نتائج البحث - Charlie Hatton

تنقيح النتائج
  1. 1
    MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape

    MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape حسب Sarah Naomi Olsen, Laura Godfrey, James P. Healy, Yoolim A. Choi, Kai Yan, Charlie Hatton, Florian Perner, Elena Haarer, Behnam Nabet, Guo‐Cheng Yuan, Scott A. Armstrong

    منشور في 2022
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    Artigo
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  2. 2
    Combined inhibition of KAT6A/B and Menin reverses estrogen receptor-driven gene expression programs in breast cancer

    Combined inhibition of KAT6A/B and Menin reverses estrogen receptor-driven gene expression programs in breast cancer حسب Sarah Naomi Olsen, Bryn Anderson, Charlie Hatton, Zhengtao Chu, Christopher E. Simpkins, Yanhe Wen, Wallace Bourgeois, Elena Haarer, Myles Brown, Rinath Jeselsohn, Alana L. Welm, Eneda Toska, Scott A. Armstrong

    منشور في 2025
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  3. 3
    Pharmacological Inhibition of the Histone Lysine Demethylase KDM1A Suppresses the Growth of Multiple Acute Myeloid Leukemia Subtypes

    Pharmacological Inhibition of the Histone Lysine Demethylase KDM1A Suppresses the Growth of Multiple Acute Myeloid Leukemia Subtypes حسب John P. McGrath, Kaylyn E. Williamson, Srividya Balasubramanian, Shobu Odate, Shilpi Arora, Charlie Hatton, Thomas M. Edwards, Thomas O’Brien, Steven Magnuson, David Stokoe, Danette L. Daniels, Barbara M. Bryant, Patrick Trojer

    منشور في 2016
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  4. 4
    Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia

    Mutant NPM1 Directly Regulates Oncogenic Transcription in Acute Myeloid Leukemia حسب Hannah J. Uckelmann, Elena Haarer, Reina Takeda, Eric Wong, Charlie Hatton, Christian Marinaccio, Florian Perner, Masooma Rajput, Noa J.C. Antonissen, Yanhe Wen, Lu Yang, Lorenzo Brunetti, Chun–Wei Chen, Scott A. Armstrong

    منشور في 2022
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  5. 5
    Omega-3 polyunsaturated fatty acids preserve retinal function in type 2 diabetic mice

    Omega-3 polyunsaturated fatty acids preserve retinal function in type 2 diabetic mice حسب Przemysław Sapieha, J. Chen, Andreas Stahl, Molly R. Seaward, Tara L. Favazza, Aimee M. Juan, Charlie Hatton, J-S Joyal, Nathan M. Krah, Roberta J. Dennison, Jie Tang, Timothy S. Kern, James D. Akula, Lois E. H. Smith

    منشور في 2012
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  6. 6
    Therapeutic targeting of preleukemia cells in a mouse model of <i>NPM1</i> mutant acute myeloid leukemia

    Therapeutic targeting of preleukemia cells in a mouse model of <i>NPM1</i> mutant acute myeloid leukemia حسب Hannah J. Uckelmann, Stephanie M. Kim, Eric Wong, Charlie Hatton, Hugh Giovinazzo, Jayant Y. Gadrey, Andrei V. Krivtsov, Frank G. Rücker, Konstanze Döhner, Gerard M. McGeehan, Ross L. Levine, Lars Bullinger, George S. Vassiliou, Scott A. Armstrong

    منشور في 2020
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  7. 7
    An Alternative Approach to ChIP-Seq Normalization Enables Detection of Genome-Wide Changes in Histone H3 Lysine 27 Trimethylation upon EZH2 Inhibition

    An Alternative Approach to ChIP-Seq Normalization Enables Detection of Genome-Wide Changes in Histone H3 Lysine 27 Trimethylation upon EZH2 Inhibition حسب Brian Egan, Chih-Chi Yuan, Madeleine Craske, Paul Labhart, Gulfem D. Guler, David Arnott, Tobias M Maile, Jennifer Busby, Chisato Henry, Theresa K. Kelly, Charles Tindell, Suchit Jhunjhunwala, Feng Zhao, Charlie Hatton, Barbara M. Bryant, Marie Classon, Patrick Trojer

    منشور في 2016
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  8. 8
    MEK1 mutations confer resistance to MEK and B-RAF inhibition

    MEK1 mutations confer resistance to MEK and B-RAF inhibition حسب W. Marston Linehan, Krishna G. Vijayendran, Marie Zipser, Allison M. Sawyer, Lili Niu, Jessica Kim, Charlie Hatton, Rajiv Chopra, Patrick A. Oberholzer, Maria B. Karpova, Laura E. MacConaill, Jianming Zhang, Nathanael S. Gray, William R. Sellers, Reinhard Dummer, Levi A. Garraway

