Search Results - Alisa K. Manning

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  1. 1
    The (in)famous GWAS P-value threshold revisited and updated for low-frequency variants

    The (in)famous GWAS P-value threshold revisited and updated for low-frequency variants by João Fadista, Alisa K. Manning, José C. Florez, Leif Groop

    Published 2016
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  2. 2
    Polygenic scores capture genetic modification of the adiposity-cardiometabolic risk factor relationship

    Polygenic scores capture genetic modification of the adiposity-cardiometabolic risk factor relationship by Kenneth E. Westerman, Julie Gervis, Luke J. O’Connor, Miriam S. Udler, Alisa K. Manning

    Published 2025
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  3. 3
    Genome-wide association with diabetes-related traits in the Framingham Heart Study

    Genome-wide association with diabetes-related traits in the Framingham Heart Study by James B. Meigs, Alisa K. Manning, Caroline S. Fox, José C. Florez, Chunyu Liu, L. Adrienne Cupples, Josée Dupuis

    Published 2007
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  4. 4
    A common polymorphism decreases low-density lipoprotein receptor exon 12 splicing efficiency and associates with increased cholesterol

    A common polymorphism decreases low-density lipoprotein receptor exon 12 splicing efficiency and associates with increased cholesterol by Haiyan Zhu, H. Michael Tucker, Karrie E. Grear, James F. Simpson, Alisa K. Manning, L. Adrienne Cupples, Steven Estus

    Published 2007
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  5. 5
    GEM: scalable and flexible gene–environment interaction analysis in millions of samples

    GEM: scalable and flexible gene–environment interaction analysis in millions of samples by Kenneth E. Westerman, Duy T. Pham, Hong Liang, Ye Chen, Magdalena Sevilla-González, Yun Ju Sung, Yan V. Sun, Alanna C. Morrison, Han Chen, Alisa K. Manning

    Published 2021
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  6. 6
    A 100K Genome-Wide Association Scan for Diabetes and Related Traits in the Framingham Heart Study

    A 100K Genome-Wide Association Scan for Diabetes and Related Traits in the Framingham Heart Study by José C. Florez, Alisa K. Manning, Josée Dupuis, Jarred B. McAteer, Kathryn Irenze, Lauren Gianniny, Daniel B. Mirel, Caroline S. Fox, L. Adrienne Cupples, James B. Meigs

    Published 2007
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  7. 7
    <i>TCF7L2</i> Genetic Variation Augments Incretin Resistance and Influences Response to a Sulfonylurea and Metformin: The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH)

    <i>TCF7L2</i> Genetic Variation Augments Incretin Resistance and Influences Response to a Sulfonylurea and Metformin: The Study to Understand the Genetics of the Acute Response to... by Shylaja Srinivasan, Varinderpal Kaur, Bindu Chamarthi, Katherine R. Littleton, Ling Chen, Alisa K. Manning, Jordi Merino, Melissa K. Thomas, Margo Hudson, Allison B. Goldfine, José C. Florez

    Published 2018
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  8. 8
    Variance-quantitative trait loci enable systematic discovery of gene-environment interactions for cardiometabolic serum biomarkers

    Variance-quantitative trait loci enable systematic discovery of gene-environment interactions for cardiometabolic serum biomarkers by Kenneth E. Westerman, Timothy D. Majarian, Franco Giulianini, Dongkeun Jang, Jenkai Miao, José C. Florez, Han Chen, Daniel I. Chasman, Miriam S. Udler, Alisa K. Manning, Joanne B. Cole

    Published 2022
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  9. 9
    Genetic Risk Reclassification for Type 2 Diabetes by Age Below or Above 50 Years Using 40 Type 2 Diabetes Risk Single Nucleotide Polymorphisms

