Search Results - Amy Saur

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  1. 1
    KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells

    KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells by Julia Etchin, Alla Berezovskaya, Amy Saur Conway, Ilene Galinsky, Richard M. Stone, Erkan Baloglu, William Senapedis, Yosef Landesman, Michael Kauffman, Sharon Shacham, Jean Wang, A. Thomas Look

    Published 2016
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  2. 2
    Targeting EZH2 for the treatment of hepatosplenic T-cell lymphoma

    Targeting EZH2 for the treatment of hepatosplenic T-cell lymphoma by Pikman, Yana, Conway, Amy Saur, Robichaud, Amanda L., Kitara, Samuel, Church, Alanna J., Kennedy, Alyssa L., Silverman, Lewis B., Billett, Amy L., Weinstock, David M., Harris, Marian H., Stegmaier, Kimberly

    Published 2020
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  3. 3
    Synergistic Drug Combinations with a CDK4/6 Inhibitor in T-cell Acute Lymphoblastic Leukemia

    Synergistic Drug Combinations with a CDK4/6 Inhibitor in T-cell Acute Lymphoblastic Leukemia by Pikman, Yana, Alexe, Gabriela, Roti, Giovanni, Conway, Amy Saur, Furman, Andrew, Lee, Emily S., Place, Andrew E., Kim, Sunkyu, Saran, Chitra, Modiste, Rebecca, Weinstock, David M., Harris, Marian, Kung, Andrew L., Silverman, Lewis B., Stegmaier, Kimberly

    Published 2016
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  4. 4
    Synergistic Drug Combinations with a CDK4/6 Inhibitor in T-cell Acute Lymphoblastic Leukemia

    Synergistic Drug Combinations with a CDK4/6 Inhibitor in T-cell Acute Lymphoblastic Leukemia by Yana Pikman, Gabriela Alexe, Giovanni Roti, Amy Saur Conway, Andrew Furman, Emily S. Lee, Andrew E. Place, Sunkyu Kim, Chitra Saran, Rebecca Modiste, David M. Weinstock, Marian H. Harris, Andrew L. Kung, Lewis B. Silverman, Kimberly Stegmaier

    Published 2016
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  5. 5
    Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules

    Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules by Behnam Nabet, Fleur M. Ferguson, Bo Kyung A. Seong, Miljan Kuljanin, Alan L. Leggett, Mikaela L. Mohardt, Amanda L. Robichaud, Amy Saur Conway, Dennis L. Buckley, Joseph D. Mancias, James E. Bradner, Kimberly Stegmaier, Nathanael S. Gray

    Published 2020
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  6. 6
    Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in <i>TP53</i> wild-type Ewing sarcoma

    Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in <i>TP53</i> wild-type Ewing sarcoma by Björn Stolte, Amanda Balboni Iniguez, Neekesh V. Dharia, Amanda L. Robichaud, Amy Saur Conway, Ann M. Morgan, Gabriela Alexe, Nathan J. Schauer, Xiaoxi Liu, Gregory H. Bird, Aviad Tsherniak, Francisca Vázquez, Sara J. Buhrlage, Loren D. Walensky, Kimberly Stegmaier

    Published 2018
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  7. 7
    Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma

    Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma by Stolte, Björn, Iniguez, Amanda Balboni, Dharia, Neekesh V., Robichaud, Amanda L., Conway, Amy Saur, Morgan, Ann M., Alexe, Gabriela, Schauer, Nathan J., Liu, Xiaoxi, Bird, Gregory H., Tsherniak, Aviad, Vazquez, Francisca, Buhrlage, Sara J., Walensky, Loren D., Stegmaier, Kimberly

    Published 2018
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  8. 8
    Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy

    Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy by Yana Pikman, Nicole Ocasio-Martinez, Gabriela Alexe, Boris Dimitrov, Samuel Kitara, Frances F. Diehl, Amanda L. Robichaud, Amy Saur Conway, Linda S. Ross, Angela Su, Frank Ling, Jun Qi, Giovanni Roti, Caroline A. Lewis, Alexandre Puissant, Matthew G. Vander Heiden, Kimberly Stegmaier

