Search Results - Adam Sharp

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  1. 1
    A New Old Target: Androgen Receptor Signaling and Advanced Prostate Cancer

    A New Old Target: Androgen Receptor Signaling and Advanced Prostate Cancer by Daniel Westaby, Maria D. Fenor de la Maza, Alec Paschalis, Juan M. Jiménez‐Vacas, Jon Welti, Johann S. de Bono, Adam Sharp

    Published 2021
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  2. 2
    Treatment-related adverse events of antibody drug-conjugates in clinical trials

    Treatment-related adverse events of antibody drug-conjugates in clinical trials by Harold Nathan Tan, Marta Ascanio Morcillo, Juanita Lopez, Anna Minchom, Adam Sharp, Alec Paschalis, Georgina Silva-Fortes, Bindumalini Raobaikady, Udai Banerji

    Published 2025
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  3. 3
    Analytical Validation and Clinical Qualification of a New Immunohistochemical Assay for Androgen Receptor Splice Variant-7 Protein Expression in Metastatic Castration-resistant Prostate Cancer

    Analytical Validation and Clinical Qualification of a New Immunohistochemical Assay for Androgen Receptor Splice Variant-7 Protein Expression in Metastatic Castration-resistant Pro... by Jonathan Welti, Daniel Nava Rodrigues, Adam Sharp, Shihua Sun, David Lorente, Ruth Riisnaes, Ines Figueiredo, Zafeiris Zafeiriou, Pasquale Rescigno, Johann S. de Bono, Stephen R. Plymate

    Published 2016
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  4. 4
    Treatment with abiraterone and enzalutamide does not overcome poor outcome from metastatic castration-resistant prostate cancer in men with the germline homozygous HSD3B1 c.1245C genotype

    Treatment with abiraterone and enzalutamide does not overcome poor outcome from metastatic castration-resistant prostate cancer in men with the germline homozygous HSD3B1 c.1245C g... by Changxue Lu, Angelika Terbuch, David Dolling, Jun Yu, Haopeng Wang, Y. Chen, Julia Fountain, Cláudia Bertan, Adam Sharp, Suzanne Carreira, William B. Isaacs, Emmanuel S. Antonarakis, Johann S. de Bono, Jun Luo

    Published 2020
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  5. 5
    Abstract CT007: PETRA: First in class, first in human trial of the next generation PARP1-selective inhibitor AZD5305 in patients (pts) with BRCA1/2, PALB2 or RAD51C/D mutations

    Abstract CT007: PETRA: First in class, first in human trial of the next generation PARP1-selective inhibitor AZD5305 in patients (pts) with BRCA1/2, PALB2 or RAD51C/D mutations by Timothy A. Yap, Seock‐Ah Im, Alison M. Schram, Adam Sharp, Judith Balmañà, Richard D. Baird, Jessica Brown, Maria Schwaederlé, Elizabeth A. Pilling, Ganesh Moorthy, Spiros Linardopoulos, Adam Dowson, Carol Pound, Edit Lukacs, Sabina Cosulich, Stephen J. Luen

    Published 2022
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  6. 6
    Activation of MAPK Signaling by CXCR7 Leads to Enzalutamide Resistance in Prostate Cancer

    Activation of MAPK Signaling by CXCR7 Leads to Enzalutamide Resistance in Prostate Cancer by Shangze Li, Ka-wing Fong, Galina Gritsina, Ali Zhang, Jonathan C. Zhao, Jung Kim, Adam Sharp, Wei Yuan, Caterina Aversa, Ximing J. Yang, Peter S. Nelson, Felix Y. Feng, Arul M. Chinnaiyan, Johann S. de Bono, Colm Morrissey, Matthew B. Rettig, Jindan Yu

    Published 2019
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  7. 7
    RB1 Heterogeneity in Advanced Metastatic Castration-Resistant Prostate Cancer

