Хайлтын үр дүнгүүд - Andrea Testa

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  1. 1
    Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds

    Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and T... -н Kwok-Ho Chan, Michael Zengerle, Andrea Testa, Alessio Ciulli

    Хэвлэсэн 2017
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    Artigo
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  2. 2
    The rise and rise of protein degradation: Opportunities and challenges ahead

    The rise and rise of protein degradation: Opportunities and challenges ahead -н Scott J. Hughes, Andrea Testa, Nicola Thompson, Ian Churcher

    Хэвлэсэн 2021
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    Revisão
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  3. 3
    Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs

    Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs -н Miriam Girardini, Chiara Maniaci, Scott J. Hughes, Andrea Testa, Alessio Ciulli

    Хэвлэсэн 2019
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    Artigo
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  4. 4
    Structure‐Based Design of a Macrocyclic PROTAC

    Structure‐Based Design of a Macrocyclic PROTAC -н Andrea Testa, Scott J. Hughes, Xavier Lucas, Jane E. Wright, Alessio Ciulli

    Хэвлэсэн 2019
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    Artigo
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  5. 5
    Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader

    Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader -н Hannah Tovell, Andrea Testa, Houjiang Zhou, Natalia Shpiro, Claire Crafter, Alessio Ciulli, Dario R. Alessi

    Хэвлэсэн 2019
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    Artigo
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  6. 6
    Relation among Perceived Weight Change, Sedentary Activities and Sleep Quality during COVID-19 Lockdown: A Study in an Academic Community in Northern Italy

    Relation among Perceived Weight Change, Sedentary Activities and Sleep Quality during COVID-19 Lockdown: A Study in an Academic Community in Northern Italy -н Margherita Micheletti Cremasco, Anna Mulasso, Alessia Moroni, Andrea Testa, Raffaella Degan, Alberto Rainoldi, Emanuela Rabaglietti

    Хэвлэсэн 2021
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    Artigo
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  7. 7
    Phase-separated droplets swim to their dissolution

    Phase-separated droplets swim to their dissolution -н Etienne Jambon-Puillet, Andrea Testa, Charlotta Lorenz, Robert W. Style, Aleksander A. Rebane, Eric R. Dufresne

    Хэвлэсэн 2024
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    Artigo
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  8. 8
    Structural basis of PROTAC cooperative recognition for selective protein degradation

    Structural basis of PROTAC cooperative recognition for selective protein degradation -н Morgan S. Gadd, Andrea Testa, Xavier Lucas, Kwok-Ho Chan, Wenzhang Chen, Douglas J. Lamont, Michael Zengerle, Alessio Ciulli

    Хэвлэсэн 2017
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    Artigo
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  9. 9
    Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader

    Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader -н Hannah Tovell, Andrea Testa, Chiara Maniaci, Houjiang Zhou, Alan R. Prescott, Thomas Macartney, Alessio Ciulli, Dario R. Alessi

    Хэвлэсэн 2019
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    Artigo
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  10. 10
    Sustained enzymatic activity and flow in crowded protein droplets

    Sustained enzymatic activity and flow in crowded protein droplets -н Andrea Testa, Mirco Dindo, Aleksander A. Rebane, Babak Nasouri, Robert W. Style, Ramin Golestanian, Eric R. Dufresne, Paola Laurino

    Хэвлэсэн 2021
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    Artigo
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  11. 11
    Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

    Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation -н Chiara Maniaci, Scott J. Hughes, Andrea Testa, Wenzhang Chen, Douglas J. Lamont, Sónia Rocha, Dario R. Alessi, Roberto Romeo, Alessio Ciulli

    Хэвлэсэн 2017
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    Artigo
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  12. 12
    Understanding and Improving the Membrane Permeability of VH032-Based PROTACs

    Understanding and Improving the Membrane Permeability of VH032-Based PROTACs -н Victoria G. Klein, Chad E. Townsend, Andrea Testa, Michael Zengerle, Chiara Maniaci, Scott J. Hughes, Kwok-Ho Chan, Alessio Ciulli, R. Scott Lokey

    Хэвлэсэн 2020
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    Artigo
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  13. 13
    Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2

    Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2 -н Sarath Ramachandran, Nikolai Makukhin, Kevin Haubrich, Manjula Nagala, Beth Forrester, Dylan M. Lynch, Ryan Casement, Andrea Testa, Elvira Bruno, Rosaria Gitto, Alessio Ciulli

    Хэвлэсэн 2023
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    Artigo
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  14. 14
    Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System

    Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System -н Luke M. Simpson, Thomas Macartney, Alice Nardin, Luke J. Fulcher, Sascha Röth, Andrea Testa, Chiara Maniaci, Alessio Ciulli, Ian G. Ganley, Gopal P. Sapkota

    Хэвлэсэн 2020
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    Artigo
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  15. 15
    Development of BromoTag: A “Bump-and-Hole”–PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins

    Development of BromoTag: A “Bump-and-Hole”–PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins -н Adam G. Bond, Conner Craigon, Kwok-Ho Chan, Andrea Testa, Athanasios Karapetsas, Rotimi Fasimoye, Thomas Macartney, J. Julian Blow, Dario R. Alessi, Alessio Ciulli

    Хэвлэсэн 2021
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    Artigo
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  16. 16
    Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7

    Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual... -н Vittoria Zoppi, Scott J. Hughes, Chiara Maniaci, Andrea Testa, Teresa Gmaschitz, Corinna Wieshofer, Manfred Koegl, Kristin M. Riching, Danette L. Daniels, Andrea Spallarossa, Alessio Ciulli

    Хэвлэсэн 2018
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    Artigo
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  17. 17
    Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders

    Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders -н Alexander Hanzl, Ryan Casement, Hana Imrichová, Scott J. Hughes, Eleonora Barone, Andrea Testa, Sophie Bauer, Jane E. Wright, Matthias Brand, Alessio Ciulli, Georg E. Winter

    Хэвлэсэн 2022
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    Artigo
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  18. 18
    3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation

    3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation -н Andrea Testa, Xavier Lucas, Guilherme V. Castro, Kwok-Ho Chan, Jane E. Wright, Andrew C. Runcie, Morgan S. Gadd, William T. A. Harrison, Eun Jung Ko, Daniel A. Fletcher, Alessio Ciulli

    Хэвлэсэн 2018
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    Artigo
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  19. 19
    Optimization of a “bump-and-hole” approach to allele-selective BET bromodomain inhibition

    Optimization of a “bump-and-hole” approach to allele-selective BET bromodomain inhibition -н Andrew C. Runcie, Michael Zengerle, Kwok-Ho Chan, Andrea Testa, L. van Beurden, Matthias G. J. Baud, Ola Epemolu, Lucy C.J. Ellis, Kevin D. Read, V. Coulthard, Ailbhe O Brien, Alessio Ciulli

    Хэвлэсэн 2018
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    Artigo
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  20. 20
    Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

    Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity -н Satomi Imaide, Kristin M. Riching, Nikolai Makukhin, Vesna Vetma, Claire Whitworth, Scott J. Hughes, Nicole Trainor, Sarah D. Mahan, Nancy E. Murphy, Angus D. Cowan, Kwok-Ho Chan, Conner Craigon, Andrea Testa, Chiara Maniaci, Marjeta Urh, Danette L. Daniels, Alessio Ciulli

    Хэвлэсэн 2021
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    Artigo
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