检索结果 - Amy M. Pooler

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  1. 1
    Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture

    Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture 由 Claire J. Garwood, Amy M. Pooler, Joseph Atherton, Diane P. Hanger, Wendy Noble

    出版 2011
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  2. 2
    Physiological release of endogenous tau is stimulated by neuronal activity

    Physiological release of endogenous tau is stimulated by neuronal activity 由 Amy M. Pooler, Emma C. Phillips, Dawn H. W. Lau, Wendy Noble, Diane P. Hanger

    出版 2013
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  3. 3
    Propagation of tau pathology in Alzheimer’s disease: identification of novel therapeutic targets

    Propagation of tau pathology in Alzheimer’s disease: identification of novel therapeutic targets 由 Amy M. Pooler, Manuela Polydoro, Susanne Wegmann, Samantha B. Nicholls, Tara L. Spires‐Jones, Bradley T. Hyman

    出版 2013
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    Revisão
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  4. 4
    Copines‐1, ‐2, ‐3, ‐6 and ‐7 show different calcium‐dependent intracellular membrane translocation and targeting

    Copines‐1, ‐2, ‐3, ‐6 and ‐7 show different calcium‐dependent intracellular membrane translocation and targeting 由 Pavel V. Perestenko, Amy M. Pooler, Maryam Noorbakhshnia, Adrian Gray, Charlotte Bauccio, R. A. Jeffrey McIlhinney

    出版 2010
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  5. 5
    Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau

    Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau 由 Alessia Usardi, Amy M. Pooler, Anjan Seereeram, C. Hugh Reynolds, Pascal Derkinderen, Brian Anderton, Diane P. Hanger, Wendy Noble, Ritchie Williamson

    出版 2011
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  6. 6
    Progressive Neuronal Pathology and Synaptic Loss Induced by Prediabetes and Type 2 Diabetes in a Mouse Model of Alzheimer’s Disease

    Progressive Neuronal Pathology and Synaptic Loss Induced by Prediabetes and Type 2 Diabetes in a Mouse Model of Alzheimer’s Disease 由 Juan José Ramos‐Rodríguez, Tara L. Spires‐Jones, Amy M. Pooler, Alfonso M. Lechuga‐Sancho, Brian J. Bacskai, Mónica García‐Alloza

    出版 2016
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  7. 7
    Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer’s disease

    Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer’s disease 由 Dawn H. W. Lau, Marte Hogseth, Emma C. Phillips, Michael J. O’Neill, Amy M. Pooler, Wendy Noble, Diane P. Hanger

    出版 2016
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  8. 8
    Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons

    Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons 由 Teresa Rodríguez-Martín, Amy M. Pooler, Dawn H. W. Lau, Gábor M. Mórotz, Kurt J. De Vos, Jonathan Gilley, Michael P. Coleman, Diane P. Hanger

    出版 2015
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  9. 9
    Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures

    Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures 由 Cara L. Croft, Matthew Wade, Ksenia Kurbatskaya, Pavlina Mastrandreas, Martina M. Hughes, Emma C. Phillips, Amy M. Pooler, Michael S. Perkinton, Diane P. Hanger, Wendy Noble

    出版 2017
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  10. 10
    Apolipoprotein E4 Expression Causes Gain of Toxic Function in Isogenic Human Induced Pluripotent Stem Cell-Derived Endothelial Cells

    Apolipoprotein E4 Expression Causes Gain of Toxic Function in Isogenic Human Induced Pluripotent Stem Cell-Derived Endothelial Cells 由 Claus Rieker, Eugenia Migliavacca, Angélique Vaucher, Fiona C. Mayer, Gilles Baud, Julien Marquis, Aline Charpagne, Nagabhooshan Hegde, Laurence Guignard, Michael J. McLachlan, Amy M. Pooler

    出版 2019
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  11. 11
    Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer’s disease model

    Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer’s disease model 由 Manuela Polydoro, Volodymyr Dzhala, Amy M. Pooler, Samantha B. Nicholls, A. Patrick McKinney, Laura Sánchez, Rose Pitstick, George A. Carlson, Kevin J. Staley, Tara L. Spires‐Jones, Bradley T. Hyman

