检索结果 - Birkus, Gabriel

No magnesium is needed for binding of the stimulator of interferon genes to cyclic dinucleotides 由 Smola, Miroslav, Birkus, Gabriel, Boura, Evzen

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Assessment of Mitochondrial Toxicity in Human Cells Treated with Tenofovir: Comparison with Other Nucleoside Reverse Transcriptase Inhibitors 由 Birkus, Gabriel, Hitchcock, Michael J. M., Cihlar, Tomas

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Tenofovir Diphosphate Is a Poor Substrate and a Weak Inhibitor of Rat DNA Polymerases α, δ, and ɛ* 由 Birkuš, Gabriel, Hájek, Miroslav, Kramata, Pavel, Votruba, Ivan, Holý, Antonín, Otová, Berta

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Multiple Classes of Antiviral Agents Exhibit In Vitro Activity against Human Rhinovirus Type C 由 Mello, Chris, Aguayo, Esmeralda, Rodriguez, Madeleine, Lee, Gary, Jordan, Robert, Cihlar, Tomas, Birkus, Gabriel

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Synthesis of phosphonate derivatives of 2′-deoxy-2′-fluorotetradialdose d-nucleosides and tetradialdose d-nucleosides 由 Lášek, Tomáš, Dobiáš, Juraj, Buděšínský, Miloš, Kozák, Jaroslav, Lapuníková, Barbora, Rosenberg, Ivan, Birkuš, Gabriel, Páv, Ondřej

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Role of Cathepsin A and Lysosomes in the Intracellular Activation of Novel Antipapillomavirus Agent GS-9191 由 Birkus, Gabriel, Kutty, Nilima, Frey, Christian R., Shribata, Riri, Chou, Tsuifen, Wagner, Carston, McDermott, Martin, Cihlar, Tomas

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Evaluation of the Effect of Cobicistat on the In Vitro Renal Transport and Cytotoxicity Potential of Tenofovir 由 Stray, Kirsten M., Bam, Rujuta A., Birkus, Gabriel, Hao, Jia, Lepist, Eve-Irene, Yant, Stephen R., Ray, Adrian S., Cihlar, Tomas

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Catalytically-active complex of HIV-1 integrase with a viral DNA substrate binds anti-integrase drugs 由 Alian, Akram, Griner, Sarah L., Chiang, Vicki, Tsiang, Manuel, Jones, Gregg, Birkus, Gabriel, Geleziunas, Romas, Leavitt, Andrew D., Stroud, Robert M.

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Cathepsin A Is the Major Hydrolase Catalyzing the Intracellular Hydrolysis of the Antiretroviral Nucleotide Phosphonoamidate Prodrugs GS-7340 and GS-9131 由 Birkus, Gabriel, Wang, Ruth, Liu, Xiaohong, Kutty, Nilima, MacArthur, Holly, Cihlar, Tomas, Gibbs, Craig, Swaminathan, Swami, Lee, William, McDermott, Martin

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Ligand Strain and Its Conformational Complexity Is a Major Factor in the Binding of Cyclic Dinucleotides to STING Protein 由 Smola, Miroslav, Gutten, Ondrej, Dejmek, Milan, Kožíšek, Milan, Evangelidis, Thomas, Tehrani, Zahra Aliakbar, Novotná, Barbora, Nencka, Radim, Birkuš, Gabriel, Rulíšek, Lubomír, Boura, Evzen

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Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat 由 Lepist, Eve-Irene, Zhang, Xuexiang, Hao, Jia, Huang, Jane, Kosaka, Alan, Birkus, Gabriel, Murray, Bernard P, Bannister, Roy, Cihlar, Tomas, Huang, Yong, Ray, Adrian S

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Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Polymerase activity and mechanisms of action of nucleotide analogs 由 Barauskas, Ona, Xing, Weimei, Aguayo, Esmeralda, Willkom, Madeleine, Sapre, Annapurna, Clarke, Michael, Birkus, Gabriel, Schultz, Brian E., Sakowicz, Roman, Kwon, HyockJoo, Feng, Joy Y.

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Purine analogs as phosphatidylinositol 4-kinase IIIβ inhibitors 由 Šála, Michal, Kögler, Martin, Plačková, Pavla, Mejdrová, Ivana, Hřebabecký, Hubert, Procházková, Eliška, Strunin, Dmytro, Lee, Gary, Birkus, Gabriel, Weber, Jan, Mertlíková-Kaiserová, Helena, Nencka, Radim

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GS-9191 Is a Novel Topical Prodrug of the Nucleotide Analog 9-(2-Phosphonylmethoxyethyl)Guanine with Antiproliferative Activity and Possible Utility in the Treatment of Human Papil... 由 Wolfgang, Grushenka H. I., Shibata, Riri, Wang, Jianying, Ray, Adrian S., Wu, Sylvia, Doerrfler, Edward, Reiser, Hans, Lee, William A., Birkus, Gabriel, Christensen, Neil D., Andrei, Graciela, Snoeck, Robert

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Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Endonuclease activity and evaluation of inhibitors 由 Xing, Weimei, Barauskas, Ona, Kirschberg, Thorsten, Niedziela-Majka, Anita, Clarke, Michael, Birkus, Gabriel, Weissburg, Perry, Liu, Xiaohong, Schultz, Brian E., Sakowicz, Roman, Kwon, HyockJoo, Feng, Joy Y.

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Metabolism and Pharmacokinetics of the Anti-Hepatitis C Virus Nucleotide Prodrug GS-6620 由 Murakami, Eisuke, Wang, Ting, Babusis, Darius, Lepist, Eve-Irene, Sauer, Dorothea, Park, Yeojin, Vela, Jennifer E., Shih, Robert, Birkus, Gabriel, Stefanidis, Dimitrios, Kim, Choung U., Cho, Aesop, Ray, Adrian S.

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Nucleotide Prodrug Containing a Nonproteinogenic Amino Acid To Improve Oral Delivery of a Hepatitis C Virus Treatment 由 Feng, Joy Y., Wang, Ting, Park, Yeojin, Babusis, Darius, Birkus, Gabriel, Xu, Yili, Voitenleitner, Christian, Fenaux, Martijn, Yang, Huiling, Eng, Stacey, Tirunagari, Neeraj, Kirschberg, Thorsten, Cho, Aesop, Ray, Adrian S.

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Inhibition of Hepatitis C Virus Replication by GS-6620, a Potent C-Nucleoside Monophosphate Prodrug 由 Feng, Joy Y., Cheng, Guofeng, Perry, Jason, Barauskas, Ona, Xu, Yili, Fenaux, Martijn, Eng, Stacey, Tirunagari, Neeraj, Peng, Betty, Yu, Mei, Tian, Yang, Lee, Yu-Jen, Stepan, George, Lagpacan, Leanna L., Jin, Debi, Hung, Magdeleine, Ku, Karin S., Han, Bin, Kitrinos, Kathryn, Perron, Michel, Birkus, Gabriel, Wong, Kelly A., Zhong, Weidong, Kim, Choung U., Carey, Anne, Cho, Aesop, Ray, Adrian S.

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