Resultats de la cerca - Alejandra Tomás

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  1. 1
    The Interplay of Glucagon-Like Peptide-1 Receptor Trafficking and Signalling in Pancreatic Beta Cells

    The Interplay of Glucagon-Like Peptide-1 Receptor Trafficking and Signalling in Pancreatic Beta Cells per Amaara Marzook, Alejandra Tomás, Ben Jones

    Publicat 2021
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  2. 2
    Focal Adhesion Remodeling Is Crucial for Glucose-Stimulated Insulin Secretion and Involves Activation of Focal Adhesion Kinase and Paxillin

    Focal Adhesion Remodeling Is Crucial for Glucose-Stimulated Insulin Secretion and Involves Activation of Focal Adhesion Kinase and Paxillin per Dieter Rondas, Alejandra Tomás, Philippe A. Halban

    Publicat 2011
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  3. 3
    Annexin 11 is required for midbody formation and completion of the terminal phase of cytokinesis

    Annexin 11 is required for midbody formation and completion of the terminal phase of cytokinesis per Alejandra Tomás, Clare E. Futter, Stephen E. Moss

    Publicat 2004
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  4. 4
    EGF receptor trafficking: consequences for signaling and cancer

    EGF receptor trafficking: consequences for signaling and cancer per Alejandra Tomás, Clare E. Futter, Emily R. Eden

    Publicat 2013
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  5. 5
    Congenital melanocytic neoplasms: clinical, histopathological and recent molecular developments

    Congenital melanocytic neoplasms: clinical, histopathological and recent molecular developments per Cláudia Salgado, Alejandra Tomás‐­Velázquez, Miguel Reyes‐Múgica

    Publicat 2025
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  6. 6
    Biased agonism and polymorphic variation at the GLP-1 receptor: Implications for the development of personalised therapeutics

    Biased agonism and polymorphic variation at the GLP-1 receptor: Implications for the development of personalised therapeutics per Liliane El Eid, Christopher A. Reynolds, Alejandra Tomás, Ben Jones

    Publicat 2022
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  7. 7
    Regulation of pancreatic β-cell insulin secretion by actin cytoskeleton remodelling: role of gelsolin and cooperation with the MAPK signalling pathway

    Regulation of pancreatic β-cell insulin secretion by actin cytoskeleton remodelling: role of gelsolin and cooperation with the MAPK signalling pathway per Alejandra Tomás, Barbara Yermen, Le Min, Jeffrey E. Pessin, Philippe A. Halban

    Publicat 2006
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  8. 8
    Novel Mechanistic Link between Focal Adhesion Remodeling and Glucose-stimulated Insulin Secretion

    Novel Mechanistic Link between Focal Adhesion Remodeling and Glucose-stimulated Insulin Secretion per Dieter Rondas, Alejandra Tomás, Martinho Soto-Ribeiro, Bernhard Wehrle‐Haller, Philippe A. Halban

    Publicat 2011
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  9. 9
    WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway

    WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway per Alejandra Tomás, S. O. Vaughan, Thomas Burgoyne, Alexander Sorkin, John A. Hartley, Daniel Hochhauser, Clare E. Futter

    Publicat 2015
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  10. 10
    Enhanced Endosomal Signaling and Desensitization of GLP-1R vs GIPR in Pancreatic Beta Cells

    Enhanced Endosomal Signaling and Desensitization of GLP-1R vs GIPR in Pancreatic Beta Cells per Yusman Manchanda, Stavroula Bitsi, Shiqian Chen, Johannes Broichhagen, Jorge Bernardino de la Serna, Ben Jones, Alejandra Tomás

    Publicat 2023
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  11. 11
    Dual Effect of Cell-Cell Contact Disruption on Cytosolic Calcium and Insulin Secretion

    Dual Effect of Cell-Cell Contact Disruption on Cytosolic Calcium and Insulin Secretion per Fabienne Jaques, Hélène Jousset, Alejandra Tomás, Anne-Lise Prost, Claes B. Wollheim, Jean-Claude Irminger, Nicolas Demaurex, Philippe A. Halban

    Publicat 2008
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  12. 12
    Disconnect between signalling potency and in vivo efficacy of pharmacokinetically optimised biased glucagon-like peptide-1 receptor agonists

    Disconnect between signalling potency and in vivo efficacy of pharmacokinetically optimised biased glucagon-like peptide-1 receptor agonists per Maria Lucey, Philip Pickford, Stavroula Bitsi, James Minnion, Jan Ungewiss, Katja Schoeneberg, Guy A. Rutter, Stephen R. Bloom, Alejandra Tomás, Ben Jones

