Search Results - Andrew Protheroe

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  1. 1
    The Type 1 Insulin-Like Growth Factor Receptor Pathway

    The Type 1 Insulin-Like Growth Factor Receptor Pathway by Meenali Chitnis, J.S.P. Yuen, Andrew Protheroe, Michaël Pollak, Valentine M. Macaulay

    Published 2008
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  2. 2
    IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination

    IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination by Meenali Chitnis, Kunal A. Lodhia, Tamara Aleksic, Shan Gao, Andrew Protheroe, Valentine M. Macaulay

    Published 2013
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  3. 3
    Incidentally detected testicular lesions <10 mm in diameter: can orchidectomy be avoided?

    Incidentally detected testicular lesions <10 mm in diameter: can orchidectomy be avoided? by Glenda Scandura, Clare Verrill, Andrew Protheroe, Johnson Joseph, Wendy Ansell, Anju Sahdev, Jonathan Shamash, Daniel M. Berney

    Published 2017
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  4. 4
    From Clinical Trials to Real-life Clinical Practice: The Role of Immunotherapy with PD-1/PD-L1 Inhibitors in Advanced Urothelial Carcinoma

    From Clinical Trials to Real-life Clinical Practice: The Role of Immunotherapy with PD-1/PD-L1 Inhibitors in Advanced Urothelial Carcinoma by Syed A. Hussain, Alison Birtle, Simon J. Crabb, Robert Huddart, Diane Small, Maxwell Summerhayes, Robert J. Jones, Andrew Protheroe

    Published 2018
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  5. 5
    Type 1 Insulin-like Growth Factor Receptor Translocates to the Nucleus of Human Tumor Cells

    Type 1 Insulin-like Growth Factor Receptor Translocates to the Nucleus of Human Tumor Cells by Tamara Aleksic, Meenali Chitnis, Olga V. Perestenko, Shan Gao, Peter H. Thomas, Gareth D. H. Turner, Andrew Protheroe, Mark Howarth, Valentine M. Macaulay

    Published 2010
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  6. 6
    Development of a best-practice clinical guideline for the use of bleomycin in the treatment of germ cell tumours in the UK

    Development of a best-practice clinical guideline for the use of bleomycin in the treatment of germ cell tumours in the UK by Robert Watson, Hugo De La Peña, Maria Tsakok, Johnson Joseph, Sara Stoneham, Jonathan Shamash, Johnathan Joffe, Danish Mazhar, Zoë Traill, Ling‐Pei Ho, Sue Brand, Andrew Protheroe

    Published 2018
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  7. 7
    A multi-centre randomised phase III trial of Dexamethasone vs Dexamethasone and diethylstilbestrol in castration-resistant prostate cancer: immediate vs deferred Diethylstilbestrol

    A multi-centre randomised phase III trial of Dexamethasone vs Dexamethasone and diethylstilbestrol in castration-resistant prostate cancer: immediate vs deferred Diethylstilbestrol by Jonathan Shamash, Thomas Powles, Shah Jalal Sarker, Andrew Protheroe, Natasha Mithal, Robert Mills, Ralph Beard, Peter Wilson, N. L. Tranter, Neale O’Brien, Siobhan McFaul, R.T.D. Oliver

    Published 2011
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  8. 8
    Phase I study of humanized monoclonal antibody AVE1642 directed against the type 1 insulin-like growth factor receptor (IGF-1R), administered in combination with anticancer therapies to patients with advanced solid tumors

    Phase I study of humanized monoclonal antibody AVE1642 directed against the type 1 insulin-like growth factor receptor (IGF-1R), administered in combination with anticancer therapi... by Valentine M. Macaulay, Mark R. Middleton, Andrew Protheroe, Anthony W. Tolcher, Véronique Dièras, Cristiana Sessa, Rastislav Bahleda, Jean‐Yves Blay, Patricia LoRusso, D. Méry-Mignard, Jean‐Charles Soria

    Published 2012
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  9. 9
    CD31 angiogenesis and combined expression of HIF-1α and HIF-2α are prognostic in primary clear-cell renal cell carcinoma (CC-RCC), but HIFα transcriptional products are not: implications for antiangiogenic trials and HIFα biomarker studies in primary CC-RCC