    Published 2021
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  9. 9
    EWS/FLI confers tumor cell synthetic lethality to CDK12 inhibition in Ewing sarcoma

    EWS/FLI confers tumor cell synthetic lethality to CDK12 inhibition in Ewing sarcoma by Iniguez, Amanda Balboni, Stolte, Björn, Wang, Emily Jue, Conway, Amy Saur, Alexe, Gabriela, Dharia, Neekesh V., Kwiatkowski, Nicholas, Zhang, Tinghu, Abraham, Brian J., Mora, Jaume, Kalev, Peter, Leggett, Alan, Chowdhury, Dipanjan, Benes, Cyril H., Young, Richard A., Gray, Nathanael S., Stegmaier, Kimberly

    Published 2018
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  10. 10
    Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy

    Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy by Pikman, Yana, Ocasio-Martinez, Nicole, Alexe, Gabriela, Dimitrov, Boris, Kitara, Samuel, Diehl, Frances F., Robichaud, Amanda L., Conway, Amy Saur, Ross, Linda, Su, Angela, Ling, Frank, Qi, Jun, Roti, Giovanni, Lewis, Caroline A., Puissant, Alexandre, Vander Heiden, Matthew G., Stegmaier, Kimberly

    Published 2021
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  11. 11
    HSP90 inhibition overcomes ibrutinib resistance in mantle cell lymphoma

    HSP90 inhibition overcomes ibrutinib resistance in mantle cell lymphoma by Caron A. Jacobson, Nadja Kopp, Jacob V. Layer, Robert Redd, Sebastian Tschuri, Sarah Haebe, Diederik van Bodegom, Liat Bird, Amanda L. Christie, Alexandra Christodoulou, Amy Saur, Trevor Tivey, Stefanie Zapf, Deepak Bararia, Ursula Zimber‐Strobl, Scott J. Rodig, Oliver Weigert, David M. Weinstock

    Published 2016
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  12. 12
    EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma

    EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma by Amanda Balboni Iniguez, Björn Stolte, Emily Jue Wang, Amy Saur Conway, Gabriela Alexe, Neekesh V. Dharia, Nicholas Kwiatkowski, Tinghu Zhang, Brian J. Abraham, Jaume Mora, Peter Kalev, Alan L. Leggett, Dipanjan Chowdhury, Cyril H. Benes, Richard A. Young, Nathanael S. Gray, Kimberly Stegmaier

    Published 2018
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  13. 13
    The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia

    The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia by Nina Fenouille, Christopher F. Bassil, Issam Ben‐Sahra, Lina Benajiba, Gabriela Alexe, Azucena Ramos, Yana Pikman, Amy Saur Conway, Michael R. Burgess, Qing Li, Frédéric Luciano, Patrick Auberger, Ilene Galinsky, Daniel J. DeAngelo, Richard M. Stone, Yi Zhang, Archibald S. Perkins, Kevin Shannon, Michael T. Hemann, Alexandre Puissant, Kimberly Stegmaier

    Published 2017
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  14. 14
    Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts

    Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts by Jana M. Ellegast, Gabriela Alexe, Amanda Hamze, Shan Lin, Hannah J. Uckelmann, Philipp J. Rauch, Maxim Pimkin, Linda S. Ross, Neekesh V. Dharia, Amanda L. Robichaud, Amy Saur Conway, Delan Khalid, Jennifer A. Perry, Mark Wunderlich, Lina Benajiba, Yana Pikman, Behnam Nabet, Nathanael S. Gray, Stuart H. Orkin, Kimberly Stegmaier

    Published 2022
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  15. 15
    Unleashing cell-intrinsic inflammation as a strategy to kill AML blasts

