ray, Brian M. Suzuki, Michael H. Hsieh, Lúcia Alves de Oliveira Fraga, Conor R. Caffrey

    Publicat 2016
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  17. 17
    High Throughput and Computational Repurposing for Neglected Diseases

    High Throughput and Computational Repurposing for Neglected Diseases per H. Hernandez, Melinda Soeung, Kimberley M. Zorn, Norah E Ashoura, Melina Mottin, Carolina Horta Andrade, Conor R. Caffrey, Jair L. Siqueira-Neto, Sean Ekins

    Publicat 2018
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  18. 18
    Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors

    Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors per Pavla Fajtová, Saša Štefanić, Martin Hradílek, Jan Dvořák, Jiřı́ Vondrášek, Adéla Jílková, Lenka Ulrychová, James H. McKerrow, Conor R. Caffrey, Michael A. Mares, Martin Horn

    Publicat 2015
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  19. 19
    Drug Discovery for Schistosomiasis: Hit and Lead Compounds Identified in a Library of Known Drugs by Medium-Throughput Phenotypic Screening

    Drug Discovery for Schistosomiasis: Hit and Lead Compounds Identified in a Library of Known Drugs by Medium-Throughput Phenotypic Screening per Maha-Hamadien Abdulla, Debbie S. Ruelas, Brian Wolff, June Snedecor, Kee‐Chong Lim, Fengyun Xu, Adam R. Renslo, Janice A. Williams, James H. McKerrow, Conor R. Caffrey

    Publicat 2009
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  20. 20
    A Parasite Cysteine Protease Is Key to Host Protein Degradation and Iron Acquisition

    A Parasite Cysteine Protease Is Key to Host Protein Degradation and Iron Acquisition per Theresa C. O’Brien, Zachary B. Mackey, Richard D. Fetter, Youngchool Choe, Anthony J. O’Donoghue, Min Zhou, Charles S. Craik, Conor R. Caffrey, James H. McKerrow

    Publicat 2008
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