    منشور في 2009
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    Artigo
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  9. 9
    Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma

    Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma حسب Andrew R. Conery, Richard C. Centore, Adrianne Neiss, Patricia J. Keller, Shivangi Joshi, Kerry L. Spillane, Péter Sandy, Charlie Hatton, Eneida Pardo, Laura E. Zawadzke, Archana Bommi‐Reddy, Karen E. Gascoigne, Barbara M. Bryant, Jennifer A. Mertz, Robert J. Sims

    منشور في 2016
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  10. 10
    The menin-MLL1 interaction is a molecular dependency in <i>NUP98</i>-rearranged AML

    The menin-MLL1 interaction is a molecular dependency in <i>NUP98</i>-rearranged AML حسب Emily Heikamp, Jill A. Henrich, Florian Perner, Eric Wong, Charlie Hatton, Yanhe Wen, Sonali P. Barwe, Anilkumar Gopalakrishnapillai, Haiming Xu, Hannah J. Uckelmann, Sumiko Takao, Yaniv Kazansky, Yana Pikman, Gerard M. McGeehan, E. Anders Kolb, Alex Kentsis, Scott A. Armstrong

    منشور في 2021
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  11. 11
    High-throughput mutation profiling of CTCL samples reveals KRAS and NRAS mutations sensitizing tumors toward inhibition of the RAS/RAF/MEK signaling cascade

    High-throughput mutation profiling of CTCL samples reveals KRAS and NRAS mutations sensitizing tumors toward inhibition of the RAS/RAF/MEK signaling cascade حسب Michael K. Kießling, Patrick A. Oberholzer, Chandrani Mondal, Maria B. Karpova, Marie Zipser, William M. Lin, Michael Girardi, Laura E. MacConaill, Sarah M. Kehoe, Charlie Hatton, Lars E. French, Levi A. Garraway, Gernot Polier, Dorothee Süss, Claus‐Detlev Klemke, Peter H. Krammer, Karsten Gülow, Reinhard Dummer

    منشور في 2011
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  12. 12
    Regulation of GLI Underlies a Role for BET Bromodomains in Pancreatic Cancer Growth and the Tumor Microenvironment

    Regulation of GLI Underlies a Role for BET Bromodomains in Pancreatic Cancer Growth and the Tumor Microenvironment حسب Yinshi Huang, Sabikun Nahar, Akifumi Nakagawa, Maite G. Fernández‐Barrena, Jennifer A. Mertz, Barbara M. Bryant, Curtis E. Adams, Mari Mino‐Kenudson, Kate N. Von Alt, Kevin K. Chang, Andrew R. Conery, Charlie Hatton, Robert J. Sims, Martín E. Fernández-Zapico, Xingpeng Wang, Keith D. Lillemoe, Carlos Fernández‐del Castillo, Andrew L. Warshaw, Sarah P. Thayer, Andrew S. Liss

    منشور في 2016
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  13. 13
    Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway

    Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway حسب Courtney A. Lovejoy, Wen‐Di Li, Steven Reisenweber, Supawat Thongthip, Joanne Bruno, Titia de Lange, Saurav De, John H.J. Petrini, Patricia Sung, Maria Jasin, Joseph Rosenbluh, Yaara Zwang, Barbara A. Weir, Charlie Hatton, Elena Ivanova, Laura E. MacConaill, Megan Hanna, William C. Hahn, Neal F. Lue, Roger R. Reddel, Yuchen Jiao, Kenneth W. Kinzler, Bert Vogelstein, Nickolas Papadopoulos, Alan K. Meeker

    منشور في 2012
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  14. 14
    Drug-sensitive<i>FGFR2</i>mutations in endometrial carcinoma

    Drug-sensitive<i>FGFR2</i>mutations in endometrial carcinoma حسب Amit Dutt, Helga B. Salvesen, Tzu-Hsiu Chen, Alex H. Ramos, Robert C. Onofrio, Charlie Hatton, Richard Nicoletti, Wendy Winckler, Rupinder Grewal, Megan Hanna, Nicolas Wyhs, Liuda Ziaugra, Daniel J. Richter, Jone Trovik, Ingeborg B. Engelsen, Ingunn M. Stefansson, Tim Fennell, Kristian Cibulskis, Michael C. Zody, Lars A. Akslen, Stacey B. Gabriel, Kwok‐Kin Wong, William R. Sellers, Matthew Meyerson, Heidi Greulich

    منشور في 2008
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  15. 15
    IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia

    IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia حسب Brandon J. Aubrey, Jevon Cutler, Wallace Bourgeois, Katherine A. Donovan, Shengqing Gu, Charlie Hatton, Sarah C. Perlee, Florian Perner, Homa Rahnamoun, Alexandra C. P. Theall, Jill A. Henrich, Qian Zhu, Radosław P. Nowak, Young‐Joon Kim, Salma Parvin, Anjali Cremer, Sarah Naomi Olsen, Nicholas A. Eleuteri, Yana Pikman, Gerard M. McGeehan, Kimberly Stegmaier, Anthony Letai, Eric S. Fischer, X. Shirley Liu, Scott A. Armstrong

    منشور في 2022
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  16. 16
    MEN1 mutations mediate clinical resistance to menin inhibition

    MEN1 mutations mediate clinical resistance to menin inhibition حسب Florian Perner, Eytan M. Stein, Daniela V. Wenge, Sukrit Singh, Jeonghyeon Kim, Athina Apazidis, Homa Rahnamoun, Disha Anand, Christian Marinaccio, Charlie Hatton, Yanhe Wen, Richard M. Stone, David Schaller, Shoron Mowla, Wenbin Xiao, Holly A. Gamlen, Aaron J. Stonestrom, Sonali Persaud, Elizabeth T. Ener, Jevon Cutler, John G. Doench, Gerard M. McGeehan, Andrea Volkamer, John D. Chodera, Radosław P. Nowak, Eric S. Fischer, Ross L. Levine, Scott A. Armstrong, Sheng F. Cai

    منشور في 2023
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  17. 17
    Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma

    Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma حسب Rameen Beroukhim, Gad Getz, Leia Nghiemphu, Jordi Barretina, Teli Hsueh, David Linhart, Igor Vivanco, Jeffrey C. Lee, Julie H. Huang, Sethu Alexander, Jinyan Du, Tweeny R. Kau, Roman K. Thomas, Kinjal Shah, Horacio Soto, Sven Perner, John R. Prensner, Ralph DeBiasi, Francesca Demichelis, Charlie Hatton, Mark A. Rubin, Levi A. Garraway, Stan F. Nelson, Linda M. Liau, Paul S. Mischel, Tim Cloughesy, Matthew Meyerson, Todd Golub, Eric S. Lander, Ingo K. Mellinghoff, William R. Sellers

    منشور في 2007
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    Artigo
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  18. 18
    Prospective Enterprise-Level Molecular Genotyping of a Cohort of Cancer Patients

    Prospective Enterprise-Level Molecular Genotyping of a Cohort of Cancer Patients حسب Laura E. MacConaill, Elizabeth Garcia, Priyanka Shivdasani, Matthew D. Ducar, Ravali Adusumilli, Marc Breneiser, Mark N. Byrne, Lawrence P. Chung, Jodie Conneely, Lauren Crosby, Levi A. Garraway, Xin Gong, William C. Hahn, Charlie Hatton, Philip W. Kantoff, Michael Kluk, Frank C. Kuo, Yonghui Jia, Ruchi Joshi, Janina A. Longtine, Allison Manning, Emanuele Palescandolo, Nematullah Sharaf, Lynette M. Sholl, Paul Van Hummelen, Jacqueline E. Wade, Bruce M. Wollinson, Dimity Zepf, Barrett J. Rollins, Neal I. Lindeman

    منشور في 2014
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  19. 19
    Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples

    Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples حسب Laura E. MacConaill, Catarina D. Campbell, Sarah M. Kehoe, Adam J. Bass, Charlie Hatton, Lili Niu, Matt Davis, Keluo Yao, Megan Hanna, Chandrani Mondal, Lauren Luongo, W. Marston Linehan, Alissa C. Baker, Juliet Philips, Deborah J. Goff, Michelangelo Fiorentino, Mark A. Rubin, Kornélia Polyák, Jennifer A. Chan, Yuexiang Wang, Jonathan A. Fletcher, Sandro Santagata, Giovanni Corso, Franco Roviello, Ramesh A. Shivdasani, Mark W. Kieran, Keith L. Ligon, Charles D. Stiles, William C. Hahn, Matthew Meyerson, Levi A. Garraway

    منشور في 2009
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  20. 20
    A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia

    A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia حسب Andrei V. Krivtsov, Kathryn Evans, Jayant Y. Gadrey, Benjamin K. Eschle, Charlie Hatton, Hannah J. Uckelmann, Kenneth N. Ross, Florian Perner, Sarah Naomi Olsen, Tara Pritchard, Lisa McDermott, Connor Jones, Duohui Jing, Ali Braytee, Diego Chacon, Eric J. Earley, Brian M. McKeever, David A. Claremon, Andrew J. Gifford, Heather Lee, Beverly A. Teicher, John E. Pimanda, Dominik Beck, Jennifer A. Perry, Malcolm A. Smith, Gerard M. McGeehan, Richard B. Lock, Scott A. Armstrong

    منشور في 2019
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