Resultats de la cerca - Aleem Gangjee

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  1. 1
    The promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer

    The promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer per Larry H. Matherly, Zhanjun Hou, Aleem Gangjee

    Publicat 2017
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  2. 2
    Therapeutic Targeting of Mitochondrial One-Carbon Metabolism in Cancer

    Therapeutic Targeting of Mitochondrial One-Carbon Metabolism in Cancer per Aamod S. Dekhne, Zhanjun Hou, Aleem Gangjee, Larry H. Matherly

    Publicat 2020
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  3. 3
    The human proton-coupled folate transporter

    The human proton-coupled folate transporter per Sita Kugel Desmoulin, Zhanjun Hou, Aleem Gangjee, Larry H. Matherly

    Publicat 2012
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  4. 4
    Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection

    Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection per Khushbu, Shah, Sherry, Queener, Vivian, Cody, Jim, Pace, Aleem, Gangjee

    Publicat 2019
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  5. 5
    Trimethoprim Resistance of Dihydrofolate Reductase Variants from Clinical Isolates of Pneumocystis jirovecii

    Trimethoprim Resistance of Dihydrofolate Reductase Variants from Clinical Isolates of Pneumocystis jirovecii per Sherry F. Queener, Vivian Cody, Jim Pace, P. Torkelson, Aleem Gangjee

    Publicat 2013
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  6. 6
    Synthesis and Discovery of High Affinity Folate Receptor-Specific Glycinamide Ribonucleotide Formyltransferase Inhibitors with Antitumor Activity

    Synthesis and Discovery of High Affinity Folate Receptor-Specific Glycinamide Ribonucleotide Formyltransferase Inhibitors with Antitumor Activity per Yijun Deng, Yiqiang Wang, Christina Cherian, Zhanjun Hou, Steven Buck, Larry H. Matherly, Aleem Gangjee

    Publicat 2008
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  7. 7
    Synthesis and Biological Activity of a Novel Series of 6-Substituted Thieno[2,3-<i>d</i>]pyrimidine Antifolate Inhibitors of Purine Biosynthesis with Selectivity for High Affinity Folate Receptors over the Reduced Folate Carrier and Proton-Coupled Folate Transporter for Cellular Entry<sup>†</sup>

    Synthesis and Biological Activity of a Novel Series of 6-Substituted Thieno[2,3-<i>d</i>]pyrimidine Antifolate Inhibitors of Purine Biosynthesis with Selectivity for High Affinity... per Yijun Deng, Xilin Zhou, Sita Kugel Desmoulin, Jianmei Wu, Christina Cherian, Zhanjun Hou, Larry H. Matherly, Aleem Gangjee

    Publicat 2009
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  8. 8
    AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization

    AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization per Anja Bastian, Satoshi Matsuzaki, Kenneth M. Humphries, Gavin Pharaoh, Arpit Doshi, Nilesh Zaware, Aleem Gangjee, Michael A. Ihnat

    Publicat 2016
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  9. 9
    Synthesis and Antitumor Activity of a Novel Series of 6-Substituted Pyrrolo[2,3-<i>d</i>]pyrimidine Thienoyl Antifolate Inhibitors of Purine Biosynthesis with Selectivity for High Affinity Folate Receptors and the Proton-Coupled Folate Transporter over the Reduced Folate Carrier for Cellular Entry

    Synthesis and Antitumor Activity of a Novel Series of 6-Substituted Pyrrolo[2,3-<i>d</i>]pyrimidine Thienoyl Antifolate Inhibitors of Purine Biosynthesis with Selectivity for High... per Lei Wang, Christina Cherian, Sita Kugel Desmoulin, Lisa Polin, Yijun Deng, Jianmei Wu, Zhanjun Hou, Kathryn White, Juiwanna Kushner, Larry H. Matherly, Aleem Gangjee

    Publicat 2010
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  10. 10
    Therapeutic Targeting of a Novel 6-Substituted Pyrrolo [2,3-<i>d</i>]pyrimidine Thienoyl Antifolate to Human Solid Tumors Based on Selective Uptake by the Proton-Coupled Folate Transporter

    Therapeutic Targeting of a Novel 6-Substituted Pyrrolo [2,3-<i>d</i>]pyrimidine Thienoyl Antifolate to Human Solid Tumors Based on Selective Uptake by the Proton-Coupled Folate Tra... per Sita Kugel Desmoulin, Lei Wang, Eric C. Hales, Lisa Polin, Kathryn White, Juiwanna Kushner, Mark Stout, Zhanjun Hou, Christina Cherian, Aleem Gangjee, Larry H. Matherly

    Publicat 2011
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  11. 11
    Targeting the Proton-Coupled Folate Transporter for Selective Delivery of 6-Substituted Pyrrolo[2,3-<i>d</i>]Pyrimidine Antifolate Inhibitors of De Novo Purine Biosynthesis in the Chemotherapy of Solid Tumors

    Targeting the Proton-Coupled Folate Transporter for Selective Delivery of 6-Substituted Pyrrolo[2,3-<i>d</i>]Pyrimidine Antifolate Inhibitors of De Novo Purine Biosynthesis in the... per Sita Kugel Desmoulin, Yiqiang Wang, Jianmei Wu, Mark Stout, Zhanjun Hou, Andreas Fulterer, Min‐Hwang Chang, Michael F. Romero, Christina Cherian, Aleem Gangjee, Larry H. Matherly

    Publicat 2010
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  12. 12
    Synthesis, Biological, and Antitumor Activity of a Highly Potent 6-Substituted Pyrrolo[2,3-<i>d</i>]pyrimidine Thienoyl Antifolate Inhibitor with Proton-Coupled Folate Transporter and Folate Receptor Selectivity over the Reduced Folate Carrier That Inhibits β-Glycinamide Ribonucleotide Formyltransferase

    Synthesis, Biological, and Antitumor Activity of a Highly Potent 6-Substituted Pyrrolo[2,3-<i>d</i>]pyrimidine Thienoyl Antifolate Inhibitor with Proton-Coupled Folate Transporter... per Lei Wang, Sita Kugel Desmoulin, Christina Cherian, Lisa Polin, Kathryn White, Juiwanna Kushner, Andreas Fulterer, Min‐Hwang Chang, Shermaine Mitchell-Ryan, Mark Stout, Michael F. Romero, Zhanjun Hou, Larry H. Matherly, Aleem Gangjee

    Publicat 2011
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  13. 13
    Novel Pyrrolo[3,2-<i>d</i>]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy

    Novel Pyrrolo[3,2-<i>d</i>]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy per Aamod S. Dekhne, Khushbu Shah, Gregory S. Ducker, Jade M. Katinas, Jennifer Wong-Roushar, Md. Junayed Nayeen, Arpit Doshi, Changwen Ning, Xun Bao, Josephine Frühauf, Jenney Liu, Adrianne Wallace-Povirk, Carrie O’Connor, Sijana H. Dzinic, Kathryn White, Juiwanna Kushner, Seongho Kim, Maik Hüttemann, Lisa Polin, Joshua D. Rabinowitz, Jing Li, Zhanjun Hou, Charles E. Dann, Aleem Gangjee, Larry H. Matherly

    Publicat 2019
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