    Genetic Risk Reclassification for Type 2 Diabetes by Age Below or Above 50 Years Using 40 Type 2 Diabetes Risk Single Nucleotide Polymorphisms by José M. de Miguel‐Yanes, Peter Shrader, Michael Pencina, Caroline S. Fox, Alisa K. Manning, Richard W. Grant, Josée Dupuis, José C. Florez, Ralph B. D’Agostino, L. Adrienne Cupples, James B. Meigs

    Published 2010
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  10. 10
    Genotype Score in Addition to Common Risk Factors for Prediction of Type 2 Diabetes

    Genotype Score in Addition to Common Risk Factors for Prediction of Type 2 Diabetes by James B. Meigs, Peter Shrader, Lisa Sullivan, Jarred B. McAteer, Caroline S. Fox, Josée Dupuis, Alisa K. Manning, José C. Florez, Peter W.F. Wilson, Ralph B. D’Agostino, L. Adrienne Cupples

    Published 2008
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  11. 11
    Association and Interaction of Genetics and Area-Level Socioeconomic Factors on the Prevalence of Type 2 Diabetes and Obesity

    Association and Interaction of Genetics and Area-Level Socioeconomic Factors on the Prevalence of Type 2 Diabetes and Obesity by Sara J. Cromer, Chirag M. Lakhani, Josep M. Mercader, Timothy D. Majarian, Philip Schroeder, Joanne B. Cole, José C. Florez, Chirag J. Patel, Alisa K. Manning, Sherri‐Ann M. Burnett‐Bowie, Jordi Merino, Miriam S. Udler

    Published 2023
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  12. 12
    Standardized Measurement of Type 1 Diabetes Polygenic Risk Across Multi-Ancestry Population Cohorts

    Standardized Measurement of Type 1 Diabetes Polygenic Risk Across Multi-Ancestry Population Cohorts by Amber M. Luckett, Richard A. Oram, Aaron J. Deutsch, Héctor Ortega, Diane P. Fraser, Kaavya Ashok, Alisa K. Manning, Josep M. Mercader, Manuel A. Rivas, Miriam S. Udler, Michael N. Weedon, Anna L. Gloyn, Seth A. Sharp

    Published 2025
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  13. 13
    A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study

    A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study by Sekar Kathiresan, Alisa K. Manning, Serkalem Demissie, Ralph B. D’Agostino, Aarti Surti, Candace Guiducci, Lauren Gianniny, Noël P. Burtt, Olle Melander, Marju Orho‐Melander, Donna K. Arnett, Gina M. Peloso, José M. Ordovás, L. Adrienne Cupples

    Published 2007
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  14. 14
    High-throughput genetic clustering of type 2 diabetes loci reveals heterogeneous mechanistic pathways of metabolic disease

    High-throughput genetic clustering of type 2 diabetes loci reveals heterogeneous mechanistic pathways of metabolic disease by Hyunkyung Kim, Kenneth E. Westerman, Kirk Smith, Joshua Chiou, Joanne B. Cole, Timothy D. Majarian, Marcin von Grotthuss, Soo Heon Kwak, Jaegil Kim, Josep M. Mercader, José C. Florez, Kyle J. Gaulton, Alisa K. Manning, Miriam S. Udler

    Published 2022
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  15. 15
    Meta-analysis of gene-environment interaction: joint estimation of SNP and SNP × environment regression coefficients

    Meta-analysis of gene-environment interaction: joint estimation of SNP and SNP × environment regression coefficients by Alisa K. Manning, Michael P. LaValley, Yongmei Liu, Kenneth Rice, Ping An, Yongmei Liu, Iva Miljkovic, Laura J. Rasmussen‐Torvik, Tamara B. Harris, Michael A. Province, Ingrid B. Borecki, José C. Florez, James B. Meigs, L. Adrienne Cupples, Josée Dupuis

    Published 2010
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  16. 16
    The First Genome-Wide Association Study for Type 2 Diabetes in Youth: The Progress in Diabetes Genetics in Youth (ProDiGY) Consortium

