Resultats de la cerca - Adrian Higginbottom

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  1. 1
    An in vitro screening cascade to identify neuroprotective antioxidants in ALS

    An in vitro screening cascade to identify neuroprotective antioxidants in ALS per Siân C. Barber, Adrian Higginbottom, Richard J. Mead, Stuart Barber, Pamela J. Shaw

    Publicat 2009
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  2. 2
    A new zebrafish model produced by TILLING of SOD1-related amyotrophic lateral sclerosis replicates key features of the disease and represents a tool for <i>in vivo</i> therapeutic screening

    A new zebrafish model produced by TILLING of SOD1-related amyotrophic lateral sclerosis replicates key features of the disease and represents a tool for <i>in vivo</i> therapeutic... per Marc Da Costa, Claire Allen, Adrian Higginbottom, Tennore Ramesh, Pamela J. Shaw, Christopher McDermott

    Publicat 2013
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  3. 3
    CD81 Is Required for Hepatitis C Virus Glycoprotein-Mediated Viral Infection

    CD81 Is Required for Hepatitis C Virus Glycoprotein-Mediated Viral Infection per Jie Zhang, Glenn Randall, Adrian Higginbottom, Peter N. Monk, Charles M. Rice, Jane A. McKeating

    Publicat 2004
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  4. 4
    Dysregulation of astrocyte–motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis

    Dysregulation of astrocyte–motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis per Laura Ferraiuolo, Adrian Higginbottom, Paul R. Heath, Siân C. Barber, David Greenald, Janine Kirby, Pamela J. Shaw

    Publicat 2011
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  5. 5
    Simultaneous and independent detection of C9ORF72 alleles with low and high number of GGGGCC repeats using an optimised protocol of Southern blot hybridisation

    Simultaneous and independent detection of C9ORF72 alleles with low and high number of GGGGCC repeats using an optimised protocol of Southern blot hybridisation per Vladimir L. Buchman, Johnathan Cooper‐Knock, Natalie Connor‐Robson, Adrian Higginbottom, Janine Kirby, O D Razinskaya, Natalia Ninkina, Pamela J. Shaw

    Publicat 2013
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  6. 6
    Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features

    Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features per M. Shaw, Adrian Higginbottom, Alexander McGown, Lydia M. Castelli, E Goldman James, Guillaume M. Hautbergue, Pamela J. Shaw, Tennore Ramesh

    Publicat 2018
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  7. 7
    PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons

    PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons per Ke Ning, Carsten Drepper, Chiara F. Valori, Mansoor Ahsan, Matthew Wyles, Adrian Higginbottom, Thomas Herrmann, Pamela J. Shaw, Mimoun Azzouz, Michael Sendtner

    Publicat 2010
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  8. 8
    Recombinant Extracellular Domains of Tetraspanin Proteins Are Potent Inhibitors of the Infection of Macrophages by Human Immunodeficiency Virus Type 1

    Recombinant Extracellular Domains of Tetraspanin Proteins Are Potent Inhibitors of the Infection of Macrophages by Human Immunodeficiency Virus Type 1 per Siu‐Hong Ho, Francine Martin, Adrian Higginbottom, Lynda J. Partridge, V. Parthasarathy, Gregory W. Moseley, Peter Lopez, Cecilia Cheng‐Mayer, Peter N. Monk

    Publicat 2006
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  9. 9
    Characterization of Hepatitis C Virus E2 Glycoprotein Interaction with a Putative Cellular Receptor, CD81

    Characterization of Hepatitis C Virus E2 Glycoprotein Interaction with a Putative Cellular Receptor, CD81 per Mike Flint, Catherine Maidens, Larry D. Loomis-Price, C Shotton, Jean Dubuisson, Peter N. Monk, Adrian Higginbottom, Shoshana Levy, Jane A. McKeating

    Publicat 1999
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  10. 10
    Endothelial tetraspanin microdomains regulate leukocyte firm adhesion during extravasation

    Endothelial tetraspanin microdomains regulate leukocyte firm adhesion during extravasation per Olga Barreiro, María Yáñez‐Mó, Mónica Sala-Valdés, María Dolores Gutiérrez‐López, Susana Ovalle, Adrian Higginbottom, Peter N. Monk, Carlos Cabañas, Francisco Sánchez‐Madrid

    Publicat 2005
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  11. 11
    Oligodendrocyte pathology exceeds axonal pathology in white matter in human amyotrophic lateral sclerosis

    Oligodendrocyte pathology exceeds axonal pathology in white matter in human amyotrophic lateral sclerosis per Alejandro Lorente Pons, Adrian Higginbottom, Johnathan Cooper‐Knock, Aziza Alrafiah, Ebtisam A. Al-ofi, Janine Kirby, Pamela J. Shaw, Jonathan Wood, J. Robin Highley

