Výsledky vyhledávání - Anant A. Agrawal

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  1. 1
    U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs

    U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs Autor Jermaine L. Jenkins, Anant A. Agrawal, Ankit Gupta, Michael R. Green, Clara L. Kielkopf

    Vydáno 2013
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  2. 2
    An extended U2AF65–RNA-binding domain recognizes the 3′ splice site signal

    An extended U2AF65–RNA-binding domain recognizes the 3′ splice site signal Autor Anant A. Agrawal, Enea Salsi, Rakesh Chatrikhi, Steven T. Henderson, Jermaine L. Jenkins, Michael R. Green, Dmitri N. Ermolenko, Clara L. Kielkopf

    Vydáno 2016
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  3. 3
    Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds

    Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds Autor Constantin Cretu, Anant A. Agrawal, Andrew S. Cook, Cindy L. Will, Peter Fekkes, Peter G. Smith, Reinhard Lührmann, Nicholas Larsen, Silvia Buonamici, Vladimir Peña

    Vydáno 2018
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  4. 4
    Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors

    Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors Autor Constantin Cretu, Patricia Gee, Xiang Liu, Anant A. Agrawal, Tuong-Vi Nguyen, Arun K. Ghosh, Andrew S. Cook, Melissa S. Jurica, Nicholas Larsen, Vladimir Peña

    Vydáno 2021
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  5. 5
    The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action

    The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action Autor Lorenzo I. Finci, Xiaofeng Zhang, Xiuliang Huang, Qiang Zhou, Jennifer Tsai, Teng Teng, Anant A. Agrawal, Betty Chan, Sean Irwin, Craig Karr, Andrew S. Cook, Ping Zhu, Dominic J. Reynolds, Peter G. Smith, Peter Fekkes, Silvia Buonamici, Nicholas Larsen

    Vydáno 2018
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  6. 6
    Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts

    Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts Autor Annalisa Mupo, Magdalene J. Seiler, Vijitha Sathiaseelan, Alena Pance, Yi‐Tsung Yang, Anant A. Agrawal, Francesco Iorio, Ruben Bautista, Suruchi Pacharne, Konstantinos Tzelepis, Nicla Manes, Penny Wright, Elli Papaemmanuil, David G. Kent, Peter Campbell, Silvia Buonamici, Niccolò Bolli, George S. Vassiliou

    Vydáno 2016
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  7. 7
    H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers

    H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers Autor Michael Seiler, Akihide Yoshimi, Rachel Darman, Betty Chan, Gregg F. Keaney, Michaël Thomas, Anant A. Agrawal, Benjamin Caleb, Alfredo Csibi, E. Egan Sean, Peter Fekkes, Craig Karr, Virginia M. Klimek, George Lai, Linda Lee, Pavan Kumar, Stanley Chun-Wei Lee, Xiang Liu, Crystal MacKenzie, Carol Meeske, Yoshiharu Mizui, Eric Padron, Eunice Park, Ermira Pazolli, Shouyong Peng, Sudeep Prajapati, Justin Taylor, Teng Teng, John Wang, Markus Warmuth, Huilan Yao, Lihua Yu, Ping Zhu, Omar Abdel‐Wahab, Peter G. Smith, Silvia Buonamici

    Vydáno 2018
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  8. 8
    Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3′ Splice Site Selection through Use of a Different Branch Point

    Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3′ Splice Site Selection through Use of a Different Branch Point Autor Rachel Darman, Michael Seiler, Anant A. Agrawal, Kian‐Huat Lim, Shouyong Peng, Daniel Aird, Suzanna Bailey, Erica B. Bhavsar, Betty Chan, Simona Colla, Laura Corson, Jacob Feala, Peter Fekkes, Kana Ichikawa, Gregg F. Keaney, Linda Lee, Pavan Kumar, Kaiko Kunii, Crystal MacKenzie, Mark Matijevic, Yoshiharu Mizui, Khin Than Myint, Eun Sun Park, Xiaoling Puyang, Anand Selvaraj, Michael P. Thomas, Jennifer Tsai, John Y. Wang, Markus Warmuth, Hui Yang, Ping Zhu, Guillermo Garcia‐Manero, Richard R. Furman, Lihua Yu, Peter G. Smith, Silvia Buonamici

    Vydáno 2015
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  9. 9
    Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types

    Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types Autor Michael Seiler, Shouyong Peng, Anant A. Agrawal, James Palacino, Teng Teng, Ping Zhu, Peter G. Smith, Silvia Buonamici, Lihua Yu, Rory Johnson, John A. Demchok, Ina Felau, Melpomeni Kasapi, Martin L. Ferguson, Carolyn M. Hutter, Heidi J. Sofia, Roy Tarnuzzer, Linghua Wang, Liming Yang, Jean C. Zenklusen, Jiashan Zhang, Sudha Chudamani, Jia Liu, Laxmi Lolla, Rashi Naresh, Todd Pihl, Qiang Sun, Yunhu Wan, Ye Wu, Juok Cho, Timothy Defreitas, Scott Frazer, Nils Gehlenborg, Gad Getz, David I. Heiman, Jaegil Kim, Michael S. Lawrence, Pei Lin, Thomas J. Giordano, Michael S. Noble, Gordon Saksena, Doug Voet, Hailei Zhang, Brady Bernard, Nyasha Chambwe, Varsha Dhankani, Theo Knijnenburg, Roger Kramer, Kalle Leinonen, Yuexin Liu, Michael Miller, Sheila M. Reynolds, Ilya Shmulevich, Vésteinn Thórsson, Wei Zhang, Rehan Akbani, Bradley M. Broom, Apurva M. Hegde, Zhenlin Ju, Rupa S. Kanchi, Anil Korkut, Jun Li, Han Liang, Shiyun Ling, Wenbin Liu, Yiling Lu, Gordon B. Mills, Kwok-Shing Ng, Arvind Rao, Michaël Ryan, Jing Wang, John N. Weinstein, Jiexin Zhang, Adam Abeshouse, Joshua Armenia, Debyani Chakravarty, Walid K. Chatila, Ino de Bruijn, Galen F. Gao, Benjamin Groß, Zachary Heins, Ritika Kundra, Konnor La, Marc Ladanyi, Augustin Luna, Moriah G. Nissan, Angelica Ochoa, Sarah Phillips, Ed Reznik, Francisco Sánchez-Vega, Chris Sander, Nikolaus Schultz, Robert P. Sheridan, S. Onur Sumer, Yichao Sun, Barry S. Taylor, Jioajiao Wang, Hongxin Zhang, Pavana Anur, Myron Peto

    Vydáno 2018
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