    CD31 angiogenesis and combined expression of HIF-1α and HIF-2α are prognostic in primary clear-cell renal cell carcinoma (CC-RCC), but HIFα transcriptional products are not: implic... by Swethajit Biswas, Philip J.S. Charlesworth, Gareth D. H. Turner, Russell Leek, Paul T. Thamboo, Leticia Campo, Helen Turley, Petra Dildey, Andrew Protheroe, David Cranston, Kevin C. Gatter, Francesco Pezzella, Adrian L. Harris

    Published 2012
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  10. 10
    Abiraterone acetate plus prednisone in patients with newly diagnosed high-risk metastatic castration-sensitive prostate cancer (LATITUDE): final overall survival analysis of a randomised, double-blind, phase 3 trial

    Abiraterone acetate plus prednisone in patients with newly diagnosed high-risk metastatic castration-sensitive prostate cancer (LATITUDE): final overall survival analysis of a rand... by Karim Fizazi, NamPhuong Tran, Luis Fein, Nobuaki Matsubara, A. Rodrı́guez-Antolı́n, B. Yа. Alekseev, Mustafa Özgüroğlu, Dingwei Ye, Susan Feyerabend, Andrew Protheroe, Giri Sulur, Yesenia Luna, Susan Li, Suneel Mundle, Kim N.

    Published 2019
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  11. 11
    Activity and safety of ODM-201 in patients with progressive metastatic castration-resistant prostate cancer (ARADES): an open-label phase 1 dose-escalation and randomised phase 2 dose expansion trial

    Activity and safety of ODM-201 in patients with progressive metastatic castration-resistant prostate cancer (ARADES): an open-label phase 1 dose-escalation and randomised phase 2 d... by Karim Fizazi, Christophe Massard, Petri Bono, Robert H. Jones, Vesa Kataja, Nicholas D. James, Jorge A. García, Andrew Protheroe, Teuvo L.J. Tammela, Tony Elliott, Leena Mattila, John Aspegrén, Annamari Vuorela, Peter Langmuir, Mika Mustonen

    Published 2014
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  12. 12
    A phase I trial of ispinesib, a kinesin spindle protein inhibitor, with docetaxel in patients with advanced solid tumours

    A phase I trial of ispinesib, a kinesin spindle protein inhibitor, with docetaxel in patients with advanced solid tumours by Sarah P. Blagden, L. Rhoda Molife, A Seebaran, Miranda Payne, Alison Reid, Andrew Protheroe, Lakshmi Vasist, Daphne Williams, Chester L. Bowen, Steven J. Kathman, Jeffrey P. Hodge, Mohammed M. Dar, Johann S. de Bono, Mark R. Middleton

    Published 2008
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  13. 13
    REO-10: A Phase I Study of Intravenous Reovirus and Docetaxel in Patients with Advanced Cancer

    REO-10: A Phase I Study of Intravenous Reovirus and Docetaxel in Patients with Advanced Cancer by Charles Comins, James Spicer, Andrew Protheroe, Victoria Roulstone, Katie Twigger, Christine White, Richard G. Vile, Alan Melcher, Matt Coffey, K.L. Mettinger, Gerard J. Nuovo, David E. Cohn, Mitch A. Phelps, Kevin J. Harrington, Hardev Pandha

    Published 2010
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  14. 14
    Abiraterone plus Prednisone in Metastatic, Castration-Sensitive Prostate Cancer

    Abiraterone plus Prednisone in Metastatic, Castration-Sensitive Prostate Cancer by Karim Fizazi, NamPhuong Tran, Luis Fein, Nobuaki Matsubara, A. Rodrı́guez-Antolı́n, B. Yа. Alekseev, Mustafa Özgüroğlu, Dingwei Ye, Susan Feyerabend, Andrew Protheroe, Peter De Porre, Thian Kheoh, Youn C. Park, Mary B. Todd, Kim N.

    Published 2017
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  15. 15
    Immune checkpoint inhibitor-related colitis assessment and prognosis: can IBD scoring point the way?