    RB1 Heterogeneity in Advanced Metastatic Castration-Resistant Prostate Cancer by Daniel Nava Rodrigues, Nicola Casiraghi, Alessandro Romanel, Mateus Crespo, Susana Miranda, Pasquale Rescigno, Ines Figueiredo, Ruth Riisnaes, Suzanne Carreira, Semini Sumanasuriya, Paola Gasperini, Adam Sharp, Joaquı́n Mateo, Alan Makay, Christopher McNair, Matthew J. Schiewer, Karen E. Knudsen, Gunther Boysen, Francesca Demichelis, Johann S. de Bono

    Published 2018
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  8. 8
    Genomic Analysis of Three Metastatic Prostate Cancer Patients with Exceptional Responses to Carboplatin Indicating Different Types of DNA Repair Deficiency

    Genomic Analysis of Three Metastatic Prostate Cancer Patients with Exceptional Responses to Carboplatin Indicating Different Types of DNA Repair Deficiency by Zafeiris Zafeiriou, Diletta Bianchini, Robert W. Chandler, Pasquale Rescigno, Wei Yuan, Suzanne Carreira, Maialen Barrero, Antonella Petremolo, Susana Miranda, Ruth Riisnaes, Daniel Nava Rodrigues, Bora Gürel, Semini Sumanasuriya, Alec Paschalis, Adam Sharp, Joaquı́n Mateo, Nina Tunariu, Arul M. Chinnaiyan, Colin C. Pritchard, Kevin Kelly, Johann S. de Bono

    Published 2018
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  9. 9
    Prostate-specific Membrane Antigen Heterogeneity and DNA Repair Defects in Prostate Cancer

    Prostate-specific Membrane Antigen Heterogeneity and DNA Repair Defects in Prostate Cancer by Alec Paschalis, Beshara Sheehan, Ruth Riisnaes, Daniel Nava Rodrigues, Bora Gürel, Cláudia Bertan, Ana Ferreira, Maryou B. Lambros, George Seed, Wei Yuan, David Dolling, Jon Welti, Antje Neeb, Semini Sumanasuriya, Pasquale Rescigno, Diletta Bianchini, Nina Tunariu, Suzanne Carreira, Adam Sharp, Wim J.G. Oyen, Johann S. de Bono

    Published 2019
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  10. 10
    Androgen receptor splice variant-7 expression emerges with castration resistance in prostate cancer

    Androgen receptor splice variant-7 expression emerges with castration resistance in prostate cancer by Adam Sharp, Ilsa M. Coleman, Wei Yuan, Cynthia C.T. Sprenger, David Dolling, Daniel Nava Rodrigues, Joshua W. Russo, Ines Figueiredo, Cláudia Bertan, George Seed, Ruth Riisnaes, Takuma Uo, Antje Neeb, Jonathan Welti, Colm Morrissey, Suzanne Carreira, Jun Luo, Peter S. Nelson, Steven P. Balk, Lawrence D. True, Johann S. de Bono, Stephen R. Plymate

    Published 2018
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  11. 11
    The landscape of RNA polymerase II–associated chromatin interactions in prostate cancer

    The landscape of RNA polymerase II–associated chromatin interactions in prostate cancer by Susmita G. Ramanand, Yong Chen, Jiapei Yuan, Kelly Daescu, Maryou Lambros, Kathleen E. Houlahan, Suzanne Carreira, Wei Yuan, GuemHee Baek, Adam Sharp, Alec Paschalis, Mohammed Kanchwala, Yunpeng Gao, Adam J. Aslam, Nida Safdar, Xiaowei Zhan, Ganesh V. Raj, Chao Xing, Paul C. Boutros, Johann S. de Bono, Michael Q. Zhang, Ram S. Mani

    Published 2020
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  12. 12
    Androgen receptor-modulatory microRNAs provide insight into therapy resistance and therapeutic targets in advanced prostate cancer

