Resultados de procura - Andrew D. Rowan

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  1. 1
    Rat procathepsin B. Proteolytic processing to the mature form in vitro.

    Rat procathepsin B. Proteolytic processing to the mature form in vitro. por Andrew D. Rowan, Patrizia Mason, Lukas Mach, John S. Mort

    Publicado 1992
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  2. 2
    Adenoviral Gene Transfer of Interleukin-1 in Combination with Oncostatin M Induces Significant Joint Damage in a Murine Model

    Adenoviral Gene Transfer of Interleukin-1 in Combination with Oncostatin M Induces Significant Joint Damage in a Murine Model por Andrew D. Rowan, Hui Wang, Tim E. Cawston, Carl D. Richards

    Publicado 2003
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  3. 3
    The Mammalian Chitinase-like Lectin, YKL-40, Binds Specifically to Type I Collagen and Modulates the Rate of Type I Collagen Fibril Formation

    The Mammalian Chitinase-like Lectin, YKL-40, Binds Specifically to Type I Collagen and Modulates the Rate of Type I Collagen Fibril Formation por Heather F. Bigg, Robin Wait, Andrew D. Rowan, Tim E. Cawston

    Publicado 2006
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  4. 4
    Serine proteinases in the turnover of the cartilage extracellular matrix in the joint: implications for therapeutics

    Serine proteinases in the turnover of the cartilage extracellular matrix in the joint: implications for therapeutics por D. Wilkinson, María del Carmen Arques, Carmen Huesa, Andrew D. Rowan

    Publicado 2018
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  5. 5
    Activity of matrix metalloproteinase‐9 against native collagen types I and III

    Activity of matrix metalloproteinase‐9 against native collagen types I and III por Heather F. Bigg, Andrew D. Rowan, Michael D. Barker, Tim E. Cawston

    Publicado 2007
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  6. 6
    Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis

    Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis por Jennifer M Milner, Andrew D. Rowan, Tim E. Cawston, David A. Young

    Publicado 2006
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  7. 7
    Activation of procathepsin B in human hepatoma cells: the conversion into the mature enzyme relies on the action of cathepsin B itself

    Activation of procathepsin B in human hepatoma cells: the conversion into the mature enzyme relies on the action of cathepsin B itself por Lukas Mach, Herwig Schwihla, K Stüwe, Andrew D. Rowan, John S. Mort, Josef Glössl

    Publicado 1993
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  8. 8
    Differential changes in the association and dissociation rate constants for binding of cystatins to target proteinases occurring on N-terminal truncation of the inhibitors indicate that the interaction mechanism varies with different enzymes

    Differential changes in the association and dissociation rate constants for binding of cystatins to target proteinases occurring on N-terminal truncation of the inhibitors indicate... por Ingemar Björk, Ewa Pol, Elke Raub‐Segall, Magnus Abrahamson, Andrew D. Rowan, John S. Mort

    Publicado 1994
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  9. 9
    Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage

    Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage por Hui Wang, David A. Young, Andrew D. Rowan, Xin Xu, Tim E. Cawston, Carole J. Proctor

    Publicado 2014
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  10. 10
    Macrophage Migration and Invasion Is Regulated by MMP10 Expression

    Macrophage Migration and Invasion Is Regulated by MMP10 Expression por Megan Y. Murray, Timothy P. Birkland, Jonathan D. Howe, Andrew D. Rowan, Mark Fidock, William C. Parks, Jelena Gavrilović

    Publicado 2013
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  11. 11
    Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases

    Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases por Hui Wang, Gary J. Litherland, Martina S. Elias, Gareth I Kitson, Tim E. Cawston, Andrew D. Rowan, David A. Young

    Publicado 2011
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  12. 12
    Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA

    Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA por Yaobo Xu, Matt J. Barter, Daniel Swan, Kenneth S. Rankin, Andrew D. Rowan, Mauro Santibanez‐Koref, John Loughlin, David A. Young

    Publicado 2012
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  13. 13
    Synergistic Collagenase Expression and Cartilage Collagenolysis Are Phosphatidylinositol 3-Kinase/Akt Signaling-dependent

    Synergistic Collagenase Expression and Cartilage Collagenolysis Are Phosphatidylinositol 3-Kinase/Akt Signaling-dependent por Gary J. Litherland, Craig Dixon, Rachel Lakey, Timothy Robson, Debra Jones, David A. Young, Tim E. Cawston, Andrew D. Rowan

    Publicado 2008
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  14. 14
    The Comparative Role of Activator Protein 1 and Smad Factors in the Regulation of Timp-1 and MMP-1 Gene Expression by Transforming Growth Factor-β1

    The Comparative Role of Activator Protein 1 and Smad Factors in the Regulation of Timp-1 and MMP-1 Gene Expression by Transforming Growth Factor-β1 por Marie-Claire Hall, David A. Young, Jasmine G. Waters, Andrew D. Rowan, Andrew Chantry, Dylan R. Edwards, Ian M. Clark

    Publicado 2003
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  15. 15
    Transcriptional activity of the human tissue inhibitor of metalloproteinases 1 (TIMP-1) gene in fibroblasts involves elements in the promoter, exon 1 and intron 1

    Transcriptional activity of the human tissue inhibitor of metalloproteinases 1 (TIMP-1) gene in fibroblasts involves elements in the promoter, exon 1 and intron 1 por Ian M. Clark, Andrew D. Rowan, Dylan R. Edwards, Torben Bech-Hansen, Derek A. Mann, Mathias Bähr, Timothy E. Cawston

    Publicado 1997
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  16. 16
    Cytokine-induced MMP13 Expression in Human Chondrocytes Is Dependent on Activating Transcription Factor 3 (ATF3) Regulation

    Cytokine-induced MMP13 Expression in Human Chondrocytes Is Dependent on Activating Transcription Factor 3 (ATF3) Regulation por Chun Ming Chan, Christopher D. Macdonald, Gary J. Litherland, D. Wilkinson, Andrew Skelton, G. Nicholas Europe‐Finner, Andrew D. Rowan

    Publicado 2016
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  17. 17
    Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway

    Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway por Hui Wang, Gary J. Litherland, Matthew Jefferson, Matt J. Barter, Martina S. Elias, Tim E. Cawston, Andrew D. Rowan, David A. Young

    Publicado 2010
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  18. 18
    HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes

    HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes por Matt J. Barter, Leon P. Pybus, Gary J. Litherland, Andrew D. Rowan, Ian M. Clark, Dylan R. Edwards, Tim E. Cawston, David A. Young

    Publicado 2010
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  19. 19
    Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis.

    Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis. por Jennifer M Milner, Lara Kevorkian, David A. Young, Debra Jones, Robin Wait, Simon Donell, Emma Barksby, Angela Patterson, Jim Middleton, Benjamin F. Cravatt, Ian M. Clark, Andrew D. Rowan, Timothy E. Cawston

    Publicado 2006
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  20. 20
    Matrix metalloproteinase‐13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha‐1 antitrypsin: Implications for osteoarthritis

    Matrix metalloproteinase‐13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha‐1 antitrypsin: Implications for osteoarthritis por D. Wilkinson, Adrian M. D. Falconer, Helen L. Wright, Hua Lin, Kazuhiro Yamamoto, Kathleen Cheung, Sarah Charlton, María del Carmen Arques, Sabina Janciauskiene, Ramsay Refaie, Kenneth S. Rankin, David A. Young, Andrew D. Rowan

    Publicado 2021
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