    Immune checkpoint inhibitor-related colitis assessment and prognosis: can IBD scoring point the way? by Vincent Cheung, Tarun Gupta, Anna Olsson‐Brown, Sreedhar Subramanian, Sarah C. Sasson, Jonathan Heseltine, Eve Fryer, Elena Collantes, Joseph J. Sacco, Munir Pirmohamed, Alison Simmons, Paul Klenerman, Mark Tuthill, Andrew Protheroe, Meenali Chitnis, Benjamin P. Fairfax, Miranda Payne, Mark R. Middleton, Oliver Brain

    Published 2020
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  16. 16
    Celecoxib plus hormone therapy versus hormone therapy alone for hormone-sensitive prostate cancer: first results from the STAMPEDE multiarm, multistage, randomised controlled trial

    Celecoxib plus hormone therapy versus hormone therapy alone for hormone-sensitive prostate cancer: first results from the STAMPEDE multiarm, multistage, randomised controlled trial by Nicholas D. James, Matthew R. Sydes, Malcolm D. Mason, Noel W. Clarke, John Anderson, David P. Dearnaley, John Dwyer, Gordana Jovic, A.W.S. Ritchie, John M. Russell, Karen Sanders, George N. Thalmann, Gianfilippo Bertelli, Alison Birtle, Joe M. O’Sullivan, Andrew Protheroe, Denise Sheehan, Narayanan Srihari, Mahesh Parmar

    Published 2012
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  17. 17
    Everolimus versus sunitinib for patients with metastatic non-clear cell renal cell carcinoma (ASPEN): a multicentre, open-label, randomised phase 2 trial

    Everolimus versus sunitinib for patients with metastatic non-clear cell renal cell carcinoma (ASPEN): a multicentre, open-label, randomised phase 2 trial by Andrew J. Armstrong, Susan Halabi, Tim Eisen, Samuel Broderick, Walter M. Stadler, Robert J. Jones, Jorge A. García, Ulka N. Vaishampayan, Joel Picus, Robert E. Hawkins, John D. Hainsworth, Christian Kollmannsberger, Theodore F. Logan, Igor Puzanov, Lisa Pickering, Christopher W. Ryan, Andrew Protheroe, Christine M. Lusk, Sadie Oberg, Daniel J. George

    Published 2016
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  18. 18
    Safety and Efficacy of Pazopanib Therapy Prior to Planned Nephrectomy in Metastatic Clear Cell Renal Cancer

    Safety and Efficacy of Pazopanib Therapy Prior to Planned Nephrectomy in Metastatic Clear Cell Renal Cancer by Thomas Powles, Naveed Sarwar, Andrew Stockdale, Shah‐Jalal Sarker, Ekaterini Boleti, Andrew Protheroe, Robert J. Jones, Simon Chowdhury, John Peters, Grenville Oades, Tim O’Brien, Mark Sullivan, Michael Aitchison, Luis Beltrán, Daniel C. Worth, Katherine Smith, Constance Michel, Giorgia Trevisan, Elizabeth Harvey-Jones, Akhila Wimalasingham, Anju Sahdev, Charlotte Ackerman, Simon J. Crabb

    Published 2016
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  19. 19
    Clinical efficacy and biomarker analysis of neoadjuvant atezolizumab in operable urothelial carcinoma in the ABACUS trial

    Clinical efficacy and biomarker analysis of neoadjuvant atezolizumab in operable urothelial carcinoma in the ABACUS trial by Thomas Powles, Mark Kockx, Alejo Rodríguez‐Vida, Ignacio Durán, Simon J. Crabb, Michiel S. van der Heijden, Bernadett Szabados, Albert Font Pous, Gwénaëlle Gravis, Urbano Anido, Andrew Protheroe, Alain Ravaud, Denis Maillet, María José Méndez, Cristina Suárez, Mark Linch, Aaron Prendergast, Pieter‐Jan van Dam, Diana Stanoeva, Sofie Daelemans, Sanjeev Mariathasan, Joy S. Tea, Kelly Mousa, Romain Banchereau, Daniel Castellano

    Published 2019
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  20. 20
    Safety and immunogenicity of novel 5T4 viral vectored vaccination regimens in early stage prostate cancer: a phase I clinical trial

    Safety and immunogenicity of novel 5T4 viral vectored vaccination regimens in early stage prostate cancer: a phase I clinical trial by Federica Cappuccini, Richard J. Bryant, Emily Pollock, L. M. Carter, Clare Verrill, Julianne Hollidge, Ian Poulton, Megan Baker, Celia Mitton, Andrea Baines, Armin Meier, Guenter Schmidt, Richard Harrop, Andrew Protheroe, Ruth E. Macpherson, Steven Kennish, Susan Morgan, Selena Viganó, Pedro Romero, Thomas G. Evans, James W.F. Catto, Freddie C. Hamdy, Adrian V. S. Hill, Irina Redchenko

    Published 2020
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