    Androgen receptor-modulatory microRNAs provide insight into therapy resistance and therapeutic targets in advanced prostate cancer by Claire Fletcher, Eric Sulpice, Stéphanie Combe, Akifumi Shibakawa, Damien A. Leach, Mark P. Hamilton, Stelios Chrysostomou, Adam Sharp, Jon Welti, Wei Yuan, D. Alwyn Dart, Eleanor Knight, Jian Ning, Jeffrey C. Francis, Evangelia E. Kounatidou, Luke Gaughan, Amanda Swain, Shawn E. Lupold, Johann S. de Bono, Sean E. McGuire, Xavier Gidrol, Charlotte L. Bevan

    Published 2019
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  13. 13
    Novel Junction-specific and Quantifiable In Situ Detection of AR-V7 and its Clinical Correlates in Metastatic Castration-resistant Prostate Cancer

    Novel Junction-specific and Quantifiable In Situ Detection of AR-V7 and its Clinical Correlates in Metastatic Castration-resistant Prostate Cancer by Yezi Zhu, Adam Sharp, Courtney Anderson, John L. Silberstein, Maritza N. Taylor, Changxue Lu, Pei Zhao, Angelo M. De Marzo, Emmanuel S. Antonarakis, Mindy Wang, Xingyong Wu, Yuling Luo, Nan Su, Daniel Nava Rodrigues, Ines Figueiredo, Jonathan Welti, Emily Park, Xiao-Jun Ma, Ilsa M. Coleman, Colm Morrissey, Stephen R. Plymate, Peter S. Nelson, Johann S. de Bono, Jun Luo

    Published 2017
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  14. 14
    BRD4 Promotes DNA Repair and Mediates the Formation of TMPRSS2-ERG Gene Rearrangements in Prostate Cancer

    BRD4 Promotes DNA Repair and Mediates the Formation of TMPRSS2-ERG Gene Rearrangements in Prostate Cancer by Xiangyi Li, GuemHee Baek, Susmita G. Ramanand, Adam Sharp, Yunpeng Gao, Wei Yuan, Jon Welti, Daniel Nava Rodrigues, David Dolling, Ines Figueiredo, Semini Sumanasuriya, Mateus Crespo, Adam J. Aslam, Rui Li, Yi Yin, Bipasha Mukherjee, Mohammed Kanchwala, Ashley M. Hughes, Wendy S. Halsey, Cheng-Ming Chiang, Chao Xing, Ganesh V. Raj, Sandeep Burma, Johann S. de Bono, Ram S. Mani

    Published 2018
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  15. 15
    Targeting Bromodomain and Extra-Terminal (BET) Family Proteins in Castration-Resistant Prostate Cancer (CRPC)

    Targeting Bromodomain and Extra-Terminal (BET) Family Proteins in Castration-Resistant Prostate Cancer (CRPC) by Jonathan Welti, Adam Sharp, Wei Yuan, David Dolling, Daniel Nava Rodrigues, Ines Figueiredo, Veronica Gil, Antje Neeb, Matthew Clarke, George Seed, Mateus Crespo, Semini Sumanasuriya, Jian Ning, Eleanor Knight, Jeffrey C. Francis, Ashley M. Hughes, Wendy S. Halsey, Alec Paschalis, Ram S. Mani, Ganesh V. Raj, Stephen R. Plymate, Suzanne Carreira, Gunther Boysen, Arul M. Chinnaiyan, Amanda Swain, Johann S. de Bono

    Published 2018
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  16. 16
    Characterizing CDK12-Mutated Prostate Cancers

    Characterizing CDK12-Mutated Prostate Cancers by Pasquale Rescigno, Bora Gürel, Rita Pereira, Mateus Crespo, Jan Rekowski, Mattia Rediti, Maialen Barrero, Joaquı́n Mateo, Diletta Bianchini, Carlo Messina, Maria D. Fenor de la Maza, Khobe Chandran, Juliet Carmichael, Christina Guo, Alec Paschalis, Adam Sharp, George Seed, Ines Figueiredo, Maryou Lambros, Susana Miranda, Ana Ferreira, Cláudia Bertan, Ruth Riisnaes, Núria Porta, Wei Yuan, Suzanne Carreira, Johann S. de Bono

    Published 2020
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  17. 17
    IL-23 secreted by myeloid cells drives castration-resistant prostate cancer