    Publicat 2020
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  13. 13
    Abolishing β‐arrestin recruitment is necessary for the full metabolic benefits of G protein‐biased glucagon‐like peptide‐1 receptor agonists

    Abolishing β‐arrestin recruitment is necessary for the full metabolic benefits of G protein‐biased glucagon‐like peptide‐1 receptor agonists per Charlotte E. Hinds, Ellie Peace, Shiqian Chen, Iona Davies, Liliane El Eid, Alejandra Tomás, Tricia Tan, James Minnion, Ben Jones, Stephen R. Bloom

    Publicat 2023
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  14. 14
    The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion

    The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion per Antonia Solomou, Gargi Meur, Elisa A. Bellomo, David J. Hodson, Alejandra Tomás, Stéphanie Migrenne Li, Erwann Philippe, Pedro L. Herrera, Chr̀istophe Magnan, Guy A. Rutter

    Publicat 2015
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  15. 15
    Divergent acute versus prolonged pharmacological GLP-1R responses in adult β cell–specific β-arrestin 2 knockout mice

    Divergent acute versus prolonged pharmacological GLP-1R responses in adult β cell–specific β-arrestin 2 knockout mice per Stavroula Bitsi, Liliane El Eid, Yusman Manchanda, Affiong I Oqua, Nimco Mohamed, Ben Hansen, Kinga Suba, Guy A. Rutter, Victoria Salem, Ben Jones, Alejandra Tomás

    Publicat 2023
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  16. 16
    Binding Kinetics, Bias, Receptor Internalization and Effects on Insulin Secretion<i>in vitro</i>and<i>in vivo</i>of a Novel GLP-1R/GIPR Dual Agonist, HISHS-2001

    Binding Kinetics, Bias, Receptor Internalization and Effects on Insulin Secretion<i>in vitro</i>and<i>in vivo</i>of a Novel GLP-1R/GIPR Dual Agonist, HISHS-2001 per Yusman Manchanda, Ben Jones, Gaëlle Carrat, Zenouska Ramchunder, Piero Marchetti, Isabelle Leclerc, Rajamannar Thennati, Vinod Burade, Muthukumaran Natarajan, Pradeep Shahi, Alejandra Tomás, Guy A. Rutter

    Publicat 2025
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  17. 17
    Biomimetic electromechanical stimulation to maintain adult myocardial slices in vitro

    Biomimetic electromechanical stimulation to maintain adult myocardial slices in vitro per Samuel Watson, James Duff, Ifigeneia Bardi, Magdalena A. Zabielska-Kaczorowska, Santosh S. Atanur, Richard J. Jabbour, A. Simón, Alejandra Tomás, Ryszard T. Smoleński, Siân E. Harding, Filippo Perbellini, Cesare M. Terracciano

    Publicat 2019
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  18. 18
    Signalling, trafficking and glucoregulatory properties of glucagon‐like peptide‐1 receptor agonists exendin‐4 and lixisenatide

    Signalling, trafficking and glucoregulatory properties of glucagon‐like peptide‐1 receptor agonists exendin‐4 and lixisenatide per Philip Pickford, Maria Lucey, Zijian Fang, Stavroula Bitsi, Jorge Bernardino de la Serna, Johannes Broichhagen, David J. Hodson, James Minnion, Guy A. Rutter, Stephen R. Bloom, Alejandra Tomás, Ben Jones

    Publicat 2020
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  19. 19
    A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells

    A Targeted RNAi Screen Identifies Endocytic Trafficking Factors That Control GLP-1 Receptor Signaling in Pancreatic β-Cells per Teresa Buenaventura, Nisha Kanda, Phoebe C. Douzenis, Ben Jones, Stephen R. Bloom, Pauline Chabosseau, Ivan R. Corrêa, Domenico Bosco, Lorenzo Piemonti, Piero Marchetti, Paul Johnson, A. M. James Shapiro, Guy A. Rutter, Alejandra Tomás

    Publicat 2017
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  20. 20
    DRP1 levels determine the apoptotic threshold during embryonic differentiation through a mitophagy-dependent mechanism

    DRP1 levels determine the apoptotic threshold during embryonic differentiation through a mitophagy-dependent mechanism per Bárbara Pernaute, Salvador Pérez-Montero, Juan Miguel Sánchez Nieto, Aida Di Gregorio, Ana Lima, Katerina Lawlor, Sarah Bowling, Gianmaria Liccardi, Alejandra Tomás, Pascal Meier, Hiromi Sesaki, Guy A. Rutter, Ivana Barbaric, Tristan A. Rodríguez

    Publicat 2022
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