    出版 2013
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  12. 12
    Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer’s disease

    Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer’s disease 由 Amy M. Pooler, Manuela Polydoro, Eduardo A. Maury, Samantha B. Nicholls, Snigdha Reddy, Susanne Wegmann, Christopher William, Lubna Saqran, Ozge Cagsal‐Getkin, Rose Pitstick, David R. Beier, George A. Carlson, Tara L. Spires‐Jones, Bradley T. Hyman

    出版 2015
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  13. 13
    Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity

    Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity 由 Susanne Wegmann, Eduardo A. Maury, Molly J. Kirk, Lubna Saqran, Allyson D. Roe, Sarah L. DeVos, Samantha B. Nicholls, Zhanyun Fan, Shuko Takeda, Ozge Cagsal‐Getkin, Christopher William, Tara L. Spires‐Jones, Rose Pitstick, George A. Carlson, Amy M. Pooler, Bradley T. Hyman

    出版 2015
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  14. 14
    Studying synapses in human brain with array tomography and electron microscopy

    Studying synapses in human brain with array tomography and electron microscopy 由 Kevin R. Kay, Colin Smith, Ann K. Wright, Alberto Serrano‐Pozo, Amy M. Pooler, Robert M. Koffie, Mark E. Bastin, Thomas H. Bak, Sharon Abrahams, Katherine J. Kopeikina, Declan McGuone, Matthew P. Frosch, Thomas H. Gillingwater, Bradley T. Hyman, Tara L. Spires‐Jones

    出版 2013
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  15. 15
    Persistent repression of tau in the brain using engineered zinc finger protein transcription factors

    Persistent repression of tau in the brain using engineered zinc finger protein transcription factors 由 Susanne Wegmann, Sarah L. DeVos, Bryan Zeitler, Kimberly Marlen, Rachel E. Bennett, Marta Pérez-Rando, Danny MacKenzie, Qi Yu, Caitlin Commins, Riley N. Bannon, Bianca T. Corjuc, Alison Chase, Lisa Diez, Hoang-Oanh B. Nguyen, Sarah J. Hinkley, Lei Zhang, Alicia Goodwin, Annemarie Ledeboer, Stephen C.-T. Lam, Irina Ankoudinova, Hung Tran, Nicholas A. Scarlott, Rainier Amora, Richard Surosky, Jeffrey C. Miller, Ashley B. Robbins, Edward J. Rebar, Fyodor D. Urnov, Michael C. Holmes, Amy M. Pooler, Brigit E. Riley, H. Steve Zhang, Bradley T. Hyman

    出版 2021
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  16. 16
    Zinc Finger Repressors mediate widespread PRNP lowering in the nonhuman primate brain and profoundly extend survival in prion disease mice

    Zinc Finger Repressors mediate widespread PRNP lowering in the nonhuman primate brain and profoundly extend survival in prion disease mice 由 Shih‐Wei Chou, Meredith A Mortberg, Kimberly Marlen, David S. Ojala, Toufan Parman, Michael W. Howard, Kendrick DeSouza-Lenz, Yuan Lian, Mohadeseh Mehrabian, Matthew Tiffany, Annemarie Ledeboer, Patrick Dunn, Jing Hu, Kenia Guzman, N. Kamath, M. H. Cass, Samantha Graffam, Li Xu, Vanessa Laversenne, Taylor L Corridon, Alaric Falcon, Garrett Lew, Satria P. Sajuthi, Lei Zhang, Giulia Cisbani, Finn Peters, Tim Fieblinger, Chiara Melis, Janica Barenberg, Marharyta Hnatiuk, Yu Qi, Daniel W. Chung, Mihika Jalan, Sarah J. Hinkley, Yanmei Lu, Kathleen Meyer, Alissa A. Coffey, Amy M. Pooler, Sonia M. Vallabh, Eric Vallabh Minikel, Bryan Zeitler

    出版 2025
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