    Publicat 2020
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  12. 12
    A neuronal <scp>DNA</scp> damage response is detected at the earliest stages of <scp>A</scp>lzheimer's neuropathology and correlates with cognitive impairment in the <scp>M</scp>edical <scp>R</scp>esearch <scp>C</scp>ouncil's <scp>C</scp>ognitive <scp>F</scp>unction and <scp>A</scp>geing <scp>S</scp>tudy ageing brain cohort

    A neuronal <scp>DNA</scp> damage response is detected at the earliest stages of <scp>A</scp>lzheimer's neuropathology and correlates with cognitive impairment in the <scp>M</scp>ed... per Julie E. Simpson, Paul G. Ince, Fiona E. Matthews, Pamela J. Shaw, Paul R. Heath, Carol Brayne, Claire J. Garwood, Adrian Higginbottom, Stephen B. Wharton

    Publicat 2014
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  13. 13
    Distinct roles for tetraspanins CD9, CD63 and CD81 in the formation of multinucleated giant cells

    Distinct roles for tetraspanins CD9, CD63 and CD81 in the formation of multinucleated giant cells per V. Parthasarathy, Francine Martin, Adrian Higginbottom, Helen C. Murray, Gregory W. Moseley, Robert C. Read, Gorakh Mal, Rachel Hulme, Peter N. Monk, Lynda J. Partridge

    Publicat 2009
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  14. 14
    Identification of Amino Acid Residues in CD81 Critical for Interaction with Hepatitis C Virus Envelope Glycoprotein E2

    Identification of Amino Acid Residues in CD81 Critical for Interaction with Hepatitis C Virus Envelope Glycoprotein E2 per Adrian Higginbottom, Elizabeth R. Quinn, Chiung-Chi Kuo, Mike Flint, Louise H. Wilson, Elisabetta Bianchi, Alfredo Nicosia, Peter N. Monk, Jane A. McKeating, Shoshana Levy

    Publicat 2000
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  15. 15
    Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy

    Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy per Johnathan Cooper‐Knock, Adrian Higginbottom, Matthew J. Stopford, J. Robin Highley, Paul G. Ince, Stephen B. Wharton, Stuart Pickering‐Brown, Janine Kirby, Guillaume M. Hautbergue, Pamela J. Shaw

    Publicat 2015
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  16. 16
    C9ORF72 GGGGCC Expanded Repeats Produce Splicing Dysregulation which Correlates with Disease Severity in Amyotrophic Lateral Sclerosis

    C9ORF72 GGGGCC Expanded Repeats Produce Splicing Dysregulation which Correlates with Disease Severity in Amyotrophic Lateral Sclerosis per Johnathan Cooper‐Knock, Joanna J. Bury, Paul R. Heath, Matthew Wyles, Adrian Higginbottom, Catherine Gelsthorpe, J. Robin Highley, Guillaume M. Hautbergue, Magnus Rattray, Janine Kirby, Pamela J. Shaw

    Publicat 2015
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  17. 17
    A bacterial artificial chromosome mouse model of amyotrophic lateral sclerosis manifests ‘space cadet syndrome’ on two FVB backgrounds

    A bacterial artificial chromosome mouse model of amyotrophic lateral sclerosis manifests ‘space cadet syndrome’ on two FVB backgrounds per Shirlene Badger, Ian Coldicott, Ergita Kyrgiou-Balli, Adrian Higginbottom, Chloé Moutin, Kamallia Mohd Imran, John C. C. Day, Johnathan Cooper‐Knock, Richard J. Mead, James J. P. Alix

    Publicat 2025
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  18. 18
    TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons

    TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons per Miriam A. Vogt, Zahra Ehsaei, Philip Knuckles, Adrian Higginbottom, Michaela S. Helmbrecht, Tilo Kunath, Kevin Eggan, Luis A. Williams, Pamela J. Shaw, Wolfgang Wurst, Thomas Floß, Andrea B. Huber, Verdon Taylor

    Publicat 2018
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  19. 19
    S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis

    S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis per Richard J. Mead, Adrian Higginbottom, Scott P. Allen, Janine Kirby, Ellen Bennett, Siân C. Barber, Paul R. Heath, Antonio Coluccia, Neelam Patel, Iain Gardner, Andrea Brancale, Andrew J. Grierson, Pamela J. Shaw

    Publicat 2013
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  20. 20
    Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions

    Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions per Johnathan Cooper‐Knock, Matthew J. Walsh, Adrian Higginbottom, J. Robin Highley, Mark J. Dickman, Dieter Edbauer, Paul G. Ince, Stephen B. Wharton, Stuart A. Wilson, Janine Kirby, Guillaume M. Hautbergue, Pamela J. Shaw

    Publicat 2014
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