Rezultati - Adrian Higginbottom
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A new zebrafish model produced by TILLING of SOD1-related amyotrophic lateral sclerosis replicates key features of the disease and represents a tool for <i>in vivo</i> therapeutic... od Marc Da Costa, Claire Allen, Adrian Higginbottom, Tennore Ramesh, Pamela J. Shaw, Christopher McDermott
Izdano 2013Artigo -
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Simultaneous and independent detection of C9ORF72 alleles with low and high number of GGGGCC repeats using an optimised protocol of Southern blot hybridisation od Vladimir L. Buchman, Johnathan Cooper‐Knock, Natalie Connor‐Robson, Adrian Higginbottom, Janine Kirby, O D Razinskaya, Natalia Ninkina, Pamela J. Shaw
Izdano 2013Artigo -
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Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features od M. Shaw, Adrian Higginbottom, Alexander McGown, Lydia M. Castelli, E Goldman James, Guillaume M. Hautbergue, Pamela J. Shaw, Tennore Ramesh
Izdano 2018Artigo -
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PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons od Ke Ning, Carsten Drepper, Chiara F. Valori, Mansoor Ahsan, Matthew Wyles, Adrian Higginbottom, Thomas Herrmann, Pamela J. Shaw, Mimoun Azzouz, Michael Sendtner
Izdano 2010Artigo -
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Recombinant Extracellular Domains of Tetraspanin Proteins Are Potent Inhibitors of the Infection of Macrophages by Human Immunodeficiency Virus Type 1 od Siu‐Hong Ho, Francine Martin, Adrian Higginbottom, Lynda J. Partridge, V. Parthasarathy, Gregory W. Moseley, Peter Lopez, Cecilia Cheng‐Mayer, Peter N. Monk
Izdano 2006Artigo -
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Characterization of Hepatitis C Virus E2 Glycoprotein Interaction with a Putative Cellular Receptor, CD81 od Mike Flint, Catherine Maidens, Larry D. Loomis-Price, C Shotton, Jean Dubuisson, Peter N. Monk, Adrian Higginbottom, Shoshana Levy, Jane A. McKeating
Izdano 1999Artigo -
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Endothelial tetraspanin microdomains regulate leukocyte firm adhesion during extravasation od Olga Barreiro, María Yáñez‐Mó, Mónica Sala-Valdés, María Dolores Gutiérrez‐López, Susana Ovalle, Adrian Higginbottom, Peter N. Monk, Carlos Cabañas, Francisco Sánchez‐Madrid
Izdano 2005Artigo -
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Oligodendrocyte pathology exceeds axonal pathology in white matter in human amyotrophic lateral sclerosis od Alejandro Lorente Pons, Adrian Higginbottom, Johnathan Cooper‐Knock, Aziza Alrafiah, Ebtisam A. Al-ofi, Janine Kirby, Pamela J. Shaw, Jonathan Wood, J. Robin Highley
Izdano 2020Artigo -
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A neuronal <scp>DNA</scp> damage response is detected at the earliest stages of <scp>A</scp>lzheimer's neuropathology and correlates with cognitive impairment in the <scp>M</scp>ed... od Julie E. Simpson, Paul G. Ince, Fiona E. Matthews, Pamela J. Shaw, Paul R. Heath, Carol Brayne, Claire J. Garwood, Adrian Higginbottom, Stephen B. Wharton
Izdano 2014Artigo -
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Distinct roles for tetraspanins CD9, CD63 and CD81 in the formation of multinucleated giant cells od V. Parthasarathy, Francine Martin, Adrian Higginbottom, Helen C. Murray, Gregory W. Moseley, Robert C. Read, Gorakh Mal, Rachel Hulme, Peter N. Monk, Lynda J. Partridge
Izdano 2009Artigo -
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Identification of Amino Acid Residues in CD81 Critical for Interaction with Hepatitis C Virus Envelope Glycoprotein E2 od Adrian Higginbottom, Elizabeth R. Quinn, Chiung-Chi Kuo, Mike Flint, Louise H. Wilson, Elisabetta Bianchi, Alfredo Nicosia, Peter N. Monk, Jane A. McKeating, Shoshana Levy
Izdano 2000Artigo -
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Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy od Johnathan Cooper‐Knock, Adrian Higginbottom, Matthew J. Stopford, J. Robin Highley, Paul G. Ince, Stephen B. Wharton, Stuart Pickering‐Brown, Janine Kirby, Guillaume M. Hautbergue, Pamela J. Shaw
Izdano 2015Artigo -
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C9ORF72 GGGGCC Expanded Repeats Produce Splicing Dysregulation which Correlates with Disease Severity in Amyotrophic Lateral Sclerosis od Johnathan Cooper‐Knock, Joanna J. Bury, Paul R. Heath, Matthew Wyles, Adrian Higginbottom, Catherine Gelsthorpe, J. Robin Highley, Guillaume M. Hautbergue, Magnus Rattray, Janine Kirby, Pamela J. Shaw
Izdano 2015Artigo -
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A bacterial artificial chromosome mouse model of amyotrophic lateral sclerosis manifests ‘space cadet syndrome’ on two FVB backgrounds od Shirlene Badger, Ian Coldicott, Ergita Kyrgiou-Balli, Adrian Higginbottom, Chloé Moutin, Kamallia Mohd Imran, John C. C. Day, Johnathan Cooper‐Knock, Richard J. Mead, James J. P. Alix
Izdano 2025Artigo -
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TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons od Miriam A. Vogt, Zahra Ehsaei, Philip Knuckles, Adrian Higginbottom, Michaela S. Helmbrecht, Tilo Kunath, Kevin Eggan, Luis A. Williams, Pamela J. Shaw, Wolfgang Wurst, Thomas Floß, Andrea B. Huber, Verdon Taylor
Izdano 2018Artigo -
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S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis od Richard J. Mead, Adrian Higginbottom, Scott P. Allen, Janine Kirby, Ellen Bennett, Siân C. Barber, Paul R. Heath, Antonio Coluccia, Neelam Patel, Iain Gardner, Andrea Brancale, Andrew J. Grierson, Pamela J. Shaw
Izdano 2013Artigo -
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Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions od Johnathan Cooper‐Knock, Matthew J. Walsh, Adrian Higginbottom, J. Robin Highley, Mark J. Dickman, Dieter Edbauer, Paul G. Ince, Stephen B. Wharton, Stuart A. Wilson, Janine Kirby, Guillaume M. Hautbergue, Pamela J. Shaw
Izdano 2014Artigo
Iskalna orodja:
Sorodne teme
Biology
Medicine
Disease
Amyotrophic lateral sclerosis
Gene
Genetics
Cell biology
Neuroscience
Pathology
C9orf72
Allele
Trinucleotide repeat expansion
Biochemistry
Chemistry
Internal medicine
Molecular biology
Dementia
Frontotemporal dementia
Spinal cord
CD81
Hepatitis C virus
Motor neuron
Neurodegeneration
Virus
Cell
Glycoprotein
Oxidative stress
RNA
SOD1
Tetraspanin