Výsledky vyhledávání - Brian A. Joughin

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  1. 1
    Multiplexed relative and absolute quantitative immunopeptidomics reveals MHC I repertoire alterations induced by CDK4/6 inhibition

    Multiplexed relative and absolute quantitative immunopeptidomics reveals MHC I repertoire alterations induced by CDK4/6 inhibition Autor Lauren Stopfer, Joshua M. Mesfin, Brian A. Joughin, Douglas A. Lauffenburger, Forest M. White

    Vydáno 2020
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  2. 2
    ROS and Oxidative Stress Are Elevated in Mitosis during Asynchronous Cell Cycle Progression and Are Exacerbated by Mitotic Arrest

    ROS and Oxidative Stress Are Elevated in Mitosis during Asynchronous Cell Cycle Progression and Are Exacerbated by Mitotic Arrest Autor Jesse C. Patterson, Brian A. Joughin, Bert van de Kooij, Daniel Lim, Douglas A. Lauffenburger, Michael B. Yaffe

    Vydáno 2019
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  3. 3
    Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function

    Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function Autor Haitham Amal, Boaz Barak, Vadiraja B. Bhat, Guanyu Gong, Brian A. Joughin, Xin Wang, John S. Wishnok, Guoping Feng, Steven R. Tannenbaum

    Vydáno 2018
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  4. 4
    DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme

    DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme Autor Zachary D. Nagel, Gaspar J. Kitange, Shiv K. Gupta, Brian A. Joughin, Isaac A. Chaim, Patrizia Mazzucato, Douglas A. Lauffenburger, Jann N. Sarkaria, Leona D. Samson

    Vydáno 2016
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  5. 5
    The injury response to DNA damage in live tumor cells promotes antitumor immunity

    The injury response to DNA damage in live tumor cells promotes antitumor immunity Autor Ganapathy Sriram, Lauren E. Milling, Jung-Kuei Chen, Yi Wen Kong, Brian A. Joughin, Wuhbet Abraham, Susanne Swartwout, Erika D. Handly, Darrell J. Irvine, Michael B. Yaffe

    Vydáno 2021
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  6. 6
    Quantitative Phospho-proteomics to Investigate the Polo-like Kinase 1-Dependent Phospho-proteome

    Quantitative Phospho-proteomics to Investigate the Polo-like Kinase 1-Dependent Phospho-proteome Autor Karin Grosstessner‐Hain, Björn Hegemann, Maria Novatchkova, Jonathan Rameseder, Brian A. Joughin, Otto Hudecz, Elisabeth Roitinger, Peter Pichler, Norbert Kraut, Michael B. Yaffe, Jan‐Michael Peters, Karl Mechtler

    Vydáno 2011
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  7. 7
    A genome-scale in vivo loss-of-function screen identifies <i>Phf6</i> as a lineage-specific regulator of leukemia cell growth

    A genome-scale in vivo loss-of-function screen identifies <i>Phf6</i> as a lineage-specific regulator of leukemia cell growth Autor Corbin E. Meacham, Lee N. Lawton, Yadira M. Soto-Feliciano, Justin R. Pritchard, Brian A. Joughin, Tobias Ehrenberger, Nina Fenouille, Johannes Zuber, Richard T. Williams, Richard A. Young, Michael T. Hemann

    Vydáno 2015
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  8. 8
    Biphasic JNK-Erk signaling separates the induction and maintenance of cell senescence after DNA damage induced by topoisomerase II inhibition

    Biphasic JNK-Erk signaling separates the induction and maintenance of cell senescence after DNA damage induced by topoisomerase II inhibition Autor Tatiana S. Netterfield, Gerard J. Ostheimer, Andrea R. Tentner, Brian A. Joughin, Alexandra M. Dakoyannis, Charvi D. Sharma, Peter K. Sorger, Kevin A. Janes, Douglas A. Lauffenburger, Michael B. Yaffe

    Vydáno 2023
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  9. 9
    Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs

    Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs Autor Bert van de Kooij, Pau Creixell, Anne van Vlimmeren, Brian A. Joughin, Chad J. Miller, Nasir Haider, Craig D. Simpson, Rune Linding, Vuk Stambolic, Benjamin E. Turk, Michael B. Yaffe

    Vydáno 2019
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  10. 10
    Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation

    Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation Autor Douglas K. Brubaker, João A. Paulo, Shikha Sheth, Emily J. Poulin, Olesja Popow, Brian A. Joughin, Samantha Dale Strasser, Alina Starchenko, Steven P. Gygi, Douglas A. Lauffenburger, Kevin M. Haigis

    Vydáno 2019
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  11. 11
    Robustness and applicability of transcription factor and pathway analysis tools on single-cell RNA-seq data

    Robustness and applicability of transcription factor and pathway analysis tools on single-cell RNA-seq data Autor Christian H. Holland, Jovan Tanevski, Javier Perales-Patón, Jan Gleixner, Manu P. Kumar, Elisabetta Mereu, Brian A. Joughin, Oliver Stegle, Douglas A. Lauffenburger, Holger Heyn, Bence Szalai, Julio Sáez-Rodríguez

    Vydáno 2020
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  12. 12
    Transite: A Computational Motif-Based Analysis Platform That Identifies RNA-Binding Proteins Modulating Changes in Gene Expression

    Transite: A Computational Motif-Based Analysis Platform That Identifies RNA-Binding Proteins Modulating Changes in Gene Expression Autor Konstantin Krismer, Molly A. Bird, Shohreh Varmeh, Erika D. Handly, Anna Gattinger, Thomas Bernwinkler, Daniel A. Anderson, Andreas Heinzel, Brian A. Joughin, Yi Wen Kong, Ian G. Cannell, Michael B. Yaffe

    Vydáno 2020
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  13. 13
    Proteomic Identification of 14-3-3ζ as a Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Substrate: Role in Dimer Formation and Ligand Binding

    Proteomic Identification of 14-3-3ζ as a Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Substrate: Role in Dimer Formation and Ligand Binding Autor David W. Powell, Madhavi J. Rane, Brian A. Joughin, Ralitsa Kalmukova, Jeong‐Ho Hong, Bruce Tidor, William L. Dean, William M. Pierce, Jon B. Klein, Michael B. Yaffe, Kenneth R. McLeish

    Vydáno 2003
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  14. 14
    Acidification of Tumor at Stromal Boundaries Drives Transcriptome Alterations Associated with Aggressive Phenotypes

    Acidification of Tumor at Stromal Boundaries Drives Transcriptome Alterations Associated with Aggressive Phenotypes Autor Nazanin Rohani, Liangliang Hao, Maria S. Alexis, Brian A. Joughin, Konstantin Krismer, Mira N. Moufarrej, Anthony R. Soltis, Douglas A. Lauffenburger, Michael B. Yaffe, Christopher B. Burge, Sangeeta N. Bhatia, Frank B. Gertler

    Vydáno 2019
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  15. 15
    Screening for CD19-specific chimaeric antigen receptors with enhanced signalling via a barcoded library of intracellular domains

    Screening for CD19-specific chimaeric antigen receptors with enhanced signalling via a barcoded library of intracellular domains Autor Khloe S. Gordon, Taeyoon Kyung, Caleb R. Perez, Patrick V. Holec, Azucena Ramos, Angela Q. Zhang, Yash Agarwal, Yunpeng Liu, Catherine Koch, Alina Starchenko, Brian A. Joughin, Douglas A. Lauffenburger, Darrell J. Irvine, Michael T. Hemann, Michael E. Birnbaum

    Vydáno 2022
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  16. 16
    The Fanconi anemia core complex promotes CtIP-dependent end resection to drive homologous recombination at DNA double-strand breaks

