Resultats de la cerca - Chris C.A. Spencer

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  1. 1
    SelSim: a program to simulate population genetic data with natural selection and recombination

    SelSim: a program to simulate population genetic data with natural selection and recombination per Chris C. A. Spencer, Graham Coop

    Publicat 2004
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  2. 2
    Efficient computation with a linear mixed model on large-scale data sets with applications to genetic studies

    Efficient computation with a linear mixed model on large-scale data sets with applications to genetic studies per Matti Pirinen, Peter Donnelly, Chris C. A. Spencer

    Publicat 2013
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  3. 3
    A novel locus of resistance to severe malaria in a region of ancient balancing selection

    A novel locus of resistance to severe malaria in a region of ancient balancing selection per Kirk A. Rockett, Chris C. A. Spencer, Dominic Kwiatkowski

    Publicat 2015
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  4. 4
    Progress and promise in understanding the genetic basis of common diseases

    Progress and promise in understanding the genetic basis of common diseases per Alkes L. Price, Chris C. A. Spencer, Peter Donnelly

    Publicat 2015
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  5. 5
    Perspectives on Human Genetic Variation from the HapMap Project

    Perspectives on Human Genetic Variation from the HapMap Project per Gil McVean, Chris C. A Spencer, Raphaëlle Chaix

    Publicat 2005
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  6. 6
    Designing Genome-Wide Association Studies: Sample Size, Power, Imputation, and the Choice of Genotyping Chip

    Designing Genome-Wide Association Studies: Sample Size, Power, Imputation, and the Choice of Genotyping Chip per Chris C. A. Spencer, Zhan Su, Peter Donnelly, Jonathan Marchini

    Publicat 2009
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  7. 7
    A robust clustering algorithm for identifying problematic samples in genome-wide association studies

    A robust clustering algorithm for identifying problematic samples in genome-wide association studies per Céline Bellenguez, Amy Strange, Colin Freeman, Peter Donnelly, Chris C. A. Spencer

    Publicat 2011
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  8. 8
    FINEMAP: efficient variable selection using summary data from genome-wide association studies

    FINEMAP: efficient variable selection using summary data from genome-wide association studies per Christian Benner, Chris C. A. Spencer, Aki S. Havulinna, Veikko Salomaa, Samuli Ripatti, Matti Pirinen

    Publicat 2016
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  9. 9
    The Influence of Recombination on Human Genetic Diversity

    The Influence of Recombination on Human Genetic Diversity per Chris C. A. Spencer, Panos Deloukas, Sarah Hunt, Jim Mullikin, Simon Myers, Bernard W. Silverman, Peter Donnelly, David Bentley, Gil McVean

    Publicat 2006
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  10. 10
    Pneumococcal genome sequencing tracks a vaccine escape variant formed through a multi-fragment recombination event

    Pneumococcal genome sequencing tracks a vaccine escape variant formed through a multi-fragment recombination event per Tanya Golubchik, Angela B. Brueggemann, Teresa Street, Robert E. Gertz, Chris C. A. Spencer, Thiện Hồ, Eleni Giannoulatou, Ruth Link‐Gelles, Rosalind M. Harding, Bernard Beall, Tim Peto, Matthew R. Moore, Peter Donnelly, Derrick W. Crook, Rory Bowden

    Publicat 2012
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  11. 11
    Admixture into and within sub-Saharan Africa

    Admixture into and within sub-Saharan Africa per George B. J. Busby, Gavin Band, Si Quang Le, Muminatou Jallow, Edith Bougama, Valentina Mangano, Lucas Amenga–Etego, Anthony Enimil, Tobias O. Apinjoh, Carolyne Ndila, Alphaxard Manjurano, Vysaul Nyirongo, Ogobara Doumba, Kirk A. Rockett, Dominic Kwiatkowski, Chris C. A. Spencer

    Publicat 2016
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  12. 12
    Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease

    Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease per Derek Klarin, Qiuyu Zhu, Connor A. Emdin, Mark Chaffin, Steven Horner, Brian J. McMillan, Alison Leed, Michael E. Weale, Chris C. A. Spencer, François Aguet, Ayellet V. Segrè, Kristin Ardlie, Amit V. Khera, Virendar K. Kaushik, Pradeep Natarajan, Sekar Kathiresan

    Publicat 2017
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  13. 13
    Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis

    Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis per Kaixin Zhou, Louise A. Donnelly, Jian Yang, Miaoxin Li, Harshal Deshmukh, Natalie Van Zuydam, Emma Ahlqvist, Chris C. A. Spencer, Leif Groop, Andrew D. Morris, Helen M. Colhoun, Pak C. Sham, Mark I. McCarthy, Colin N. A. Palmer, Ewan R. Pearson

    Publicat 2014
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  14. 14
    Identifying lineage effects when controlling for population structure improves power in bacterial association studies

    Identifying lineage effects when controlling for population structure improves power in bacterial association studies per Sarah G. Earle, Chieh‐Hsi Wu, Jane Charlesworth, Nicole Stoesser, N Claire Gordon, Timothy M. Walker, Chris C. A. Spencer, Zamin Iqbal, David A. Clifton, Katie L. Hopkins, Neil Woodford, E. Grace Smith, Nazir Ismail, Martin Llewelyn, Tim Peto, Derrick W. Crook, Gil McVean, Timothy M. Walker, Daniel J. Wilson

    Publicat 2016
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  15. 15
    Integrated Polygenic Tool Substantially Enhances Coronary Artery Disease Prediction