    The First Genome-Wide Association Study for Type 2 Diabetes in Youth: The Progress in Diabetes Genetics in Youth (ProDiGY) Consortium by Shylaja Srinivasan, Ling Chen, Jennifer N. Todd, Jasmin Divers, Samuel S. Gidding, Steven D. Chernausek, Rose Gubitosi‐Klug, Megan M. Kelsey, Rachana Shah, Mary Helen Black, Lynne E. Wagenknecht, Alisa K. Manning, Jason Flannick, Giuseppina Imperatore, Josep M. Mercader, Dana Dabelea, José C. Florez

    Published 2021
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  17. 17
    A Partial Loss-of-Function Variant in <i>AKT2</i> Is Associated With Reduced Insulin-Mediated Glucose Uptake in Multiple Insulin-Sensitive Tissues: A Genotype-Based Callback Positron Emission Tomography Study

    A Partial Loss-of-Function Variant in <i>AKT2</i> Is Associated With Reduced Insulin-Mediated Glucose Uptake in Multiple Insulin-Sensitive Tissues: A Genotype-Based Callback Positr... by Aino Latva‐Rasku, Miikka‐Juhani Honka, Alena Stančáková, Heikki A. Koistinen, Johanna Kuusisto, Li Guan, Alisa K. Manning, Heather M. Stringham, Anna L. Gloyn, Cecilia M. Lindgren, Francis S. Collins, Karen L. Mohlke, Laura J. Scott, Tomi Karjalainen, Lauri Nummenmaa, Michael Boehnke, Pirjo Nuutila, Markku Laakso

    Published 2017
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  18. 18
    Multi-ancestry polygenic mechanisms of type 2 diabetes

    Multi-ancestry polygenic mechanisms of type 2 diabetes by Kirk Smith, Aaron J. Deutsch, Carolyn McGrail, Hyunkyung Kim, Sarah Hsu, Alicia Huerta-Chagoya, Ravi Mandla, Philip Schroeder, Kenneth E. Westerman, Łukasz Szczerbiński, Timothy D. Majarian, Varinderpal Kaur, Alice Williamson, Noah Zaitlen, Melina Claussnitzer, José C. Florez, Alisa K. Manning, Josep M. Mercader, Kyle J. Gaulton, Miriam S. Udler

    Published 2024
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  19. 19
    Gene-lifestyle interactions in the genomics of human complex traits

    Gene-lifestyle interactions in the genomics of human complex traits by Vincent Laville, Timothy D. Majarian, Yan V. Sun, Karen Schwander, Mary F. Feitosa, Daniel I. Chasman, Amy R. Bentley, Charles N. Rotimi, L. Adrienne Cupples, Paul S. de Vries, Michael R. Brown, Alanna C. Morrison, Aldi T. Kraja, Mike Province, C. Charles Gu, W. James Gauderman, Vincent Laville, Timothy D. Majarian, Yan V. Sun, Karen Schwander, Mary F. Feitosa, Daniel I. Chasman, Amy R. Bentley, Charles N. Rotimi, L. Adrienne Cupples, Paul S. de Vries, Michael R. Brown, Alanna C. Morrison, Aldi T. Kraja, Mike Province, C. Charles Gu, W. James Gauderman, D. C. Rao, Alisa K. Manning, Hugues Aschard, D. C. Rao, Alisa K. Manning, Hugues Aschard

    Published 2022
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  20. 20
    Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans

    Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans by Andrew C. Edmondson, Robert Brown, Sekar Kathiresan, L. Adrienne Cupples, Serkalem Demissie, Alisa K. Manning, Majken K. Jensen, Eric B. Rimm, Jian Wang, Amrith Rodrigues, Vaneeta Bamba, Sumeet A. Khetarpal, Megan L. Wolfe, Stephanie DerOhannessian, Mingyao Li, Muredach P. Reilly, Jens Aberle, D. Gareth Evans, Robert A. Hegele, Daniel J. Rader

    Published 2009
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