    The Fanconi anemia core complex promotes CtIP-dependent end resection to drive homologous recombination at DNA double-strand breaks Autor Bert van de Kooij, Fenna J. van der Wal, Magdalena B. Rother, Wouter W. Wiegant, Pau Creixell, Merula Stout, Brian A. Joughin, Julia Vornberger, Matthias Altmeyer, Marcel A.T.M. van Vugt, Michael B. Yaffe, Haico van Attikum

    Vydáno 2024
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  17. 17
    Spatial Exclusivity Combined with Positive and Negative Selection of Phosphorylation Motifs Is the Basis for Context-Dependent Mitotic Signaling

    Spatial Exclusivity Combined with Positive and Negative Selection of Phosphorylation Motifs Is the Basis for Context-Dependent Mitotic Signaling Autor Jes Alexander, Daniel Lim, Brian A. Joughin, Björn Hegemann, James R. A. Hutchins, Tobias Ehrenberger, Frank J. Ivins, Fabio Sessa, Otto Hudecz, Erich A. Nigg, Andrew M. Fry, Andrea Musacchio, P. Todd Stukenberg, Karl Mechtler, Jan‐Michael Peters, Stephen J. Smerdon, Michael B. Yaffe

    Vydáno 2011
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  18. 18
    Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma

    Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma Autor Elizabeth C. Randall, Kristina B. Emdal, Janice K. Laramy, Minjee Kim, Alison Roos, David Calligaris, Michael S. Regan, Shiv K. Gupta, Ann C. Mladek, Brett L. Carlson, Aaron J. Johnson, Fa-Ke Lu, Xiaoliang Sunney Xie, Brian A. Joughin, Raven J. Reddy, Sen Peng, Walid M. Abdelmoula, Pamela Jackson, Aarti Kolluri, Katherine A. Kellersberger, Jeffrey N. Agar, Douglas A. Lauffenburger, Kristin R. Swanson, Nhan L. Tran, William F. Elmquist, Forest M. White, Jann N. Sarkaria, Nathalie Y.R. Agar

    Vydáno 2018
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  19. 19
    Tissue-Specific Oncogenic Activity of KRASA146T

    Tissue-Specific Oncogenic Activity of KRASA146T Autor Emily J. Poulin, Asim K. Bera, Jia Lu, Yi-Jang Lin, Samantha Dale Strasser, João A. Paulo, Tannie Q. Huang, Carolina E. Morales, Wei Yan, Joshua Cook, Jonathan A. Nowak, Douglas K. Brubaker, Brian A. Joughin, Christian W. Johnson, Rebecca A. DeStefanis, Phaedra C. Ghazi, Sudershan Reddy Gondi, Thomas E. Wales, Roxana E. Iacob, Lana Bogdanova, Jessica J. Gierut, Yina Li, John R. Engen, Pedro A. Pérez–Mancera, Benjamin S. Braun, Steven P. Gygi, Douglas A. Lauffenburger, Kenneth D. Westover, Kevin M. Haigis

    Vydáno 2019
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  20. 20
    The intrinsic substrate specificity of the human tyrosine kinome

    The intrinsic substrate specificity of the human tyrosine kinome Autor Tomer M. Yaron, Brian A. Joughin, Emily M. Huntsman, Alexander Kerelsky, Daniel M. Cizin, Benjamin M. Cohen, Amit Regev, Junho Song, Neil Vasan, Ting-Yu Lin, Jose M. Orozco, Christina Schoenherr, Cari A. Sagum, Mark T. Bedford, Richard Wynn, Shih‐Chia Tso, David Chuang, Lei Li, Shawn S.‐C. Li, Pau Creixell, Konstantin Krismer, Mina Takegami, Harin Lee, Bin Zhang, Jingyi Lu, Ian Cossentino, Sean D. Landry, Mohamed Uduman, John Blenis, Olivier Elemento, Margaret C. Frame, Peter Hornbeck, Lewis C. Cantley, Benjamin E. Turk, Michael B. Yaffe, Jared L. Johnson

    Vydáno 2024
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