    Integrated Polygenic Tool Substantially Enhances Coronary Artery Disease Prediction per Fernando Riveros-Mckay, Michael E. Weale, Rachel Moore, Saskia Selzam, Eva Krapohl, R. Michael Sivley, William A. Tarran, Peter Sørensen, Alexander S. Lachapelle, Jonathan A. Griffiths, Ayden Saffari, John Deanfield, Chris C. A. Spencer, Julia Hippisley‐Cox, David J. Hunter, Jack W. O’Sullivan, Euan A. Ashley, Vincent Plagnol, Peter Donnelly

    Publicat 2021
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  16. 16
    Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus

    Genome-to-genome analysis highlights the effect of the human innate and adaptive immune systems on the hepatitis C virus per M. Azim Ansari, Vincent Pedergnana, Camilla L. C. Ip, Andrea Magrì, Annette von Delft, David Bonsall, Nimisha Chaturvedi, István Bartha, David A. Smith, George Nicholson, Gilean McVean, Amy Trebes, Paolo Piazza, Jacques Fellay, G Cooke, Graham R. Foster, Emma Hudson, John McLauchlan, Peter Simmonds, Rory Bowden, Paul Klenerman, Eleanor Barnes, Chris C. A. Spencer, Stop-Hcv Consortium

    Publicat 2017
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  17. 17
    Artificial intelligence for predictive biomarker discovery in immuno-oncology: a systematic review

    Artificial intelligence for predictive biomarker discovery in immuno-oncology: a systematic review per Arsela Prelaj, Vanja Mišković, Michele Zanitti, Francesco Trovò, Carlo Genova, Giuseppe Viscardi, Sara Elena Rebuzzi, Laura Mazzeo, Leonardo Provenzano, Sokol Kosta, M. A. Favali, Andrea Spagnoletti, L. Castelo-Branco, James M. Dolezal, Alexander T. Pearson, Giuseppe Lo Russo, Claudia Proto, Monica Ganzinelli, Carlotta Giani, Emilia Ambrosini, Samra Turajlic, Lewis Au, M. Koopman, Suzette Delaloge, Jakob Nikolas Kather, Filippo de Braud, Marina Chiara Garassino, George Pentheroudakis, Chris C. A. Spencer, A.L.G. Pedrocchi

    Publicat 2023
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  18. 18
    Imputation-Based Meta-Analysis of Severe Malaria in Three African Populations

    Imputation-Based Meta-Analysis of Severe Malaria in Three African Populations per Gavin Band, Si Quang Le, Luke Jostins, Matti Pirinen, Katja Kivinen, Muminatou Jallow, Fatoumatta Sisay-Joof, Kalifa Bojang, Margaret Pinder, Giorgio Sirugo, David J. Conway, Vysaul Nyirongo, David Kachala, Malcolm E. Molyneux, Terrie E. Taylor, Carolyne Ndila, Norbert Peshu, Kevin Marsh, Thomas N. Williams, Daniel Alcock, Robert Andrews, Sarah Edkins, Emma Gray, Christina Hubbart, Anna E. Jeffreys, Kate Rowlands, Kathrin Schuldt, Taane G. Clark, Kerrin S. Small, Yik Ying Teo, Dominic Kwiatkowski, Kirk A. Rockett, Jeffrey C. Barrett, Chris C. A. Spencer

    Publicat 2013
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  19. 19
    Phenome-wide association studies across large population cohorts support drug target validation

    Phenome-wide association studies across large population cohorts support drug target validation per Dorothée Diogo, Chao Tian, Christopher S. Franklin, Mervi Alanne-Kinnunen, Michael March, Chris C. A. Spencer, Ciara Vangjeli, Michael E. Weale, Hannele Mattsson, Elina Kilpeläinen, Patrick Sleiman, Dermot F. Reilly, Joshua McElwee, Joseph Maranville, Arnaub K. Chatterjee, Aman Bhandari, Khanh‐Dung H. Nguyen, Karol Estrada, Mary-Pat Reeve, Janna Hutz, Nan Bing, Sally John, Daniel G. MacArthur, Veikko Salomaa, Samuli Ripatti, Hákon Hákonarson, Mark J. Daly, Aarno Palotie, David A. Hinds, Peter Donnelly, Caroline S. Fox, Aaron Day-Williams, Robert M. Plenge, Heiko Runz

    Publicat 2018
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  20. 20
    Genome-wide Comparison of African-Ancestry Populations from CARe and Other Cohorts Reveals Signals of Natural Selection

    Genome-wide Comparison of African-Ancestry Populations from CARe and Other Cohorts Reveals Signals of Natural Selection per Gaurav Bhatia, Nick Patterson, Bogdan Paşaniuc, Noah Zaitlen, Giulio Genovese, Samuela Pollack, Swapan Mallick, Simon Myers, Arti Tandon, Chris C. A. Spencer, Lyle J. Palmer, Adebowale Adeyemo, Ermeg L. Akylbekova, L. Adrienne Cupples, Jasmin Divers, Myriam Fornage, W.H. Linda Kao, Leslie A. Lange, Mingyao Li, Solomon K. Musani, Josyf C. Mychaleckyj, Adesola Ogunniyi, George Papanicolaou, Charles N. Rotimi, Jerome I. Rotter, Ingo Ruczinski, Babatunde Salako, David S. Siscovick, Bamidele O. Tayo, Qiong Yang, Steve McCarroll, Pardis C. Sabeti, Guillaume Lettre, Phil De Jager, Joel N. Hirschhorn, Xiaofeng Zhu, Stephen S. Rich, David Reich, James G. Wilson, Alkes L. Price

    Publicat 2011
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