    IL-23 secreted by myeloid cells drives castration-resistant prostate cancer by Arianna Calcinotto, Clarissa Spataro, Elena Zagato, Diletta Di Mitri, Veronica Gil, Mateus Crespo, Gaston De Bernardis, Marco Losa, Michela Mirenda, Emiliano Pasquini, Andrea Rinaldi, Semini Sumanasuriya, Maryou Lambros, Antje Neeb, Roberta Lucianò, Carlo Andrea Bravi, Daniel Nava Rodrigues, David Dolling, Tommaso Prayer‐Galetti, Ana Ferreira, Alberto Briganti, Antonio Esposito, Simon T. Barry, Wei Yuan, Adam Sharp, Johann S. de Bono, Andrea Alimonti

    Published 2018
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  18. 18
    A phase I dose-escalation study of enzalutamide in combination with the AKT inhibitor AZD5363 (capivasertib) in patients with metastatic castration-resistant prostate cancer

    A phase I dose-escalation study of enzalutamide in combination with the AKT inhibitor AZD5363 (capivasertib) in patients with metastatic castration-resistant prostate cancer by Michael Paul Kolinsky, Pasquale Rescigno, Diletta Bianchini, Zafeiris Zafeiriou, Niven Mehra, Joaquı́n Mateo, Vasiliki Michalarea, Ruth Riisnaes, Mateus Crespo, I. Figueiredo, Susana Miranda, Daniel Nava Rodrigues, Penelope Flohr, Nina Tunariu, Udai Banerji, Ruth Ruddle, Adam Sharp, Jonathan Welti, Maryou Lambros, Suzanne Carreira, Florence I. Raynaud, Karen E. Swales, Stephen R. Plymate, Jun Luo, Holly Tovey, Núria Porta, Rachel M. Slade, Lorna Leonard, Emma Hall, Johann S. de Bono

    Published 2020
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  19. 19
    Elucidating Prostate Cancer Behaviour During Treatment via Low-pass Whole-genome Sequencing of Circulating Tumour DNA

    Elucidating Prostate Cancer Behaviour During Treatment via Low-pass Whole-genome Sequencing of Circulating Tumour DNA by Semini Sumanasuriya, George Seed, Harry Parr, Rossitza Christova, Lorna Pope, Cláudia Bertan, Diletta Bianchini, Pasquale Rescigno, Ines Figueiredo, Jane Goodall, Gemma Fowler, Penelope Flohr, Niven Mehra, Antje Neeb, Jan Rekowski, Mario A. Eisenberger, Oliver Sartor, Stéphane Oudard, Christine Geffriaud-Ricouard, Ayse Ӧzatılgan, Mustapha Chadjaa, Sandrine Macé, Christopher J. Lord, Joe Baxter, Stephen J. Pettitt, Maryou Lambros, Adam Sharp, Joaquı́n Mateo, Suzanne Carreira, Wei Yuan, Johann S. de Bono

    Published 2021
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  20. 20
    Circulating Cell-Free DNA to Guide Prostate Cancer Treatment with PARP Inhibition

    Circulating Cell-Free DNA to Guide Prostate Cancer Treatment with PARP Inhibition by Jane Goodall, Joaquı́n Mateo, Wei Yuan, Helen Mossop, Núria Porta, Susana Miranda, Raquel Pérez-López, David Dolling, Dan R. Robinson, Shahneen Sandhu, Gemma Fowler, Berni Ebbs, Penny Flohr, George Seed, Daniel Nava Rodrigues, Gunther Boysen, Cláudia Bertan, Mark Atkin, Matthew Clarke, Mateus Crespo, Ines Figueiredo, Ruth Riisnaes, Semini Sumanasuriya, Pasquale Rescigno, Zafeiris Zafeiriou, Adam Sharp, Nina Tunariu, Diletta Bianchini, Alexa Gillman, Christopher J. Lord, Emma Hall, Arul M. Chinnaiyan, Suzanne Carreira, Johann S. de Bono

    Published 2017
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