    Unleashing cell-intrinsic inflammation as a strategy to kill AML blasts by Ellegast, Jana M, Alexe, Gabriela, Hamze, Amanda, Lin, Shan, Uckelmann, Hannah J, Rauch, Philipp J, Pimkin, Maxim, Ross, Linda S, Dharia, Neekesh V, Robichaud, Amanda L, Conway, Amy Saur, Khalid, Delan, Perry, Jennifer A, Wunderlich, Mark, Benajiba, Lina, Pikman, Yana, Nabet, Behnam, Gray, Nathanael S, Orkin, Stuart H, Stegmaier, Kimberly

    Published 2022
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  16. 16
    Glioblastoma Eradication Following Immune Checkpoint Blockade in an Orthotopic, Immunocompetent Model

    Glioblastoma Eradication Following Immune Checkpoint Blockade in an Orthotopic, Immunocompetent Model by David A. Reardon, Prafulla C. Gokhale, Sarah R. Klein, Keith L. Ligon, Scott J. Rodig, Shakti Ramkissoon, Kristen L. Jones, Amy Saur Conway, Xiaoyun Liao, Jun Zhou, Patrick Y. Wen, Annick D. Van den Abbeele, F. Stephen Hodi, Lei Qin, Nancy E. Kohl, Arlene H. Sharpe, Glenn Dranoff, Gordon J. Freeman

    Published 2015
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  17. 17
    A Combination CDK4/6 and IGF1R Inhibitor Strategy for Ewing Sarcoma

    A Combination CDK4/6 and IGF1R Inhibitor Strategy for Ewing Sarcoma by Lillian M. Guenther, Neekesh V. Dharia, Linda S. Ross, Amy Saur Conway, Amanda L. Robichaud, Jerrel L. Catlett, Caroline S. Wechsler, Elizabeth S. Frank, Amy Goodale, Alanna J. Church, Yuen‐Yi Tseng, Rajarshi Guha, Crystal McKnight, Katherine A. Janeway, Jesse S. Boehm, Jaume Mora, Mindy I. Davis, Gabriela Alexe, Federica Piccioni, Kimberly Stegmaier

    Published 2018
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  18. 18
    TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma

    TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma by Bo Kyung A. Seong, Neekesh V. Dharia, Shan Lin, Katherine A. Donovan, Shasha Chong, Amanda L. Robichaud, Amy Saur Conway, Amanda Hamze, Linda S. Ross, Gabriela Alexe, Biniam Adane, Behnam Nabet, Fleur M. Ferguson, Björn Stolte, Emily Jue Wang, Jialin Sun, Xavier Darzacq, Federica Piccioni, Nathanael S. Gray, Eric S. Fischer, Kimberly Stegmaier

    Published 2021
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  19. 19
    An <i>In Vivo</i> CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML

    An <i>In Vivo</i> CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML by Shan Lin, Clément Larrue, Nastassja K. Scheidegger, Bo Kyung A. Seong, Neekesh V. Dharia, Miljan Kuljanin, Caroline S. Wechsler, Guillaume Kugener, Amanda L. Robichaud, Amy Saur Conway, Thelma Mashaka, Sarah Mouche, Biniam Adane, Jeremy Ryan, Joseph D. Mancias, Scott T. Younger, Federica Piccioni, Lynn Lee, Mark Wunderlich, Anthony Letai, Jérôme Tamburini, Kimberly Stegmaier

    Published 2021
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  20. 20
    The ETS transcription factor ETV6 constrains the transcriptional activity of EWS–FLI to promote Ewing sarcoma

    The ETS transcription factor ETV6 constrains the transcriptional activity of EWS–FLI to promote Ewing sarcoma by Diana Lu, Jana M. Ellegast, Kenneth N. Ross, Clare F. Malone, Shan Lin, Nathaniel W. Mabe, Neekesh V. Dharia, Ashleigh Meyer, Amy Saur Conway, Angela Su, Julia Selich‐Anderson, Cenny Taslim, Andrea K. Byrum, Bo Kyung A. Seong, Biniam Adane, Nathanael S. Gray, Miguel N. Rivera, Stephen L. Lessnick, Kimberly Stegmaier

    Published 2023
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